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Scalable and Sensor-Agnostic Software for Distributed Processing and Visualization of Multi-Site MEG/EEG Datasets

Award Number: R01NS104585
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2018
PERIOD OF PERFORMANCE END DATE: 02/28/2023

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Scalable and Sensor-Agnostic Software for Distributed Processing and Visualization of Multi-Site MEG/EEG Datasets - Project Summary During the past three decades non-invasive functional brain imaging has developed immensely in terms of measurement technologies, analysis methods, and innovative paradigms to capture information about brain function both in healthy and diseased individuals. While functional MRI (fMRI) provides a wealth of information by measuring the indirect slow hemodynamic signals. Magnetoencephalography (MEG) and electroencephalography (EEG) remain the only noninvasive techniques capable of directly measuring the electrophysiological activity directly with a millisecond resolution. During the past twelve years we have developed, with NIH support, the MNE-Python software, which covers multiple methods of data preprocessing, source localization, statistical analysis, and estimation of functional connectivity between distributed brain regions. All algorithms and utility functions are implemented in a consistent manner with well-documented interfaces, enabling users to create M/EEG data analysis pipelines by writing Python scripts. To further extend our software to meet the needs of a growing user base and reflect recent developments in MEG/EEG as well as in invasive electrophysiological recordings. Optically Pumped Magnetometers (OPMs) are sensitive room- temperature magnetic field sensors that have begun to provide movable, flexible, lightweight, on-scalp MEG systems, and may soon provide higher signal-to-noise ratio and more complete spatial frequency sampling than SQUID-based systems. However, analysis tools optimal processing of OPM-MEG data are largely missing. Therefore, in Aim 1, we will introduce tools for High-Resolution On-Scalp OPM-MEG Data Analysis. Electrocorticography (ECoG) and subcortical EEG (sEEG) provide focal spatial measurements of the electrophysiological activity. In Aim 2, we will develop sEEG and ECoG workflows, which includes electrode localization and intracranial inverse and forward modeling. Recent methodological advances by our group and the availability of on-scalp OPM-MEG systems (Aim 1) and ECoG/sEEG (Aim 2) have expanded the possibilities for improved localization of deep (cortical and subcortical) sources in basic and clinical research applications. In Aim 3, we will introduce these methods to the repertoire of MNE-Python and will use phantom recordings, human data with known ground truth, and existing MEG databases to validate the new methods. Finally, in Aim 4, we will continue to develop MNE-Python using best programming practices ensuring multiplatform compatibility, extensive web-based documentation, training and forums, and hands-on training workshops.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $455,946 )
2025	2025	AALTO-KORKEAKOULUSAATIO SR	OTAKAARI 1	ESPOO				FIN	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	12/18/2024	NON-COMPETING CONTINUATION	$458,001
2025	2022	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	1/13/2025	COMPETING CONTINUATION	-$2,055
														Subtotal = $455,946

Issue Date FY: 2024 ( Subtotal = $507,643 )
2024	2024	AALTO-KORKEAKOULUSAATIO SR	OTAKAARI 1	ESPOO				FIN	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	12/27/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$507,643
2024	2024	AALTO-KORKEAKOULUSAATIO SR	OTAKAARI 1	ESPOO				FIN	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	4/18/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$365,354
2024	2022	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	4/18/2024	COMPETING CONTINUATION	-$365,354
2024	2022	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/22/2023	COMPETING CONTINUATION	$0
														Subtotal = $507,643

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	2/13/2023	COMPETING CONTINUATION	$30,380
2023	2021	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/13/2023	NON-COMPETING CONTINUATION	-$30,380
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $671,289 )
2022	2022	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/16/2022	COMPETING CONTINUATION	$671,289
														Subtotal = $671,289

Issue Date FY: 2021 ( Subtotal = $543,993 )
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	6/15/2021	NON-COMPETING CONTINUATION	$543,993
														Subtotal = $543,993

Issue Date FY: 2020 ( Subtotal = $543,993 )
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	5/29/2020	NON-COMPETING CONTINUATION	$543,993
														Subtotal = $543,993

Issue Date FY: 2019 ( Subtotal = $543,993 )
2019	2019	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/23/2019	NON-COMPETING CONTINUATION	$543,993
														Subtotal = $543,993

Issue Date FY: 2018 ( Subtotal = $561,118 )
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/24/2018	NEW	$561,118
														Subtotal = $561,118

Grand Total All Awards = $3,827,975

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Scalable and Sensor-Agnostic Software for Distributed Processing and Visualization of Multi-Site MEG/EEG Datasets

Award Number: R01NS104585

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2018

PERIOD OF PERFORMANCE END DATE: 02/28/2023

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