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 | Issue Date FY: 2025 ( Subtotal = $28,972,876 ) (Continued on the next page) |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01EY035333 | Investigating the anti-inflammatory mechanisms of calorie restriction in the aged lacrimal gland | 000 | 2 | NIH | 2/14/2025 | $695,347 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35NS105067 | Mechanisms of force sensing in the nervous system | 000 | 8 | NIH | 11/15/2024 | $828,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI178437 | Elucidation of the interactome for the bioactive disaccharide Man(B1-4)GlcNAc | 000 | 2 | NIH | 11/19/2024 | $223,100 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01ES031863 | Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity | 000 | 4 | NIH | 11/19/2024 | $542,761 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK137675 | An Innovative Approach to Identify Correctors of Metabolic Complications in HIV | 000 | 2 | NIH | 12/2/2024 | $832,564 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R13CA298718 | 2024 SoCal Genome Stability Symposium | 000 | 1 | NIH | 12/18/2024 | $5,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK124211 | Molecular mechanisms of transthyretin amyloidosis | 001 | 5 | NIH | 12/2/2024 | $566,635 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM141868 | Investigating DNA double-strand break repair mechanisms in mammalian cells | 001 | 5 | NIH | 1/3/2025 | $414,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI183472 | Leveraging membrane Env liposome vaccine design to elicit multi-target cross-neutralization of HIV | 000 | 2 | NIH | 2/13/2025 | $839,102 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM139643 | Chemoenzymatic glycan editing for deciphering biological functions of glycans | 001 | 5 | NIH | 1/17/2025 | $711,537 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI136621 | Dissecting Polyclonal Sera to Reveal Correlates of Productive Immune Responses to HIV | 000 | 8 | NIH | 2/13/2025 | $837,382 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01EY031597 | Experience-dependent Cellular Plasticity Mechanisms | 000 | 5 | NIH | 1/14/2025 | $708,770 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HG012819 | In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues | 000 | 3 | NIH | 12/30/2024 | $668,947 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI168917 | Understanding human antibody responses to chronic viral hepatitis C | 000 | 4 | NIH | 12/12/2024 | $618,099 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS141616 | PQBP1 as a central regulator of inflammation in neurodegenerative diseases | 000 | 1 | NIH | 2/3/2025 | $35,974 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS140965 | Restoring neuronal degradative capacity as a therapeutic strategy to treat Prion Disease | 000 | 1 | NIH | 12/12/2024 | $186,363 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS140965 | Restoring neuronal degradative capacity as a therapeutic strategy to treat Prion Disease | 000 | 1 | NIH | 12/12/2024 | $722,727 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA280720 | Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools | 000 | 2 | NIH | 12/13/2024 | $522,287 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI172915 | Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence | 000 | 3 | NIH | 10/31/2024 | $775,779 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA271500 | Establishing a mechanistic basis for enhanced tumorigenesis under chronic circadian disruption | 000 | 3 | NIH | 11/13/2024 | $546,056 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI181784 | Combining membrane Env vaccine regimens to elicit multiple bnAb lineages and consistent cross-neutralization of HIV | 000 | 2 | NIH | 10/30/2024 | $912,596 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM152118 | Sulfur(VI) Fluoride Exchange (SuFEx): new developments and biological applications | 000 | 2 | NIH | 11/5/2024 | $463,680 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA028879 | Dorsal striatal phosphodiesterase 10A and compulsive ethanol use | 000 | 5 | NIH | 12/13/2024 | $372,600 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | RF1AG046495 | Discovering Small Molecule Activators of Stress-Responsive Signaling | 000 | 11 | NIH | 10/28/2024 | $169,455 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R56AI188937 | A chemical biology-based approach to the study of FOXP3 and Regulatory T Cell Fate | 000 | 1 | NIH | 3/11/2025 | $417,984 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167372 | The generation and protective function of lung tissue resident memory T cells following SARS-CoV-2 infection or vaccination | 000 | 4 | NIH | 2/24/2025 | $863,551 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL142975 | Regulation of Protein C Pathways | 000 | 8 | NIH | 3/27/2025 | $807,906 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U19AI135995 | Center for Viral Systems Biology (CViSB) | 000 | 8 | NIH | 2/18/2025 | $2,568,706 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM145323 | Synthesis at the Interface of Chemistry and Biology | 001 | 4 | NIH | 3/21/2025 | $659,088 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AA013498 | 9/10 Electrophysiology of Alcohol in Extended Amygdala | 000 | 24 | NIH | 3/5/2025 | $611,980 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31DK134167 | Molecular mechanism of PIN1-mediated regulation of the nuclear receptor PPARy | 000 | 3 | NIH | 2/26/2025 | $35,974 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DC021238 | Decoding vomeronasal activity through awake, behaving AOB imaging. | 000 | 2 | NIH | 2/20/2025 | $650,876 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI168232 | RNA Recombination in Coronaviruses | 002 | 4 | NIH | 3/14/2025 | $502,084 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K99CA290143 | Discovering and Characterizing Druggable Cysteines in Cancer Dependency Proteins | 000 | 2 | NIH | 3/14/2025 | $165,780 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL172048 | Molecular pathogenesis of COVID-19-associated coagulopathy and new therapeutic approaches | 001 | 2 | NIH | 3/14/2025 | -$21,000 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT012075 | Deconvolution of Galbulimima bark pharmacology through chemical synthesis and target assignment | 000 | 3 | NIH | 3/13/2025 | $663,419 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM122606 | Unusual Pharmacophores and New Tools for Cross-Coupling | 001 | 9 | NIH | 3/28/2025 | $704,352 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM142462 | Bridging the Glycome and Proteome with Chemical Biology | 000 | 6 | NIH | 3/28/2025 | $459,996 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 001 | 3 | NIH | 1/10/2025 | $102,065 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 001 | 3 | NIH | 1/10/2025 | $352,082 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R37DA015648 | Modulating Signaling Endocannabinoids and Fatty Acid Amides | 000 | 19 | NIH | 11/14/2024 | $372,600 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL172048 | Molecular pathogenesis of COVID-19-associated coagulopathy and new therapeutic approaches | 000 | 2 | NIH | 12/23/2024 | $659,826 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K00CA274692 | Amplifications and signaling of oncoproteins in cancer | 000 | 3 | NIH | 12/23/2024 | $96,120 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K00AA031926 | Role of parasubthalamic astrocytic dysfunction in alcohol use disorder | 000 | 3 | NIH | 1/15/2025 | $93,193 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | OT2TR005710 | DOGSURF: Database Optimized for Graph Search Using Robust Federation | 000 | 1 | NIH | 12/24/2024 | $1,746,403 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01DA056004 | Single nucleus gene expression in moderate and compulsive drug self-administration in a rodent model of HIV | 000 | 4 | NIH | 12/20/2024 | $588,372 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI130227 | Targeting Influenza A Virus by a Carbohydrate-inspired Strategy | 001 | 6 | NIH | 12/20/2024 | $446,200 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM118176 | Scalable Synthesis and New Bond Disconnections | 001 | 9 | NIH | 1/14/2025 | $39,244 |
| | 2025 | 2025 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK137470 | Pharmacologic targeting of the UPR in obesity-linked liver dysfunction | 000 | 2 | NIH | 11/26/2024 | $689,587 |
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