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 | Issue Date FY: 2024 ( Subtotal = $180,845,173 ) (Continued on the next page) |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS131281 | Targeting receptor interacting protein kinase-1 in the chronic period of intracerebral hemorrhage | 000 | 1 | NIH | 12/13/2023 | $464,068 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL169015 | Enhancing cardiovascular risk prediction in HIV using novel factors in the REPRIEVE trial | 000 | 1 | NIH | 3/6/2024 | $773,364 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K25HL169846 | Quantitative Optical Imaging Biomarkers of Interstitial Lung Disease | 000 | 1 | NIH | 3/7/2024 | $186,680 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS136385 | Resolving Human Brain Activation Across Cerebral Cortical Layers with Line-Scan Functional MRI | 000 | 1 | NIH | 3/12/2024 | $640,199 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R61CA287026 | A Real-Time AI-Driven High-Throughput Proteomics Data Acquisition Method for Clinical Applications | 000 | 1 | NIH | 2/12/2024 | $234,218 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI180866 | Does age matter for the development of pathogenic T helper 2 resident memory cells in the lung? | 000 | 1 | NIH | 11/22/2023 | $225,450 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS136224 | Brain Stimulation to Improve Neurocognitive Deficits After Subarachnoid Hemorrhage | 000 | 1 | NIH | 4/16/2024 | $477,237 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI179741 | Non-Templated Regulation of IgE Mediated Anaphylaxis | 000 | 1 | NIH | 11/16/2023 | $781,172 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08HL168238 | Advancing the clinical actionability of polygenic scores for coronary artery disease | 000 | 1 | NIH | 12/11/2023 | $170,323 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K01HL168231 | Deep learning to assess cardiovascular disease risk from chest imaging | 000 | 1 | NIH | 12/11/2023 | $175,147 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI182001 | Convergent allergen-specific antibodies in food allergy | 000 | 1 | NIH | 2/7/2024 | $751,498 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R03AG081968 | Development of Novel ?-Secretase PET Agents for the Exploration of AD Pathology | 000 | 1 | NIH | 2/27/2024 | $167,000 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R03CA280213 | Mini-gantry for proton therapy | 000 | 1 | NIH | 2/22/2024 | $83,500 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HG012867 | Integrating genomic data and protein structures to improve measures of selective constraint | 000 | 1 | NIH | 2/27/2024 | $739,649 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG085562 | Development of sensitive PET tracers of pan-Amyloid-beta species for Alzheimer's disease | 000 | 1 | NIH | 12/4/2023 | $826,732 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01EB034274 | Integrated, dynamic B0 and flip-angle shimming using multi-coil shim arrays | 000 | 1 | NIH | 2/23/2024 | $568,983 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23MH135748 | Developing and piloting a multilevel intervention to address psychosocial and structural syndemics in people with HIV in South Africa | 001 | 1 | NIH | 4/18/2024 | -$298 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG085795 | Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRI | 000 | 1 | NIH | 1/30/2024 | $250,500 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23MH135748 | Developing and piloting a multilevel intervention to address psychosocial and structural syndemics in people with HIV in South Africa | 000 | 1 | NIH | 2/14/2024 | $196,586 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99NS132984 | Revealing the Functional and Microstructural Response of Human Hippocampus to Spatial Learning with High-Gradient Strength Diffusion MRI | 000 | 1 | NIH | 2/8/2024 | $163,327 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08AI182474 | Harnessing machine learning to develop new antibiotics for Neisseria gonorrhoeae | 000 | 1 | NIH | 3/12/2024 | $196,190 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R35GM152187 | Anesthesia and Consciousness | 000 | 1 | NIH | 12/14/2023 | $412,346 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI183486 | A novel bacteria-specific pro-photosensitizer | 000 | 1 | NIH | 3/11/2024 | $187,569 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R35GM150508 | Bioorthogonal temporospatial tools | 000 | 2 | NIH | 3/20/2024 | $375,750 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R33AG075419 | Toward