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 | Issue Date FY: 2023 ( Subtotal = $184,886,999 ) (Continued on the next page) |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23HL166686 | Personalized Exercise Training to Improve Functional Capacity in Transthyretin Cardiac Amyloidosis | 000 | 1 | NIH | 5/5/2023 | $193,687 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AG078307 | PHD2 mediated loss of hypoxia signaling limits skeletal muscle regeneration and exercise response in aging | 000 | 1 | NIH | 3/24/2023 | $395,166 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00CA256497 | Integrative Prediction of Therapeutic Response in T-cell Lymphoma by Omic and Spatial Modeling | 000 | 3 | NIH | 3/27/2023 | $249,000 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL166487 | Resolution of inflammation after cardiac arrest | 000 | 1 | NIH | 12/29/2022 | $844,111 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00NS114111 | Molecular Control of Astrocytes in CNS Inflammation | 000 | 3 | NIH | 1/25/2023 | $249,000 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35HL166640 | Targeted immune therapies in heart transplantation | 000 | 1 | NIH | 1/30/2023 | $1,050,893 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL162783 | Molecular understanding of the GSDMB-regulated innate immune response | 000 | 1 | NIH | 12/9/2022 | $653,354 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R35GM146839 | Genetics of human circadian rhythms: using sequencing, novel phenotyping methods, and functional assays to move towards a deeper understanding of circadian mechanisms | 000 | 1 | NIH | 5/9/2023 | $12,824 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08AR082031 | Modifying adipocyte and pre-adipocyte cell fate in fibroadipose tissue of secondary lymphedema | 000 | 1 | NIH | 2/10/2023 | $172,760 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AI175890 | Therapeutic targeting of PD1 signaling in inflammatory bowel disease | 000 | 1 | NIH | 2/3/2023 | $211,110 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21GM144801 | Defining single-channel paracellular (tight junction) conductances using nanotechnology | 000 | 1 | NIH | 1/30/2023 | $263,400 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AI170751 | Characterization of Epstein-Barr Virus Subversion of the Host SMC5/6 Restriction Pathway | 000 | 1 | NIH | 3/9/2023 | $223,750 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DK133243 | Mechanisms of immunosuppression in the development and progression of renal disease in Tuberous Sclerosis Complex | 000 | 1 | NIH | 4/3/2023 | $539,046 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL166522 | High-throughput Imaging-integrated Vascular Model for Understanding Thromboembolism and Therapeutics Screening | 000 | 1 | NIH | 12/15/2022 | $635,893 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08ES034822 | Investigating environmental and gene-environment contributors to Parkinson's disease risk by coupling quantitative environmental exposure data to iPSC modeling | 000 | 1 | NIH | 11/24/2022 | $197,177 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AG080713 | Anastasis in age-related neurodegeneration | 000 | 1 | NIH | 11/30/2022 | $268,500 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01MD016178 | Social networks and risk of delayed arrival to the hospital during stroke | 000 | 2 | NIH | 1/20/2023 | $739,466 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21HL167173 | Consensus Framework for Cardiovascular Risk Prediction in a Clinical Setting | 000 | 1 | NIH | 2/15/2023 | $134,250 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HG012810 | Leveraging human genetics to overcome complex diagnostic challenges, evaluation of pan-ancestry polygenic scores to reduce misdiagnosis of narcolepsy and circadian rhythm sleep wake disorders. | 000 | 1 | NIH | 3/16/2023 | $716,114 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL162813 | Uncovering the genetically-driven differential susceptibility to chronic obstructive pulmonary disease and pulmonary fibrosis | 001 | 1 | NIH | 3/31/2023 | $0 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL166137 | Branched-chain Keto-acids and Aerobic Glycolysis in Vascular Smooth Muscle Cells | 000 | 1 | NIH | 5/12/2023 | $696,155 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21DA058119 | Ketamine for the treatment for opioid use disorder and suicidal ideation in the emergency department | 000 | 1 | NIH | 5/8/2023 | $223,750 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01LM014239 | Identifying and addressing missingness and bias to enhance discovery from multimodal health data | 000 | 1 | NIH | 5/9/2023 | $400,559 