| | | | | | | | | | | | | | | | |
| | |
 | Issue Date FY: 2025 ( Subtotal = $210,040,283 ) (Continued on the next page) |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA269672 | Reprogramming the tumormicroenvironment to improve immunotherapy of glioblastoma | 000 | 4 | NIH | 3/3/2025 | $341,670 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA248923 | Subclonal heterogeneity and outcome disparities in Triple-Negative Breast Cancer among African Americans | 000 | 4 | NIH | 3/5/2025 | $705,714 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG082331 | Imaging epigenetic dysregulation in the Lewy body dementias with [11C]Martinostat | 000 | 3 | NIH | 3/20/2025 | $747,872 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R24OD031955 | Developing preclinical xenograft models in zebrafish. | 000 | 4 | NIH | 2/25/2025 | $635,702 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS118187 | Toward a Validated in Vivo Imaging Marker of Axonal Damage Predictive of Progressive Disability in Multiple Sclerosis | 000 | 5 | NIH | 3/18/2025 | $516,993 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL157635 | Using Electrocardiogram Genetics to Inform Arrhythmia Risk | 000 | 4 | NIH | 3/10/2025 | $647,983 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08NS121599 | Neuronal Seizure Burden versus Cell Death after Neonatal Brain Injury | 000 | 5 | NIH | 3/19/2025 | $200,800 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | UM1DK078616 | TOPMed Omics of Type 2 Diabetes and Quantitative Traits | 000 | 17 | NIH | 2/19/2025 | $661,878 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG054598 | Astrocytes as governing pathological drivers of neurovascular dysfunction in AD | 000 | 8 | NIH | 3/11/2025 | $459,994 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS130119 | Late-onset Unexplained Epilepsy as a Risk Factor for Dementia | 001 | 2 | NIH | 3/26/2025 | $247,500 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS130119 | Late-onset Unexplained Epilepsy as a Risk Factor for Dementia | 000 | 2 | NIH | 3/6/2025 | $2,677,018 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA290785 | Novel regulation and functions of TEAD-VGLL complex | 000 | 1 | NIH | 3/11/2025 | $680,594 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R34NS139993 | Beyond Barriers: Leveraging Community Expertise for Improved Neurological Health among U.S. Resettled Refugees | 000 | 1 | NIH | 2/25/2025 | $261,589 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK134590 | A quantitative viability metric for liver transplantation using Resonance Raman Spectroscopy | 000 | 3 | NIH | 2/17/2025 | $447,809 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG076704 | Metabolic Interventions for Sleep, Anesthesia-related Neurocognitive Disorders and Alzheimer's Disease | 000 | 4 | NIH | 3/10/2025 | $477,734 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS102423 | Assembling the Genetic Architecture of X-linked Dystonia Parkinsonism | 000 | 7 | NIH | 2/14/2025 | $596,032 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01EB028782 | Genetic-engineered control of the immunogeneic state of vascular composite allografts during preservation | 000 | 5 | NIH | 3/19/2025 | $550,863 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS136224 | Brain Stimulation to Improve Neurocognitive Deficits After Subarachnoid Hemorrhage | 000 | 2 | NIH | 3/14/2025 | $452,217 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA279385 | Role of the YAP1-LATS2 negative feedback loop in cervical carcinogenesis | 000 | 3 | NIH | 3/10/2025 | $438,493 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R33HL173898 | Development of platform technology to measure kinetics and equilibrium concentration of sickle hemoglobin polymerization in single RBCs for drug potency assessment and patient risk stratification | 000 | 1 | NIH | 3/18/2025 | $483,852 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00HD101553 | Fast motion-robust fetal neuroimaging with MRI | 000 | 5 | NIH | 3/11/2025 | $223,199 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA262805 | Overcoming adaptive feedback resistance to KRAS inhibition in colorectal cancer | 000 | 4 | NIH | 3/19/2025 | $640,792 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00HD101553 | Fast motion-robust fetal neuroimaging with MRI | 001 | 5 | NIH | 4/22/2025 | $24,799 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS129857 | Role of Sedation in the Post-Cardiac Arrest Neurological Recovery | 000 | 3 | NIH | 2/13/2025 | $435,827 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R37CA288343 | A compact beam delivery system enabling ultra-fast dose delivery for upright proton therapy | 000 | 2 | NIH | 2/28/2025 | $440,035 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23DK131366 | Diet and metabolic factors in the pathogenesis of microscopic colitis | 000 | 4 | NIH | 2/18/2025 | $196,248 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS083534 | A Longitudinal Analysis Stream for FreeSurfer | 000 | 7 | NIH | 3/6/2025 | $644,219 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AR079110 | The role of neuroinflammation in human peripheral neuropathic pain | 000 | 3 | NIH | 2/17/2025 | $656,946 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK116716 | The role of salt inducible kinases in parathyroid hormone action in bone | 001 | 8 | NIH | 5/1/2025 | $442,486 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | UM1AI144295 | Targeting T cell Subsets in Autoimmune Disease | 001 | 7 | NIH | 4/21/2025 | $333,918 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG057505 | Aging of Emotion Circuitry and Risk for Alzheimer's disease: Impact of Sex, Immunity, and Fetal Origins | 000 | 7 | NIH | 3/7/2025 | $1,517,961 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01MH136059 | JASPer-MH: Jointly Assessed Scalable Phenotypes for Mental Health | 000 | 2 | NIH | 2/18/2025 | $1,792,896 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG083759 | Molecular Chemiluminescence Probes for Imaging of Amyloid beta in Animal Models | 000 | 2 | NIH | 3/5/2025 | $742,763 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01CA268933 | Microfluidic isolation and molecular analysis of circulating tumor cells for the study of neuroendocrine transdifferentiation in prostate cancer | 000 | 4 | NIH | 3/4/2025 | $550,413 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG086263 | Characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's Disease | 000 | 1 | NIH | 3/14/2025 | $831,583 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01NS077179 | Clinical Coordinating Center for the Network of Excellence in Neuroscience Clinical Trials (NEXT - CCC) | 001 | 14 | NIH | 4/25/2025 | $1,180,472 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U19AI174967 | Novel Approaches to Inducing Lung Allograft Tolerance in NHPs | 000 | 3 | NIH | 2/13/2025 | $3,299,788 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01MH131687 | Characterization of schizophrenia liability genes in models of human microglial synaptic pruning | 000 | 3 | NIH | 3/14/2025 | $503,390 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA283214 | Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation | 000 | 2 | NIH | 3/14/2025 | $543,658 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI176533 | Investigating the Protective Efficacy of SIV/HIV T and B cell Immunity Induced by RNA Replicons | 000 | 3 | NIH | 3/18/2025 | $865,387 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI153142 | Single-cell genomic profiling to identify immune signatures of bacterial sepsis in humans | 000 | 5 | NIH | 2/13/2025 | $970,158 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99NS132984 | Revealing the Functional and Microstructural Response of Human Hippocampus to Spatial Learning with High-Gradient Strength Diffusion MRI | 000 | 2 | NIH | 2/13/2025 | $163,361 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | DP1DA058360 | The neuropharmacology of brain activation during stages of drug abuse | 000 | 3 | NIH | 2/14/2025 | $450,900 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | DP1DA058360 | The neuropharmacology of brain activation during stages of drug abuse | 001 | 3 | NIH | 4/11/2025 | $50,100 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG075899 | Addressing the chronic pain-early cognitive decline comorbidity among older adults; The Active Brains study | 000 | 4 | NIH | 3/14/2025 | $535,200 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23AT012789 | Pain Disengagement Training: A self-directed intervention for pain catastrophizing | 001 | 2 | NIH | 3/20/2025 | $170,522 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01EB034274 | Integrated, dynamic B0 and flip-angle shimming using multi-coil shim arrays | 000 | 2 | NIH | 2/19/2025 | $655,298 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG085795 | Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRI | 001 | 2 | NIH | 4/28/2025 | $20,875 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG085795 | Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRI | 000 | 2 | NIH | 3/6/2025 | $187,875 |
|
