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 | Issue Date FY: 2022 ( Subtotal = $346,361,561 ) (Continued on the next page) |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | OT2HL161841 | Interactive Data Portals and Robust Analytic Tools to Wrap PASC Cohorts (iDRAW) OTA-21-015A | 000 | 1 | NIH | 11/26/2021 | $2,099,947 |
| | 2022 | 2022 | Massachusetts General Hospital, The | 55 Fruit Street | Boston | MA | 02114-2621 | SUFFOLK | USA | T2537602 | Addiction Medicine Fellowship | 00 | 3 | HRSA | 5/10/2022 | $799,850 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K24AT011760 | Mentoring in technology enhanced mind body and lifestyle interventions | 000 | 1 | NIH | 1/20/2022 | $182,118 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI168393 | Effects of combining anti-CD40 and anti-CD11b mAb107 on survival of pig kidney xenografts in cynomolgus monkeys | 000 | 1 | NIH | 5/6/2022 | $242,440 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL159187 | Immune checkpoint inhibitors and accelerated coronary atherosclerosis | 000 | 1 | NIH | 4/22/2022 | $1,041,129 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL157221 | Defining the lineage, mechanisms of maintenance, and function of a new injury-resistant airway epithelial structure: the hillock | 000 | 1 | NIH | 4/28/2022 | $467,438 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI152499 | Host Responses to Coccidioides by Human Airway Epithelium | 000 | 1 | NIH | 5/2/2022 | $252,000 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG073750 | Investigation of a Novel Biomarker of Postoperative Delirium | 000 | 1 | NIH | 6/8/2022 | $210,000 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | F32DK131793 | Determinants of Uremic Symptoms in CKD and Associations to Clinical Outcomes | 000 | 1 | NIH | 5/3/2022 | $80,747 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | F32HS028943 | Decreasing Sedative Requirements for Peripheral Vascular Interventions using Preoperative Guided Meditation | 000 | 1 | AHRQ | 5/1/2022 | $85,796 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | S10OD032211 | HD Upgrade to a Nikon A1R Confocal Imaging Platform | 000 | 1 | NIH | 5/1/2022 | $296,099 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL165241 | Optogenetic regulation of intra-ciliary calcium signaling in cardiac situs development | 000 | 1 | NIH | 6/8/2022 | $555,104 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R03HL162677 | Histologic and Transcriptional Profiling of Endothelial Cells During Progressive Pulmonary Fibrosis | 000 | 1 | NIH | 5/1/2022 | $83,320 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL164697 | Survival prediction in patients with progressive fibrosing interstitial lung disease | 000 | 1 | NIH | 6/13/2022 | $420,000 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HD104756 | Glycemic Observation Using A1C for Gestational Diabetes Diagnosis | 000 | 1 | NIH | 6/14/2022 | $730,534 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG076612 | Targeting neurogenesis-inhibition coupling to improve memory in aging | 000 | 1 | NIH | 5/26/2022 | $744,096 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG073894 | Exploring the sequence identity of cytoplasmic chromatin in senescence | 000 | 1 | NIH | 5/26/2022 | $252,000 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | F32AI172641 | Immune response and viral dynamics within the female genital tract during hyperacute and acute HIV infection | 000 | 1 | NIH | 6/20/2022 | $67,174 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG077611 | Neural Circuit Disruption in Freely-Behaving models of Alzheimer's Disease. | 000 | 1 | NIH | 5/5/2022 | $765,473 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | RF1NS126547 | Mechanisms of Circadian and Synaptic Dysfunction After Repetitive Mild TBI | 000 | 1 | NIH | 5/16/2022 | $2,366,184 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08CA270417 | Elucidating cancer-intrinsic mechanisms of perineural invasion in pancreatic cancer | 000 | 1 | NIH | 6/16/2022 | $315,115 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL159170 | Using Wearable Technology to Assess Recovery and Detect Post-Operative Complications Following Cardiothoracic Surgery | 000 | 1 | NIH | 6/15/2022 | $748,852 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08NS124991 | Sex differences in the role of gonadal hormones and the hypothalamus in migraine with aura. | 000 | 1 | NIH | 6/20/2022 | $195,635 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R03AG076389 | Investigation of sirtuin 1 expression in mice model of Alzheimer's disease over age | 000 | 1 | NIH | 5/19/2022 | $323,760 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI163517 | Effect of Th2-type microenvironment on CD8 TRM-mediated protection from infection | 000 | 1 | NIH | 5/19/2022 | $579,303 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK133185 | A novel psychological-behavioral