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32HL160061 | Exploring the role of genomic copy number variation in cardiovascular disease risk | 000 | 2 | NIH | 11/17/2022 | $69,874 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | P01AI148102 | Differentiation of immune cells and fibrobalsts in inflamed tissue in RA and SLE | 000 | 3 | NIH | 3/27/2023 | $2,491,765 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32HG012318 | Decoding the role of transcription factor isoforms | 000 | 2 | NIH | 12/16/2022 | $37,601 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23DK127248 | Association of Dialysate Bicarbonate with Hemodynamic Instability and Arrhythmia | 001 | 2 | NIH | 4/17/2023 | $194,888 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32HL160061 | Exploring the role of genomic copy number variation in cardiovascular disease risk | 001 | 2 | NIH | 4/1/2023 | -$794 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | F32DC019839 | Gene Editing for DFNA9 Deafness | 000 | 2 | NIH | 11/18/2022 | $13,235 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K23AI163371 | Clinical Impact and Epidemiology of Nonsteroidal Anti-inflammatory Drug Allergies | 000 | 3 | NIH | 5/16/2023 | $163,723 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AI175040 | Rapid, Breath Volatile Metabolite-Based Diagnosis, Species Identification, and Antibiotic Resistance Profiling in Bacterial Pneumonia | 000 | 1 | NIH | 2/15/2023 | $1,001,442 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21AI175907 | Investigating the skin-immune system in dirty mice | 000 | 1 | NIH | 2/8/2023 | $317,477 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01HL162813 | Uncovering the genetically-driven differential susceptibility to chronic obstructive pulmonary disease and pulmonary fibrosis | 000 | 1 | NIH | 12/14/2022 | $781,643 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01DC021104 | Genetic Approach to Therapy for DFNA9 | 000 | 1 | NIH | 4/20/2023 | $774,053 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99AR081896 | Decoding synovial CD4+ T cell antigen specificities in Rheumatoid Arthritis | 000 | 1 | NIH | 4/26/2023 | $93,960 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB034223 | Generating High Quality, High Resolution, Patient-Specific 4D Models of Cerebral Vasculature | 000 | 1 | NIH | 3/16/2023 | $402,750 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01CA272489 | Methodologic Innovations in Cancer Epidemiology | 000 | 1 | NIH | 2/28/2023 | $486,936 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R21DA057701 | Surmounting substance use disorder using an ultra-long acting injectable platform. | 000 | 1 | NIH | 4/21/2023 | $255,860 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01EB032826 | Simplified Single Molecule Protein Assays with Unprecedented Sensitivity | 000 | 1 | NIH | 5/3/2023 | $127,967 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K08HL165047 | Endothelial Metabolic Reprogramming by Interferon-gamma in Coronary Artery Disease | 000 | 1 | NIH | 3/17/2023 | $168,867 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR080659 | Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases | 001 | 1 | NIH | 3/17/2023 | $0 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R01AR080659 | Immunologic and Clinical Sequelae after COVID-19 in Patients with Systemic Autoimmune Rheumatic Diseases | 000 | 1 | NIH | 1/19/2023 | $782,510 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00MD015767 | Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma | 000 | 3 | NIH | 12/15/2022 | $224,100 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00MD015767 | Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma | 002 | 3 | NIH | 2/1/2023 | -$224,100 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | U01NS134357 | Center for Integrated Approaches to Undiagnosed Diseases | 000 | 9 | NIH | 4/28/2023 | $518,031 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | K99GM148723 | Stress tolerant annual killifish: a new model for the cellular stress response | 000 | 1 | NIH | 2/22/2023 | $124,702 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00MD015767 | Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma | 003 | 3 | NIH | 2/7/2023 | $249,000 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00MD015767 | Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma | 001 | 3 | NIH | 1/10/2023 | -$224,100 |
| | 2023 | 2023 | BRIGHAM & WOMENS HOSPITAL INC | 75 FRANCIS ST | BOSTON | MA | 02115-6110 | SUFFOLK | USA | R00MD015767 | Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma | 001 | 3 | NIH | 1/10/2023 | $224,100 |
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