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 | Issue Date FY: 2025 ( Subtotal = $377,512,422 ) (Continued on the next page) |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21HG014015 | From Text to Translation: Using Language Models to Resolve and Classify Variants | 000 | 1 | NIH | 8/15/2025 | $240,647 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23AR080203 | Multi-omic Studies of Local and Systemic Immune Dysregulation in Rosacea | 000 | 4 | NIH | 3/13/2025 | $169,884 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35GM157032 | Molecular Mechanisms of Hormone-Mediated Sex Differences in Wound Healing | 002 | 2 | NIH | 8/27/2025 | $442,444 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL180621 | Characterization of lung interstitial neutrophils | 000 | 1 | NIH | 8/21/2025 | $710,302 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG087356 | Identification of brain metabolomic profiles associated with dementia | 001 | 2 | NIH | 6/9/2025 | $67,443 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG087356 | Identification of brain metabolomic profiles associated with dementia | 000 | 2 | NIH | 3/7/2025 | $758,747 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23HL171893 | Interplay of Inflammation, Angiogenesis, and Coronary Microvascular Perfusion in Advanced Kidney Disease | 000 | 1 | NIH | 8/13/2025 | $193,984 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB035679 | An AI-Assisted Strategy for Monitoring Pulmonary Congestion in Acute Heart Failure Patients in Emergency Settings | 002 | 1 | NIH | 9/9/2025 | $0 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB035679 | An AI-Assisted Strategy for Monitoring Pulmonary Congestion in Acute Heart Failure Patients in Emergency Settings | 001 | 1 | NIH | 8/26/2025 | $84,172 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB035679 | An AI-Assisted Strategy for Monitoring Pulmonary Congestion in Acute Heart Failure Patients in Emergency Settings | 000 | 1 | NIH | 1/30/2025 | $608,944 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01CA268810 | Polygenic risk stratification combined with mpMRI to identify clinically relevant prostate cancer | 000 | 3 | NIH | 5/8/2025 | $707,952 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL157725 | High-dimensional single-cell mapping to define immune signatures of cytomegalovirus-associated rejection in cardiac transplantation | 002 | 5 | NIH | 2/20/2025 | $169,560 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00NS114111 | Molecular Control of Astrocytes in CNS Inflammation | 000 | 5 | NIH | 1/27/2025 | $249,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA280619 | Increasing Engagement in Patient Reported Outcome Measurement to Improve Breast Cancer Care using Health Information Technology in Community Cancer Settings | 002 | 3 | NIH | 9/1/2025 | $1,346,704 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08EB034299 | Rapid Anatomic and Quantitative MR Imaging of the Skull Base and Face | 000 | 2 | NIH | 1/27/2025 | $191,138 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R03DE034380 | Medicaid coverage of treatment for periodontal disease and its impact on health outcomes | 000 | 1 | NIH | 1/27/2025 | $185,918 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R33HL164688 | A hybrid effectiveness-implementation trial evaluating behavioral treatments for insomnia for socioeconomic disadvantaged adults in primary care | 000 | 3 | NIH | 8/26/2025 | $683,248 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00NS114111 | Molecular Control of Astrocytes in CNS Inflammation | 001 | 5 | NIH | 3/20/2025 | -$24,899 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA235134 | Adaptive Percutaneous Prostate Interventions using Sensorized Needle | 002 | 5 | NIH | 5/22/2025 | $61,989 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA235134 | Adaptive Percutaneous Prostate Interventions using Sensorized Needle | 001 | 5 | NIH | 2/13/2025 | $557,907 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD016178 | Social networks and risk of delayed arrival to the hospital during stroke | 001 | 4 | NIH | 7/31/2025 | $73,730 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080429 | Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia | 001 | 3 | NIH | 6/17/2025 | $109,693 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD016178 | Social networks and risk of delayed arrival to the hospital during stroke | 000 | 4 | NIH | 2/21/2025 | $663,585 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG080429 | Leveraging Longitudinal Data and Informatics Technology to Understand the Role of Bilingualism