Saturday, May 31, 2025
5/31/2025
PATHOGEN DIAGNOSTIC PRODUCTS--BIODEFENSE DEVELOPMENTS - DESCRIPTION (provided by applicant): We have developed technology known as TIGER (Triangulation Identification for Genetic Evaluation of Risk), which provides a novel and universal approach to the identification of human and animal pathogens. The process uses mass spectrometry, signal processing, and base composition analysis of PCR amplification products from biologically conserved regions of microbial genomes to simultaneously identify the bacterial or viral agents without need for culture. While TIGER technology has been extensively validated and prototype instruments are being deployed to government biodefense laboratories, significant product development tasks must be achieved in order to commercialize the technology for human clinical diagnostics. We propose a cost-sharing model for development and validation of reagent products for identification of a broad range of respiratory and blood-borne infectious agents, including all bacteria and viruses on the NIAID ABC list. Our in-kind contribution will be development of hardware and analysis and control software to create an instrument suitable for clinical laboratory use. The clinical diagnostic system developed here will be a significant advance in human clinical diagnostics that will simultaneously provide national biodefense surveillance on an unprecedented scale.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).