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 | Issue Date FY: 2025 ( Subtotal = $91,242,465 ) (Continued on the next page) |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR080659 | Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases | 001 | 3 | NIH | 2/19/2025 | $655,247 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR063759 | Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state | 000 | 10 | NIH | 3/14/2025 | $416,448 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK129574 | Modulation of cystogenesis | 000 | 4 | NIH | 3/14/2025 | $537,390 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS121096 | Gene Edited and Engineered Tumor Cell Therapeutics for Cancer | 000 | 5 | NIH | 3/14/2025 | $373,424 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS123557 | Improved Delivery of Gene Therapies to the Central Nervous System by Focused Ultrasound-Mediated Disruption of the Blood-Brain Barrier | 000 | 4 | NIH | 3/18/2025 | $524,739 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI176579 | Single-cell Proteogenomic profiling of HIV-1 reservoir cells | 000 | 3 | NIH | 3/21/2025 | $100,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI176579 | Single-cell Proteogenomic profiling of HIV-1 reservoir cells | 000 | 3 | NIH | 3/21/2025 | $989,140 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL169300 | Better utilization of omics data to inform precision medicine for asthma throughout the life course | 000 | 2 | NIH | 3/17/2025 | $679,228 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23AR080203 | Multi-omic Studies of Local and Systemic Immune Dysregulation in Rosacea | 000 | 4 | NIH | 3/13/2025 | $169,884 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23NS136767 | Predicting Dependency after Traumatic Brain Injury | 000 | 2 | NIH | 3/20/2025 | $227,707 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL159318 | Multi-omic Risk Prediction of Chronic Obstructive Pulmonary Disease in European- and African-Ancestry Populations | 000 | 4 | NIH | 3/17/2025 | $168,480 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL168199 | Identifying Subtypes of COPD Using Metabolomic and Genomic Approaches | 000 | 2 | NIH | 3/19/2025 | $627,879 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL164885 | Development of strategies to enhance titin (TTN) expression and treat dilated cardiomyopathy caused by TTN haploinsufficiency | 001 | 3 | NIH | 3/28/2025 | $169,020 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA228700 | Epstein-Barr virus LMP1 mediated oncogenicity | 001 | 6 | NIH | 3/20/2025 | $615,982 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB035790 | Instant and reversible wet tissue adhesive tape | 000 | 1 | NIH | 3/20/2025 | $625,168 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00NS114111 | Molecular Control of Astrocytes in CNS Inflammation | 001 | 5 | NIH | 3/20/2025 | -$24,899 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS110942 | Oncolytic Virus Therapeutic Responses Occur from Changes in the Glioblastoma Immune Microenvironment | 002 | 7 | NIH | 3/20/2025 | $412,964 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA111754 | Developing new therapeutic strategies for distinct Ras-driven cancers | 000 | 20 | NIH | 3/19/2025 | $430,203 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI123420 | Targeting Epstein-Barr Virus Super-Enhancer | 000 | 10 | NIH | 3/25/2025 | $447,500 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081023 | Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC) | 000 | 4 | NIH | 2/14/2025 | $500,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081023 | Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC) | 000 | 4 | NIH | 2/14/2025 | $100,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI175149 | Prostaglandin E2-Dependent Control of a Mast Cell IL-33/ST2 Pathway in Asthma | 000 | 3 | NIH | 3/24/2025 | $859,874 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL163099 | Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal Hematopoiesis | 000 | 4 | NIH | 2/14/2025 | $585,400 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08AR082031 | Modifying adipocyte and pre-adipocyte cell fate in fibroadipose tissue of secondary lymphedema | 000 | 3 | NIH | 3/24/2025 | $172,760 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL170000 | Role of CLCA1 as a MIF decoy inhibitor in abdominal aortic aneurysms | 000 | 2 | NIH | 3/10/2025 | $642,975 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA235589 | Lymph Node Quantification System for Multisite Clinical Trials | 001 | 6 | NIH | 3/10/2025 | $703,707 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL167021 | The Comparative Effectiveness and Safety of Oral Anticoagulants in Patients with Cirrhosis and Atrial Fibrillation | 000 | 3 | NIH | 3/11/2025 | $760,106 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01ES036206 | Per- and polyfluoroalkyl substances, apolipoproteins, and risk of coronary heart disease | 000 | 2 | NIH | 2/14/2025 | $702,691 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00CA256497 | Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling | 000 | 5 | NIH | 2/14/2025 | $224,099 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL065095 | Regulators of immune complex mediated neutrophil antigen presentation | 000 | 26 | NIH | 3/11/2025 | $676,617 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL171877 | Etiology of naturally-occurring anti-ABO antibodies | 000 | 2 | NIH | 3/10/2025 | $168,480 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99HG013345 | Functional genomics approaches to decode the roles of transcription factor isoforms | 000 | 2 | NIH | 3/10/2025 | $127,170 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS119476 | Next Generation Gene Therapy for Refractory Pain | 000 | 4 | NIH | 3/4/2025 | $634,215 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS127892 | Using Brain Lesions and Deep Brain Stimulation to Identify an Epilepsy Circuit | 000 | 4 | NIH | 3/21/2025 | $632,070 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB034223 | Generating High Quality, High Resolution, Patient-Specific 4D Models of Cerebral Vasculature | 000 | 3 | NIH | 3/21/2025 | $362,475 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD016178 | Social networks and risk of delayed arrival to the hospital during stroke | 000 | 4 | NIH | 2/21/2025 | $663,585 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI049313 | T cell responses to CD1-restricted lipids in tuberculosis | 000 | 25 | NIH | 2/18/2025 | $450,325 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG078256 | Using instrumented everyday gait to predict falls in older adults using the WHS cohort | 000 | 3 | NIH | 3/21/2025 | $557,070 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35GM139430 | Evaluating Resolution Mechanisms for Infectious Inflammation | 001 | 5 | NIH | 3/21/2025 | $671,220 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081031 | Single cell and spatial genomic analyses of specimens from patients with autoimmune diseases (Technology Core) | 000 | 4 | NIH | 3/21/2025 | $200,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01CA250476 | Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities | 001 | 5 | NIH | 2/18/2025 | $759,992 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081031 | Single cell and spatial genomic analyses of specimens from patients with autoimmune diseases (Technology Core) | 000 | 4 | NIH | 3/21/2025 | $100,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK136617 | Urine levels of Glycated CD59 for screening and diagnosis of pregnancy-induced glucose intolerance | 000 | 2 | NIH | 2/17/2025 | $647,442 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK137856 | Validation of a novel cerebellar-striatal satiety circuit in human | 000 | 2 | NIH | 2/18/2025 | $673,005 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DC020965 | Naturalistic Neuroimaging for Presurgical Language Mapping | 000 | 3 | NIH | 2/25/2025 | $561,270 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MH129360 | Discrimination and racial socialization on Asian American parent and youth mental health | 000 | 4 | NIH | 3/21/2025 | $726,486 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL177156 | Immuno-Metabolic Regulation of Vascular Dysfunction by CD70 | 000 | 1 | NIH | 2/24/2025 | $167,400 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AR080849 | Osteoclasts or RANKL: Which is the critical target in treatment of fibrous dysplasia bone lesions? | 000 | 2 | NIH | 2/17/2025 | $174,545 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080429 | Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia | 000 | 3 | NIH | 3/6/2025 | $1,234,055 |
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