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 | Issue Date FY: 2025 ( Subtotal = $46,703,064 ) (Continued on the next page) |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK124211 | Molecular mechanisms of transthyretin amyloidosis | 001 | 5 | NIH | 12/2/2024 | $566,635 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI130227 | Targeting Influenza A Virus by a Carbohydrate-inspired Strategy | 001 | 6 | NIH | 12/20/2024 | $446,200 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI136621 | Dissecting Polyclonal Sera to Reveal Correlates of Productive Immune Responses to HIV | 000 | 8 | NIH | 2/13/2025 | $837,382 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P01AI177683 | The Multi-omics Vaccine Evaluation (MOVE) Consortium | 000 | 3 | NIH | 4/4/2025 | $1,796,659 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM130385 | Metabolomics Technologies to Advance Biomedical Research | 003 | 7 | NIH | 4/4/2025 | $460,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL142975 | Regulation of Protein C Pathways | 000 | 8 | NIH | 3/27/2025 | $807,906 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI181784 | Combining membrane Env vaccine regimens to elicit multiple bnAb lineages and consistent cross-neutralization of HIV | 000 | 2 | NIH | 10/30/2024 | $912,596 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS095892 | IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY | 000 | 10 | NIH | 5/7/2025 | $627,282 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM118176 | Scalable Synthesis and New Bond Disconnections | 001 | 9 | NIH | 1/14/2025 | $39,244 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL118114 | Managing Atherosclerosis by Modulating HDL Function | 000 | 12 | NIH | 4/23/2025 | $707,820 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K01DK132957 | Deconstructing brainstem circuits for visceral senses | 002 | 3 | NIH | 5/2/2025 | $153,360 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT012075 | Deconvolution of Galbulimima bark pharmacology through chemical synthesis and target assignment | 000 | 3 | NIH | 3/13/2025 | $663,419 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI185735 | Germline targeting for neuraminidase broadly neutralizing antibodies | 000 | 1 | NIH | 1/23/2025 | $230,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | OT2TR005710 | DOGSURF: Database Optimized for Graph Search Using Robust Federation | 000 | 1 | NIH | 12/24/2024 | $1,746,403 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01EY031597 | Experience-dependent Cellular Plasticity Mechanisms | 000 | 5 | NIH | 1/14/2025 | $708,770 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL166410 | Applying Spatial Covariance to Understand Human Variation in Genetic Disease | 000 | 3 | NIH | 4/9/2025 | $460,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | UG3DK142188 | Studying the mechanisms of initiation and progression of Beta cell death in T1D | 000 | 1 | NIH | 12/20/2024 | $1,232,846 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI178437 | Elucidation of the interactome for the bioactive disaccharide Man(B1-4)GlcNAc | 000 | 2 | NIH | 11/19/2024 | $223,100 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K00CA274692 | Amplifications and signaling of oncoproteins in cancer | 000 | 3 | NIH | 12/23/2024 | $96,120 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI182439 | Chemoproteomic discovery and functional analysis microbiota bile acid-protein targets in host immunity | 000 | 1 | NIH | 12/9/2024 | $891,678 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG088908 | Structure-function studies of DELE1-mediated activation of the integrated stress response | 000 | 2 | NIH | 5/8/2025 | $569,401 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R13CA298718 | 2024 SoCal Genome Stability Symposium | 000 | 1 | NIH | 12/18/2024 | $5,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS140965 | Restoring neuronal degradative capacity as a therapeutic strategy to treat Prion Disease | 000 | 1 | NIH | 12/12/2024 | $186,363 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS140965 | Restoring neuronal degradative capacity as a therapeutic strategy to treat Prion Disease | 000 | 1 | NIH | 12/12/2024 | $722,727 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI168917 | Understanding human antibody responses to chronic viral hepatitis C | 000 | 4 | NIH | 12/12/2024 | $618,099 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA271500 | Establishing a mechanistic basis for enhanced tumorigenesis under chronic circadian disruption | 000 | 3 | NIH | 11/13/2024 | $546,056 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167003 | In vivo engineering of B cells for the secretion of HIV broadly neutralizing antibodies | 000 | 4 | NIH | 11/15/2024 | $700,174 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM122606 | Unusual Pharmacophores and New Tools for Cross-Coupling | 001 | 9 | NIH | 3/28/2025 | $704,352 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P01AI157299 | Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates | 000 | 5 | NIH | 4/25/2025 | $2,794,109 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA028879 | Dorsal striatal phosphodiesterase 10A and compulsive ethanol use | 000 | 5 | NIH | 12/13/2024 | $372,600 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG070209 | Using Genetic Diversity to Manage Neurological Disease | 000 | 5 | NIH | 12/5/2024 | $414,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01DA056004 | Single nucleus gene expression in moderate and compulsive drug self-administration in a rodent model of HIV | 000 | 4 | NIH | 12/20/2024 | $588,372 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01DA056004 | Single nucleus gene expression in moderate and compulsive drug self-administration in a rodent model of HIV | 001 | 4 | NIH | 4/4/2025 | $65,374 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AI160338 | Mechanistic Studies of Combination Adjuvants to Target B Cells in Vaccines | 000 | 5 | NIH | 4/18/2025 | $694,960 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM152084 | Structure-based in-silico prediction of peptide interactions. | 001 | 2 | NIH | 4/3/2025 | $460,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK134609 | Neural Mechanisms of Energy Expenditure-Induced Compensatory Food Intake | 000 | 3 | NIH | 4/29/2025 | $707,310 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21EB036298 | Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution | 000 | 2 | NIH | 4/30/2025 | $230,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R37AG059418 | FoxO transcription factors in joint aging and osteoarthritis pathogenesis | 002 | 8 | NIH | 5/2/2025 | $515,710 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HG012819 | In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues | 000 | 3 | NIH | 12/30/2024 | $668,947 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | RF1AG046495 | Discovering Small Molecule Activators of Stress-Responsive Signaling | 000 | 11 | NIH | 10/28/2024 | $169,455 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK137675 | An Innovative Approach to Identify Correctors of Metabolic Complications in HIV | 000 | 2 | NIH | 12/2/2024 | $832,564 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K00AA031926 | Role of parasubthalamic astrocytic dysfunction in alcohol use disorder | 000 | 3 | NIH | 1/15/2025 | $93,193 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P01AI172525 | Multidimensional development of high-affinity anti-glycan antibodies to fight deadly bacterial infections | 000 | 3 | NIH | 4/25/2025 | $1,961,391 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK137470 | Pharmacologic targeting of the UPR in obesity-linked liver dysfunction | 000 | 2 | NIH | 11/26/2024 | $689,587 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS136003 | Investigating the mechanism of decision-making in the mitochondrial Protease YME1 | 000 | 2 | NIH | 1/20/2025 | $35,974 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA280720 | Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools | 000 | 2 | NIH | 12/13/2024 | $522,287 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 001 | 3 | NIH | 1/10/2025 | $102,065 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 001 | 3 | NIH | 1/10/2025 | $352,082 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01ES031863 | Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity | 000 | 4 | NIH | 11/19/2024 | $542,761 |
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