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Genetic basis and evolution of thermotolerance in the Saccharomyces yeast species

Award Number: R01GM080669
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/10/2007
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Genetic basis and evolution of thermotolerance in the Saccharomyces yeast species - PROJECT SUMMARY The goal of the project is to understand the genetic basis and evolution of thermotolerance in the Saccharomyces species. Whereas much has been learned about the causes of phenotypic variation within species, reproductive barriers have limited genetic analysis to closely related, inter-fertile species. Consequently, we know little about the genetic basis of substantial phenotypic differences that arise over longer time periods and the importance of evolutionary hotspots and historical contingency. To overcome this reproductive barrier we will use hybrid, proteomic and transgenic analysis of yeast species. In Aim 1 we will map thermotolerance in interspecific hybrids using reciprocal chromosome loss and CRISPR induced mitotic recombination. This will enable us to measure the combined effects of many genes, but also identify thermotolerance genes and determine: whether they evolved through the cumulative effects of multiple changes, and whether their effects depend on changes in other genes. In Aim 2 we will investigate divergence in protein thermal stability and whether it results in temperature dependent fitness effects not detected by mapping. In Aim 3 we will examine the reuse of thermotolerance genes during thermal divergence along independent lineages. Doing so will determine whether thermal divergence requires certain genes or can be achieved in different ways. Together, these aims will push the limits of interspecific genetic analysis in order to provide insight into the acquisition of a complex and broadly relevant phenotype that has taken millions of years to evolve.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $283,802 )
2025	2025	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Biomedical Research and Research Training	000	18	2/17/2025	NON-COMPETING CONTINUATION	$283,802
														Subtotal = $283,802

Issue Date FY: 2024 ( Subtotal = $315,335 )
2024	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Biomedical Research and Research Training	001	17	7/22/2024	NON-COMPETING CONTINUATION	$31,533
2024	2024	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Biomedical Research and Research Training	000	17	2/8/2024	NON-COMPETING CONTINUATION	$283,802
														Subtotal = $315,335

Issue Date FY: 2023 ( Subtotal = $315,335 )
2023	2023	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	000	16	2/22/2023	NON-COMPETING CONTINUATION	$315,335
														Subtotal = $315,335

Issue Date FY: 2022 ( Subtotal = $315,335 )
2022	2022	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	000	15	5/11/2022	COMPETING CONTINUATION	$315,335
2022	2021	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	001	14	7/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $315,335

Issue Date FY: 2021 ( Subtotal = $308,000 )
2021	2021	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	000	14	2/26/2021	NON-COMPETING CONTINUATION	$308,000
														Subtotal = $308,000

Issue Date FY: 2020 ( Subtotal = $308,000 )
2020	2020	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	000	13	2/12/2020	NON-COMPETING CONTINUATION	$308,000
														Subtotal = $308,000

Issue Date FY: 2019 ( Subtotal = $308,000 )
2019	2019	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	002	12	2/1/2019	NON-COMPETING CONTINUATION	$308,000
2019	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	000	11	11/19/2018	COMPETING CONTINUATION	$226
2019	2016	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	001	10	11/19/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$226
														Subtotal = $308,000

Issue Date FY: 2018 ( Subtotal = $309,249 )
2018	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	004	11	4/6/2018	COMPETING CONTINUATION	$308,000
2018	2016	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	003	10	3/9/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$127
2018	2016	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	005	10	4/6/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2018	2016	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Biomedical Research and Research Training	001	10	12/1/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$128,282
2018	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	002	9	3/9/2018	EXTENSION WITH OR WITHOUT FUNDS	-$127
2018	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	000	9	11/30/2017	EXTENSION WITH OR WITHOUT FUNDS	-$127,033
														Subtotal = $309,249

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	001	9	1/14/2017	EXTENSION WITH OR WITHOUT FUNDS	$75,820
2017	2015	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	000	8	1/14/2017	NON-COMPETING CONTINUATION	-$75,820
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $288,800 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	9	8/17/2016	EXTENSION WITH OR WITHOUT FUNDS	$288,800
														Subtotal = $288,800

Issue Date FY: 2015 ( Subtotal = $288,800 )
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	8	8/13/2015	NON-COMPETING CONTINUATION	$288,800
														Subtotal = $288,800

Issue Date FY: 2014 ( Subtotal = $288,800 )
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	7	8/18/2014	NON-COMPETING CONTINUATION	$288,800
														Subtotal = $288,800

Issue Date FY: 2013 ( Subtotal = $288,800 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	6	8/15/2013	COMPETING CONTINUATION	$288,800
														Subtotal = $288,800

Issue Date FY: 2012 ( Subtotal = $86,903 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	001	5	8/20/2012	SUPPLEMENT FOR EXPANSION	$86,903
2012	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	5	8/20/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $86,903

Issue Date FY: 2011 ( Subtotal = $260,707 )
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	5	5/23/2011	NON-COMPETING CONTINUATION	$260,707
														Subtotal = $260,707

Issue Date FY: 2010 ( Subtotal = $263,340 )
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	4	5/21/2010	NON-COMPETING CONTINUATION	$263,340
														Subtotal = $263,340

Issue Date FY: 2009 ( Subtotal = $525,777 )
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	3	5/1/2009	NON-COMPETING CONTINUATION	$266,000
2009	2009	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Trans-NIH Recovery Act Research Support	001	3	8/12/2009	SUPPLEMENT FOR EXPANSION	$259,777
														Subtotal = $525,777

Issue Date FY: 2008 ( Subtotal = $266,000 )
2008	2008	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	2	6/2/2008	NON-COMPETING CONTINUATION	$266,000
														Subtotal = $266,000

Issue Date FY: 2007 ( Subtotal = $266,000 )
2007	2007	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Biomedical Research and Research Training	000	1	8/10/2007	NEW	$266,000
														Subtotal = $266,000

Grand Total All Awards = $5,286,983

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Award Information

Genetic basis and evolution of thermotolerance in the Saccharomyces yeast species

Award Number: R01GM080669

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/10/2007

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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