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 | Issue Date FY: 2025 ( Subtotal = $159,056,702 ) (Continued on the next page) |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32DK136301 | Discovery of metabolic pathways using phenotypic screening and chemical proteomics | 000 | 3 | NIH | 7/9/2025 | $80,224 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K99CA290143 | Discovering and Characterizing Druggable Cysteines in Cancer Dependency Proteins | 000 | 2 | NIH | 3/14/2025 | $165,780 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | T32DA062586 | Addiction Training in Discovery, Computation, and Translation to Medicine | 000 | 1 | NIH | 6/13/2025 | $288,107 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21DA062132 | Preparation and Investigation of Monoclonal Antibodies to Block Xylazine's Mechanism of Action and Adverse Effects | 000 | 1 | NIH | 7/3/2025 | $506,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AA013498 | 9/10 Electrophysiology of Alcohol in Extended Amygdala | 001 | 24 | NIH | 8/5/2025 | $56,911 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AA013498 | 9/10 Electrophysiology of Alcohol in Extended Amygdala | 000 | 24 | NIH | 3/5/2025 | $611,980 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R03LM014974 | Expanding BioThings as a community API gateway for sharing biomedical knowledge | 000 | 1 | NIH | 8/25/2025 | $276,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI194052 | Development of siRNA-peptide libraries for delivery screening | 000 | 1 | NIH | 7/9/2025 | $506,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS125674 | Defining Endoplasmic Reticulum Stress-Development Mitochondria Remodeling | 000 | 2 | NIH | 7/2/2025 | $684,451 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA032709 | Role of BK channels in alcohol-induced dysmyelination | 000 | 1 | NIH | 8/28/2025 | $657,156 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U19AI135995 | Center for Viral Systems Biology (CViSB) | 000 | 8 | NIH | 2/18/2025 | $2,568,706 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | T32GM159580 | Scripps Research Translational Chemical Biology | 000 | 1 | NIH | 8/8/2025 | $404,450 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | T32GM159580 | Scripps Research Translational Chemical Biology | 001 | 1 | NIH | 8/26/2025 | $0 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT013748 | Building a somatosensory atlas for interoception | 000 | 1 | NIH | 8/12/2025 | $2,804,900 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21NS142779 | Mechanisms of ATAD3A in Regulating the Mitochondrial Genome | 000 | 1 | NIH | 7/23/2025 | $506,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM158311 | Enantioselective and site-selective C-H activation reactions with Bifunctional ligands | 000 | 1 | NIH | 7/22/2025 | $874,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167372 | The generation and protective function of lung tissue resident memory T cells following SARS-CoV-2 infection or vaccination | 000 | 4 | NIH | 2/24/2025 | $863,551 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG070775 | Role of PLD3 in nucleic acid recognition and brain function | 000 | 2 | NIH | 7/29/2025 | $450,798 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21HD119928 | Defining the structure-interactome relationships of the basigin glycoprotein in endometriosis | 000 | 1 | NIH | 7/23/2025 | $506,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM158320 | Accelerating Discovery by Merging Kinetics with Data Science Methods in Catalytic Organic Reactions | 000 | 1 | NIH | 7/22/2025 | $582,422 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA280720 | Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools | 001 | 2 | NIH | 6/2/2025 | $58,031 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA280720 | Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools | 000 | 2 | NIH | 12/13/2024 | $522,287 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS136003 | Investigating the mechanism of decision-making in the mitochondrial Protease YME1 | 001 | 2 | NIH | 8/14/2025 | $564 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS136003 | Investigating the mechanism of decision-making in the mitochondrial Protease YME1 | 000 | 2 | NIH | 1/20/2025 | $35,974 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | UM1TR004407 | Scripps Clinical and Translational Science Hub | 000 | 3 | NIH | 6/14/2025 | $6,078,076 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL088256 | Vesicular trafficking mechanisms regulating granulocyte function | 001 | 15 | NIH | 8/15/2025 | $727,183 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AG088679 | Aberrant protein S-nitrosylation mediates Gene-Environment Interactions in AD/ADRD | 001 | 2 | NIH | 7/22/2025 | $895,482 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01ES031863 | Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity | 000 | 4 | NIH | 11/19/2024 | $542,761 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI183472 | Leveraging membrane Env liposome vaccine design to elicit multi-target cross-neutralization of HIV | 000 | 2 | NIH | 2/13/2025 | $839,102 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS141616 | PQBP1 as a central regulator of inflammation in neurodegenerative diseases | 001 | 1 | NIH | 9/17/2025 | $564 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS141616 | PQBP1 as a central regulator of inflammation in neurodegenerative diseases | 000 | 1 | NIH | 2/3/2025 | $35,974 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL169631 | Managing Alpha-1-Antitrypsin Deficiency (AATD) through Proteostasis Signaling Pathways | 001 | 2 | NIH | 8/26/2025 | $87,314 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL169631 | Managing Alpha-1-Antitrypsin Deficiency (AATD) through Proteostasis Signaling Pathways | 000 | 2 | NIH | 2/14/2025 | $785,843 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R56AI188937 | A chemical biology-based approach to the study of FOXP3 and Regulatory T Cell Fate | 000 | 1 | NIH | 3/11/2025 | $417,984 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01EY035333 | Investigating the anti-inflammatory mechanisms of calorie restriction in the aged lacrimal gland | 000 | 2 | NIH | 2/14/2025 | $695,347 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT012075 | Deconvolution of Galbulimima bark pharmacology through chemical synthesis and target assignment | 000 | 3 | NIH | 3/13/2025 | $663,419 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K01DK132957 | Deconstructing brainstem circuits for visceral senses | 002 | 3 | NIH | 5/2/2025 | $153,360 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P01AI157299 | Eliciting neutralizing antibodies and B cell responses using novel HIV Env immunogens in non-human primates | 000 | 5 | NIH | 4/25/2025 | $2,794,109 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K99AA031718 | Extended amygdala somatostatin role in post-traumatic stress and alcohol use disorder | 000 | 2 | NIH | 8/25/2025 | $180,360 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01MH137042 | Scalable functional analysis of neuropsychiatric risk genes with spatially integrated in vivo Perturb-seq | 000 | 2 | NIH | 6/13/2025 | $890,929 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM152084 | Structure-based in-silico prediction of peptide interactions. | 001 | 2 | NIH | 4/3/2025 | $460,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AI160338 | Mechanistic Studies of Combination Adjuvants to Target B Cells in Vaccines | 000 | 5 | NIH | 4/18/2025 | $694,960 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21GM154216 | Developing graphene grids to overcome air-water-interface issues | 000 | 2 | NIH | 8/21/2025 | $230,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK137470 | Pharmacologic targeting of the UPR in obesity-linked liver dysfunction | 000 | 2 | NIH | 11/26/2024 | $689,587 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21ES035980 | A novel model of severe inflammatory arthritis induced by pulmonary silica exposure | 000 | 2 | NIH | 7/18/2025 | $230,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK136034 | Intestine to adipose tissue interorgan communication in homeostasis and obesity | 000 | 2 | NIH | 7/15/2025 | $640,762 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32NS136266 | How does mechanosensation contribute to choroid plexus function in health and disease? | 000 | 2 | NIH | 5/23/2025 | $78,040 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA294646 | Investigating DNA polymerase O in replication stress and cancer therapy | 001 | 2 | NIH | 8/26/2025 | $610,063 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA028879 | Dorsal striatal phosphodiesterase 10A and compulsive ethanol use | 001 | 5 | NIH | 8/19/2025 | $34,650 |
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