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 | Issue Date FY: 2025 ( Subtotal = $186,559,612 ) (Continued on the next page) |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R21AI186034 | Applied Metatranscriptomics and Metatranslatomics to identify new mechanisms of Salmonella-microbiota competition | 000 | 2 | NIH | 3/11/2025 | $178,331 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U24DK097771 | dkNET Coordinating Unit: Harnessing the Power of AI and Data Science forCollaborative Discovery and Sharing in the DK Community | 002 | 12 | NIH | 4/17/2025 | $2,000,000 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01MH130396 | Transdiagnostic Reward System Dynamics and Social Disconnection in Suicide | 000 | 3 | NIH | 2/17/2025 | $644,305 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R21CA289083 | Cancer therapy by targeting innate immune cells in vivo using novel virus-like particles | 000 | 1 | NIH | 3/10/2025 | $222,998 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HL161361 | CRISPR-based transistors for high throughput multiplexed monitoring of CRISPR-based editing efficiency for Sickle cell disease | 000 | 4 | NIH | 3/3/2025 | $388,206 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DK136117 | Reverse Metabolomics for the Discovery of Disease Associated Microbial Molecules | 000 | 3 | NIH | 2/26/2025 | $656,841 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG087407 | Intrinsic CSF outflow metrics for mild cognitive impairment and Alzheimer's disease | 000 | 2 | NIH | 2/14/2025 | $688,104 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R25MH108389 | Sustained Training in Aging and HIV Research (STAHR) | 000 | 8 | NIH | 3/13/2025 | $209,974 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AI163327 | Suppressing Inflammation by Blocking IKK Oligomer | 000 | 4 | NIH | 2/20/2025 | $513,448 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HG010149 | Refining Mendelian disease analysis via detection of clinically relevant repeat variants | 001 | 7 | NIH | 4/29/2025 | $54,234 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HG010149 | Refining Mendelian disease analysis via detection of clinically relevant repeat variants | 000 | 7 | NIH | 3/4/2025 | $488,109 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R21NS137131 | Cross species molecular analysis of glial and endothelial blood-brain barriers | 000 | 2 | NIH | 2/14/2025 | $197,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DE030497 | Signal Transduction by PI3K/mTOR | 000 | 5 | NIH | 3/10/2025 | $435,132 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K01AG070376 | Novel imaging genetic biomarkers for sporadic frontotemporal dementia through machine learning | 001 | 5 | NIH | 3/13/2025 | $83,363 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R37CA239072 | Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions | 001 | 7 | NIH | 2/13/2025 | $318,535 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS139872 | Development of photocaged DREADD agonists for high-efficiency, target-specific optical silencing of synaptic transmission | 000 | 1 | NIH | 1/31/2025 | $1,124,850 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R35GM156288 | Regulated assembly and function of macromolecular complexes in genome maintenance | 000 | 1 | NIH | 1/31/2025 | $254,919 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS131151 | Developing a Synthetic Adeno-Associated Virus (AAV) for Engineering Safer Gene Therapies | 000 | 3 | NIH | 1/27/2025 | $386,587 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R00NS121511 | Elucidating the role of RNA oxidation on amyotrophic lateral sclerosis onset and progression | 000 | 4 | NIH | 11/21/2024 | $327,197 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R00NS121511 | Elucidating the role of RNA oxidation on amyotrophic lateral sclerosis onset and progression | 001 | 4 | NIH | 11/22/2024 | $88,683 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AI189984 | Crosstalk of Immune Dysregulation and Impaired Wound Healing in inherited STAT4-mediated Autoinflammatory Disease | 000 | 1 | NIH | 1/30/2025 | $385,575 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K01ES036991 | From Risk to Resilience: Assessing Adverse Birth Outcome Risks and Adaptive Capacity to Fine Soil Dust and Heat Exposures in California | 000 | 1 | NIH | 1/28/2025 | $162,024 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01NS131560 | NEURAXIAL AAVS TARGETING DRG CHANNELS INVOLVED IN CHRONIC POST INFLAMMATORY PAIN | 000 | 2 | NIH | 1/28/2025 | $561,031 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | UM1AI069432 | UCSD Collaborative Clinical Trials Unit | 000 | 19 | NIH | 11/26/2024 | $544,909 