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 | Issue Date FY: 2025 ( Subtotal = $79,944,216 ) (Continued on the next page) |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23AR083505 | Integrating multiomic analyses for gene discovery andgenetic diagnosis of Mendelian myopathies | 000 | 2 | NIH | 2/19/2025 | $173,880 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK039773 | Mechanisms of Ischemic Kidney Injury and Repair | 000 | 38 | NIH | 1/8/2025 | $641,082 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI184118 | Quantifying integrase resistance among Nigerian children failing dolutegravir to inform rapid diagnostic development in partnership with Nigerian scientists | 000 | 2 | NIH | 1/22/2025 | $418,170 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL170000 | Role of CLCA1 as a MIF decoy inhibitor in abdominal aortic aneurysms | 000 | 2 | NIH | 3/10/2025 | $642,975 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080992 | Role of a novel risk loci HAVCR2 of late-onset Alzheimer's disease in the regulation of microglial response in neurodegeneration | 000 | 3 | NIH | 3/6/2025 | $746,921 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01AG086168 | Understanding Interorgan Communication Through Heterochronic Organ Transplantation | 000 | 2 | NIH | 3/6/2025 | $617,098 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01ES036206 | Per- and polyfluoroalkyl substances, apolipoproteins, and risk of coronary heart disease | 000 | 2 | NIH | 2/14/2025 | $702,691 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08AR085165 | DISSECTING THE SPATIAL HETEROGENEITY OF SYNOVIAL INFLAMMATION IN RHEUMATOID ARTHRITIS | 000 | 1 | NIH | 12/24/2024 | $170,101 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS136297 | Optimizing Neuromodulation Therapies for Epilepsy: Identifying the Right Patient, Right Place, and Right Time for Stimulation | 000 | 1 | NIH | 11/29/2024 | $690,763 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HD114708 | An integrated intervention to address the double burden of maternal child malnutrition in Guatemala | 000 | 1 | NIH | 12/25/2024 | $641,647 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL177156 | Immuno-Metabolic Regulation of Vascular Dysfunction by CD70 | 000 | 1 | NIH | 2/24/2025 | $167,400 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA295752 | DNA damage-related stemness program during BRCA1 breast cancer initiation | 000 | 1 | NIH | 12/6/2024 | $527,159 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB035679 | An AI-Assisted Strategy for Monitoring Pulmonary Congestion in Acute Heart Failure Patients in Emergency Settings | 000 | 1 | NIH | 1/30/2025 | $608,944 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35GM153468 | Decoding the Molecular Mechanisms Governing Regulation and Reprogramming of Cellular Identity | 001 | 2 | NIH | 1/28/2025 | $403,650 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG084531 | Combination Therapy with Semaglutide and Anti-Amyloid Antibodies for Alzheimers Disease | 000 | 2 | NIH | 1/28/2025 | $765,619 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01CA250476 | Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities | 001 | 5 | NIH | 2/18/2025 | $759,992 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UM1AI069412 | Boston HIV CTU | 000 | 19 | NIH | 11/15/2024 | $412,287 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UM1AI069412 | Boston HIV CTU | 000 | 19 | NIH | 11/15/2024 | $1,840,919 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99HG013345 | Functional genomics approaches to decode the roles of transcription factor isoforms | 000 | 2 | NIH | 3/10/2025 | $127,170 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR077132 | Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle loss | 000 | 5 | NIH | 2/14/2025 | $453,645 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R03AI178363 | Clinically Recognized Congenital Cytomegalovirus Infection and Risk of Long-Term Neurologic and Non-neurologic Complications: Evidence from a Nationwide Cohort | 000 | 2 | NIH | 11/19/2024 | $86,815 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08DE030216 | Development of an artificial intelligence-driven, imaging-based platform for pretreatment identification of extranodal extension in head and neck cancer | 000 | 5 | NIH | 12/31/2024 | $168,240 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL130974 | Clinical Genetics and Screening for Pulmonary Fibrosis | 000 | 8 | NIH | 11/30/2024 | $1,155,112 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI136041 | Eicosanoid Networks in Aspirin Hypersensitivity | 000 | 12 | NIH | 