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PATHOGEN DIAGNOSTIC PRODUCTS--BIODEFENSE DEVELOPMENTS

Award Number: UC1AI067232
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2005
PERIOD OF PERFORMANCE END DATE: 07/31/2007

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PATHOGEN DIAGNOSTIC PRODUCTS--BIODEFENSE DEVELOPMENTS - DESCRIPTION (provided by applicant): We have developed technology known as TIGER (Triangulation Identification for Genetic Evaluation of Risk), which provides a novel and universal approach to the identification of human and animal pathogens. The process uses mass spectrometry, signal processing, and base composition analysis of PCR amplification products from biologically conserved regions of microbial genomes to simultaneously identify the bacterial or viral agents without need for culture. While TIGER technology has been extensively validated and prototype instruments are being deployed to government biodefense laboratories, significant product development tasks must be achieved in order to commercialize the technology for human clinical diagnostics. We propose a cost-sharing model for development and validation of reagent products for identification of a broad range of respiratory and blood-borne infectious agents, including all bacteria and viruses on the NIAID ABC list. Our in-kind contribution will be development of hardware and analysis and control software to create an instrument suitable for clinical laboratory use. The clinical diagnostic system developed here will be a significant advance in human clinical diagnostics that will simultaneously provide national biodefense surveillance on an unprecedented scale.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2005	IBIS BIOSCIENCES INC	1896 RUTHERFORD ROAD	CARLSBAD	CA	92008	SAN DIEGO	USA	Microbiology and Infectious Diseases Research	000	2	4/12/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1,367,400
2010	2005	ISIS PHARMACEUTICALS	1896 Rutherford Rd	Carlsbad	CA	92008	SAN DIEGO	USA	Microbiology and Infectious Diseases Research	001	1	4/12/2010	NEW	$1,367,400
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2005	ISIS PHARMACEUTICALS	1896 Rutherford Rd	Carlsbad	CA	92008	SAN DIEGO	USA	Microbiology and Infectious Diseases Research	000	1	8/4/2009	NEW	-$1,591,169
2009	2005	IBIS BIOSCIENCES INC	1896 RUTHERFORD ROAD	CARLSBAD	CA	92008	SAN DIEGO	USA	Microbiology and Infectious Diseases Research	001	2	8/4/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,591,169
														Subtotal = $0

Grand Total All Awards = $0

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PATHOGEN DIAGNOSTIC PRODUCTS--BIODEFENSE DEVELOPMENTS

Award Number: UC1AI067232

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2005

PERIOD OF PERFORMANCE END DATE: 07/31/2007

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