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 | Issue Date FY: 2025 ( Subtotal = $65,898,055 ) (Continued on the next page) |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08HL166687 | Clonal hematopoiesis as a mediator of cardiovascular disease in women with premature menopause | 000 | 3 | NIH | 12/20/2024 | $169,003 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99CA286966 | Explainable Artificial Intelligence for Melanoma Recurrence Prediction via Integrative Modeling of Multiplexed Imaging with Transcriptomics and Histopathology | 000 | 2 | NIH | 12/20/2024 | $176,040 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08CA270430 | Health Opportunities & Promoters of Equitable Screening for Lung Cancer (Hopes for Lung Cancer) | 000 | 3 | NIH | 12/19/2024 | $280,777 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08AG078447 | Physiology of Lifespan Extension and Metabolic Hormesis with Riboflavin Depletion | 000 | 3 | NIH | 12/20/2024 | $169,176 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23MH125143 | The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative Emotions | 000 | 5 | NIH | 12/20/2024 | $199,519 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AG087072 | Reactive Astrogliosis and the Tripartite Synapse in Alzheimer's Disease | 000 | 1 | NIH | 12/13/2024 | $452,550 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21EY037019 | Auto-sensing, instantaneous adaptive ranging OCT | 000 | 1 | NIH | 12/16/2024 | $256,296 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS126187 | Co-Targeting IL-6 and EGFRsignaling for the Treatment of Schwannomatosis and Associated Pain | 000 | 3 | NIH | 12/13/2024 | $429,559 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA255602 | High-flow microfluidics of leukapheresis blood products for functional analysis of breast circulating tumor cells | 000 | 5 | NIH | 12/18/2024 | $582,866 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK134675 | An NADH-ChREBP axis in fatty liver disease and dyslipidemia | 000 | 3 | NIH | 12/13/2024 | $471,860 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K01DK135854 | Prediction of outcomes in diverticulitis using a deep-learning framework | 000 | 2 | NIH | 12/13/2024 | $156,244 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21EY037018 | A one and done therapeutic strategy to correct ELP1 splicing defect in familial dysautonomia | 000 | 1 | NIH | 12/16/2024 | $250,500 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS120973 | Timing of Neuronal Chloride Uptake for Control of Neonatal Seizure | 000 | 4 | NIH | 12/17/2024 | $362,700 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS131281 | Targeting receptor interacting protein kinase-1 in the chronic period of intracerebral hemorrhage | 000 | 2 | NIH | 12/16/2024 | $339,547 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS131281 | Targeting receptor interacting protein kinase-1 in the chronic period of intracerebral hemorrhage | 000 | 2 | NIH | 12/16/2024 | $100,154 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AG090302 | Thalamocortical interactions and the effect of thalamic stimulation on sleep oscillations | 000 | 1 | NIH | 12/13/2024 | $698,870 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK120663 | Molecular Magnetic Resonance Imaging of Inflammation | 001 | 6 | NIH | 12/27/2024 | $713,467 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01MH128421 | Near real-time system for high-resolution computationalTMS navigation | 000 | 4 | NIH | 12/13/2024 | $666,109 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23HL148017 | Testing the feasibility and preliminary efficacy of a psychological and behavioral intervention to promote physical activity after weight loss surgery | 000 | 5 | NIH | 11/6/2024 | $175,999 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI177414 | Staphylococcal protease-mediated epithelial barrier perturbation and allergen sensitization | 000 | 2 | NIH | 11/7/2024 | $635,901 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS131347 | Comparative Effectiveness of EEG-Guided Anti-Seizure Treatment in Acute Brain Injury | 000 | 2 | NIH | 11/21/2024 | $591,352 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK119210 | Characterizing neurogenic progenitors in the adult intestine | 002 | 6 | NIH | 12/12/2024 | $320,607 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI153068 | The Immunopathogenesis of Familial Transverse Myelitis Due to Mutations in VPS37a | 000 | 3 | NIH | 12/31/2024 | $404,975 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL173028 | Effects of IL-1 beta inhibition on vascular inflammation in TET2 clonal hematopoiesis | 000 | 1 | NIH | 