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Neurostimulation and Recording of Real World Spatial Navigation in Humans

Award Number: U01NS117838
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Neurostimulation and Recording of Real World Spatial Navigation in Humans - Project Summary/Abstract Decades of research and clinical observations have established that successful spatial navigation and memory depend on the hippocampus and associated structures in the medial temporal lobe (MTL), including entorhinal, perirhinal and parahippocampal cortices [1, 2]. It is thought that the supporting neuronal mechanisms rely on key oscillatory patterns of activity within the MTL that change dynamically when navigating through an environment [3-10]. However, traditional human neuroimaging methodologies do now allow for recording of MTL oscillatory activity during spatial navigation let alone physical movement. The proposed project will implement a first-of-its- kind platform for wireless deep brain recording and stimulation of MTL oscillatory activity during freely moving behaviors to investigate the relationship between spatial navigation, memory, and oscillatory activity, using intracranial electroencephalographic (iEEG) recordings in participants who are implanted with the Neuropace Responsive Neurostimulator (RNS®) for clinical evaluation and treatment of epilepsy. The RNS device will allow for the stimulation and recording of MTL iEEG activity during virtual reality (VR), augmented reality (AR), and real world (RW) spatial navigation tasks with simultaneous recording full-body and eye position and movement using wearable technologies. Together these studies will have access to 70 rare participants implanted with the RNS system over the project period through an ongoing multi-institutional collaboration among clinical and basic science leaders at UCLA, Stanford, and UCSF. Since our studies address basic questions about the role of oscillations in memory, the results will allow for the bridging of findings between species and lay the scientific foundation for helping future patients with diseases where memory is impaired such as Alzheimer’s disease and epilepsy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $45,691 )
2026	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/18/2025	NON-COMPETING CONTINUATION	$0
2026	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	1/6/2026	NON-COMPETING CONTINUATION	-$162,168
2026	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	1/30/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2026	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	1/9/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$207,859
														Subtotal = $45,691

Issue Date FY: 2024 ( Subtotal = $964,397 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	7/15/2024	NON-COMPETING CONTINUATION	$964,397
														Subtotal = $964,397

Issue Date FY: 2023 ( Subtotal = $1,067,010 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/21/2023	NON-COMPETING CONTINUATION	$1,067,010
														Subtotal = $1,067,010

Issue Date FY: 2022 ( Subtotal = $1,074,651 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	7/14/2022	NON-COMPETING CONTINUATION	$1,074,651
2022	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	4/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,074,651

Issue Date FY: 2021 ( Subtotal = $1,102,664 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	7/16/2021	NON-COMPETING CONTINUATION	$1,102,664
														Subtotal = $1,102,664

Issue Date FY: 2020 ( Subtotal = $1,089,050 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/24/2020	NEW	$0
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/21/2020	NEW	$1,089,050
														Subtotal = $1,089,050

Grand Total All Awards = $5,343,463

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Neurostimulation and Recording of Real World Spatial Navigation in Humans

Award Number: U01NS117838

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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