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 | Issue Date FY: 2023 ( Subtotal = $59,262,828 ) (Continued on the next page) |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA245292 | Translation of commensal bacteria mechanism for immunotherapy | 000 | 5 | NIH | 12/19/2022 | $499,794 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM118176 | Scalable Synthesis and New Bond Disconnections | 000 | 8 | NIH | 3/9/2023 | $1,115,784 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA041101 | Biologically Active Cyclic Peptides | 001 | 38 | NIH | 3/16/2023 | $36,765 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31GM145186 | Allosteric Pharmacologic Chaperones for alpha-1 Antitrypsin Mutants | 000 | 2 | NIH | 1/12/2023 | $33,752 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI161014 | How antigen exposure shapes the subsequent NK cell response to HIV | 000 | 3 | NIH | 2/1/2023 | $857,121 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM140287 | Haplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populations | 000 | 3 | NIH | 11/28/2022 | $562,255 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA245292 | Translation of commensal bacteria mechanism for immunotherapy | 001 | 5 | NIH | 3/15/2023 | $44,425 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS095892 | Impacting mitochondrial function through altered protease activity | 000 | 7 | NIH | 1/9/2023 | $35,501 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA028982 | Alcohol-Induced Neuroinflammation and AUD Therapeutic Mechanisms | 000 | 2 | NIH | 2/28/2023 | $407,250 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM140287 | Haplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populations | 001 | 3 | NIH | 3/28/2023 | $62,472 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P01AI157299 | Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates | 000 | 3 | NIH | 3/3/2023 | $3,402,658 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R37DA015648 | Modulating Signaling Endocannabinoids and Fatty Acid Amides | 000 | 17 | NIH | 11/22/2022 | $359,438 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 000 | 40 | NIH | 12/26/2022 | $1,834,175 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32GM145143 | Defining Structural and Molecular Mechanisms of The Human Multifunctional Mitochondrial Protease, LONP1 | 001 | 2 | NIH | 2/15/2023 | $1,918 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM139643 | Chemoenzymatic glycan editing for deciphering biological functions of glycans | 000 | 3 | NIH | 1/31/2023 | $687,817 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA028879 | Dorsal striatal phosphodiesterase 10A and compulsive ethanol use | 001 | 3 | NIH | 3/14/2023 | $39,937 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HG012819 | In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues | 000 | 1 | NIH | 3/2/2023 | $773,298 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | RF1AG046495 | Discovering Small Molecule Activators of Stress-Responsive Signaling | 000 | 11 | NIH | 3/23/2023 | $2,621,070 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AG080376 | Lifespan extension by reverse fasting | 000 | 1 | NIH | 2/28/2023 | $271,500 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | UM1TR004407 | Scripps Clinical and Translational Science Hub | 000 | 1 | NIH | 3/14/2023 | $6,029,792 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI172915 | Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence | 000 | 1 | NIH | 11/10/2022 | $771,519 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI170928 | Development of pan-betacoronavirus vaccines | 000 | 1 | NIH | 3/3/2023 | $805,612 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F30AG081061 | Alleviating Mitochondrial Dysfunction in PERK-deficient Neurodegenerative Disease | 000 | 1 | NIH | 3/24/2023 | $34,694 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA271500 | Establishing a mechanistic basis for enhanced tumorigenesis under chronic circadian disruption | 000 | 1 | NIH | 12/15/2022 | $640,055 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI176215 | Initiation of HIV Capsid Assembly Monitored by Mass Photometry | 000 | 1 | NIH | 1/13/2023 | $226,250 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K99AG080109 | Role of selective autophagy in aging and neurodegeneration: a small molecule approach | 000 | 1 | NIH | 2/3/2023 | $126,250 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01DA056004 | Single nucleus gene expression in moderate and compulsive drug self-administration in a rodent model of HIV | 001 | 2 | NIH | 1/18/2023 | $131,890 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS087026 | Transcriptional Control of Synaptic Plasticity by Class IIa HDACs | 000 | 8 | NIH | 3/23/2023 | $687,601 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI168917 | Understanding human antibody responses to chronic viral hepatitis C | 001 | 2 | NIH | 1/4/2023 | $621,806 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01ES031863 | Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity | 000 | 2 | NIH | 11/25/2022 | $523,588 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01EY031597 | Experience-dependent Cellular Plasticity Mechanisms | 000 | 3 | NIH | 1/17/2023 | $683,732 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI145055 | N-glycan baiting to target the highly effective HIV Env shield | 000 | 4 | NIH | 3/15/2023 | $961,798 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35NS105067 | Mechanisms of force sensing in the nervous system | 001 | 6 | NIH | 12/19/2022 | $266,250 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167372 | The generation and protective function of lung tissue resident memory T cells following SARS-CoV-2 infection or vaccination | 000 | 2 | NIH | 2/3/2023 | $878,617 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167003 | In vivo engineering of B cells for the secretion of HIV broadly neutralizing antibodies | 000 | 2 | NIH | 11/14/2022 | $738,581 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35NS105067 | Mechanisms of force sensing in the nervous system | 000 | 6 | NIH | 12/13/2022 | $677,250 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL118114 | Managing Atherosclerosis by Modulating HDL Function | 000 | 10 | NIH | 3/24/2023 | $773,645 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG066750 | Compound repositioning for Alzheimer's Disease using knowledge graphs, insurance claims data, and gene expression complementarity | 000 | 4 | NIH | 1/19/2023 | $885,966 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM122606 | Unusual Pharmacophores and New Tools for Cross-Coupling | 002 | 7 | NIH | 3/29/2023 | $692,868 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AA013498 | 9/10 Electrophysiology of Alcohol in Extended Amygdala | 000 | 22 | NIH | 1/30/2023 | $655,957 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM136412 | Dynamics of the Bacterial Ribosome and Proteome | 000 | 4 | NIH | 2/23/2023 | $713,574 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM130385 | Metabolomics Technologies to Advance Biomedical Research | 000 | 5 | NIH | 2/28/2023 | $483,750 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | OT2TR003445 | Expanding the landscape of Translator Knowledge Providers using BioThings SDK and SmartAPI | 001 | 1 | NIH | 12/7/2022 | $561,644 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI143931 | Non-immunosuppressive Sanglifehrin Analogs as Therapeutic Agents for Viral Hepatitis-induced Liver Damage Development | 000 | 4 | NIH | 3/29/2023 | $443,750 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI144070 | Endosomal TLR transport in B cell signaling and autoimmunity | 000 | 5 | NIH | 1/17/2023 | $483,750 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI143884 | Engineer Immune Cells via Chemoenzymatic Glycan Editing | 000 | 5 | NIH | 3/7/2023 | $944,319 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM117145 | Sulfur(VI) Fluoride Exchange (SuFEx): new developments and biological applications | 001 | 8 | NIH | 2/10/2023 | $44,373 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | OT2TR003427 | BioThings Explorer: A platform for distributed knowledge integration across biomedical APIs | 002 | 1 | NIH | 3/25/2023 | $0 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI152523 | Expediting elicitation of HIV-1 bnAbs with membrane Env vaccines | 000 | 4 | NIH | 2/6/2023 | $891,174 |
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