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 | Issue Date FY: 2024 ( Subtotal = $371,654,314 ) (Continued on the next page) |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR076973 | Development of enthesopathy in the mouse model of X-linked hypophosphatemia | 000 | 4 | NIH | 1/5/2024 | $338,567 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21HL168656 | Modeling Sex-Specific Cardiac Hypertrophy-on-a-Chip | 000 | 1 | NIH | 12/15/2023 | $268,500 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080429 | Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia | 000 | 2 | NIH | 1/8/2024 | $1,231,014 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R03AG089320 | Early detection & monitoring of memory decline in a representative sample of older adults at risk for Alzheimer's disease and related dementias | 000 | 1 | NIH | 8/26/2024 | $353,391 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U19NS130617 | Harvard PRECISION Human Pain Center | 002 | 3 | NIH | 8/7/2024 | $2,574,551 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | T32AI007387 | Multidisciplinary AIDS Training Program | 000 | 35 | NIH | 6/6/2024 | $449,938 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F99AG088431 | Using causal aging biomarkers and protein design to develop novel anti-aging interventions | 000 | 1 | NIH | 8/22/2024 | $37,463 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08CA251654 | A Positive Psychology Intervention for Allogeneic Stem Cell Transplant Patients. | 001 | 5 | NIH | 8/21/2024 | $236,712 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS115951 | Role of the Intestinal Microbiota in ALS | 000 | 4 | NIH | 1/24/2024 | $621,167 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA279410 | MMS22L loss and PARP inhibition in prostate cancer | 000 | 2 | NIH | 3/8/2024 | $368,516 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS115951 | Role of the Intestinal Microbiota in ALS | 001 | 4 | NIH | 4/10/2024 | $48,312 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080429 | Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia | 002 | 2 | NIH | 6/10/2024 | $136,779 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL168199 | Identifying Subtypes of COPD Using Metabolomic and Genomic Approaches | 000 | 1 | NIH | 5/10/2024 | $737,142 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA279410 | MMS22L loss and PARP inhibition in prostate cancer | 001 | 2 | NIH | 4/16/2024 | $20,474 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AI174197 | Development of a model of Gonococcal conjunctivitis for vaccine evaluations | 000 | 2 | NIH | 4/4/2024 | $221,854 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080429 | Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia | 001 | 2 | NIH | 5/2/2024 | $0 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD018997 | Multi-level intervention to promote healthy beverage choices among Navajo families | 002 | 2 | NIH | 4/9/2024 | $501,673 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL168199 | Identifying Subtypes of COPD Using Metabolomic and Genomic Approaches | 001 | 1 | NIH | 5/27/2024 | $0 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35HL166640 | Targeted immune therapies in heart transplantation | 000 | 2 | NIH | 1/25/2024 | $944,211 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35HL166640 | Targeted immune therapies in heart transplantation | 001 | 2 | NIH | 6/20/2024 | $83,929 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG087356 | Identification of brain metabolomic profiles associated with dementia | 000 | 1 | NIH | 6/14/2024 | $897,661 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | DP2HD112176 | Identifying plasma proteomic profiles of chronic pain development in endometriosis from adolescence to adulthood | 002 | 1 | NIH | 7/2/2024 | -$1,377,464 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL174622 | Determining drivers of mast cell expansion and function during human airway disease | 000 | 1 | NIH | 6/28/2024 | $715,968 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32CA284615 | Dual targeting of cGAS-STING and splicing to prime lung cancer immunogenicity | 000 | 2 | NIH | 6/4/2024 | $83,932 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21EB034075 | Deep Learning Assisted Scoring of Point of Care Lung Ultrasound for Acute Decompensated Heart Failure in the Emergency Department | 000 | 2 | NIH | 7/2/2024 | $358,000 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | DP2HD112176 | Identifying plasma proteomic profiles of chronic pain development in endometriosis from adolescence to adulthood | 000 | 1 | NIH | 6/25/2024 | $1,377,464 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR080659 | Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases | 000 | 2 | NIH | 1/30/2024 | $664,642 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00CA256497 | Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling | 000 | 4 | NIH | 2/9/2024 | $224,099 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS121096 | Gene Edited and Engineered Tumor Cell Therapeutics for Cancer | 000 | 4 | NIH | 3/13/2024 | $373,424 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL154034 | Examining the Mechanisms of RBC Alloimmunization Hyperresponders | 000 | 5 | NIH | 9/6/2024 | $432,332 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 002 | 17 | NIH | 8/12/2024 | $1,956,770 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI181221 | Interrogating Clonal Repertoire in Drug Hypersensitivity Reactions | 001 | 1 | NIH | 9/4/2024 | $86,763 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R13NS132544 | 17th Annual Counteract Network Symposium | 000 | 1 | NIH | 4/16/2024 | $141,000 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR080659 | Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases | 001 | 2 | NIH | 5/29/2024 | $51,694 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK136617 | Urine levels of Glycated CD59 for screening and diagnosis of pregnancy-induced glucose intolerance | 000 | 1 | NIH | 3/25/2024 | $734,290 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS121096 | Gene Edited and Engineered Tumor Cell Therapeutics for Cancer | 001 | 4 | NIH | 4/9/2024 | $29,043 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32AG087642 | Development of an Ultrasensitive Blood-based Diagnostic for Alzheimer's Disease | 000 | 1 | NIH | 5/24/2024 | $76,528 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR063759 | Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state | 000 | 9 | NIH | 4/11/2024 | $444,839 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HD107759 | Comparative Safety of Antibiotics for Common Bacterial Infections During Pregnancy | 000 | 3 | NIH | 5/22/2024 | $555,663 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08CA282969 | Tumor-Immune Interactions and Cisplatin Resistance in Bladder Cancer | 000 | 1 | NIH | 8/20/2024 | $210,973 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | T32CA272386 | Cancer Neuroscience Training Program | 000 | 2 | NIH | 6/25/2024 | $550,907 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR063759 | Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state | 001 | 9 | NIH | 6/11/2024 | $34,598 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL162356 | Identifying unrecognized genetic causes of congenital heart disease | 000 | 1 | NIH | 5/23/2024 | $782,672 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00CA256497 | Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling | 001 | 4 | NIH | 4/17/2024 | $24,901 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK126855 | "A microbiome-dependent bile acid metabolite improves type 2 diabetes." | 001 | 4 | NIH | 5/8/2024 | $39,292 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K01MH136417 | Characterization and Digital Phenotyping of Migraine and Affective Disorders during Hormonal Fluctuations across the Life Course | 000 | 1 | NIH | 9/5/2024 | $185,220 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23MH134771 | Development and Pilot RCT of a "Healthy Welcome" Intervention to Increase PrEP Uptake and Adherence Among Migrant Men in Johannesburg | 000 | 1 | NIH | 7/12/2024 | $201,006 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23AI182453 | The development & pilot implementation of a Cas13a-based low-cost point-of-care assay for detecting Neisseria gonorrhoeae and molecular markers of antimicrobial resistance in resource-limited settings | 000 | 1 | NIH | 8/19/2024 | $195,480 |
| | 2024 | 2024 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00AG075190 | Antecedents and Outcomes of Subjective Cognitive Decline: An Electronic Health Records and Artificial Intelligence Approach | 000 | 3 | NIH | 8/23/2024 | $249,000 |
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