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 | Issue Date FY: 2023 ( Subtotal = $223,646,980 ) (Continued on the next page) |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | OT2TR003427 | BioThings Explorer: A platform for distributed knowledge integration across biomedical APIs | 001 | 1 | NIH | 11/30/2022 | $1,062,675 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG070209 | Using Genetic Diversity to Manage Neurological Disease | 001 | 3 | NIH | 3/14/2023 | $449,077 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG067331 | Lowering Mitochondrial ATP Synthase Activity Slows Aging and Alzheimer's Disease | 001 | 4 | NIH | 9/15/2023 | $0 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DA048882 | Omics Analyses of HIV and Substance Use Disorder | 000 | 5 | NIH | 7/31/2023 | $835,968 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI137252 | Functional Analysis of MicroRNAs and Target Genes in Immune Tolerance | 000 | 4 | NIH | 5/12/2023 | $649,382 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS112482 | A RIPK2-Targeting Apoptosis-Inducing Small Molecule for the Treatment of Glioblastoma | 000 | 5 | NIH | 4/14/2023 | $429,916 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS095892 | IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY | 002 | 8 | NIH | 5/10/2023 | $106,500 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI073148 | Knock-in mice expressing germline-reverted broadly neutralizing HIV antibodies | 000 | 15 | NIH | 6/6/2023 | $635,270 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167372 | The generation and protective function of lung tissue resident memory T cells following SARS-CoV-2 infection or vaccination | 000 | 2 | NIH | 2/3/2023 | $878,617 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167003 | In vivo engineering of B cells for the secretion of HIV broadly neutralizing antibodies | 000 | 2 | NIH | 11/14/2022 | $738,581 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35AG071734 | Leadership in AD/ADRD Drug Discovery | 001 | 3 | NIH | 8/2/2023 | $1,083,553 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG070209 | Using Genetic Diversity to Manage Neurological Disease | 000 | 3 | NIH | 1/4/2023 | $443,750 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG067331 | Lowering Mitochondrial ATP Synthase Activity Slows Aging and Alzheimer's Disease | 000 | 4 | NIH | 5/4/2023 | $910,978 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DA048882 | Omics Analyses of HIV and Substance Use Disorder | 001 | 5 | NIH | 8/11/2023 | $0 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI145055 | N-glycan baiting to target the highly effective HIV Env shield | 000 | 4 | NIH | 3/15/2023 | $961,798 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R37AG059418 | FoxO transcription factors in joint aging and osteoarthritis pathogenesis | 001 | 6 | NIH | 9/15/2023 | $0 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK110162 | Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis | 001 | 6 | NIH | 6/15/2023 | $107,666 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS095892 | IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY | 000 | 7 | NIH | 1/9/2023 | $35,501 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM087544 | Studies on Protein Lipidation | 000 | 13 | NIH | 6/8/2023 | $288,176 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL088256 | Vesicular trafficking mechanisms regulating granulocyte function | 001 | 13 | NIH | 8/17/2023 | $715,326 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA014351 | The Nociceptin ORL1 System: Treatment Target for Relapse | 000 | 17 | NIH | 5/24/2023 | $342,864 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK128547 | Role of NLRP3 signals in ischemia/reperfusion-induced organ injury | 001 | 3 | NIH | 7/7/2023 | $904,991 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI150885 | High-throughput assays and small-molecule discovery of antiviral candidates targeting influenza hemagglutinin | 000 | 3 | NIH | 4/19/2023 | $678,526 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL148815 | Toward Personalized Therapeutics: Directed Remodeling of the Gut Microbiome to Treat Atherosclerosis | 000 | 4 | NIH | 4/3/2023 | $748,564 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R37AG059418 | FoxO transcription factors in joint aging and osteoarthritis pathogenesis | 000 | 6 | NIH | 6/1/2023 | $563,668 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK110162 | Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis | 002 | 6 | NIH | 6/17/2023 | $0 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM120604 | Modeling and Interacting with the Visible Molecular Cell | 000 | 7 | NIH | 8/8/2023 | $454,508 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG049617 | Integrative Omics analysis of human cartilage in aging and osteoarthritis | 001 | 8 | NIH | 9/14/2023 | $0 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM084019 | Ligand-Promoted Enantioselective C-H Activation Reaction | 000 | 15 | NIH | 5/24/2023 | $109,546 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM102265 | Catalyst-Controlled Site-Selective C-H Functionalizations of Arenes and Heteroarenes | 000 | 12 | NIH | 7/14/2023 | $384,953 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK046335 | Probing the biochemical mechanism of amyloid disease | 000 | 32 | NIH | 8/24/2023 | $635,273 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA028982 | Alcohol-Induced Neuroinflammation and AUD Therapeutic Mechanisms | 000 | 2 | NIH | 2/28/2023 | $407,250 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DE031044 | Salivary gland ionocyte organization and function during homeostasis, repair, and disease | 000 | 3 | NIH | 5/25/2023 | $596,425 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI154138 | Exploring Siglec-glycan ligand interactions using chemoenzymatic approaches | 001 | 3 | NIH | 6/21/2023 | -$73,386 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM139643 | Chemoenzymatic glycan editing for deciphering biological functions of glycans | 001 | 3 | NIH | 4/6/2023 | $76,424 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA027555 | The dark side of addiction: Significance of environmental conditioning to negative reinforcement by EtOH in subjects with a dependence history | 001 | 4 | NIH | 3/14/2023 | $39,698 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK107604 | Establishing Strategies to Ameliorate Amyloid Pathology in Light Chain Amyloidosis | 000 | 8 | NIH | 6/29/2023 | $519,068 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA042056 | Antitumor Antibiotics | 000 | 39 | NIH | 3/28/2023 | $430,894 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32GM145143 | Defining Structural and Molecular Mechanisms of The Human Multifunctional Mitochondrial Protease, LONP1 | 001 | 2 | NIH | 2/15/2023 | $1,918 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM139627 | Link extracellular function of tRNA synthetase with pathological mechanism of disease | 000 | 3 | NIH | 5/25/2023 | $452,500 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | OT2TR003445 | Expanding the landscape of Translator Knowledge Providers using BioThings SDK and SmartAPI | 001 | 1 | NIH | 12/7/2022 | $561,644 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM139643 | Chemoenzymatic glycan editing for deciphering biological functions of glycans | 000 | 3 | NIH | 1/31/2023 | $687,817 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA028879 | Dorsal striatal phosphodiesterase 10A and compulsive ethanol use | 001 | 3 | NIH | 3/14/2023 | $39,937 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK123038 | UNDERSTANDING HEPATIC PROTEOSTASIS IN SYSTEMIC AMYLOID DISEASES | 000 | 4 | NIH | 4/7/2023 | $640,815 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA027555 | The dark side of addiction: Significance of environmental conditioning to negative reinforcement by EtOH in subjects with a dependence history | 000 | 4 | NIH | 1/4/2023 | $357,280 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM122606 | Unusual Pharmacophores and New Tools for Cross-Coupling | 002 | 7 | NIH | 3/29/2023 | $692,868 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM118176 | Scalable Synthesis and New Bond Disconnections | 000 | 8 | NIH | 3/9/2023 | $1,115,784 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM096888 | In-silico prediction of protein-peptide interactions. | 000 | 13 | NIH | 8/4/2023 | $407,250 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA041101 | Biologically Active Cyclic Peptides | 002 | 38 | NIH | 9/19/2023 | $9,192 |
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