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 | Issue Date FY: 2023 ( Subtotal = $8,446,503 ) |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM140287 | Haplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populations | 000 | 3 | NIH | 11/28/2022 | $562,255 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI140844 | Uncleaved prefusion-optimized trimers on nanoparticles as HIV vaccines | 000 | 5 | NIH | 11/9/2022 | $969,072 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R37DA015648 | Modulating Signaling Endocannabinoids and Fatty Acid Amides | 000 | 17 | NIH | 11/22/2022 | $359,438 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167003 | In vivo engineering of B cells for the secretion of HIV broadly neutralizing antibodies | 000 | 2 | NIH | 11/14/2022 | $738,581 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI172915 | Microbiota, Probiotic and Dietary Metabolite Control of Enteric Pathogen Virulence | 000 | 1 | NIH | 11/10/2022 | $771,519 |
| | 2023 | 2023 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01ES031863 | Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity | 000 | 2 | NIH | 11/25/2022 | $523,588 |
| | 2023 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | UM1AI164561 | Reversing Immune Dysfunction for HIV-1 Eradication | 001 | 2 | NIH | 10/12/2022 | $4,476,454 |
| | 2023 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32GM137567 | Proteomic discovery and characterization of chemical tools that degrade the NuRD chromatin regulatory complex | 000 | 2 | NIH | 11/8/2022 | -$19,284 |
| | 2023 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM122606 | Unusual Pharmacophores and New Tools for Cross-Coupling | 001 | 6 | NIH | 11/7/2022 | $106,833 |
| | 2023 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K01DA054449 | Control of opioid-motivated approach and avoidance behavior by neuronal ensembles in the basolateral amygdala and their projection targets in the nucleus accumbens | 000 | 1 | NIH | 10/17/2022 | $0 |
| | 2023 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | RF1AG070775 | Role of PLD3 in nucleic acid recognition and brain function | 000 | 1 | NIH | 10/18/2022 | $591 |
| | 2023 | 2021 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R56AG070775 | Role of PLD3 in nucleic acid recognition and brain function | 000 | 1 | NIH | 10/18/2022 | -$591 |
| | 2023 | 2021 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K99GM138758 | A universal high-throughput platform to improve biological functions of small molecules | 000 | 2 | NIH | 11/25/2022 | $0 |
| | 2023 | 2021 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21GM137193 | Purifying Membrane Proteins within Native Lipid Bilayers | 000 | 2 | NIH | 10/27/2022 | $0 |
| | 2023 | 2021 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21GM135734 | Development of selective chemical tools to investigate sialyltransferases and sialoside products | 000 | 2 | NIH | 10/27/2022 | $0 |
| | 2023 | 2021 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM122606 | Unusual Pharmacophores and New Tools for Cross-Coupling | 000 | 5 | NIH | 11/7/2022 | -$106,833 |
| | 2023 | 2021 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA025012 | Epigenetic regulation of alcohol tolerance and dependence by methyl CpG binding protein 2 | 000 | 5 | NIH | 10/19/2022 | $0 |
| | 2023 | 2021 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AR050631 | The role of microRNAs in cartilage homeostasis and osteoarthritis arthritis treatment | 000 | 15 | NIH | 11/2/2022 | $0 |
| | 2023 | 2020 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI150381 | CAR T CELLS ENGINEERED TO KILL HIV-INFECTED CELLS WHILE SECRETING BROADLY NEUTRALIZING ANTIBODIES | 000 | 1 | NIH | 10/21/2022 | -$19,072 |
| | 2023 | 2020 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U54AI150472 | HIV Interactions In Viral Evolution | 000 | 9 | NIH | 11/28/2022 | $146,907 |
| | 2023 | 2020 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI143529 | Novel Regulators of B Cell Tolerance | 000 | 2 | NIH | 10/28/2022 | $0 |
| | 2023 | 2020 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM122987 | Role of TZAP in telomere homoeostasis | 000 | 4 | NIH | 11/29/2022 | $1,177 |
| | 2023 | 2020 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R50CA211526 | Application of (chemo)proteomic methods to map cancer biochemical pathways | 000 | 5 | NIH | 10/24/2022 | -$27,828 |
| | 2023 | 2019 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | RF1AG061846 | Protein conformer-resolved analysis of protein aggregates in Alzheimer's disease with mass spectrometry | 001 | 1 | NIH | 11/25/2022 | $0 |