11/18/2024 | $636,768 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MH132632 | Control of ETV1 transcriptional networks in amygdalar astrocytes | 000 | 2 | NIH | 11/20/2024 | $369,631 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI175582 | Skin vaccination and generation of protective lung-tropic memory T cells | 000 | 2 | NIH | 11/4/2024 | $912,384 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG082346 | Mechanisms of Somatic Mutation in Alzheimer's Disease Using Single Neuron Analysis | 000 | 2 | NIH | 12/6/2024 | $804,192 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K24HL171900 | Mentoring in Patient Oriented Research in Lung Disease through a Sex and Gender Lens | 000 | 2 | NIH | 12/7/2024 | $128,650 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI179986 | The novel role of MIF-CD74 inflammatory pathway in immune regulation | 000 | 2 | NIH | 11/7/2024 | $408,062 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL171279 | NK cell inflammation resolution circuits in pediatric RSV infection | 000 | 2 | NIH | 12/6/2024 | $633,035 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL168899 | Traffic-Related Ultrafine Particles Disrupt The Resolution Of Lung Inflammation | 000 | 2 | NIH | 11/25/2024 | $623,328 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD016910 | Disasters and Hospital Systems Serving Health Disparity Populations: Identifying the Long Term effects of the COVID-19 Pandemic to Mitigate Future Challenges | 000 | 3 | NIH | 12/22/2024 | $614,364 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI144166 | Role of Tim-3:Bat-3 pathway in inducing tolerogenic DCs and peripheral tolerance | 000 | 6 | NIH | 12/11/2024 | $496,340 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K24AI180296 | Patient-Oriented Research Mentorship and Training in Upper Airway Allergic and Inflammatory Diseases | 000 | 2 | NIH | 11/19/2024 | $174,031 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK138260 | Development of novel PD1 agonist therapeutic strategies for inflammatory bowel disease | 000 | 2 | NIH | 11/27/2024 | $417,284 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR076973 | Development of enthesopathy in the mouse model of X-linked hypophosphatemia | 000 | 5 | NIH | 2/14/2025 | $338,567 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA267479 | MicroRNA control of tumor-promoting inflammation in colon cancer | 000 | 4 | NIH | 1/22/2025 | $347,698 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI165382 | KSHV Latency Regulation | 000 | 4 | NIH | 11/1/2024 | $671,213 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K01HL166705 | Linking endotype and phenotype to understand COPD heterogeneity via deep learning and network science | 000 | 3 | NIH | 12/23/2024 | $178,200 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL161087 | Skin-Intrinsic Immunosuppressive Mesenchymal Stem Cells and aGVHD | 000 | 4 | NIH | 12/19/2024 | $372,391 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL163246 | Improving COPD Outcomes: Using Real-World Data to Analyze Treatment Effectiveness, Safety, and Adherence | 000 | 3 | NIH | 11/18/2024 | $165,741 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21HL168656 | Modeling Sex-Specific Cardiac Hypertrophy-on-a-Chip | 000 | 2 | NIH | 12/12/2024 | $223,750 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA288535 | Cell surface receptor targeted therapies for brain tumors | 000 | 1 | NIH | 1/7/2025 | $417,858 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R03CA295675 | Mixed Lineage Kinase 2 (MLK2) in tumor angiogenesis | 000 | 1 | NIH | 12/11/2024 | $83,180 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K00CA274651 | Development of Lipid Nanoparticles for B-cell Mediated Immunotherapies | 000 | 3 | NIH | 1/14/2025 | $90,765 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | AY2AX000058 | DEMOCRATIZE: Driving Equitable Medical Care in Rural America Through Innovative vehicalZE | 000 | 1 | NIH | 11/25/2024 | $4,380,160 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21HD117308 | Continuous Non-Invasive Blood Pressure Monitoring in Neonates using Wearable Wireless NIRS | 000 | 1 | NIH | 12/10/2024 | $237,827 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK141535 | The role of SRCAP in therapy related clonal hematopoiesis | 000 | 1 | NIH | 12/24/2024 | $465,155 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99CA296755 | Inflammation and Hepatocellular Carcinoma: A Multiomics Approach to Improve Early Detection, Causal Inference, and Lifestyle Based Prevention | 000 | 1 | NIH | 1/22/2025 | $165,883 |
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