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Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)

Award Number: UG1CA275414
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub) - PROJECT ABSTRACT The overarching goal of the “Partnership for Advancing Cervical Cancer Prevention in Women Living with HIV” is to improve the cascade of cervical cancer prevention for women living with HIV (WLWH), including increasing uptake of cervical cancer screening services, improving management of screen positive women, and optimizing precancer treatment outcomes, particularly in resource-constrained settings. Research Base members have established collaborations with a history of conducting successful clinical trials and impacting clinical care. As a ‘CASCADE’ Research Base, we will provide impactful scientific and statistical direction for pragmatic clinical trials to be conducted at the ‘CASCADE’ Clinical Sites. We will establish a central administrative infrastructure to facilitate the conduct of three pragmatic trials. The proposed trials will include an investigation of primary HPV screening to facilitate uptake of cervical cancer screening, triage strategies for women who screen positive with high-risk HPV, and adjunctive treatment to improve outcomes to cervical precancer treatments. We will also provide opportunities for early-stage investigators to develop clinical research skills within ‘CASCADE’. We have administrative expertise and experience in operationalizing international clinical trials and supporting clinical research sites in the timely implementation of projects. Our highly experienced investigators and our proposed trials will be of substantial benefit to the ‘CASCADE’ Network and the shared goal of eliminating cervical cancer in WLWH. This grant is part of the NCI-supported ‘CASCADE’ Network, which focuses on scientifically justified, accountable U.S.-international clinical trials to generate rigorous evidence that improves HIV-associated cancer prevention, screening, and clinical care. By evaluating interventions across relevant populations and care settings, the ‘CASCADE’ Network is designed to produce findings that are translatable to U.S. patients, including populations disproportionately affected by HIV and cancer, while also benefitting global populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $87,368 )
2026	2026	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Control	000	6	8/14/2026	NON-COMPETING CONTINUATION	$87,368
														Subtotal = $87,368

Issue Date FY: 2025 ( Subtotal = $772,023 )
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Control	002	5	8/27/2025	NON-COMPETING CONTINUATION	$772,023
2025	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Cancer Control	001	3	3/18/2025	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Control	000	4	10/21/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $772,023

Issue Date FY: 2024 ( Subtotal = $743,632 )
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Cancer Control	000	3	6/25/2024	NON-COMPETING CONTINUATION	$649,979
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Cancer Control	001	3	9/11/2024	NON-COMPETING CONTINUATION	-$585,651
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Cancer Control	002	4	9/11/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$679,304
														Subtotal = $743,632

Issue Date FY: 2023 ( Subtotal = $650,074 )
2023	2023	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Control	000	2	5/23/2023	NON-COMPETING CONTINUATION	$650,074
														Subtotal = $650,074

Issue Date FY: 2022 ( Subtotal = $702,199 )
2022	2022	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	1300 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Cancer Control	000	1	9/20/2022	NEW	$702,199
														Subtotal = $702,199

Grand Total All Awards = $2,955,296

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Partnership for advancing cervical cancer prevention in women living with HIV (CASCADE - Research Hub)

Award Number: UG1CA275414

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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