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Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes

Award Number: U54AG062322
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes - The Brigham and Women’s Hospital (BWH)/Harvard Medical School (HMS) Reproductive Outcomes of Stress and Aging (ROSA) SCORE focuses on stress exposures and how neural regulation transmits stress to worsen women’s health during and after menopause. The overarching scientific goal of the ROSA SCORE renewal is to investigate the impact of both individual- and neighborhood-level stress exposures on vasomotor symptoms (VMS) and problems with sleep, mood, memory, and cognition during menopause. Disturbances in these neurocognitive domains greatly disrupt the health and activities of women during this pivotal reproductive health transition and may accelerate cognitive aging, including dementia, which is more common in aging women than men. Stress has been linked with many health conditions in women, but important gaps remain related to menopause and neurocognitive aging. One vital exposure the ROSA SCORE will investigate is artificial light at night (ALAN) at both neighborhood and individual levels, which appears elevated in menopausal women due to VMS-related sleep disruption, with consequences for stress responsivity, mood, and cognition (including memory). ROSA SCORE research will include innovative, inter-related animal and human projects; human projects that share a study cohort and neurocognitive outcomes; and an innovative Sleep and Light Research Core that supports all projects. Project A (epidemiology) leverages a 25+ year cohort study with rich neighborhood- and individual-level data. Project B (clinical) uses a randomized controlled trial to test the impact of ALAN exposure on sleep, mood, and cognitive outcomes in women with VMS. Project C (pre-clinical) uses a mouse model of menopause to characterize the roles of hypothalamic KNDy neurons in the arcuate nucleus and neurokinin B receptor-expressing neurons in the median preoptic area in sensing and transmitting stress signals to modulate core body and skin temperature changes of VMS, sleep, and cognition. A robust Career Enhancement Core will continue our objective of catalyzing research on aging women’s neurocognitive health by funding, mentoring, and educating early-career investigators through pilot grants and educational programming. The ROSA SCORE has engaged an outstanding interdisciplinary team of renowned scientific leaders who continue to be supported by the BWH Connors Center for Women’s Health Research, the leading women’s health research program at BWH/HMS, which will contribute significant institutional resources, including supplemental funding for ROSA Center pilot grants, and which interfaces with synergistic research programs focused on women’s brain health, including on dementia, to augment the impact of the ROSA Center locally and across the SCORE Consortium. The ROSA Center, thus, is uniquely well positioned to contribute critical knowledge about the impact of stress on neurocognitive performance in aging women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	6	11/26/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,495,337 )
2025	2025	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	003	6	9/9/2025	COMPETING CONTINUATION	$1,495,337
2025	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	5	3/10/2025	NON-COMPETING CONTINUATION	$0
2025	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	002	5	8/21/2025	NON-COMPETING CONTINUATION	$0
2025	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	5	11/25/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,495,337

Issue Date FY: 2024 ( Subtotal = $2,101,051 )
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	002	5	7/5/2024	NON-COMPETING CONTINUATION	$1,895,006
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	003	5	8/20/2024	SUPPLEMENT FOR EXPANSION	$130,134
2024	2024	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	4	10/26/2023	SUPPLEMENT FOR EXPANSION	$75,911
2024	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	4	5/23/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,101,051

Issue Date FY: 2023 ( Subtotal = $1,940,829 )
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	002	4	8/1/2023	SUPPLEMENT FOR EXPANSION	$224,040
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	003	4	8/15/2023	NON-COMPETING CONTINUATION	$0
2023	2023	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	4	6/16/2023	NON-COMPETING CONTINUATION	$1,716,789
2023	2022	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	3	2/2/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,940,829

Issue Date FY: 2022 ( Subtotal = $1,707,851 )
2022	2022	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	3	7/20/2022	NON-COMPETING CONTINUATION	$1,707,851
														Subtotal = $1,707,851

Issue Date FY: 2021 ( Subtotal = $1,741,691 )
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	001	2	7/26/2021	NON-COMPETING CONTINUATION	$0
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	2	6/8/2021	NON-COMPETING CONTINUATION	$1,741,691
														Subtotal = $1,741,691

Issue Date FY: 2020 ( Subtotal = $1,772,835 )
2020	2020	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Aging Research	000	1	5/20/2020	NEW	$1,772,835
														Subtotal = $1,772,835

Grand Total All Awards = $10,759,594

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Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes

Award Number: U54AG062322

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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