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Supraspinal Processing of Sensory Aspects of Pain

Award Number: R01NS039426
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/22/2000
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Supraspinal Processing of Sensory Aspects of Pain - PROJECT SUMMARY Chronic pain affects approximately 20% of both adults and children in the US and is a source of substantial disability and health care costs. Chronic pain can be challenging to diagnose due to the presence of poorly understood symptoms. When diagnosed, current pharmacologic treatments for pain are remarkably ineffective, while effective non-pharmacologic treatments remain under-utilized. These shortcomings in the diagnosis and treatment of pain arise from tremendous gaps in our knowledge about the basic central nervous system systems that process nociceptive information and instantiate an experience of pain. These gaps are further amplified in the case of pediatric chronic pain due to a lack of basic/translational research. Our team of basic scientists and clinician scientists is uniquely positioned to perform human pediatric studies integrating functional neuroimaging with quantitative sensory testing and psychological assessments to delineate brain systems engaged during chronic pain. We will examine four distinct chronic pain syndromes: migraine, complex regional pain syndrome, functional abdominal pain, and musculoskeletal pain. We seek to 1) Identify shared and distinct brain systems engaged by different forms of pediatric chronic pain, 2) Determine if predictors of recovery differ across different chronic pain conditions, 3) Delineate brain systems associated with the spread of pain. We will follow patients longitudinally for 1 year after initiation of treatment to assess the degree of recovery and spread of pain. This study will provide a critical foundation of basic knowledge for future clinical trials of diagnostic markers for different forms of chronic pain and for the development of new treatments for chronic pain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $636,853 )
2024	2024	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	16	8/22/2024	NON-COMPETING CONTINUATION	$636,853
														Subtotal = $636,853

Issue Date FY: 2023 ( Subtotal = $656,705 )
2023	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	15	9/18/2023	NON-COMPETING CONTINUATION	$656,705
														Subtotal = $656,705

Issue Date FY: 2022 ( Subtotal = $656,705 )
2022	2022	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	14	9/5/2022	COMPETING CONTINUATION	$638,055
2022	2022	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	14	9/13/2022	COMPETING CONTINUATION	$18,650
														Subtotal = $656,705

Issue Date FY: 2013 ( Subtotal = $368,876 )
2013	2013	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	13	5/24/2013	NON-COMPETING CONTINUATION	$24,846
2013	2013	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	13	3/21/2013	NON-COMPETING CONTINUATION	$344,030
														Subtotal = $368,876

Issue Date FY: 2012 ( Subtotal = $382,218 )
2012	2012	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	3/28/2012	NON-COMPETING CONTINUATION	$382,218
														Subtotal = $382,218

Issue Date FY: 2011 ( Subtotal = $382,181 )
2011	2011	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	11	7/13/2011	NON-COMPETING CONTINUATION	$24,436
2011	2011	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	4/12/2011	NON-COMPETING CONTINUATION	$357,745
														Subtotal = $382,181

Issue Date FY: 2010 ( Subtotal = $376,068 )
2010	2010	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	10	3/30/2010	NON-COMPETING CONTINUATION	$382,137
2010	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Trans-NIH Recovery Act Research Support	000	9	12/17/2009	SUPPLEMENT FOR EXPANSION	-$6,069
														Subtotal = $376,068

Issue Date FY: 2009 ( Subtotal = $543,826 )
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	4/22/2009	COMPETING CONTINUATION	$374,840
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Trans-NIH Recovery Act Research Support	001	9	9/25/2009	SUPPLEMENT FOR EXPANSION	$168,986
														Subtotal = $543,826

Issue Date FY: 2008 ( Subtotal = $301,336 )
2008	2008	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	3/26/2008	NON-COMPETING CONTINUATION	$301,336
														Subtotal = $301,336

Issue Date FY: 2007 ( Subtotal = $299,993 )
2007	2007	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	4/2/2007	NON-COMPETING CONTINUATION	$299,993
														Subtotal = $299,993

Issue Date FY: 2006 ( Subtotal = $308,917 )
2006	2006	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	4/4/2006	NON-COMPETING CONTINUATION	$308,917
														Subtotal = $308,917

Issue Date FY: 2005 ( Subtotal = $315,105 )
2005	2005	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	4/1/2005	COMPETING CONTINUATION	$315,105
														Subtotal = $315,105

Issue Date FY: 2004 ( Subtotal = $340,200 )
2004	2004	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	2/20/2004	NON-COMPETING CONTINUATION	$340,200
														Subtotal = $340,200

Issue Date FY: 2003 ( Subtotal = $340,200 )
2003	2003	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3		NON-COMPETING CONTINUATION	$340,200
														Subtotal = $340,200

Issue Date FY: 2002 ( Subtotal = $340,797 )
2002	2002	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Biological Basis Research in the Neurosciences	000	2	11/19/2001	NON-COMPETING CONTINUATION	$340,797
														Subtotal = $340,797

Issue Date FY: 2001 ( Subtotal = $331,073 )
2001	2001	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/5/2001	NEW	$331,073
														Subtotal = $331,073

Grand Total All Awards = $6,581,053

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Supraspinal Processing of Sensory Aspects of Pain

Award Number: R01NS039426

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/22/2000

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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