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 | Issue Date FY: 2025 ( Subtotal = $198,223,886 ) (Continued on the next page) |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS127808 | Local Skull Marrow Sensing and Response to CNS Inflammation | 000 | 4 | NIH | 4/11/2025 | $681,725 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DA053316 | Evaluation of Cannabidiol for Reduction of Brain Neuroinflammation | 001 | 5 | NIH | 4/11/2025 | $75,335 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG081681 | Contribution of locus coeruleus activity patterns on tau deposition in Alzheimer's disease | 001 | 3 | NIH | 4/11/2025 | $150,300 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | P41EB015903 | Center for Biomedical OCT Research and Translation | 000 | 14 | NIH | 4/11/2025 | $1,259,210 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R24OD031955 | Developing preclinical xenograft models in zebrafish. | 000 | 4 | NIH | 2/25/2025 | $635,702 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA276116 | Mechanisms of aggressive Rhabdomyosarcoma. | 000 | 3 | NIH | 2/17/2025 | $485,997 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK134590 | A quantitative viability metric for liver transplantation using Resonance Raman Spectroscopy | 000 | 3 | NIH | 2/17/2025 | $447,809 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA288855 | Targeting chromatin acetylation factors in multiple myeloma | 000 | 1 | NIH | 2/24/2025 | $623,120 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AR079110 | The role of neuroinflammation in human peripheral neuropathic pain | 000 | 3 | NIH | 2/17/2025 | $656,946 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL162373 | Statistical Methods in COVID-19/PASC Clinical Research | 000 | 3 | NIH | 2/15/2025 | $377,202 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG085643 | Influence of the Menopausal Transition and Lifetime Ovarian Exposure on Neural Metabolism, Connectivity and Pathology | 000 | 2 | NIH | 3/7/2025 | $742,792 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG082785 | Nucleus-to-cytoplasm trafficking of chromatin fragments in senescence and aging | 000 | 3 | NIH | 3/24/2025 | $495,650 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K01AI153558 | Integrating the genome, metabolome, and microbiome for childhood asthma: Risk and endotypes | 000 | 5 | NIH | 3/21/2025 | $123,596 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG081841 | The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brain | 000 | 3 | NIH | 2/14/2025 | $683,192 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG057505 | Aging of Emotion Circuitry and Risk for Alzheimer's disease: Impact of Sex, Immunity, and Fetal Origins | 000 | 7 | NIH | 3/7/2025 | $1,517,961 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL173059 | Defining neutrophil pathobiology in pediatric Long COVID | 000 | 2 | NIH | 3/7/2025 | $715,054 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R03AG081968 | Development of Novel γ-Secretase PET Agents for the Exploration of AD Pathology | 000 | 2 | NIH | 3/7/2025 | $150,300 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS122829 | Circadian Effects in the Stroke Penumbra | 000 | 4 | NIH | 2/14/2025 | $452,157 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08HG012811 | Genome-first approach to treatable genetic conditions in adults | 000 | 3 | NIH | 3/7/2025 | $232,870 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08CA255932 | Reprogramming the chimeric antigen receptor T cell epigenome to augment anti-tumor activity | 000 | 5 | NIH | 2/14/2025 | $188,676 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08DK138287 | Insulin receptor condensates in health and disease | 000 | 1 | NIH | 2/21/2025 | $172,140 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R37CA245523 | Dissecting the cellular hierarchies of malignant gliomas by single-cell functional genomics | 000 | 6 | NIH | 3/11/2025 | $352,450 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01CK000633 | CK21-001 - Global TravEpiNet (GTEN): U.S. Travelers' Health Research, Surveillance, Communication and Outreach Network Supplement - Pregnant Travelers | 01 | 4 | CDC | 3/7/2025 | $149,939 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS121233 | Forecasting Migraine Attacks | 000 | 4 | NIH | 2/14/2025 | $375,325 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00HD101553 | Fast motion-robust fetal neuroimaging with MRI | 000 | 5 | NIH | 3/11/2025 | $223,199 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG076704 | Metabolic Interventions for Sleep, Anesthesia-related Neurocognitive