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 | Issue Date FY: 2025 ( Subtotal = $440,948,044 ) (Continued on the next page) |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R35GM159938 | Metabolic Control of Membrane Lysis | 000 | 1 | NIH | 8/7/2025 | $453,750 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R33NS133083 | Establishment and Validation of a Novel Animal Model of Fibromyalgia | 000 | 2 | NIH | 8/7/2025 | $811,652 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI183051 | Role of cholinergic neuroimmune signaling pathway disruption in the pathogenesis of Hirschsprung-associated enterocolitis | 000 | 1 | NIH | 7/8/2025 | $439,216 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AR079110 | The role of neuroinflammation in human peripheral neuropathic pain | 001 | 3 | NIH | 6/9/2025 | $51,096 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG083759 | Molecular Chemiluminescence Probes for Imaging of Amyloid beta in Animal Models | 000 | 2 | NIH | 3/5/2025 | $742,763 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AR079110 | The role of neuroinflammation in human peripheral neuropathic pain | 000 | 3 | NIH | 2/17/2025 | $656,946 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23MD020098 | Variability in emergency demographic data and clinical outcomes | 000 | 1 | NIH | 7/31/2025 | $169,079 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG057505 | Aging of Emotion Circuitry and Risk for Alzheimer's disease: Impact of Sex, Immunity, and Fetal Origins | 001 | 7 | NIH | 6/9/2025 | $134,930 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI193280 | Sex differences in a cytokine controlling antibody class switch recombination | 000 | 1 | NIH | 7/8/2025 | $439,088 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG057505 | Aging of Emotion Circuitry and Risk for Alzheimer's disease: Impact of Sex, Immunity, and Fetal Origins | 000 | 7 | NIH | 3/7/2025 | $1,517,961 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R34DA063088 | Peer Recovery Coaching for Promoting Tobacco Abstinence in People with Opioid Use Disorder | 000 | 1 | NIH | 7/4/2025 | $742,500 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS083534 | A Longitudinal Analysis Stream for FreeSurfer | 000 | 7 | NIH | 3/6/2025 | $644,219 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01NS077179 | Clinical Coordinating Center for the Network of Excellence in Neuroscience Clinical Trials (NEXT - CCC) | 001 | 14 | NIH | 4/25/2025 | $1,180,472 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS117598 | Neuroprotective B Cell Immunotherapy for Contusion Traumatic Brain Injury | 000 | 5 | NIH | 3/4/2025 | $380,939 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01MH131687 | Characterization of schizophrenia liability genes in models of human microglial synaptic pruning | 000 | 3 | NIH | 3/14/2025 | $503,390 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01MH136059 | JASPer-MH: Jointly Assessed Scalable Phenotypes for Mental Health | 000 | 2 | NIH | 2/18/2025 | $1,792,896 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK116716 | The role of salt inducible kinases in parathyroid hormone action in bone | 001 | 8 | NIH | 5/1/2025 | $442,486 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA283214 | Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation | 001 | 2 | NIH | 5/22/2025 | $60,405 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA283214 | Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation | 000 | 2 | NIH | 3/14/2025 | $543,658 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG083759 | Molecular Chemiluminescence Probes for Imaging of Amyloid beta in Animal Models | 001 | 2 | NIH | 6/17/2025 | $66,023 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | UM1AI144295 | Targeting T cell Subsets in Autoimmune Disease | 001 | 7 | NIH | 4/21/2025 | $333,918 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HD120282 | Noninvasive Neonatal Blood Gas Monitoring | 000 | 1 | NIH | 8/7/2025 | $2,453,962 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23AT012789 | Pain Disengagement Training: A self-directed intervention for pain catastrophizing | 001 | 2 | NIH | 3/20/2025 | $170,522 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23NS140388 | Neurophysiological Correlates of Cognition Over Multi-Day Timescales in Epilepsy | 000 | 1 | NIH | 7/29/2025 | $234,630 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21HD117132 | siRNA-based treatment approach to enhance Gs alpha-mediated hormone signaling | 000 | 1 | NIH | 7/23/2025 | $449,636 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI182936 | Harnessing the soluble guanylate cyclase