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Molecular Pathways to Pathogenesis in Toxicology

Award Number: T32ES007046
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/1977
PERIOD OF PERFORMANCE END DATE: 06/30/2031

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Molecular Pathways to Pathogenesis in Toxicology - ABSTRACT The Molecular Pathways to Pathogenesis in Toxicology (MPPT) T32 Training Grant (TG) at NC State, supported by the National Institute of Environmental Health Sciences (NIEHS), is a long-standing, multidisciplinary program with a 44-year history of excellence. It has trained over 200 scientists who are now key opinion leaders in academia, government institutions, and the private sector. Anchored within NC State’s highly ranked Toxicology Program, the MPPT T32 TG consists of highly qualified mentors, strong trainees, and a robust connection to local universities and institutions. Our mission is to provide future generations of Toxicologists/Environmental Health Science (EHS) researchers with the didactic, scientific and professional skills necessary to conduct high impact EHS research, communicate effectively to a wide variety of audiences, and work within multidisciplinary teams to understand how human health is impacted by environmental factors. This renewal continues our training focus on Molecular Pathways to Pathogenesis in Toxicology within a systems biology framework that spans molecular, cellular, organismal, and population-based biology. This approach integrates multiple levels of biological organization from biomolecules to human populations to elucidate the fundamental mechanisms through which environmental stressors influence human health outcomes. We propose a training team of 28 active research mentors, including 9 new mentors, and request continued support for six predoctoral trainees per year for a two-year duration. We propose to further enhance our trainee experience with greater career development opportunities for our trainees; an extensive alumni community to help our trainees prepare for entry into the workforce; enhanced training for mentors; updated curricula in mechanisms of toxicology, including a broader set of elective classes that are responsive to student demand and reflect contemporary advances in the field; and key research foci to better accomplish our training mission in conjunction with key thematic priorities in mechanistic toxicology and environmental health sciences. We also propose improving integration with NC State’s newly established Genetics and Genomics Scholars Program, offering applicants additional pathways for Toxicology/EHS training. Our mentors are supported by substantial funding from NIEHS, other NIH institutes, federal and state agencies (including DOD, EPA, NSF), and private foundations. The recent renewal of the NIEHS EHS Core Center (P30), launch of the Southern Liver Health Study, and establishment of the NC Center for Coastal Algae, People, and Environment further strengthen our research ecosystem and offers exceptional resources for trainee development. Our EHS centers serve as an extraordinary resource for trainees through access to core facilities, sponsored symposia, seminars, workshops and professional development opportunities. The MPPT T32 TG remains the cornerstone of Toxicology graduate education at NC State. With a dedicated team of mentors, competitive trainee pool, and a dynamic research environment, the program is well-positioned to continue its legacy of excellence in training the next generation of toxicology/EHS leaders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $224,905 )
2026	2026	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	46	7/3/2026	COMPETING CONTINUATION	$224,905
														Subtotal = $224,905

Issue Date FY: 2025 ( Subtotal = $121,060 )
2025	2025	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	45	7/15/2025	NON-COMPETING CONTINUATION	$121,060
														Subtotal = $121,060

Issue Date FY: 2024 ( Subtotal = $250,398 )
2024	2024	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	44	7/3/2024	NON-COMPETING CONTINUATION	$250,398
														Subtotal = $250,398

Issue Date FY: 2023 ( Subtotal = $238,643 )
2023	2023	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	000	43	5/16/2023	NON-COMPETING CONTINUATION	$238,643
														Subtotal = $238,643

Issue Date FY: 2022 ( Subtotal = $1 )
2022	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	005	42	5/24/2022	NON-COMPETING CONTINUATION	$1
2022	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	002	41	2/2/2022	COMPETING CONTINUATION	$326,355
2022	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	004	41	2/28/2022	COMPETING CONTINUATION	$0
2022	2020	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	003	40	2/2/2022	SUPPLEMENT FOR EXPANSION	-$160,464
2022	2019	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	001	40	2/2/2022	NON-COMPETING CONTINUATION	-$64,600
2022	2018	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	000	39	2/2/2022	NON-COMPETING CONTINUATION	-$101,291
														Subtotal = $1

