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 | Issue Date FY: 2025 ( Subtotal = $144,853,105 ) (Continued on the next page) |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG086433 | New epigenetic inhibitors for Alzheimer's disease treatment | 000 | 2 | NIH | 3/5/2025 | $726,260 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS083534 | A Longitudinal Analysis Stream for FreeSurfer | 000 | 7 | NIH | 3/6/2025 | $644,219 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00HG012222 | An integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics. | 000 | 4 | NIH | 3/5/2025 | $224,101 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HG012867 | Integrating genomic data and protein structures to improve measures of selective constraint | 000 | 2 | NIH | 3/5/2025 | $745,661 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23DK131366 | Diet and metabolic factors in the pathogenesis of microscopic colitis | 000 | 4 | NIH | 2/18/2025 | $196,248 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA248923 | Subclonal heterogeneity and outcome disparities in Triple-Negative Breast Cancer among African Americans | 000 | 4 | NIH | 3/5/2025 | $705,714 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG083759 | Molecular Chemiluminescence Probes for Imaging of Amyloid beta in Animal Models | 000 | 2 | NIH | 3/5/2025 | $742,763 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA258763 | Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics | 000 | 5 | NIH | 3/6/2025 | $502,258 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG085795 | Developing a validated biomarker of cortical neurodegeneration in Alzheimer's disease using high-gradient diffusion MRI | 000 | 2 | NIH | 3/6/2025 | $187,875 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG079142 | Building predictive algorithms to identify resilience and resistance to Alzheimer's disease | 000 | 3 | NIH | 3/6/2025 | $883,899 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R37NS136068 | The Skull Bone Marrow Niche After Stroke | 000 | 1 | NIH | 2/27/2025 | $798,848 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI155662 | Harnessing the anti-inflammatory activity of extracellular sialylation of IgG. | 000 | 5 | NIH | 2/19/2025 | $533,224 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99CA296772 | Elucidating Thiol Reductive Stress in Lung Cancer Growth and Metastasis | 000 | 1 | NIH | 2/20/2025 | $140,130 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01MD014023 | Racial disparities in police use of deadly force as a cause of racial disparities in sleep health across the life course | 000 | 5 | NIH | 2/20/2025 | $499,615 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | UM1DK078616 | TOPMed Omics of Type 2 Diabetes and Quantitative Traits | 000 | 17 | NIH | 2/19/2025 | $661,878 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS130119 | Late-onset Unexplained Epilepsy as a Risk Factor for Dementia | 000 | 2 | NIH | 3/6/2025 | $2,677,018 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL109448 | PET Imaging of Thrombus | 000 | 12 | NIH | 2/20/2025 | $725,992 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS118929 | Reprogramming the Tumor Microenvironment to Improve Immunotherapy of Glioblastoma by Co-Targeting VEGF and Ang2 | 000 | 5 | NIH | 3/5/2025 | $363,077 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01ES035401 | Environmental chemicals impair epigenetic suppression of the endogenous retrovirus HML-2 in human primordial germ cells, predisposing the next generation to malignancies through HML-2 reactivation | 000 | 2 | NIH | 3/6/2025 | $604,191 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA129933 | Modeling Metastasis and Acquired Drug Resistance Using Circulating Tumor Cells | 000 | 18 | NIH | 3/5/2025 | $378,000 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01MH125802 | Defining Neurobiological Subtypes of Motor Functional Neurological Disorder | 000 | 5 | NIH | 3/6/2025 | $661,960 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG057505 | Aging of Emotion Circuitry and Risk for Alzheimer's disease: Impact of Sex, Immunity, and Fetal Origins | 000 | 7 | NIH | 3/7/2025 | $1,517,961 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08CA255932 | Reprogramming the chimeric antigen receptor T cell epigenome to augment anti-tumor activity | 000 | 5 | NIH | 2/14/2025 | $188,676 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL173059 | Defining neutrophil pathobiology in pediatric Long COVID | 000 | 2 | NIH | 3/7/2025 | $715,054 