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HL162302 | AMPK Regulation of ACE2 in Endothelial Health and Disease | 000 | 4 | NIH | 2/27/2025 | $591,251 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HL132141 | A novel treatment of aortic disease in Marfan Syndrome targeting oxidative stress and PKG dysregulation | 000 | 8 | NIH | 3/4/2025 | $658,459 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG079280 | Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease | 000 | 3 | NIH | 3/14/2025 | $1,410,701 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG065356 | Targeted Physical and Cognitive Activity in a VR Environment in Older Adults at Risk for Alzheimer's Disease | 000 | 5 | NIH | 2/13/2025 | $1,192,636 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG074273 | Mechanisms by which the ketone body β-hydroxybutyrate counteracts tau pathogenesis | 000 | 4 | NIH | 3/6/2025 | $520,906 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01AG086443 | Understanding the mechanism of rescue of Alzheimers disease by hematopoietic stem cell transplantation | 000 | 2 | NIH | 3/4/2025 | $355,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K22AI170797 | Elucidating the roles of the beta-2 adrenergic receptor and epidermal growth factor receptor in flavivirus NS1-mediated endothelial dysfunction | 000 | 2 | NIH | 3/20/2025 | $108,000 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DA053372 | Effect of methadone on the developmental properties of human brain organoids | 001 | 4 | NIH | 4/10/2025 | $62,026 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01DA053372 | Effect of methadone on the developmental properties of human brain organoids | 000 | 4 | NIH | 2/26/2025 | $558,239 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01MH106595 | Psychiatric Genomics Consortium for PTSD | 002 | 10 | NIH | 3/19/2025 | $204,864 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R37MH132924 | Testing the accuracy of eye tracking as a screening tool for ASD in the general population | 000 | 3 | NIH | 3/17/2025 | $662,830 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U01DA056006 | Single Cell Transcriptomics of the Cocaine Use Disorder in the Context of HIV | 001 | 4 | NIH | 3/31/2025 | $1,690,196 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K23DK132680 | Non Invasive Assessment of Microcirculation Function and Kidney Disease | 000 | 4 | NIH | 2/19/2025 | $194,037 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HL136395 | Regulation of Inflammation by the Fibrinolytic System | 000 | 8 | NIH | 2/19/2025 | $395,000 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R21GM153048 | New Chemical Tools to Measure Cell Membrane Tension in Vivo | 000 | 2 | NIH | 2/26/2025 | $213,300 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HL170002 | Molecular basis of ASNA1 cardiomyopathy | 000 | 2 | NIH | 2/25/2025 | $491,573 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U24DK138512 | An interactive resource to generate and provide integrated knowledge of the human pancreas | 000 | 2 | NIH | 2/19/2025 | $1,714,904 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R61MH129380 | Targeting Dopamine-Mediated Social Reward Sensitivity to Remediate Social Disconnection | 000 | 2 | NIH | 3/6/2025 | $1,191,148 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | K23DK134880 | Reducing Hyperinsulinemia and Insulin Resistance in Type 1 Diabetes Using Adjunctive Therapies | 000 | 2 | NIH | 2/19/2025 | $197,208 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HG012351 | Next generation massively multiplexed combinatorial genetic screens | 001 | 3 | NIH | 4/25/2025 | $67,881 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01HG012351 | Next generation massively multiplexed combinatorial genetic screens | 000 | 3 | NIH | 3/20/2025 | $610,933 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U2RTW012228 | 2/2 GeoHealth Hub for Climate Change and Health in the Middle East and North Africa-U.S. | 000 | 4 | NIH | 3/10/2025 | $117,729 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U2RTW012228 | 2/2 GeoHealth Hub for Climate Change and Health in the Middle East and North Africa-U.S. | 000 | 4 | NIH | 3/10/2025 | $73,901 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | U2RTW012228 | 2/2 GeoHealth Hub for Climate Change and Health in the Middle East and North Africa-U.S. | 000 | 4 | NIH | 3/10/2025 | $100,000 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA, SAN DIEGO | 9500 GILMAN DR | LA JOLLA | CA | 92093-0021 | SAN DIEGO | USA | R01GM148476 | Recognition of Synthetic Unnatural Base Pairs by RNA Polymerase | 000 | 3 | NIH | 2/17/2025 | $363,427 |
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