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 | Issue Date FY: 2026 ( Subtotal = $88,835,258 ) (Continued on the next page) |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT012075 | Deconvolution of Galbulimima bark pharmacology through chemical synthesis and target assignment | 000 | 4 | NIH | 5/14/2026 | $737,132 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS141616 | PQBP1 as a central regulator of inflammation in neurodegenerative diseases | 001 | 2 | NIH | 4/16/2026 | $576 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS141616 | PQBP1 as a central regulator of inflammation in neurodegenerative diseases | 000 | 2 | NIH | 1/14/2026 | $36,538 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI183472 | Leveraging membrane Env liposome vaccine design to elicit multi-target cross-neutralization of HIV | 000 | 3 | NIH | 2/20/2026 | $868,899 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01ES031863 | Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity | 000 | 5 | NIH | 1/16/2026 | $542,761 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | UM1TR004407 | Scripps Clinical and Translational Science Hub | 000 | 4 | NIH | 4/28/2026 | $6,074,495 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK136034 | Intestine to adipose tissue interorgan communication in homeostasis and obesity | 000 | 3 | NIH | 6/30/2026 | $640,762 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK137470 | Pharmacologic targeting of the UPR in obesity-linked liver dysfunction | 000 | 3 | NIH | 12/5/2025 | $766,207 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA280720 | Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools | 001 | 3 | NIH | 4/22/2026 | $58,031 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA280720 | Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools | 000 | 3 | NIH | 1/15/2026 | $522,287 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM152084 | Structure-based in-silico prediction of peptide interactions. | 000 | 3 | NIH | 3/30/2026 | $460,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL172048 | Molecular pathogenesis of COVID-19-associated coagulopathy and new therapeutic approaches | 001 | 3 | NIH | 3/23/2026 | $21,294 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL172048 | Molecular pathogenesis of COVID-19-associated coagulopathy and new therapeutic approaches | 000 | 3 | NIH | 3/6/2026 | $674,316 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01DA058399 | Single nucleus gene expression in moderate and compulsive opioid self-administration in a rodent model of HIV | 000 | 4 | NIH | 7/16/2026 | $1,348,437 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01DA056004 | Single nucleus gene expression in moderate and compulsive drug self-administration in a rodent model of HIV | 000 | 5 | NIH | 2/9/2026 | $653,746 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM151347 | Innate lymphocyte responses to early-life infections | 000 | 4 | NIH | 5/22/2026 | $460,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AI181212 | Novel Lassa fever live-attenuated vaccine platform with safety features ensuring unbreachable attenuation | 000 | 3 | NIH | 7/14/2026 | $469,396 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32NS136266 | How does mechanosensation contribute to choroid plexus function in health and disease? | 000 | 3 | NIH | 4/27/2026 | $64,285 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK134609 | Neural Mechanisms of Energy Expenditure-Induced Compensatory Food Intake | 000 | 4 | NIH | 4/27/2026 | $707,310 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI177265 | Determinants of HIV-1 innate immune sensing and its role in shaping the lymphoid environment. | 000 | 4 | NIH | 6/16/2026 | $840,133 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K12TR004410 | CTSA K12 Program at The Scripps Research Institute | 000 | 4 | NIH | 7/7/2026 | $971,929 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21EB036298 | Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution | 000 | 3 | NIH | 5/5/2026 | $230,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DA059393 | Mapping brain-wide opioid actions by profiling neuronal activities and in vivo cellular target engagement | 000 | 4 | NIH | 6/23/2026 | $830,063 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI178605 | A NOVEL STRATEGY TO INHIBIT SARS-COV-2 INFECTION AND COVID-19 | 000 | 3 | NIH | 5/13/2026 | $749,787 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R37AG059418 | FoxO transcription factors in joint aging and osteoarthritis pathogenesis | 001 | 9 | NIH | 5/18/2026 | $573,011 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK137675 | An Innovative Approach to Identify Correctors of Metabolic Complications in HIV | 000 | 3 | NIH | 12/22/2025 | $930,383 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HG012819 | In vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissues | 001 | 4 | NIH | 4/2/2026 | $765,499 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM148226 | Structural characterization of large eukaryotic proteins containing both folded and disordered domains | 000 | 4 | NIH | 7/10/2026 | $460,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32DK148145 | Defining the Impact of Hepatic ER Stress on the Integrity of the Secreted Proteome | 001 | 1 | NIH | 6/26/2026 | $0 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32DK148145 | Defining the Impact of Hepatic ER Stress on the Integrity of the Secreted Proteome | 000 | 1 | NIH | 6/26/2026 | $76,300 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F30DK145195 | Mapping MicroRNA-target Interactions in the Zonated Liver | 001 | 1 | NIH | 4/8/2026 | $0 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F30DK145195 | Mapping MicroRNA-target Interactions in the Zonated Liver | 000 | 1 | NIH | 4/8/2026 | $37,114 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21EY038948 | Mapping lacrimal gland ionocyte RNA and protein secretion in homeostasis andinflammation" | 000 | 1 | NIH | 7/1/2026 | $506,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI196104 | Structural and functional insights into mpox entry and neutralization | 000 | 1 | NIH | 6/26/2026 | $897,277 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG095974 | A druggable mito-nuclear feedback mechanism that preserves mitochondrial and synaptic function in old-age | 000 | 2 | NIH | 6/3/2026 | $857,190 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS140755 | Post-transcriptional mechanisms of interneuron development | 000 | 1 | NIH | 1/27/2026 | $710,155 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI203583 | Evaluation of HIV-1 Env-C3d constructs on nanoparticles for structure, function and immunogenicity. | 000 | 1 | NIH | 7/1/2026 | $276,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R61AI197037 | A Single Long-Acting Injection For HBV Treatment Using Novel Entecavir Prodrugs For PWLH | 000 | 1 | NIH | 3/30/2026 | $899,741 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM165767 | Deciphering the molecular principles linking PopZ filament structure to condensate function | 000 | 1 | NIH | 6/23/2026 | $506,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA304089 | Targeted degradation of glycoimmune checkpoints Siglec-7 and -9 for cancer immunotherapy | 000 | 1 | NIH | 6/23/2026 | $748,410 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI199873 | Host-specific profiles of Defective Viral Genomes of influenza virus | 000 | 1 | NIH | 6/23/2026 | $270,443 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R03AI196996 | Proximal regulation of innate immune signals in ischemia reperfusion injury | 000 | 1 | NIH | 3/30/2026 | $184,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI194636 | Targeting the polymerase and endonuclease activities of the L protein of human pathogenic mammarenaviruses | 000 | 1 | NIH | 7/16/2026 | $1,620,145 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI200873 | A Modular Cross-Linker Platform for Proteome-Scale Mapping of Dynamic Protein-Protein Interactions in Cells | 000 | 1 | NIH | 4/28/2026 | $230,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | DP2AI200982 | Understanding plasma cell longevity and their roles beyond antibody production | 000 | 1 | NIH | 7/16/2026 | $552,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI199600 | A PROTAC Strategy to Combat Botulinum Neurotoxicity | 000 | 1 | NIH | 6/11/2026 | $518,450 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35HL184173 | The protein C pathway: Mechanisms, Structure-function, and Translation | 000 | 1 | NIH | 4/3/2026 | $863,954 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT013598 | Interoceptive network that co-regulates emotional and autonomic responses | 000 | 1 | NIH | 4/21/2026 | $831,984 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R56AI200473 | Glycoengineering core a(1,3)-fucose motifs to enhance HIV-1 envelope vaccine immunogenicity | 000 | 1 | NIH | 6/11/2026 | $931,385 |
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