| | 2023 | 2018 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | RF1AG061846 | Protein conformer-resolved analysis of protein aggregates in Alzheimer's disease with mass spectrometry | 000 | 1 | NIH | 11/23/2022 | $0 |
| | 2023 | 2018 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P01AI104722 | High Resolution Analysis of Env-directed B Cells to Accelerate Vaccine Design | 000 | 5 | NIH | 11/29/2022 | $0 |
| | 2023 | 2017 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HG003709 | Single-Molecule DNA Sequencing with Engineered Nanopores | 000 | 13 | NIH | 10/1/2022 | -$36,304 |
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| Issue Date FY: 2022 ( Subtotal = $290,708,643 ) (Continued on the next page) |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM143805 | Automated, optimized, intelligent data collection for cryo-EM | 000 | 2 | NIH | 6/17/2022 | $586,242 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31HL154732 | Potent and specific small molecule stabilizers of amyloidogenic antibody light chains | 000 | 2 | NIH | 2/28/2022 | $30,883 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI167003 | In vivo engineering of B cells for the secretion of HIV broadly neutralizing antibodies | 000 | 1 | NIH | 12/2/2021 | $645,746 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT012051 | The Role of Sensory Neurons Innervating Internal Organs | 000 | 1 | NIH | 8/17/2022 | $588,828 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31HL154732 | Potent and specific small molecule stabilizers of amyloidogenic antibody light chains | 001 | 2 | NIH | 7/22/2022 | $2,869 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS112482 | A RIPK2-Targeting Apoptosis-Inducing Small Molecule for the Treatment of Glioblastoma | 000 | 4 | NIH | 6/15/2022 | $528,172 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK124706 | Internal State Sensing Via The Gut-Brain Axis | 000 | 3 | NIH | 7/22/2022 | $509,603 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P01HL152958 | Neutrophil lineage in inflammation | 000 | 2 | NIH | 6/22/2022 | $2,487,326 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01GM102265 | Catalyst-Controlled Site-Selective C-H Functionalizations of Arenes and Heteroarenes | 000 | 11 | NIH | 7/1/2022 | $377,509 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | DP5OD026380 | Targeting crotonyl-lysine chromatin readers to disrupt pathogenic gene expression in leukemia | 001 | 5 | NIH | 8/30/2022 | $1 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | DP5OD026380 | Targeting crotonyl-lysine chromatin readers to disrupt pathogenic gene expression in leukemia | 001 | 5 | NIH | 8/30/2022 | $483,749 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | UM1AI164561 | Reversing Immune Dysfunction for HIV-1 Eradication | 001 | 2 | NIH | 4/8/2022 | $4,984,542 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI171438 | Genetic, structural and functional profiling of the human antibody response to arenavirus infection | 000 | 1 | NIH | 8/22/2022 | $887,255 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | OT2CA278692 | eDyNAmiC - SCRIPPS | 000 | 1 | NIH | 6/24/2022 | $332,321 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG077046 | Analysis of protein interactions in neurodegenerative disease | 000 | 1 | NIH | 4/26/2022 | $693,264 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG076745 | Mechanisms of Mutant Prion Protein Aggregation Within Endolysosomal Pathways | 000 | 1 | NIH | 5/6/2022 | $726,467 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG078756 | Crosstalk between innate-immunity human microglia and adaptive-immunity Tregs in Alzheimer's disease | 000 | 1 | NIH | 8/19/2022 | $443,750 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK110162 | Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis | 000 | 5 | NIH | 8/12/2022 | $725,337 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AA026999 | Pivotal role of thalamic hypocretin transmission during EtOH seeking and relapse | 000 | 5 | NIH | 7/1/2022 | $435,375 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31GM145186 | Allosteric Pharmacologic Chaperones for alpha-1 Antitrypsin Mutants | 002 | 1 | NIH | 6/8/2022 | $716 |
| | 2022 | 2022 | SCRIPPS RESEARCH INSTITUTE, THE | 10550 NORTH TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31GM145186 | Allosteric Pharmacologic Chaperones for alpha-1 Antitrypsin Mutants | 001 | 1 | NIH | 5/25/2022 | $0 |
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