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 | Issue Date FY: 2025 ( Subtotal = $146,761,353 ) (Continued on the next page) |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08AR082031 | Modifying adipocyte and pre-adipocyte cell fate in fibroadipose tissue of secondary lymphedema | 000 | 3 | NIH | 3/24/2025 | $172,760 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23HL166686 | Personalized Exercise Training to Improve Functional Capacity in Transthyretin Cardiac Amyloidosis | 000 | 3 | NIH | 5/3/2025 | $184,537 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MH132610 | Mapping of the intrinsic and extrinsic cerebellar connectome at ultra high resolution with expert neuroanatomical curation | 000 | 3 | NIH | 4/15/2025 | $680,892 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35HL166640 | Targeted immune therapies in heart transplantation | 000 | 3 | NIH | 1/22/2025 | $935,335 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL162813 | Uncovering the genetically-driven differential susceptibility to chronic obstructive pulmonary disease and pulmonary fibrosis | 000 | 3 | NIH | 11/29/2024 | $697,156 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI179986 | The novel role of MIF-CD74 inflammatory pathway in immune regulation | 000 | 2 | NIH | 11/7/2024 | $408,062 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD016910 | Disasters and Hospital Systems Serving Health Disparity Populations: Identifying the Long Term effects of the COVID-19 Pandemic to Mitigate Future Challenges | 000 | 3 | NIH | 12/22/2024 | $614,364 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UM1AI069412 | Boston HIV CTU | 001 | 19 | NIH | 4/24/2025 | $412,287 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UM1AI069412 | Boston HIV CTU | 001 | 19 | NIH | 4/24/2025 | $1,840,918 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UM1AI069412 | Boston HIV CTU | 000 | 19 | NIH | 11/15/2024 | $412,287 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UM1AI069412 | Boston HIV CTU | 000 | 19 | NIH | 11/15/2024 | $1,840,919 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23DK125672 | Novel Pathways and Therapeutic Targets for Cisplatin-Associated Acute Kidney Injury | 000 | 4 | NIH | 11/22/2024 | $188,266 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL155749 | Leveraging Variant-perturbed Gene Regulation to Support Precision Medicine in COPD | 000 | 4 | NIH | 4/21/2025 | $789,689 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS124916 | Systematic Study of Extracellular Vesicles and their Integrative Analysis with Parkinson's Organoids MAP | 000 | 4 | NIH | 4/8/2025 | $738,375 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL166487 | Resolution of inflammation after cardiac arrest | 000 | 3 | NIH | 12/23/2024 | $690,435 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R33CA278393 | Clonal analysis of cancer by mitochondrial DNA barcoding | 000 | 3 | NIH | 4/9/2025 | $398,899 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL167021 | The Comparative Effectiveness and Safety of Oral Anticoagulants in Patients with Cirrhosis and Atrial Fibrillation | 000 | 3 | NIH | 3/11/2025 | $760,106 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U19AI095219 | Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease | 001 | 15 | NIH | 4/16/2025 | $1,535,611 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL157073 | Role of group 2 innate lymphoid cells in myocardial infarction | 000 | 4 | NIH | 11/26/2024 | $613,929 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35GM149229 | Chemical Approaches to Understanding Reversible Lysine Modifications | 001 | 3 | NIH | 4/10/2025 | $447,500 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99CA286891 | A multi-omics approach to evaluate the role of chronic inflammation in breast cancer development | 000 | 2 | NIH | 12/27/2024 | $164,570 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL167905 | miR-130b, angiogenesis, and diabetic critical limb ischemia | 000 | 2 | NIH | 11/8/2024 | $594,287 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01ES025530 | Role of AHR in Dendritic Cells in the Control of CNS Autoimmunity | 000 | 9 | NIH | 11/26/2024 | $372,171 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL171141 | Using statistical network methods to elucidate the multi-omic modulators of the effect of maternal vitamin D levels on childhood asthma | 000 | 2 | NIH | 11/25/2024 | $805,344 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K24HL171900 | Mentoring in Patient