Sunday, May 11, 2025 5/11/2025

Studies on Protein Lipidation

Award Number: R01GM087544
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Studies on Protein Lipidation - PROJECT SUMMARY To elucidate the antiviral mechanism of S-palmitoylated IFITMs (1, 2 and 3) in host immunity against viruses, we propose to perform detailed biochemical, biophysical and cellular studies of these lipidated immune effectors in this grant renewal. For biochemical and structural studies of IFITMs, we will perform computational modeling and reconstitute site-specifically lipidated IFITM3 in vitro (Aim 1). Moreover, we have discovered direct interactions of IFITMs with specific cellular lipids and will investigate their significance biochemically in vitro and in mammalian cells during virus infections (Aim 2). Lastly, we will investigate S-palmitoylated IFITM interactions with key cellular factors involved their regulation and antiviral activity (Aim 3). These studies should help determine how IFITMs prevent virus entry and elucidate biochemical mechanisms by which site-specific lipidation controls membrane protein structure and function in host immunity. Determining the mechanisms that control S-palmitoylated IFITMs function is crucial for understanding host immunity and may reveal new strategies for combatting virus infection in humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	13	3/4/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	13	10/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $288,176 )
2023	2023	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	13	6/8/2023	NON-COMPETING CONTINUATION	$288,176
														Subtotal = $288,176

Issue Date FY: 2022 ( Subtotal = $286,729 )
2022	2022	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	12	6/22/2022	NON-COMPETING CONTINUATION	$286,729
														Subtotal = $286,729

Issue Date FY: 2021 ( Subtotal = $296,766 )
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	11	9/20/2021	NON-COMPETING CONTINUATION	$0
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	11	6/24/2021	NON-COMPETING CONTINUATION	$296,766
														Subtotal = $296,766

Issue Date FY: 2020 ( Subtotal = $364,872 )
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	10	9/7/2020	COMPETING CONTINUATION	$364,872
2020	2019	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	9	8/25/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $364,872

Issue Date FY: 2019 ( Subtotal = $362,730 )
2019	2019	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	9	4/25/2019	NON-COMPETING CONTINUATION	$362,730
														Subtotal = $362,730

Issue Date FY: 2018 ( Subtotal = $441,385 )
2018	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	001	8	5/18/2018	NON-COMPETING CONTINUATION	$36,273
2018	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	002	8	9/13/2018	SUPPLEMENT FOR EXPANSION	$78,655
2018	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	8	3/15/2018	NON-COMPETING CONTINUATION	$326,457
														Subtotal = $441,385

Issue Date FY: 2017 ( Subtotal = $362,730 )
2017	2017	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	002	7	8/15/2017	NON-COMPETING CONTINUATION	$36,273
2017	2017	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	001	7	3/9/2017	NON-COMPETING CONTINUATION	$326,457
2017	2014	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Biomedical Research and Research Training	000	5	1/14/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $362,730

Issue Date FY: 2016 ( Subtotal = $362,730 )
2016	2016	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Biomedical Research and Research Training	001	6	5/25/2016	COMPETING CONTINUATION	$362,730
2016	2014	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Biomedical Research and Research Training	000	5	5/20/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $362,730

Issue Date FY: 2014 ( Subtotal = $323,745 )
2014	2014	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Biomedical Research and Research Training	000	5	7/22/2014	NON-COMPETING CONTINUATION	$323,745
														Subtotal = $323,745

Issue Date FY: 2013 ( Subtotal = $312,414 )
2013	2013	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Biomedical Research and Research Training	000	4	7/25/2013	NON-COMPETING CONTINUATION	$312,414
														Subtotal = $312,414

Issue Date FY: 2012 ( Subtotal = $323,745 )
2012	2012	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Biomedical Research and Research Training	000	3	7/30/2012	NON-COMPETING CONTINUATION	$323,745
														Subtotal = $323,745

Issue Date FY: 2011 ( Subtotal = $323,745 )
2011	2011	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Biomedical Research and Research Training	000	2	8/1/2011	NON-COMPETING CONTINUATION	$323,745
														Subtotal = $323,745

Issue Date FY: 2010 ( Subtotal = $327,015 )
2010	2010	ROCKEFELLER UNIVERSITY	EAST 66TH STREET & YORK AVENUE	NEW YORK	NY	10021	NEW YORK	USA	Biomedical Research and Research Training	000	1	7/26/2010	NEW	$327,015
														Subtotal = $327,015

Grand Total All Awards = $4,376,782

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Studies on Protein Lipidation

Award Number: R01GM087544

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer