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Neuroimaging Phenotypes of Post-Traumatic Epilepsy

Award Number: K23NS135101
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/01/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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Neuroimaging Phenotypes of Post-Traumatic Epilepsy - Project Summary/Abstract Dr. James Gugger is an Assistant Professor of Neurology at the University of Pennsylvania with clinical expertise in both epilepsy and traumatic brain injury (TBI). His long-term goal as a physician-scientist is to use quantitative neuroimaging to define neurobiologically grounded phenotypes of neurological disorders, which will improve our understanding of disorders such as epilepsy and TBI and ultimately improve care. The neurobiological phenotype of TBI involves both focal and diffuse injury mechanisms. Both animal and human data implicate damage to the limbic network in those with epilepsy after head injury. This proposal tests the hypothesis that the effects of focal and diffuse injury mechanisms on the limbic network can be used to distinguish patients with TBI who will develop epilepsy from those who do not. Experiments will utilize neuroimaging data from a large, well-phenotyped cohort of participants with TBI and uninjured controls. The specific aims are (1) to define the relationship between focal post-traumatic lesions and brain networks implicated in post-traumatic epilepsy (PTE) and (2) to determine the profile of diffuse injury in brain networks implicated in PTE. This project will uncover neuroimaging phenotypes present prior to the onset of PTE and advance us towards identification of biomarkers for epilepsy risk stratification. The proposal builds on Dr. Gugger’s prior research on quantitative multimodal neuroimaging in TBI and epilepsy. With the support of a team of mentors at the University of Pennsylvania who are leaders in the field, he will gain expertise in functional neuroimaging, statistical modeling of multimodal neuroimaging data, and the conduct of prospective neuroimaging studies. Dr. Gugger’s team of mentors at the University of Pennsylvania (Drs. Diaz-Arrastia, Davis, Shinohara, and Detre) have strong track records of mentorship and will provide specific expertise in his areas of skill development. He will also leverage his existing relationships with large multicenter consortia focused on PTE research (Transforming Research and Clinical Knowledge in TBI [TRACK-TBI] Network, Military Injuries—Understanding PTE: Bioinformatics with big data to examine multi- modal PTE biomarkers [MINUTE], and the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy [EpiBioS4Rx]) to launch future studies as an independent physician scientist. Dr. Gugger’s clinical background in epilepsy and TBI, with the additional support of this career development award and his unique mentorship opportunities, will position him to succeed as an independent physician-scientist focused on using quantitative neuroimaging to improve the lives of people with epilepsy and TBI.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $221,410 )
2025	2025	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	2	4/25/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$101,768
2025	2025	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	1/10/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$221,410
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/8/2025	NEW	$0
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	4/25/2025	NEW	-$101,768
														Subtotal = $221,410

Issue Date FY: 2024 ( Subtotal = $221,505 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/26/2023	NEW	$221,505
														Subtotal = $221,505

Grand Total All Awards = $442,915

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Neuroimaging Phenotypes of Post-Traumatic Epilepsy

Award Number: K23NS135101

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/01/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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