Oriented Research in Lung Disease through a Sex and Gender Lens | 000 | 2 | NIH | 12/7/2024 | $128,650 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS113890 | Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism | 000 | 5 | NIH | 1/8/2025 | $602,529 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI189319 | KSHV Infection And Persistence | 000 | 1 | NIH | 4/9/2025 | $877,104 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01CA250476 | Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities | 001 | 5 | NIH | 2/18/2025 | $759,992 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U10CA180821 | Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension | 004 | 11 | NIH | 4/16/2025 | $3,950,153 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081031 | Single cell and spatial genomic analyses of specimens from patients with autoimmune diseases (Technology Core) | 000 | 4 | NIH | 3/21/2025 | $200,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI176341 | A TCF1:Glucocorticoid regulatory circuit controls IL-23-driven Th17 pathogenicity | 000 | 3 | NIH | 12/17/2024 | $501,978 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | UC2AR081031 | Single cell and spatial genomic analyses of specimens from patients with autoimmune diseases (Technology Core) | 000 | 4 | NIH | 3/21/2025 | $100,000 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG074899 | Autophagon: an Autophagy-Functionalizing Gene Therapy Tool for Neurodegenerative Diseases | 000 | 5 | NIH | 11/27/2024 | $688,634 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K25HL173665 | Methods for Unraveling the Impact of Dietary Xenobiotics on COPD Exacerbations with Multi-Dimensional Networks | 000 | 2 | NIH | 1/9/2025 | $160,949 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL162356 | Identifying unrecognized genetic causes of congenital heart disease | 000 | 2 | NIH | 4/22/2025 | $686,631 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK139580 | Decoding the Molecular Mechanisms Underlying Reprogramming to Functional Hepatic and Intestinal Cell Types | 001 | 7 | NIH | 4/17/2025 | $566,790 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01NS129778 | Pathogenic Astrocyte Populations in EAE and MS | 000 | 3 | NIH | 5/6/2025 | $440,048 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA272489 | Methodologic Innovations in Cancer Epidemiology | 000 | 3 | NIH | 1/22/2025 | $402,691 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL155107 | L-2-Hydroxyglutarate and Metabolic Remodeling in Hypoxia | 000 | 5 | NIH | 12/13/2024 | $689,774 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI184094 | Immune selection of HIV-1 reservoir cells in human clinical trials | 000 | 2 | NIH | 4/15/2025 | $871,246 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01ES034079 | Geospatially modeled environmental risk factors for lymphoid malignancies | 000 | 2 | NIH | 10/28/2024 | $690,548 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DE033907 | Epstein-Barr Virus Driven Tonsillar Versus Peripheral B-cell One-Carbon Metabolic Network Remodeling | 000 | 2 | NIH | 4/3/2025 | $457,629 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG084017 | Ahead of the Curve: Early detection and monitoring of learning decrements in Alzheimers disease | 000 | 2 | NIH | 4/11/2025 | $759,882 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K25EB035166 | New Tools for Enhancing Cerebral Angiography: From Planning to Navigation | 000 | 2 | NIH | 3/24/2025 | $124,042 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AI186023 | Genetic targeting of intraepithelial mast cells | 000 | 2 | NIH | 3/24/2025 | $215,850 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA247957 | Functional analysis of a novelintegrin-dependent metastasis pathway in melanoma | 000 | 5 | NIH | 12/20/2024 | $460,639 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB036015 | Robot-assisted catheter placement with novel shape-sensing stylet to facilitate adaptive image guided pelvic brachytherapy | 000 | 2 | NIH | 5/12/2025 | $637,461 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG075509 | Gender-dependent APOE4 regulation of neutrophil-microglia crosstalk in Alzheimer's disease | 000 | 4 | NIH | 11/22/2024 | $664,270 |
| | 2025 | 2025 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K01HL166705 | Linking endotype and phenotype to understand COPD heterogeneity via deep learning and network science | 000 | 3 | NIH | 12/23/2024 | $178,200 |
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