intervention to promote physical activity in type 2 diabetes. | 000 | 1 | NIH | 6/3/2022 | $718,042 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AR079495 | Regulation of Axin2-expressing cells in the adult tendon | 000 | 1 | NIH | 6/10/2022 | $493,542 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21MH128619 | Circadian influence on fear extinction resulting from prolonged exposure therapy for PTSD | 000 | 1 | NIH | 5/9/2022 | $198,748 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI155714 | Bcl-2 and Mcl-1 inhibition for induction of hematopoietic chimerism and renal allograft tolerance without myelosuppression in nonhuman primates | 000 | 1 | NIH | 6/3/2022 | $922,719 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00MH119314 | Data-Driven Models of Symptom Heterogeneity to Empower Transdiagnostic Multimodal Biomarker Discovery in Mood Disorders | 000 | 3 | NIH | 5/13/2022 | $227,109 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AR079442 | Deep Learning Technology for Rapid Morphological and Quantitative Imaging of Knee Pathology | 000 | 1 | NIH | 5/30/2022 | $396,077 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00MH119314 | Data-Driven Models of Symptom Heterogeneity to Empower Transdiagnostic Multimodal Biomarker Discovery in Mood Disorders | 001 | 3 | NIH | 5/18/2022 | $0 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08CA263549 | Optimizing Supportive Care for Patients with Metastatic Lung Cancer in the Era of Precision Oncology | 000 | 1 | NIH | 5/24/2022 | $271,934 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K01DK129438 | Integrin ?v?3 preclinical PET imaging to detect early stage NASH and treatment response | 000 | 1 | NIH | 5/27/2022 | $151,800 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS124777 | Simultaneous PET/phMR studies on interplay of mGlu/dopamine receptors in PD-like neurodegeneration | 000 | 1 | NIH | 5/12/2022 | $689,722 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R25AG076388 | Diversifying and Strengthening Dementia Palliative Care Clinical Trials | 000 | 1 | NIH | 5/23/2022 | $371,129 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R61HL158529 | A novel psychological-behavioral intervention to promote physical activity after acute coronary syndrome | 000 | 1 | NIH | 5/30/2022 | $820,552 |
| | 2022 | 2022 | Massachusetts General Hospital, The | 55 Fruit St | Boston | MA | 02114-2621 | SUFFOLK | USA | NU50CK000622 | Strengthening Healthcare Infection Prevention and Control and Improving Patient Safety in the United States | 00 | 1 | CDC | 6/17/2022 | $1,851,473 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | F32DK131792 | Modifying the intestinal extracellular matrix to optimize enteric neuronal stem cell therapy for Hirschsprung disease | 000 | 1 | NIH | 6/10/2022 | $76,934 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG076704 | Metabolic Interventions for Sleep, Anesthesia-related Neurocognitive Disorders and Alzheimer's Disease | 000 | 1 | NIH | 6/2/2022 | $555,816 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23HL159313 | Antiangiogenic Therapy to Reduce Bleeding and Improve Health-Related Quality of Life in Hereditary Hemorrhagic Telangiectasia | 000 | 1 | NIH | 6/10/2022 | $199,800 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA271380 | Assessing the effect of virtual navigation interventions to improve health insurance literacy and decrease financial burden: A CCSS randomized trial | 000 | 1 | NIH | 6/1/2022 | $689,962 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG077040 | A Long Noncoding RNA SALTe Links Heart Failure to Alzheimer's Disease | 000 | 1 | NIH | 4/7/2022 | $445,522 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI166396 | Rapid antibody screening systems to identify and engineer antiviral protection | 000 | 1 | NIH | 2/25/2022 | $265,139 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | UG3DE031920 | MOLAR: Mapping Oral health and Local Area Resources | 000 | 1 | NIH | 4/12/2022 | $519,579 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI169188 | Molecular Pathways Regulating Tissue-resident Memory T cells in the Gut | 000 | 1 | NIH | 2/24/2022 | $612,247 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG071567 | Microvascular Stress as a Pathway to Neurodegeneration in Alzheimer's | 000 | 1 | NIH | 1/25/2022 | $395,242 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23HL157612 | Identifying Modifiable Practices Related to Outcome Variation and Enhancement in Transcatheter Aortic Valve Replacement (IMPROVE TAVR) | 000 | 1 | NIH | 1/21/2022 | $192,251 |
| | 2022 | 2022 | MASSACHUSETTS GENERAL HOSPITAL, THE | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R03MH126143 | Longitudinal Immune Dysregulation in Low-Weight Eating Disorders and Association with Weight Fluctuations | 000 | 1 | NIH | 1/31/2022 | $84,000 |
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