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 | Issue Date FY: 2025 ( Subtotal = $231,310,436 ) (Continued on the next page) |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DE030497 | Signal Transduction by PI3K/mTOR | 000 | 5 | NIH | 3/10/2025 | $435,132 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG087407 | Intrinsic CSF outflow metrics for mild cognitive impairment and Alzheimer's disease | 000 | 2 | NIH | 2/14/2025 | $688,104 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R25MH108389 | Sustained Training in Aging and HIV Research (STAHR) | 000 | 8 | NIH | 3/13/2025 | $209,974 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01MH130396 | Transdiagnostic Reward System Dynamics and Social Disconnection in Suicide | 000 | 3 | NIH | 2/17/2025 | $644,305 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R21CA289083 | Cancer therapy by targeting innate immune cells in vivo using novel virus-like particles | 000 | 1 | NIH | 3/10/2025 | $222,998 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HG010149 | Refining Mendelian disease analysis via detection of clinically relevant repeat variants | 001 | 7 | NIH | 4/29/2025 | $54,234 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AI163327 | Suppressing Inflammation by Blocking IKK Oligomer | 000 | 4 | NIH | 2/20/2025 | $513,448 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HG010149 | Refining Mendelian disease analysis via detection of clinically relevant repeat variants | 000 | 7 | NIH | 3/4/2025 | $488,109 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R21NS137131 | Cross species molecular analysis of glial and endothelial blood-brain barriers | 000 | 2 | NIH | 2/14/2025 | $197,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K01AG070376 | Novel imaging genetic biomarkers for sporadic frontotemporal dementia through machine learning | 001 | 5 | NIH | 3/13/2025 | $83,363 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R37CA239072 | Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions | 001 | 7 | NIH | 2/13/2025 | $318,535 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS131151 | Developing a Synthetic Adeno-Associated Virus (AAV) for Engineering Safer Gene Therapies | 000 | 3 | NIH | 1/27/2025 | $386,587 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS139872 | Development of photocaged DREADD agonists for high-efficiency, target-specific optical silencing of synaptic transmission | 000 | 1 | NIH | 1/31/2025 | $1,124,850 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R35GM156288 | Regulated assembly and function of macromolecular complexes in genome maintenance | 000 | 1 | NIH | 1/31/2025 | $254,919 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U01CA276642 | Chronic Exposure to House Dust Mites: A New Risk Factor for Lung Cancer in Never Smokers | 001 | 3 | NIH | 5/29/2025 | $619,804 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HL162302 | AMPK Regulation of ACE2 in Endothelial Health and Disease | 000 | 4 | NIH | 2/27/2025 | $591,251 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01MH134120 | Chronobiological Basis of Depression during the Menopause Transition | 000 | 2 | NIH | 3/14/2025 | $668,102 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | P30MH062512 | HIV Neurobehavioral Research Center | 000 | 25 | NIH | 2/13/2025 | $1,499,994 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG086443 | Understanding the mechanism of rescue of Alzheimers disease by hematopoietic stem cell transplantation | 001 | 2 | NIH | 6/13/2025 | $31,600 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG086443 | Understanding the mechanism of rescue of Alzheimers disease by hematopoietic stem cell transplantation | 000 | 2 | NIH | 3/4/2025 | $355,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG065356 | Targeted Physical and Cognitive Activity in a VR Environment in Older Adults at Risk for Alzheimer's Disease | 000 | 5 | NIH | 2/13/2025 | $1,192,636 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG074273 | Mechanisms by which the ketone body β-hydroxybutyrate counteracts tau pathogenesis | 000 | 4 | NIH | 3/6/2025 | $520,906 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG079280 | Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease | 000 | 3 | NIH | 3/14/2025 | $1,410,701 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K22AI170797 | Elucidating the roles of the beta-2 adrenergic receptor and epidermal growth factor receptor in flavivirus NS1-mediated endothelial dysfunction | 000 | 2 | NIH | 3/20/2025 | $108,000 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R61MH129380 | Targeting Dopamine-Mediated Social Reward Sensitivity to Remediate Social Disconnection | 000 | 2 | NIH | 3/6/2025 | $1,191,148 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HG012351 | Next generation massively multiplexed combinatorial genetic screens | 001 | 3 | NIH | 4/25/2025 | $67,881 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HG012351 | Next generation massively multiplexed combinatorial genetic screens | 000 | 3 | NIH | 3/20/2025 | $610,933 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HL170002 | Molecular basis of ASNA1 cardiomyopathy | 000 | 2 | NIH | 2/25/2025 | $491,573 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U24DK138512 | An interactive resource to generate and provide integrated knowledge of the human pancreas | 001 | 2 | NIH | 5/7/2025 | $279,000 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U24DK138512 | An interactive resource to generate and provide integrated knowledge of the human pancreas | 000 | 2 | NIH | 2/19/2025 | $1,714,904 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K23DK134880 | Reducing Hyperinsulinemia and Insulin Resistance in Type 1 Diabetes Using Adjunctive Therapies | 000 | 2 | NIH | 2/19/2025 | $197,208 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HL136395 | Regulation of Inflammation by the Fibrinolytic System | 000 | 8 | NIH | 2/19/2025 | $395,000 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R21GM153048 | New Chemical Tools to Measure Cell Membrane Tension in Vivo | 000 | 2 | NIH | 2/26/2025 | $213,300 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01CA251414 | FEN1-Nuclease-Targeted Therapy for Ewing Sarcoma | 001 | 5 | NIH | 5/23/2025 | $62,429 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01CA251414 | FEN1-Nuclease-Targeted Therapy for Ewing Sarcoma | 000 | 5 | NIH | 3/11/2025 | $561,859 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K08NS123543 | Defining the forebrain neurophysiological representation of pain | 000 | 3 | NIH | 2/17/2025 | $195,561 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DA056058 | Effects of Cannabidiol and Tetrahydrocannabinol on the Microbiome, Endocannabinoids and Neuroinflammation in HIV | 000 | 4 | NIH | 3/14/2025 | $806,505 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01EY029259 | Circuit Engagement in Prosthetically Driven Retina | 001 | 6 | NIH | 5/27/2025 | $417,090 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS121604 | TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation | 000 | 5 | NIH | 3/19/2025 | $536,567 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS121604 | TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation | 000 | 5 | NIH | 3/19/2025 | $20,248 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS121604 | TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation | 000 | 5 | NIH | 3/19/2025 | $118,114 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DA056058 | Effects of Cannabidiol and Tetrahydrocannabinol on the Microbiome, Endocannabinoids and Neuroinflammation in HIV | 001 | 4 | NIH | 4/11/2025 | $89,611 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DA053372 | Effect of methadone on the developmental properties of human brain organoids | 001 | 4 | NIH | 4/10/2025 | $62,026 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DA053372 | Effect of methadone on the developmental properties of human brain organoids | 000 | 4 | NIH | 2/26/2025 | $558,239 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K23DK128604 | The Clinical Applications of the Difference in Estimated Glomerular Filtration Rate by Cystatin C vs. Creatinine (eGFRDiff) | 000 | 5 | NIH | 2/28/2025 | $189,599 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AI167860 | Bacterial adaptions in host-microbe interactions. | 000 | 4 | NIH | 2/28/2025 | $530,839 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS123435 | Neural basis of limb selection in unimanual reaching | 000 | 4 | NIH | 3/7/2025 | $385,764 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01GM148476 | Recognition of Synthetic Unnatural Base Pairs by RNA Polymerase | 000 | 3 | NIH | 2/17/2025 | $363,427 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01CA257505 | Targeting Systems Vulnerabilities in the Gαq/GNAQ Oncogenic Signaling Circuitry: New Precision Therapies for Uveal Melanoma | 000 | 5 | NIH | 3/6/2025 | $469,899 |
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