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 | Issue Date FY: 2026 ( Subtotal = $133,240,363 ) (Continued on the next page) |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK146789 | Novel Genetic Pathways Underlying Brain-Gut Communication in C. elegans | 000 | 1 | NIH | 8/14/2026 | $701,896 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R13AI202922 | Neutrophil 2026: the Eighth Neutrophil International Symposium | 000 | 1 | NIH | 7/24/2026 | $8,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R56AI200473 | Glycoengineering core a(1,3)-fucose motifs to enhance HIV-1 envelope vaccine immunogenicity | 000 | 1 | NIH | 6/11/2026 | $931,385 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI198218 | Dissecting mechanisms of action of next-generation saponin combination adjuvants. | 000 | 1 | NIH | 7/23/2026 | $865,432 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI198816 | Antibody-guided design of a human astrovirus vaccine | 000 | 1 | NIH | 6/11/2026 | $919,605 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI200742 | Optimizing vaccine-elicited cross-neutralizing antibody responses to the HIV Env trimer apex | 000 | 1 | NIH | 7/31/2026 | $937,343 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI198771 | Mechanistic Studies of Combination Adjuvants in the Establishment of B Cell Memory | 000 | 1 | NIH | 7/23/2026 | $772,010 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35HL184173 | The protein C pathway: Mechanisms, Structure-function, and Translation | 000 | 1 | NIH | 4/3/2026 | $863,954 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI199600 | A PROTAC Strategy to Combat Botulinum Neurotoxicity | 000 | 1 | NIH | 6/11/2026 | $518,450 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT013598 | Interoceptive network that co-regulates emotional and autonomic responses | 000 | 1 | NIH | 4/21/2026 | $831,984 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL184492 | Engineering functionally addressable direct-acting thrombolytic enzymes | 000 | 1 | NIH | 8/5/2026 | $1,101,338 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R56AI203658 | Germline-Targeted Vaccines Using Membrane Env Liposomes to Elicit HIV-1 MPER bnAbs | 000 | 1 | NIH | 8/17/2026 | $1,097,774 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI200873 | A Modular Cross-Linker Platform for Proteome-Scale Mapping of Dynamic Protein-Protein Interactions in Cells | 000 | 1 | NIH | 4/28/2026 | $230,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI201328 | Self-Assembling Protein Nanoparticles Presenting Stabilized Hemagglutinin, Neuraminidase, and M2e Antigens for Universal Influenza Vaccine Development | 000 | 1 | NIH | 8/5/2026 | $3,679,976 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI201398 | Investigation of the rules dictating plasma cell longevity | 000 | 1 | NIH | 8/17/2026 | $919,363 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | DP2AI200982 | Understanding plasma cell longevity and their roles beyond antibody production | 000 | 1 | NIH | 7/16/2026 | $552,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI194636 | Targeting the polymerase and endonuclease activities of the L protein of human pathogenic mammarenaviruses | 000 | 1 | NIH | 7/16/2026 | $1,620,145 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R61AI197037 | A Single Long-Acting Injection For HBV Treatment Using Novel Entecavir Prodrugs For PWLH | 000 | 1 | NIH | 3/30/2026 | $899,741 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI199873 | Host-specific profiles of Defective Viral Genomes of influenza virus | 000 | 1 | NIH | 6/23/2026 | $270,443 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R03AI196996 | Proximal regulation of innate immune signals in ischemia reperfusion injury | 000 | 1 | NIH | 3/30/2026 | $184,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01NS140755 | Post-transcriptional mechanisms of interneuron development | 000 | 1 | NIH | 1/27/2026 | $710,155 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R35GM165767 | Deciphering the molecular principles linking PopZ filament structure to condensate function | 000 | 1 | NIH | 6/23/2026 | $506,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA304089 | Targeted degradation of glycoimmune checkpoints Siglec-7 and -9 for cancer immunotherapy | 000 | 1 | NIH | 6/23/2026 | $748,410 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | P01HL183482 | PlanB2CureHIV (the 'PlanB' consortium) | 000 | 2 | NIH | 7/24/2026 | $3,479,555 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI203583 | Evaluation of HIV-1 Env-C3d constructs on nanoparticles for structure, function and immunogenicity. | 000 | 1 | NIH | 7/1/2026 | $276,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI196104 | Structural and functional insights into mpox entry and neutralization | 000 | 1 | NIH | 6/26/2026 | $897,277 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21EY038948 | Mapping lacrimal gland ionocyte RNA and protein secretion in homeostasis andinflammation" | 000 | 1 | NIH | 7/1/2026 | $506,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AG095974 | A druggable mito-nuclear feedback mechanism that preserves mitochondrial and synaptic function in old-age | 000 | 2 | NIH | 6/3/2026 | $857,190 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32DK148145 | Defining the Impact of Hepatic ER Stress on the Integrity of the Secreted Proteome | 001 | 1 | NIH | 6/26/2026 | $0 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F30DK145195 | Mapping MicroRNA-target Interactions in the Zonated Liver | 001 | 1 | NIH | 4/8/2026 | $0 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F32DK148145 | Defining the Impact of Hepatic ER Stress on the Integrity of the Secreted Proteome | 000 | 1 | NIH | 6/26/2026 | $76,300 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F30DK145195 | Mapping MicroRNA-target Interactions in the Zonated Liver | 000 | 1 | NIH | 4/8/2026 | $37,114 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U19AI201696 | Center for Rational HCV Vaccine Design & Evaluation | 000 | 1 | NIH | 9/2/2026 | $3,282,170 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI199864 | Generation of a biologically contained mouse model of Ebola virus infection for mechanistic studies | 000 | 1 | NIH | 9/4/2026 | $276,000 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | U01AG088679 | Aberrant protein S-nitrosylation mediates Gene-Environment Interactions in AD/ADRD | 000 | 3 | NIH | 8/10/2026 | $913,756 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | UM1TR004407 | Scripps Clinical and Translational Science Hub | 000 | 4 | NIH | 4/28/2026 | $6,074,495 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01ES031863 | Early Pathogenic Steps in Xenobiotic-Induced Autoimmunity | 000 | 5 | NIH | 1/16/2026 | $542,761 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01DK137470 | Pharmacologic targeting of the UPR in obesity-linked liver dysfunction | 000 | 3 | NIH | 12/5/2025 | $766,207 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA280720 | Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools | 001 | 3 | NIH | 4/22/2026 | $58,031 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01CA280720 | Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools | 000 | 3 | NIH | 1/15/2026 | $522,287 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R21AI200711 | Establish HIV infection, treatment, and engineered B cell memory responses in the THX mouse model | 000 | 1 | NIH | 5/22/2026 | $253,256 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL088256 | Vesicular trafficking mechanisms regulating granulocyte function | 000 | 16 | NIH | 8/7/2026 | $727,183 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS141616 | PQBP1 as a central regulator of inflammation in neurodegenerative diseases | 000 | 2 | NIH | 1/14/2026 | $36,538 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AI183472 | Leveraging membrane Env liposome vaccine design to elicit multi-target cross-neutralization of HIV | 000 | 3 | NIH | 2/20/2026 | $868,899 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | F31NS141616 | PQBP1 as a central regulator of inflammation in neurodegenerative diseases | 001 | 2 | NIH | 4/16/2026 | $576 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01AT012075 | Deconvolution of Galbulimima bark pharmacology through chemical synthesis and target assignment | 000 | 4 | NIH | 5/14/2026 | $737,132 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | K01DK132957 | Deconstructing brainstem circuits for visceral senses | 000 | 4 | NIH | 4/21/2026 | $153,360 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01EY035333 | Investigating the anti-inflammatory mechanisms of calorie restriction in the aged lacrimal gland | 000 | 3 | NIH | 4/2/2026 | $688,585 |
| | 2026 | 2026 | SCRIPPS RESEARCH INSTITUTE | 10550 N TORREY PINES RD | LA JOLLA | CA | 92037-1000 | SAN DIEGO | USA | R01HL169631 | Managing Alpha-1-Antitrypsin Deficiency (AATD) through Proteostasis Signaling Pathways | 001 | 3 | NIH | 3/25/2026 | $26,193 |
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