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 | Issue Date FY: 2025 ( Subtotal = $288,342,829 ) (Continued on the next page) |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DC020965 | Naturalistic Neuroimaging for Presurgical Language Mapping | 000 | 3 | NIH | 2/25/2025 | $561,270 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL065095 | Regulators of immune complex mediated neutrophil antigen presentation | 000 | 26 | NIH | 3/11/2025 | $676,617 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL163099 | Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal Hematopoiesis | 001 | 4 | NIH | 7/25/2025 | $65,045 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL163099 | Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal Hematopoiesis | 000 | 4 | NIH | 2/14/2025 | $585,400 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AR080849 | Osteoclasts or RANKL: Which is the critical target in treatment of fibrous dysplasia bone lesions? | 000 | 2 | NIH | 2/17/2025 | $174,545 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01ES036206 | Per- and polyfluoroalkyl substances, apolipoproteins, and risk of coronary heart disease | 000 | 2 | NIH | 2/14/2025 | $702,691 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD016178 | Social networks and risk of delayed arrival to the hospital during stroke | 000 | 4 | NIH | 2/21/2025 | $663,585 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080429 | Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia | 001 | 3 | NIH | 6/17/2025 | $109,693 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080429 | Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia | 000 | 3 | NIH | 3/6/2025 | $1,234,055 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS119476 | Next Generation Gene Therapy for Refractory Pain | 000 | 4 | NIH | 3/4/2025 | $634,215 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HD101101 | Mechanistic pathways of the effects of human-animal interaction on depression and psychosocial stress | 001 | 5 | NIH | 5/19/2025 | $66,726 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HD101101 | Mechanistic pathways of the effects of human-animal interaction on depression and psychosocial stress | 000 | 5 | NIH | 2/19/2025 | $600,539 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK136617 | Urine levels of Glycated CD59 for screening and diagnosis of pregnancy-induced glucose intolerance | 000 | 2 | NIH | 2/17/2025 | $647,442 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD016178 | Social networks and risk of delayed arrival to the hospital during stroke | 001 | 4 | NIH | 7/31/2025 | $73,730 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA235134 | Adaptive Percutaneous Prostate Interventions using Sensorized Needle | 002 | 5 | NIH | 5/22/2025 | $61,989 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA235134 | Adaptive Percutaneous Prostate Interventions using Sensorized Needle | 001 | 5 | NIH | 2/13/2025 | $557,907 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR077132 | Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle loss | 001 | 5 | NIH | 5/22/2025 | $35,284 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR077132 | Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle loss | 000 | 5 | NIH | 2/14/2025 | $453,645 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R03DE034380 | Medicaid coverage of treatment for periodontal disease and its impact on health outcomes | 000 | 1 | NIH | 1/27/2025 | $185,918 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00NS114111 | Molecular Control of Astrocytes in CNS Inflammation | 001 | 5 | NIH | 3/20/2025 | -$24,899 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00NS114111 | Molecular Control of Astrocytes in CNS Inflammation | 000 | 5 | NIH | 1/27/2025 | $249,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08EB034299 | Rapid Anatomic and Quantitative MR Imaging of the Skull Base and Face | 000 | 2 | NIH | 1/27/2025 | $191,138 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08DK131321 | IL1 as a Driver of Mucosal Immune Dysregulation in Inflammatory Bowel Disease | 000 | 4 | NIH | 2/19/2025 | $168,400 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB035679 | An AI-Assisted Strategy for Monitoring Pulmonary Congestion in Acute Heart Failure Patients in Emergency Settings | 000 | 1 | NIH | 1/30/2025 | $608,944 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01CA268810 | Polygenic risk stratification combined with mpMRI to identify clinically relevant prostate cancer | 000 | 3 | NIH | 5/8/2025 | $707,952 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL157725 | High-dimensional single-cell mapping to define immune signatures of cytomegalovirus-associated rejection in cardiac transplantation | 002 | 5 | NIH | 2/20/2025 | $169,560 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK138036 | Novel approaches to improve comparative effectiveness research of medical and surgical weight reduction strategies in clinical practice | 000 | 2 | NIH | 3/5/2025 | $695,317 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL168199 | Identifying Subtypes of COPD Using Metabolomic and Genomic Approaches | 000 | 2 | NIH | 3/19/2025 | $627,879 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23HL179493 | Computed tomography for early detection and phenotyping of pulmonary hypertension associated with chronic obstructive pulmonary disease with implications for treatment | 000 | 1 | NIH | 7/23/2025 | $171,858 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08AI187322 | Genomic- informed development of a cheap, portable assay to rapidly profile drug-resistant bacterial infections | 000 | 1 | NIH | 7/23/2025 | $198,630 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R61NS138810 | Optimization of New Drugs for the Treatment of Essential Tremor | 000 | 1 | NIH | 7/31/2025 | $864,552 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR080194 | New approaches to safety monitoring of novel systemic treatments for atopic dermatitis in clinical practice and underrepresented populations | 001 | 4 | NIH | 6/11/2025 | $44,504 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR080194 | New approaches to safety monitoring of novel systemic treatments for atopic dermatitis in clinical practice and underrepresented populations | 000 | 4 | NIH | 2/19/2025 | $572,186 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080992 | Role of a novel risk loci HAVCR2 of late-onset Alzheimer's disease in the regulation of microglial response in neurodegeneration | 001 | 3 | NIH | 6/17/2025 | $66,393 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080992 | Role of a novel risk loci HAVCR2 of late-onset Alzheimer's disease in the regulation of microglial response in neurodegeneration | 000 | 3 | NIH | 3/6/2025 | $746,921 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23HD118179 | Nourishing Growing Brains: Maternal Micronutrient Supplementation during Lactation, Human Milk B-Complex Vitamins, and Infant Neurodevelopment | 000 | 1 | NIH | 8/1/2025 | $167,400 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01AG086168 | Understanding Interorgan Communication Through Heterochronic Organ Transplantation | 001 | 2 | NIH | 6/9/2025 | $54,852 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01AG086168 | Understanding Interorgan Communication Through Heterochronic Organ Transplantation | 000 | 2 | NIH | 3/6/2025 | $617,098 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00MH131850 | Towards Developing Biomarkers for Premature Aging in Schizophrenia | 000 | 3 | NIH | 8/12/2025 | $249,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23NS136767 | Predicting Dependency after Traumatic Brain Injury | 000 | 2 | NIH | 3/20/2025 | $227,707 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R33NS114383 | Development of Drugs that Modify CNS Innate Immunity for the Treatment of Multiple Sclerosis | 000 | 3 | NIH | 8/12/2025 | $434,860 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR084712 | A Randomized, Double-Blind, Controlled, Multi-Center Trial of Colchicine in Calcium Pyrophosphate Deposition Disease | 000 | 1 | NIH | 7/31/2025 | $777,869 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB036996 | Trackerless Surgical Navigation for Dynamic Environments in Minimally Invasive Liver Surgery | 000 | 1 | NIH | 8/1/2025 | $1,554,122 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32HL178207 | Innovative implementation of artificial intelligence techniques for enhanced management of aortic abdominal aneurysms | 000 | 1 | NIH | 8/12/2025 | $75,520 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R33MH131043 | Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand | 000 | 3 | NIH | 7/31/2025 | $173,865 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R33MH131043 | Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand | 001 | 3 | NIH | 8/6/2025 | $100,800 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R03OD039974 | Accurate, fast, and distributed atlas-scale integration of scRNAseq data | 000 | 1 | NIH | 6/10/2025 | $1 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R03OD039974 | Accurate, fast, and distributed atlas-scale integration of scRNAseq data | 000 | 1 | NIH | 6/10/2025 | $357,999 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UG3AI190114 | Harnessing translational research to advance understanding and clinical care in antibiotic allergy | 000 | 1 | NIH | 7/23/2025 | $443,527 |
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