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 | Issue Date FY: 2025 ( Subtotal = $282,247,024 ) (Continued on the next page) |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00HD101553 | Fast motion-robust fetal neuroimaging with MRI | 000 | 5 | NIH | 3/11/2025 | $223,199 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00HD101553 | Fast motion-robust fetal neuroimaging with MRI | 001 | 5 | NIH | 4/22/2025 | $24,799 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R33HL173898 | Development of platform technology to measure kinetics and equilibrium concentration of sickle hemoglobin polymerization in single RBCs for drug potency assessment and patient risk stratification | 000 | 1 | NIH | 3/18/2025 | $483,852 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA279385 | Role of the YAP1-LATS2 negative feedback loop in cervical carcinogenesis | 001 | 3 | NIH | 5/23/2025 | $48,722 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS129857 | Role of Sedation in the Post-Cardiac Arrest Neurological Recovery | 000 | 3 | NIH | 2/13/2025 | $435,827 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA279385 | Role of the YAP1-LATS2 negative feedback loop in cervical carcinogenesis | 000 | 3 | NIH | 3/10/2025 | $438,493 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA262805 | Overcoming adaptive feedback resistance to KRAS inhibition in colorectal cancer | 001 | 4 | NIH | 5/22/2025 | $71,198 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA262805 | Overcoming adaptive feedback resistance to KRAS inhibition in colorectal cancer | 000 | 4 | NIH | 3/19/2025 | $640,792 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA276116 | Mechanisms of aggressive Rhabdomyosarcoma. | 001 | 3 | NIH | 5/23/2025 | $54,000 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA276116 | Mechanisms of aggressive Rhabdomyosarcoma. | 000 | 3 | NIH | 2/17/2025 | $485,997 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99DK139461 | Integration of dietary factors and multi-omic signatures of genetic subtypes to understand diabetes heterogeneity | 000 | 1 | NIH | 2/28/2025 | $90,000 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | DP1DA060607 | Polyclonal Bi-Specific Vectored ImmunoTherapy to Functionally Cure HIV Infection | 001 | 2 | NIH | 4/14/2025 | $105,210 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | DP1DA060607 | Polyclonal Bi-Specific Vectored ImmunoTherapy to Functionally Cure HIV Infection | 000 | 2 | NIH | 3/13/2025 | $946,890 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U19AI174967 | Novel Approaches to Inducing Lung Allograft Tolerance in NHPs | 000 | 3 | NIH | 2/13/2025 | $3,299,788 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01MH131687 | Characterization of schizophrenia liability genes in models of human microglial synaptic pruning | 000 | 3 | NIH | 3/14/2025 | $503,390 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA283214 | Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation | 001 | 2 | NIH | 5/22/2025 | $60,405 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA283214 | Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation | 000 | 2 | NIH | 3/14/2025 | $543,658 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS117598 | Neuroprotective B Cell Immunotherapy for Contusion Traumatic Brain Injury | 000 | 5 | NIH | 3/4/2025 | $380,939 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | DP1DA058360 | The neuropharmacology of brain activation during stages of drug abuse | 000 | 3 | NIH | 2/14/2025 | $450,900 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | DP1DA058360 | The neuropharmacology of brain activation during stages of drug abuse | 001 | 3 | NIH | 4/11/2025 | $50,100 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99NS132984 | Revealing the Functional and Microstructural Response of Human Hippocampus to Spatial Learning with High-Gradient Strength Diffusion MRI | 000 | 2 | NIH | 2/13/2025 | $163,361 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI153142 | Single-cell genomic profiling to identify immune signatures of bacterial sepsis in humans | 000 | 5 | NIH | 2/13/2025 | $970,158 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG075899 | Addressing the chronic pain-early cognitive decline comorbidity among older adults; The Active Brains study | 001 | 4 | NIH | 6/18/2025 | $47,573 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG075899 | Addressing the chronic pain-early cognitive decline comorbidity among older adults; The Active Brains study | 000 | 4 | NIH | 3/14/2025 | $535,200 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01CA268933 | Microfluidic isolation