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS122829 | Circadian Effects in the Stroke Penumbra | 000 | 4 | NIH | 2/14/2025 | $452,157 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08HL173572 | The Impact of Soluble ST2 on Lung Injury Onset and Resolution | 000 | 2 | NIH | 3/24/2025 | $170,640 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG081841 | The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brain | 000 | 3 | NIH | 2/14/2025 | $683,192 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23AR080791 | Predictive modeling of cutaneous immune checkpoint inhibitor toxicities | 000 | 3 | NIH | 3/24/2025 | $176,040 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08DK138287 | Insulin receptor condensates in health and disease | 000 | 1 | NIH | 2/21/2025 | $172,140 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG076704 | Metabolic Interventions for Sleep, Anesthesia-related Neurocognitive Disorders and Alzheimer's Disease | 000 | 4 | NIH | 3/10/2025 | $477,734 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01CK000633 | CK21-001 - Global TravEpiNet (GTEN): U.S. Travelers' Health Research, Surveillance, Communication and Outreach Network Supplement - Pregnant Travelers | 01 | 4 | CDC | 3/7/2025 | $149,939 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS121233 | Forecasting Migraine Attacks | 000 | 4 | NIH | 2/14/2025 | $375,325 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG054598 | Astrocytes as governing pathological drivers of neurovascular dysfunction in AD | 000 | 8 | NIH | 3/11/2025 | $459,994 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA269672 | Reprogramming the tumormicroenvironment to improve immunotherapy of glioblastoma | 000 | 4 | NIH | 3/3/2025 | $341,670 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00HD101553 | Fast motion-robust fetal neuroimaging with MRI | 000 | 5 | NIH | 3/11/2025 | $223,199 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | U01CA268933 | Microfluidic isolation and molecular analysis of circulating tumor cells for the study of neuroendocrine transdifferentiation in prostate cancer | 000 | 4 | NIH | 3/4/2025 | $550,413 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA293888 | Expanding the therapeutic window of chemoradiation through radiation-responsive nanoparticle drug depots | 000 | 1 | NIH | 3/11/2025 | $644,034 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA291779 | Imaging radiation-enhanced drug delivery for safer and more effective chemoradiotherapy | 000 | 1 | NIH | 3/3/2025 | $662,516 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA279385 | Role of the YAP1-LATS2 negative feedback loop in cervical carcinogenesis | 000 | 3 | NIH | 3/10/2025 | $438,493 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA290785 | Novel regulation and functions of TEAD-VGLL complex | 000 | 1 | NIH | 3/11/2025 | $680,594 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R37CA245523 | Dissecting the cellular hierarchies of malignant gliomas by single-cell functional genomics | 000 | 6 | NIH | 3/11/2025 | $352,450 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R35GM131743 | Functional Analysis of Epigenetic Complexes | 002 | 7 | NIH | 2/21/2025 | $801,767 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG071567 | Microvascular Stress as a Pathway to Neurodegeneration in Alzheimer's | 000 | 4 | NIH | 3/4/2025 | $376,449 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG082377 | Submillimeter resolution diffusion MRI of the medial temporal lobe in the earliest stages of Alzheimer's disease | 001 | 2 | NIH | 3/4/2025 | $225,450 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL157635 | Using Electrocardiogram Genetics to Inform Arrhythmia Risk | 000 | 4 | NIH | 3/10/2025 | $647,983 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA289485 | Analyzing DNA replication and damage vulnerability in IDH mutant glioma | 000 | 2 | NIH | 3/3/2025 | $361,028 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HS029319 | Improving Equitable Access to Penicillin Allergy De-Labeling | 002 | 4 | AHRQ | 2/21/2025 | $249,967 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS129059 | Spatiotemporal Alterations of Thalamocortical Circuitry Functioning Underlie Pain | 000 | 3 | NIH | 3/4/2025 | $560,057 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23DK135798 | REACH-Es: Adapting a digital health tool to improve diabetes medication adherence among Latino adults | 000 | 3 | NIH | 2/21/2025 | $196,170 |
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