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Inter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury

Award Number: UH3NS116238
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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SUMMARY ABSTRACT More than 1.2 million people in the United States have a spinal cord injury (SCI), and each year there are 10,000 new cases. In the last few years, we have shown that neuromodulation using epidural stimulation of the lumbosacral spinal cord can activate latent neural circuits and restore voluntary movement, standing and stepping in individuals with chronic SCI. One participant in this study also reported gains in bladder function following training with spinal cord epidural stimulation. However, there are persistent gaps that need to be filled in order to advance the field of neuromodulation forward. Technological advances to upgrade the stimulator’s programming and wireless communication platforms are critically needed in order to integrate multiple training paradigms across multiple systems (i.e. motor and autonomic), as well as take advantage of wireless monitoring technology that could improve the patient experience. For this study, first we will acquire data necessary for the implementation of learning algorithms and closed-loop systems with the implanted neurostimulator. Second, 8 additional individuals will be randomized into training interventions for locomotion and bladder. The purpose of this phase is to implement the closed-loop controls and learning algorithms developed with data from phase 1. This two phase design will allow us to acquire necessary data for the development of technical tools with a group of 8 individuals, and test the closed-loop controls with a second group of individuals that have not received prior to training. This trial will upgrade technology for epidural stimulation and make it specific for use by individuals with spinal cord injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	9/13/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/29/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $1,639,225 )
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/15/2022	NON-COMPETING CONTINUATION	$1,639,225
2022	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/8/2022	NEW	$0
														Subtotal = $1,639,225

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/21/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,645,830 )
2020	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/9/2020	NEW	$1,645,830
														Subtotal = $1,645,830

Grand Total All Awards = $3,285,055

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Inter-System Closed-Loop Control of Locomotor and Bladder Function in Individuals with Acute Spinal Cord Injury

Award Number: UH3NS116238

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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