in Cognitive Resilience, Aging and Dementia | 000 | 3 | NIH | 3/6/2025 | $1,234,055 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08DK131321 | IL1 as a Driver of Mucosal Immune Dysregulation in Inflammatory Bowel Disease | 001 | 4 | NIH | 8/19/2025 | $75,600 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08DK131321 | IL1 as a Driver of Mucosal Immune Dysregulation in Inflammatory Bowel Disease | 000 | 4 | NIH | 2/19/2025 | $168,400 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS119476 | Next Generation Gene Therapy for Refractory Pain | 000 | 4 | NIH | 3/4/2025 | $634,215 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HD101101 | Mechanistic pathways of the effects of human-animal interaction on depression and psychosocial stress | 001 | 5 | NIH | 5/19/2025 | $66,726 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HD101101 | Mechanistic pathways of the effects of human-animal interaction on depression and psychosocial stress | 000 | 5 | NIH | 2/19/2025 | $600,539 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR077132 | Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle loss | 000 | 5 | NIH | 2/14/2025 | $453,645 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK136617 | Urine levels of Glycated CD59 for screening and diagnosis of pregnancy-induced glucose intolerance | 000 | 2 | NIH | 2/17/2025 | $647,442 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR077132 | Suturable bioprinted vascularized muscle constructs for treatment of skeletal muscle loss | 001 | 5 | NIH | 5/22/2025 | $35,284 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AR080849 | Osteoclasts or RANKL: Which is the critical target in treatment of fibrous dysplasia bone lesions? | 000 | 2 | NIH | 2/17/2025 | $174,545 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01ES036206 | Per- and polyfluoroalkyl substances, apolipoproteins, and risk of coronary heart disease | 000 | 2 | NIH | 2/14/2025 | $702,691 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL163099 | Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal Hematopoiesis | 001 | 4 | NIH | 7/25/2025 | $65,045 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL163099 | Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal Hematopoiesis | 000 | 4 | NIH | 2/14/2025 | $585,400 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL171877 | Etiology of naturally-occurring anti-ABO antibodies | 000 | 2 | NIH | 3/10/2025 | $168,480 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99HL177272 | Phosphate dysregulation as a driver of age-related vascular disease | 000 | 1 | NIH | 7/15/2025 | $138,523 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081023 | Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC) | 002 | 4 | NIH | 7/8/2025 | $0 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081023 | Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC) | 002 | 4 | NIH | 7/8/2025 | $0 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081023 | Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC) | 001 | 4 | NIH | 6/6/2025 | $0 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00CA256497 | Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling | 001 | 5 | NIH | 5/22/2025 | $24,901 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23HL159279 | (Administrative Supplement) Cardiac Perfusion, Structure, and Function across the Primary Aldosteronism Spectrum | 000 | 4 | NIH | 2/28/2025 | $192,896 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23HL159279 | (Administrative Supplement) Cardiac Perfusion, Structure, and Function across the Primary Aldosteronism Spectrum | 001 | 4 | NIH | 4/15/2025 | $75,460 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL175295 | Beyond BMI: Role of Body Composition, Coronary Microvascular Dysfunction and HFpEF in Characterizing Cardiometabolic Disease Phenotypes | 000 | 1 | NIH | 8/15/2025 | $784,362 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA296008 | Magnetic Resonance Fingerprinting of Glutamate Metabolism for Guiding Glioma Cancer Care | 000 | 1 | NIH | 8/14/2025 | $3,155,815 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R25DK101398 | Harvard Summer Research Program in Kidney Medicine | 002 | 12 | NIH | 8/5/2025 | $126,930 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK068271 | Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease. | 001 | 20 | NIH | 7/31/2025 | $760,807 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K24HL179901 | Linking Mechanism to Outcome in Airway Inflammation and Remodeling | 000 | 1 | NIH | 9/12/2025 | $133,221 |
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