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A Lung-chip microphysiological system to model SARS-CoV-2 infection and test novel therapeutics

Award Number: UG3NS105703
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2022

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A Lung-chip microphysiological system to model SARS-CoV-2 infection and test novel therapeutics - Project Abstract SARS-CoV-2 novel coronavirus has caused a pandemic, presenting us with an urgent need to develop new models to study the pathophysiology of infection and test innovative therapeutics to combat disease. This proposal aims to use chip-based microphysiological systems to establish a model of the human lung to investigate SARS-CoV-2 infection and test novel antisense oligonucleotide (ASO) therapies to reduce viral entry and replication. Using human primary and induced pluripotent stem cell (iPSC)-derived lung epithelium, we will generate both proximal and distal airway chip models, infect with live SARS-CoV-2, and test newly designed ASOs to target host cell components to prevent viral entry and conserved viral sequences to prevent replication. We have assembled an expert team of lung biologists, virologists, and pharmaceutical industry partners to complement the iPSC and organ-chip technologies our lab has been developing over the past five years. We feel that the approach presented in this proposal will yield rapid results by generating human- relevant models to better understand the pathological mechanisms of SARS-CoV-2 infection and test novel therapeutic strategies currently in development by our pharmaceutical industry partner.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/9/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $855,077 )
2022	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	10/13/2021	SUPPLEMENT FOR EXPANSION	$855,077
2022	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	10/18/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	2/7/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $855,077

Issue Date FY: 2021 ( Subtotal = -$855,077 )
2021	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/14/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	9/12/2021	SUPPLEMENT FOR EXPANSION	-$855,077
														Subtotal = -$855,077

Issue Date FY: 2020 ( Subtotal = $1,163,750 )
2020	2020	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	9/2/2020	SUPPLEMENT FOR EXPANSION	$1,163,750
2020	2019	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/27/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,163,750

Issue Date FY: 2019 ( Subtotal = $1,248,105 )
2019	2019	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	9/10/2019	NON-COMPETING CONTINUATION	$1,248,105
														Subtotal = $1,248,105

Issue Date FY: 2018 ( Subtotal = $1,584,256 )
2018	2018	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	9/19/2018	SUPPLEMENT FOR EXPANSION	$330,851
2018	2018	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/14/2018	NON-COMPETING CONTINUATION	$1,253,405
														Subtotal = $1,584,256

Issue Date FY: 2017 ( Subtotal = $1,223,655 )
2017	2017	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	LOS ANGELES	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/8/2017	NEW	$1,223,655
														Subtotal = $1,223,655

Grand Total All Awards = $5,219,766

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A Lung-chip microphysiological system to model SARS-CoV-2 infection and test novel therapeutics

Award Number: UG3NS105703

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2022

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