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 | Issue Date FY: 2026 ( Subtotal = $272,191,068 ) (Continued on the next page) |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21NS146759 | Identification of the Palmitoyltransferase for Glucocerebrosidase Trafficking Receptor LIMP2 and Restoration of GBA1 Function in Parkinson Disease and Lewy Body Dementia. | 000 | 1 | NIH | 7/10/2026 | $492,250 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99HL183694 | Exploring the Molecular Landscape of Lung Health and Aging Through a Multi-Omics Lens | 000 | 1 | NIH | 4/3/2026 | $170,570 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL185567 | Integrating Multi-Trait Genetics, Proteomics, and Deep Learning to Uncover Biomarkers and Therapeutic Targets for COPD Exacerbations | 000 | 1 | NIH | 7/8/2026 | $894,314 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL180582 | Recognizing and resolving laterally directed pharyngeal collapse for successful hypoglossal nerve stimulation therapy in OSA | 000 | 1 | NIH | 7/9/2026 | $894,690 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R37AR048632 | CD1 autoreactive T cells in human inflammatory skin disease | 003 | 25 | NIH | 6/29/2026 | $551,761 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R37AR048632 | CD1 autoreactive T cells in human inflammatory skin disease | 003 | 25 | NIH | 6/29/2026 | -$551,761 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R37AR048632 | CD1 autoreactive T cells in human inflammatory skin disease | 002 | 25 | NIH | 6/19/2026 | $551,761 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB037010 | Development of a multifunctional interventional device for biopsy and optical imaging-based phase-0 drug response measurements | 000 | 1 | NIH | 4/28/2026 | $749,901 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35GM161257 | Cellular Therapy for Sepsis and Lung Injury | 000 | 1 | NIH | 3/5/2026 | $445,983 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21NS147246 | Identifying and Restoring Mechanisms Driving DRPLA-Associated Epilepsy. | 000 | 1 | NIH | 3/6/2026 | $479,687 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08AI190123 | Defining the T cell state that sustains chronic allergic disease | 000 | 1 | NIH | 4/1/2026 | $193,600 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UG3NS143075 | miR-10b Gene Editing Therapy for Glioblastoma | 000 | 1 | NIH | 3/27/2026 | $790,474 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08AI196234 | A Transposon-based Gene Drive to Combat Antimicrobial Resistance | 000 | 1 | NIH | 4/1/2026 | $171,046 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35HL183402 | Non-coding RNAs and chronic limb threatening ischemia | 000 | 1 | NIH | 3/1/2026 | $1,242,222 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00CA286891 | A multi-omics approach to evaluate the role of chronic inflammation in breast cancer development | 001 | 3 | NIH | 6/16/2026 | -$248,810 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01AI186972 | Harnessing Trained Immunity as a Radiation Medical Countermeasure | 001 | 2 | NIH | 8/10/2026 | $610,700 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00CA286891 | A multi-omics approach to evaluate the role of chronic inflammation in breast cancer development | 001 | 3 | NIH | 6/16/2026 | $248,810 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00CA286891 | A multi-omics approach to evaluate the role of chronic inflammation in breast cancer development | 000 | 3 | NIH | 3/26/2026 | $248,810 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK145763 | Dapagliflozin in Active Lupus Nephritis: A Pilot and Feasibility Randomized Trial | 001 | 1 | NIH | 3/30/2026 | $0 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK145763 | Dapagliflozin in Active Lupus Nephritis: A Pilot and Feasibility Randomized Trial | 000 | 1 | NIH | 2/17/2026 | $364,560 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI187143 | Th2 Memory in Chronic Type 2 Inflammation | 000 | 1 | NIH | 2/4/2026 | $3,080,416 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA311924 | AI-CChaSE: AI-enabled Cancer CHatbots for Symptom Education | 000 | 1 | NIH | 3/26/2026 | $819,628 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI196739 | Elucidating Treg defects in ALS | 000 | 1 | NIH | 2/6/2026 | $823,143 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG087356 | Identification of brain metabolomic profiles associated with dementia | 000 | 3 | NIH | 3/3/2026 | $827,317 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35GM157032 | Molecular Mechanisms of Hormone-Mediated