Precision Gene Therapy for Treatment of Severe Pain in Older Individuals | 000 | 3 | NIH | 3/15/2024 | $501,000 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | S10OD036202 | Revitalization and upgrade of cyclotron | 000 | 1 | NIH | 2/28/2024 | $597,593 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R37CA288343 | A compact beam delivery system enabling ultra-fast dose delivery for upright proton therapy | 000 | 1 | NIH | 2/29/2024 | $499,840 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL173129 | A Digital Hemodynamic Twin for Right Ventricular Dysfunction | 000 | 1 | NIH | 4/8/2024 | $459,000 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG082328 | Studying the pathogenic roles of human CD8+ T cells in Alzheimer's disease using a 3D human Peripheral immune Chip. | 000 | 1 | NIH | 3/27/2024 | $688,000 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08HL173572 | The Impact of Soluble ST2 on Lung Injury Onset and Resolution | 000 | 1 | NIH | 3/14/2024 | $170,640 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA262874 | Mechanisms of APOBEC3A-induced cancer evolution and cancer vulnerability | 000 | 1 | NIH | 4/8/2024 | $545,288 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01EB034197 | Plug-and-play Hyperpolarized MRI of Metabolism on Clinical Scanners | 000 | 1 | NIH | 1/17/2024 | $538,475 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | OT2NS138339 | Gene Therapy Consortium (GTC) for Gene-Based Clinical Trials Conducted within NeuroNEXT | 000 | 1 | NIH | 2/29/2024 | $296,964 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI177563 | Combination of Antimicrobial Blue Light and Antibiotics to Combat Multidrug-Resistant Bacteria | 000 | 1 | NIH | 2/29/2024 | $520,056 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA289485 | Analyzing DNA replication and damage vulnerability in IDH mutant glioma | 000 | 1 | NIH | 2/29/2024 | $396,982 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK131543 | Normothermic perfusion of steatotic livers for transplantation | 000 | 1 | NIH | 1/31/2024 | $268,000 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99DK136365 | Impact of HIV-associated intestinal CD8+ T cell function in mucosal homeostasis | 000 | 1 | NIH | 2/1/2024 | $91,500 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI175345 | Antibody mediated immunity against Klebsiella pneumoniae | 000 | 1 | NIH | 11/30/2023 | $660,621 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23MH132893 | The role of inflammation in cognitive dysfunction in acute depression as determined by experimental inhibition of tumor necrosis factor-alphasignaling in a randomized controlled trial. | 000 | 1 | NIH | 2/1/2024 | $197,115 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21CA286215 | A multimodal single-cell approach to developing personalized combinatorial treatments for glioblastoma | 000 | 1 | NIH | 1/22/2024 | $249,832 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS131347 | Comparative effectiveness of EEG-guided anti-seizure treatment in acute brain injury | 000 | 1 | NIH | 11/30/2023 | $698,062 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01GM152809 | Automated technology for the preservation of Drosophila embryos | 000 | 1 | NIH | 1/23/2024 | $567,229 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI174276 | Eliminating the Immunogenicity of AAV Vectored HIV Antibody Delivery | 000 | 1 | NIH | 1/8/2024 | $350,000 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI174276 | Eliminating the Immunogenicity of AAV Vectored HIV Antibody Delivery | 000 | 1 | NIH | 1/8/2024 | $472,056 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21CA282393 | Response assessment of glioblastoma using magnetic resonance elastography | 000 | 1 | NIH | 4/9/2024 | $234,218 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA283214 | Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation | 000 | 1 | NIH | 3/28/2024 | $604,063 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AT012386 | fMRI of cerebral responses to breathing of mindfulness and slow paced breathing at brainstem and higher brain | 000 | 1 | NIH | 4/8/2024 | $208,750 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA276115 | Interplay of natural killer cells and extracellular matrix proteins in solid cancers | 000 | 1 | NIH | 3/27/2024 | $660,987 |
| | 2024 | 2024 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K01NS134784 | Development of in Vivo Base Editing as a Genetic Treatment for Spinal Muscular Atrophy | 000 | 1 | NIH | 1/17/2024 | $244,458 |
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