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Boston HIV CTU

Award Number: UM1AI069412
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2007
PERIOD OF PERFORMANCE END DATE: 11/30/2027

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Boston HIV CTU - The Boston/Jackson/Providence HIV Clinical Trials Unit (BJP HIV CTU) will conduct clinical trials to address research priorities of three NIAID HIV/AIDS Clinical Trials Networks (CTNs): HIV therapeutics; integrated strategies for HIV prevention; and HIV vaccines. The BJP HIV CTU brings together a collaborative group of highly experienced investigators with decades of experience in HIV-related treatment, prevention and vaccine research. The BJP HIV CTU comprises five existing Clinical Research Sites (CRSs): therapeutics CRSs at Brigham and Women’s Hospital (BWH) and Massachusetts General Hospital in Boston, MA and The Miriam Hospital in Providence, RI; a vaccine CRS at BWH; and a combined prevention and vaccine CRS at Fenway Health (also in Boston). Two new CRSs are proposed—a prevention CRS at University of Mississippi Medical Center in Jackson, MS and a vaccine CRS at Beth Israel Deaconess Medical Center (BIDMC) in Boston. The BJP HIV CTU and its component CRSs will function as an integrated, collaborative consortium to coordinate and implement clinical trials designed by the Leadership Groups of the NIAID-funded HIV/AIDS CTNs. The five existing CRSs have been extremely effective in conducting studies and contributing substantially to the scientific agendas of their respective CTNs. Expansion of our existing CTU to include two new CRSs devoted to HIV prevention and vaccine research, respectively, substantially enhances our capacity to conduct clinical trials critical to developing more effective means of HIV prevention and testing candidate vaccines. The proposed UMMC Prevention CRS is located in Jackson, MS a city in the southeastern United States with a predominantly African American population that ranked 4th highest in HIV infection and 5th highest in the rate of AIDS diagnoses among US metropolitan areas. The proposed Vaccine CRS within the Center for Virology and Vaccine Research at BIDMC will engage investigators who have made major and sustained scientific contributions to the HIV vaccine field over the past 15 years. The BJP HIV CTU will be led by three highly experienced PIs, Drs. Daniel Kuritzkes, Kenneth Mayer and Lindsey Baden, and will include highly accomplished CRS leaders and collaborating investigators. The CTU will function as an integrated, highly collaborative consortium that will have centralized planning, resource allocation, decision-making and financial management through an efficient administration plan. Centralized resources include a Clinical Research Laboratory, a Research Pharmacy Coordinator, Data and Quality Management Plans and a Community Engagement Core. The CTU has diverse and accessible populations for study, representing communities most affected by HIV. Each CRS has well- grounded connections in the communities in which they are based. The BJP HIV CTU is well-poised to carry out efficient high-quality clinical trials to address major questions in HIV clinical research. Its leadership and administrative structure will facilitate the conduct of studies that cross traditional CTN boundaries and will enable rapid responses to new scientific priorities as they emerge.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $4,506,411 )
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	19	4/24/2025	NON-COMPETING CONTINUATION	$2,253,205
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	19	11/15/2024	NON-COMPETING CONTINUATION	$2,253,206
														Subtotal = $4,506,411

Issue Date FY: 2024 ( Subtotal = $3,541,665 )
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	18	11/14/2023	NON-COMPETING CONTINUATION	$1,358,226
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	18	6/5/2024	NON-COMPETING CONTINUATION	$2,183,439
														Subtotal = $3,541,665

Issue Date FY: 2023 ( Subtotal = $4,313,242 )
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	17	6/1/2023	NON-COMPETING CONTINUATION	$2,169,117
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	17	11/30/2022	NON-COMPETING CONTINUATION	$2,169,117
2023	2021	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	15	5/2/2023	SUPPLEMENT FOR EXPANSION	-$1
2023	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	14	3/17/2023	NON-COMPETING CONTINUATION	-$24,990
														Subtotal = $4,313,242

Issue Date FY: 2022 ( Subtotal = $4,963,587 )
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	004	16	6/15/2022	NON-COMPETING CONTINUATION	$1,833,245
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	16	11/22/2021	NON-COMPETING CONTINUATION	$2,867,383
2022	2021	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	15	3/21/2022	COMPETING CONTINUATION	$22,515
2022	2021	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	005	15	8/29/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	15	12/27/2021	SUPPLEMENT FOR EXPANSION	$262,959
2022	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	14	3/21/2022	NON-COMPETING CONTINUATION	-$22,515
														Subtotal = $4,963,587

Issue Date FY: 2021 ( Subtotal = $4,095,972 )
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	15	3/18/2021	COMPETING CONTINUATION	$2,275,350
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	15	12/17/2020	COMPETING CONTINUATION	$457,782
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	006	15	9/17/2021	SUPPLEMENT FOR EXPANSION	$1
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	004	15	8/10/2021	COMPETING CONTINUATION	$733,437
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	15	11/18/2020	COMPETING CONTINUATION	$1,625,798
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	007	15	9/20/2021	COMPETING CONTINUATION	$0
2021	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	14	8/10/2021	NON-COMPETING CONTINUATION	-$733,437
2021	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	005	14	8/10/2021	SUPPLEMENT FOR EXPANSION	-$262,959
														Subtotal = $4,095,972

Issue Date FY: 2020 ( Subtotal = $6,524,553 )
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	14	6/15/2020	SUPPLEMENT FOR EXPANSION	$900,000
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	14	6/1/2020	NON-COMPETING CONTINUATION	$2,731,117
2020	2020	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	14	11/21/2019	NON-COMPETING CONTINUATION	$2,893,436
														Subtotal = $6,524,553

Issue Date FY: 2019 ( Subtotal = $6,259,351 )
2019	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	13	11/13/2018	NON-COMPETING CONTINUATION	$2,989,363
2019	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	13	8/29/2019	NON-COMPETING CONTINUATION	$280,626
2019	2019	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	13	5/24/2019	NON-COMPETING CONTINUATION	$2,989,362
														Subtotal = $6,259,351

Issue Date FY: 2018 ( Subtotal = $3,085,778 )
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	12	2/14/2018	NON-COMPETING CONTINUATION	$509,111
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	12	11/22/2017	NON-COMPETING CONTINUATION	$1,018,221
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	12	8/1/2018	NON-COMPETING CONTINUATION	$31,114
2018	2018	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	12	5/26/2018	NON-COMPETING CONTINUATION	$1,527,332
														Subtotal = $3,085,778

Issue Date FY: 2017 ( Subtotal = $3,046,726 )
2017	2017	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	11	11/10/2016	NON-COMPETING CONTINUATION	$3,046,726
														Subtotal = $3,046,726

Issue Date FY: 2016 ( Subtotal = $3,054,663 )
2016	2016	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	10	11/12/2015	NON-COMPETING CONTINUATION	$3,054,663
														Subtotal = $3,054,663

Issue Date FY: 2015 ( Subtotal = $2,781,833 )
2015	2015	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	9	11/14/2014	NON-COMPETING CONTINUATION	$2,781,833
														Subtotal = $2,781,833

Issue Date FY: 2014 ( Subtotal = $3,756,870 ) (Continued on the next page)
2014	2014	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	8	2/10/2014	COMPETING CONTINUATION	$422,528
2014	2014	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	8	12/10/2013	COMPETING CONTINUATION	$2,603,920
2014	2014	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	8	12/23/2013	COMPETING CONTINUATION	$730,422
Grand Total All Awards = $52,112,861

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Boston HIV CTU

Award Number: UM1AI069412

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2007

PERIOD OF PERFORMANCE END DATE: 11/30/2027

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