and molecular analysis of circulating tumor cells for the study of neuroendocrine transdifferentiation in prostate cancer | 001 | 4 | NIH | 5/22/2025 | $61,157 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG086263 | Characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's Disease | 000 | 1 | NIH | 3/14/2025 | $831,583 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01CA268933 | Microfluidic isolation and molecular analysis of circulating tumor cells for the study of neuroendocrine transdifferentiation in prostate cancer | 000 | 4 | NIH | 3/4/2025 | $550,413 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI193274 | A CRISPR based organoid screen for mediators of epithelial-myeloid interactions | 000 | 1 | NIH | 6/17/2025 | $453,750 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA248923 | Subclonal heterogeneity and outcome disparities in Triple-Negative Breast Cancer among African Americans | 001 | 4 | NIH | 5/23/2025 | $78,413 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG082331 | Imaging epigenetic dysregulation in the Lewy body dementias with [11C]Martinostat | 001 | 3 | NIH | 6/10/2025 | $66,477 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA248923 | Subclonal heterogeneity and outcome disparities in Triple-Negative Breast Cancer among African Americans | 000 | 4 | NIH | 3/5/2025 | $705,714 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG082331 | Imaging epigenetic dysregulation in the Lewy body dementias with [11C]Martinostat | 000 | 3 | NIH | 3/20/2025 | $747,872 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23AT012789 | Pain Disengagement Training: A self-directed intervention for pain catastrophizing | 001 | 2 | NIH | 3/20/2025 | $170,522 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R61AR084188 | SGLT2i As Novel Gout Care (SAVE-Care): A Randomized Controlled Trial | 000 | 1 | NIH | 6/18/2025 | $228,218 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG085795 | Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRI | 001 | 2 | NIH | 4/28/2025 | $20,875 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL169015 | Enhancing cardiovascular risk prediction in HIV using novel factors in the REPRIEVE trial | 001 | 2 | NIH | 5/5/2025 | $72,631 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG085795 | Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRI | 000 | 2 | NIH | 3/6/2025 | $187,875 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL169015 | Enhancing cardiovascular risk prediction in HIV using novel factors in the REPRIEVE trial | 000 | 2 | NIH | 3/14/2025 | $653,688 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01EB034274 | Integrated, dynamic B0 and flip-angle shimming using multi-coil shim arrays | 000 | 2 | NIH | 2/19/2025 | $655,298 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00AG059946 | High-throughput optical investigation into intact large-scale nervous systems for Alzheimers disease | 001 | 5 | NIH | 6/10/2025 | $19,920 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00AG059946 | High-throughput optical investigation into intact large-scale nervous systems for Alzheimers disease | 000 | 5 | NIH | 3/18/2025 | $224,097 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA269672 | Reprogramming the tumormicroenvironment to improve immunotherapy of glioblastoma | 001 | 4 | NIH | 5/22/2025 | $37,964 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA269672 | Reprogramming the tumormicroenvironment to improve immunotherapy of glioblastoma | 000 | 4 | NIH | 3/3/2025 | $341,670 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA289485 | Analyzing DNA replication and damage vulnerability in IDH mutant glioma | 001 | 2 | NIH | 5/22/2025 | $40,112 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | T32GM007592 | Research Training for Anesthetists | 004 | 47 | NIH | 6/18/2025 | $819,930 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA289485 | Analyzing DNA replication and damage vulnerability in IDH mutant glioma | 000 | 2 | NIH | 3/3/2025 | $361,028 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI173030 | Human NLRP11 function in non-canonical inflammasome activation by bacterial pathogen LPS | 000 | 3 | NIH | 2/12/2025 | $514,981 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01MD014023 | Racial disparities in police use of deadly force as a cause of racial disparities in sleep health across the life course | 000 | 5 | NIH | 2/20/2025 | $499,615 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL168090 | Brain-immune crosstalk in myocardial infarction | 002 | 3 | NIH | 4/30/2025 | $686,432 |
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