12/20/2024 | $834,531 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23DA058200 | Peer recovery support for people experiencing homelessness with opioid use disorder | 000 | 2 | NIH | 1/6/2025 | $197,640 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R00AR080243 | Metabolic syndrome, chronic inflammation, and gout: a multi-omics approach | 000 | 3 | NIH | 12/23/2024 | $224,099 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23MH136873 | Engaging men outside the HIV prevention paradigm in rural South Africa | 000 | 1 | NIH | 12/24/2024 | $197,035 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K99MH135180 | Anxiety in Youth with Autism Spectrum Disorder | 000 | 2 | NIH | 12/24/2024 | $128,724 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | D43TW005572 | International research training program in vaccine development and public health | 000 | 25 | NIH | 12/30/2024 | $235,001 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | D43TW005572 | International research training program in vaccine development and public health | 000 | 25 | NIH | 12/30/2024 | $50,000 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01NS134799 | Mechanisms of Chronic Blood-Brain Barrier Dysfunction after Traumatic Brain Injury | 000 | 1 | NIH | 12/31/2024 | $404,100 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HL163273 | Long-Acting, Short-Residing Nanochelators for Iron Overload Therapy | 000 | 3 | NIH | 1/6/2025 | $645,497 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA255479 | Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients | 000 | 5 | NIH | 1/8/2025 | $611,167 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K01AG072046 | Optical probe and instrumentation development for in vivo near-infrared fluorescence imaging of Alzheimer's disease | 000 | 4 | NIH | 12/23/2024 | $127,320 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK114506 | High subzero preservation of liver for transplantation | 000 | 9 | NIH | 12/23/2024 | $495,967 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01DK114506 | High subzero preservation of liver for transplantation | 001 | 9 | NIH | 12/30/2024 | $43,912 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI168131 | Allergen-specific lung-resident Tregs in asthma: Targetable suppressors of resident memory Th2 cells | 000 | 4 | NIH | 1/7/2025 | $582,199 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01HD082527 | The neural basis of language comprehension: Insights from spatiotemporal imaging | 000 | 8 | NIH | 1/10/2025 | $530,588 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI174276 | Eliminating the Immunogenicity of AAV Vectored HIV Antibody Delivery | 000 | 2 | NIH | 1/10/2025 | $350,000 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01AI174276 | Eliminating the Immunogenicity of AAV Vectored HIV Antibody Delivery | 000 | 2 | NIH | 1/10/2025 | $467,309 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08DK139370 | Dysregulation of the unfolded protein response in the pathogenesis of non-alcoholic steatohepatitis | 000 | 1 | NIH | 1/9/2025 | $172,060 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI183486 | A novel bacteria-specific pro-photosensitizer | 000 | 2 | NIH | 1/9/2025 | $248,148 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R21AI184169 | Impact of in utero HIV and antiretroviral exposure on the placenta and birth weight | 000 | 1 | NIH | 1/6/2025 | $244,328 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA260890 | Synergistic combinatorial DNA damage response/repair inhibition and Sacituzumab Govitecan in triple-negative breast cancer | 000 | 4 | NIH | 12/4/2024 | $503,805 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01EB034197 | Plug-and-play Hyperpolarized MRI of Metabolism on Clinical Scanners | 000 | 2 | NIH | 12/12/2024 | $534,597 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K01MH135131 | Improving emergency psychiatric care through machine learning, causal inference, and psychometrics | 000 | 2 | NIH | 12/9/2024 | $180,635 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | R01CA285582 | Investigating CREB5-driven mechanisms of immune therapy resistance | 000 | 1 | NIH | 12/11/2024 | $620,820 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K23MH138668 | Preventing Homelessness in Transitioning Service Members with Mental Illness | 000 | 1 | NIH | 12/11/2024 | $196,120 |
| | 2025 | 2025 | THE GENERAL HOSPITAL CORPORATION | 55 FRUIT ST | BOSTON | MA | 02114-2621 | SUFFOLK | USA | K08HL168238 | Advancing the clinical actionability of polygenic scores for coronary artery disease | 000 | 2 | NIH | 12/5/2024 | $170,323 |
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