Sex Differences in Wound Healing | 000 | 3 | NIH | 7/16/2026 | $442,444 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS148118 | Pathogenic mechanisms of LRRK2 mutations | 000 | 1 | NIH | 5/4/2026 | $557,883 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23AR080203 | Multi-omic Studies of Local and Systemic Immune Dysregulation in Rosacea | 000 | 5 | NIH | 1/7/2026 | $169,884 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL180621 | Characterization of lung interstitial neutrophils | 000 | 2 | NIH | 6/3/2026 | $696,097 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01HG014621 | PopScreen: Implementing Population Genomic Screening in Primary Care | 000 | 1 | NIH | 6/23/2026 | $1,008,584 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA299219 | Hormone regulation of fallopian tube inflammation and cancer initiation via a stromal niche | 000 | 1 | NIH | 8/11/2026 | $645,233 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R34AT013522 | Harmonized Healing: Personalized Music Interventions to Address Chronic Pain in People Living with HIV | 000 | 2 | NIH | 6/5/2026 | $240,827 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA308071 | Optimizing neoadjuvant/adjuvant anti-PD-1 therapy for localized Renal Cell Carcinoma | 000 | 1 | NIH | 5/12/2026 | $740,020 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AI196527 | AI-guided Intestinal stem cell activation for mucosal restoration in ulcerative colitis | 000 | 1 | NIH | 2/18/2026 | $479,610 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL177519 | A New-Generation Lipid-Lowering and Anti-Inflammatory siRNA Therapy for Atherosclerosis | 000 | 2 | NIH | 7/8/2026 | $753,430 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99DE035580 | Modeling Epstein-Barr Virus Germinal Center Infection with Tonsil Organoids | 000 | 1 | NIH | 8/10/2026 | $68,047 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA307291 | Macrophage-directed strategies for BRCA-associated breast cancer | 000 | 1 | NIH | 4/17/2026 | $772,208 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99DE035580 | Modeling Epstein-Barr Virus Germinal Center Infection with Tonsil Organoids | 000 | 1 | NIH | 8/10/2026 | $68,046 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR085672 | Using human iPS-derived in vitro models to study the role of HOX genes in musculo-skeletal development | 000 | 1 | NIH | 5/11/2026 | $683,016 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01AI201044 | Allergen and damage sensing by chemosensory tuft cells in the airway | 000 | 1 | NIH | 7/3/2026 | $564,396 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00HL165024 | Using genomic modifiers to mechanistically link clonal hematopoiesis of indeterminate potential penetrance to coronary artery disease | 000 | 3 | NIH | 3/10/2026 | $249,000 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21HL184189 | Integrative Single-Cell Analysis of Aging-Associated Changes in Human Hematopoietic Stem Cell Heterogeneity | 001 | 1 | NIH | 4/20/2026 | $134,250 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R03HL183108 | Early Immune Signatures of COPD: Linking Inflammation to Disease Progression | 000 | 1 | NIH | 3/19/2026 | $120,825 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21HL184189 | Integrative Single-Cell Analysis of Aging-Associated Changes in Human Hematopoietic Stem Cell Heterogeneity | 000 | 1 | NIH | 3/9/2026 | $134,250 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS142764 | SocialBit2: High-fidelity Mobile Sensing of Social Connection after Stroke | 000 | 1 | NIH | 3/19/2026 | $716,816 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI189471 | Lipidomic discovery of physiological CD1 antigens and blockers for human T cells | 000 | 1 | NIH | 4/9/2026 | $893,459 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32DE035781 | Targeted gene delivery to nociceptors | 001 | 1 | NIH | 3/19/2026 | $0 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32DE035781 | Targeted gene delivery to nociceptors | 000 | 1 | NIH | 3/19/2026 | $80,352 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL176637 | Endothelial Inflammation, Src Kinase Dysregulation, and Fibrosis in Early Pulmonary Arterial Hypertension | 000 | 2 | NIH | 7/14/2026 | $739,659 |
| | 2026 | 2026 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK147058 | Real-World Evaluation of Continuous Glucose Monitoring in Older Adults With Type 2 Diabetes: A Multisite Study of Structures, Processes, and Outcome | 000 | 1 | NIH | 5/12/2026 | $891,382 |
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