Disorders and Alzheimer's Disease | 000 | 4 | NIH | 3/10/2025 | $477,734 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG054598 | Astrocytes as governing pathological drivers of neurovascular dysfunction in AD | 000 | 8 | NIH | 3/11/2025 | $459,994 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA269672 | Reprogramming the tumormicroenvironment to improve immunotherapy of glioblastoma | 000 | 4 | NIH | 3/3/2025 | $341,670 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA290785 | Novel regulation and functions of TEAD-VGLL complex | 000 | 1 | NIH | 3/11/2025 | $680,594 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA293063 | Pancreatic cancer patient-derived xenograft tumors for translational studies in precision cancer medicine | 000 | 1 | NIH | 4/8/2025 | $654,197 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA291779 | Imaging radiation-enhanced drug delivery for safer and more effective chemoradiotherapy | 000 | 1 | NIH | 3/3/2025 | $662,516 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA279385 | Role of the YAP1-LATS2 negative feedback loop in cervical carcinogenesis | 000 | 3 | NIH | 3/10/2025 | $438,493 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA293888 | Expanding the therapeutic window of chemoradiation through radiation-responsive nanoparticle drug depots | 000 | 1 | NIH | 3/11/2025 | $644,034 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG089061 | Simulation Analyses to Optimize Workplace Social Network Interventions for Improving Health Behaviors in Midlife | 001 | 2 | NIH | 4/24/2025 | $589,676 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HD102616 | Brainstem Arousal Network in Human Consciousness: Healthy development vs SIDS | 001 | 4 | NIH | 4/23/2025 | $69,747 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HG012867 | Integrating genomic data and protein structures to improve measures of selective constraint | 001 | 2 | NIH | 4/24/2025 | $82,851 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI163517 | Effect of Th2-type microenvironment on CD8 TRM-mediated protection from infection | 000 | 4 | NIH | 4/24/2025 | $579,303 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01MH137205 | Dysfunctional neurovascular interactions and neuroprogression in early-course psychosis: ex vivo investigation with patient-derived stem cells | 000 | 1 | NIH | 4/23/2025 | $836,344 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DA054145 | Characterizing Proximal Risk for Depressive Symptoms and Suicidal Ideation with Acute Cannabis Use and Withdrawal Among Adolescents Using Ecological Momentary Assessment | 000 | 2 | NIH | 4/21/2025 | $762,101 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01EB033306 | Intravascular microstructural, chemical and biomechanical characterization of coronary plaques | 001 | 4 | NIH | 4/25/2025 | $533,929 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01MH128425 | Epigenetic involvement in socio-emotional behavior studied by PET- MRI | 000 | 4 | NIH | 4/25/2025 | $615,232 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01NS121616 | An Integrated Single-Neuronal, Population-, Local Network- and Stimulation-Based Prefrontal Investigation of Human Social Cognition | 001 | 5 | NIH | 4/25/2025 | $743,093 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01NS077179 | Clinical Coordinating Center for the Network of Excellence in Neuroscience Clinical Trials (NEXT - CCC) | 001 | 14 | NIH | 4/25/2025 | $1,180,472 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AR079495 | Regulation of Axin2-expressing cells in the adult tendon | 000 | 4 | NIH | 4/23/2025 | $405,586 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08HL157620 | Mitochondrial redox regulation of adrenal steroidogenesis | 000 | 5 | NIH | 4/23/2025 | $172,800 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI184777 | Toward parsing gut microbiota-epithelium-immune metabolic crosstalk in Celiac Disease | 000 | 2 | NIH | 4/24/2025 | $599,318 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS124561 | Developing Splicing-Targeted Therapeutic Strategies for Neurological Diseases | 000 | 4 | NIH | 4/23/2025 | $420,000 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21DA059789 | Cannabinoids as an environmental risk factor of testicular cancer: Assessment using cell culture models of human and mouse primordial germ cells and by exposure of pregnant mice | 001 | 2 | NIH | 4/23/2025 | $208,750 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HD104649 | Portable MRI Technology for Neonatal Care | 000 | 5 | NIH | 4/24/2025 | $452,530 |
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