Issue Date FY: 2021 ( Subtotal = $293,657 )
2021	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	000	41	7/16/2021	COMPETING CONTINUATION	$293,657
														Subtotal = $293,657

Issue Date FY: 2020 ( Subtotal = $160,464 )
2020	2020	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	001	40	9/23/2020	SUPPLEMENT FOR EXPANSION	$160,464
2020	2019	NORTH CAROLINA STATE UNIVERSITY	2701 SULLIVAN DR STE 240	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	40	1/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $160,464

Issue Date FY: 2019 ( Subtotal = $64,600 )
2019	2019	NORTH CAROLINA STATE UNIVERSITY	2701 SULLIVAN DR STE 240	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	40	6/27/2019	NON-COMPETING CONTINUATION	$64,600
														Subtotal = $64,600

Issue Date FY: 2018 ( Subtotal = $280,212 )
2018	2018	NORTH CAROLINA STATE UNIVERSITY	2701 SULLIVAN DR STE 240	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	39	6/25/2018	NON-COMPETING CONTINUATION	$280,212
														Subtotal = $280,212

Issue Date FY: 2017 ( Subtotal = $276,021 )
2017	2017	NORTH CAROLINA STATE UNIVERSITY	2701 SULLIVAN DR STE 240 CAMPUS BX 7514	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	38	7/4/2017	NON-COMPETING CONTINUATION	$276,021
														Subtotal = $276,021

Issue Date FY: 2016 ( Subtotal = $272,987 )
2016	2016	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	37	6/30/2016	NON-COMPETING CONTINUATION	$272,987
														Subtotal = $272,987

Issue Date FY: 2015 ( Subtotal = $270,033 )
2015	2015	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	36	7/1/2015	COMPETING CONTINUATION	$270,033
														Subtotal = $270,033

Issue Date FY: 2014 ( Subtotal = $263,569 )
2014	2014	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	35	6/30/2014	NON-COMPETING CONTINUATION	$263,569
														Subtotal = $263,569

Issue Date FY: 2013 ( Subtotal = $276,446 )
2013	2013	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	34	7/1/2013	NON-COMPETING CONTINUATION	$276,446
														Subtotal = $276,446

Issue Date FY: 2012 ( Subtotal = $176,446 )
2012	2012	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	33	6/28/2012	NON-COMPETING CONTINUATION	$176,446
														Subtotal = $176,446

Issue Date FY: 2011 ( Subtotal = $266,389 )
2011	2011	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	32	7/1/2011	NON-COMPETING CONTINUATION	$266,389
														Subtotal = $266,389

Issue Date FY: 2010 ( Subtotal = $258,509 )
2010	2010	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	31	7/1/2010	COMPETING CONTINUATION	$258,509
														Subtotal = $258,509

Issue Date FY: 2009 ( Subtotal = $107,386 )
2009	2009	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	001	30	7/2/2009	SUPPLEMENT FOR EXPANSION	$107,386
2009	2008	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	30	7/2/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $107,386

Issue Date FY: 2008 ( Subtotal = $186,684 )
2008	2008	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	30	6/25/2008	NON-COMPETING CONTINUATION	$186,684
														Subtotal = $186,684

Issue Date FY: 2007 ( Subtotal = $186,684 )
2007	2007	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	29	6/29/2007	NON-COMPETING CONTINUATION	$186,684
														Subtotal = $186,684

Issue Date FY: 2006 ( Subtotal = $176,684 )
2006	2006	NORTH CAROLINA STATE UNIVERSITY AT RALEIGH	POB 7214, LEAZAR HALL RM 1	RALEIGH	NC	27695	WAKE	USA	Resource and Manpower Development in the Environmental Health Sciences	000	28	6/26/2006	NON-COMPETING CONTINUATION	$176,684
														Subtotal = $176,684

Issue Date FY: 2004 ( Subtotal = $186,684 ) (Continued on the next page)
Grand Total All Awards = $5,084,046

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Molecular Pathways to Pathogenesis in Toxicology

Award Number: T32ES007046

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/1977

PERIOD OF PERFORMANCE END DATE: 06/30/2031

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