pathway to alleviate early life RSV bronchiolitis | 000 | 1 | NIH | 7/23/2025 | $364,484 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21EB036735 | Simplifying Bedside Lung Perfusion Imaging Using Electrical Impedance Tomography | 000 | 1 | NIH | 7/23/2025 | $656,750 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21CA302986 | Improving CAR-T cell therapy in metastatic breast cancers by reprogramming obesity-aggravated tumor microenvironment via physical activity | 000 | 1 | NIH | 7/29/2025 | $416,818 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL179324 | Alveolar epithelial glycocalyx resilience in women during ARDS | 000 | 1 | NIH | 8/7/2025 | $761,615 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21DE034107 | Neural Circuit Mechanisms of Peripheral Nerve Stimulation for Trigeminal Neuropathic Pain | 000 | 1 | NIH | 7/1/2025 | $239,405 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA248923 | Subclonal heterogeneity and outcome disparities in Triple-Negative Breast Cancer among African Americans | 001 | 4 | NIH | 5/23/2025 | $78,413 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23NS140495 | Promoting Recovery from BrainInjury with Non-Invasive Thalamic Ultrasound | 000 | 1 | NIH | 7/31/2025 | $234,630 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA248923 | Subclonal heterogeneity and outcome disparities in Triple-Negative Breast Cancer among African Americans | 000 | 4 | NIH | 3/5/2025 | $705,714 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI189231 | Role of ZNF proteins in the establishment and maintenance of HIV latency | 000 | 1 | NIH | 7/23/2025 | $453,750 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | F32AI188955 | Control of intracellular Shigella in human macrophages. | 000 | 1 | NIH | 7/23/2025 | $80,477 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R33AG067916 | Molecular imaging of RIPK1/necroptosis as a key biomarker in Alzheimer's disease | 000 | 4 | NIH | 8/6/2025 | $791,560 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R35GM159855 | Investigating stem and progenitor cell quality assurance in development andregeneration. | 000 | 1 | NIH | 8/6/2025 | $412,500 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R35GM157035 | Integrating frequency and phenotypic association data to improve interpretation of rare genetic variants | 000 | 1 | NIH | 8/6/2025 | $412,500 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99NS144514 | Understanding the Genetic and Epigenetic Mechanisms in X-linked Dystonia Parkinsonism and Repeat Expansion Diseases | 000 | 1 | NIH | 7/25/2025 | $129,170 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | DP2CA311214 | Harnessing natural killer cells for cellular immunotherapy against solid tumors | 000 | 1 | NIH | 8/4/2025 | $1,457,050 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R37CA231957 | Thyroid Nodule Treatment Optimization: A Personalized Approach | 002 | 7 | NIH | 7/11/2025 | $499,823 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | UH3EB034875 | Hybrid TMS/MRI system for regionally tailored causal mapping of human cortical circuits and connectivity | 000 | 3 | NIH | 8/4/2025 | $871,998 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R33HD106578 | An interactive, narrative intervention to address the mental health treatment gap among young people living with HIV in Nigeria | 002 | 6 | NIH | 7/22/2025 | $211,305 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23HD117006 | Elucidating the Role of the FGFR1 Signaling Pathway in the Intersection of Reproduction and Metabolism | 000 | 1 | NIH | 7/31/2025 | $170,640 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99NS132984 | Revealing the Functional and Microstructural Response of Human Hippocampus to Spatial Learning with High-Gradient Strength Diffusion MRI | 000 | 2 | NIH | 2/13/2025 | $163,361 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI187948 | Pseudomonas aeruginosa Microcolony Aggregates Elicit Neutrophil Swarming | 000 | 1 | NIH | 7/28/2025 | $453,750 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | UG3NS143749 | Continuous Monitoring of Pain using Facial Expressions in ICU Environment (COMPANION) | 000 | 1 | NIH | 7/30/2025 | $1,365,701 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00AG083056 | Imaging brain-wide subarachnoid and perivascular cerebrospinal fluid flow in aging and Alzheimer's disease | 000 | 3 | NIH | 8/6/2025 | $244,020 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI188227 | Novel point-of-care liquid biopsy for early detection of sepsis-associated organ damage | 000 | 1 | NIH | 7/23/2025 | $473,937 |
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