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Functional Characterization of the Genetic and Environmental Determinants of Complex Traits

Award Number: R01GM109215
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Functional Characterization of the Genetic and Environmental Determinants of Complex Traits - Abstract Understanding the molecular and organismal function of genetic variants in non-coding regions is crucial to dissect the genetic and evolutionary basis of variation in complex traits. As we and others have shown, the effect of a genetic variant on a molecular pathway, and ultimately on the individual's phenotype, may be modulated by the environmental context (gene-environment interactions, GxE). Most contexts considered to date focus on aspects of the physical environment that can be reproduced in vitro (e.g., pathogen particles, hormones, toxicants). We also pioneered the study of GxE with psychosocial experiences (e.g., socio-economic status, neighborhood stress). Importantly, psychosocial experiences can inﬂuence an individual's ability to respond to other environmental challenges and these effects can be measured at the cellular level. However the effects of psychosocial experiences on the transcriptional response to cellular stressors has not been fully evaluated. The response to environmental challenges is often mediated by changes in transcription factor activity. Single cell genomics technology has allowed us to discover that gene regulatory changes in response to environmental perturbations are often heterogeneous both across cell types, and across individual cells within a cell type, resulting in a dynamic response. This dynamic response can in turn be regulated through GxE, and it's an important contributor to disease risk. To study the dynamic gene regulatory response to chemical and social stressors, here we will focus on peripheral blood mononuclear cells from an inner city cohort of middle-aged adults collected as part of The Heart of Detroit Study (THDS) and consider psychosocial and cellular stressors. One of the main objectives of this project will be to develop functional genomics, computational, and statistical approaches to dissect the epigenetic mechanisms underlying the response to in vitro and in vivo stressors, their interactions with genetic variants, and ultimately their role in complex trait variation. The tools developed in this project will have broad applicability in the ﬁelds of functional genomics, systems biology, and GxE, ultimately allowing for a global and integrative analysis of genetic and environmental effects on biological systems.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $340,093 )
2026	2026	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	10	4/27/2026	NON-COMPETING CONTINUATION	$340,093
														Subtotal = $340,093

Issue Date FY: 2025 ( Subtotal = $365,767 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	9	4/21/2025	COMPETING CONTINUATION	$365,767
2025	2021	WAYNE STATE UNIVERSITY	5700 CASS AVE STE 4900	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	8	11/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $365,767

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	8	4/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $297,237 )
2021	2021	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	8	5/21/2021	NON-COMPETING CONTINUATION	$297,237
														Subtotal = $297,237

Issue Date FY: 2020 ( Subtotal = $298,239 )
2020	2020	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	7	5/27/2020	NON-COMPETING CONTINUATION	$298,239
														Subtotal = $298,239

Issue Date FY: 2019 ( Subtotal = $299,309 )
2019	2019	WAYNE STATE UNIVERSITY	5057 WOODWARD 13 FLOOR	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	002	6	5/9/2019	NON-COMPETING CONTINUATION	$299,309
2019	2018	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	001	5	2/25/2019	COMPETING CONTINUATION	$81,065
2019	2017	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	4	2/25/2019	NON-COMPETING CONTINUATION	-$81,065
														Subtotal = $299,309

Issue Date FY: 2018 ( Subtotal = $313,658 )
2018	2018	WAYNE STATE UNIVERSITY	5057 WOODWARD 13 FLOOR	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	001	5	8/10/2018	COMPETING CONTINUATION	$313,658
2018	2017	WAYNE STATE UNIVERSITY	5057 WOODWARD 13 FLOOR	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	4	8/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $313,658

Issue Date FY: 2017 ( Subtotal = $274,524 )
2017	2017	WAYNE STATE UNIVERSITY	5057 WOODWARD 13 FLOOR	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	4	5/29/2017	NON-COMPETING CONTINUATION	$274,524
														Subtotal = $274,524

Issue Date FY: 2016 ( Subtotal = $274,690 )
2016	2016	WAYNE STATE UNIVERSITY	5700 CASS SUITE 4602	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	3	8/16/2016	NON-COMPETING CONTINUATION	$274,690
														Subtotal = $274,690

Issue Date FY: 2015 ( Subtotal = $477,595 )
2015	2015	WAYNE STATE UNIVERSITY	5700 CASS SUITE 4602	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	2	6/22/2015	NON-COMPETING CONTINUATION	$276,445
2015	2015	WAYNE STATE UNIVERSITY	5700 CASS SUITE 4602	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	001	2	6/23/2015	SUPPLEMENT FOR EXPANSION	$201,150
														Subtotal = $477,595

Issue Date FY: 2014 ( Subtotal = $290,309 )
2014	2014	WAYNE STATE UNIVERSITY	5700 CASS SUITE 4602	DETROIT	MI	48202	WAYNE	USA	Biomedical Research and Research Training	000	1	7/7/2014	NEW	$290,309
														Subtotal = $290,309

Grand Total All Awards = $3,231,421

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Functional Characterization of the Genetic and Environmental Determinants of Complex Traits

Award Number: R01GM109215

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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