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NATIONAL ISLET CELL CONSORTIUM COORDINATING CENTER

Award Number: U42RR017673
ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2002
PERIOD OF PERFORMANCE END DATE: 01/31/2010

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NATIONAL ISLET CELL CONSORTIUM COORDINATING CENTER - DESCRIPTION (provided by applicant): This application is to establish the Islet Cell Resources (ICR) Administrative and Bioinformatics Coordinating Center (ABCC) within the Division of Information Sciences at City of Hope National Medical Center. The Principal Investigator (PI) will provide expertise and experience in multi-center study coordination, biomedical informatics, and biostatistics to support the ICR project objectives by carrying out the following specific aims: 1) serving the administrative functions common to the ICRs and coordinating ICR activities that are best housed in a generally accessible single core; 2) providing administrative support and oversight to the ICR Steering Committee and an Information Standards Subcommittee; 3) promoting translational research through the coordination of islet cell distribution, interacting closely with the National Islet and Beta Cell Registry for the efficient exchange of data and facilitation of cell distribution; 4) housing the core informatics resources required to create and maintain the consolidated central database, using innovative leading technology and security and confidentiality practices; and 5) collecting, managing, and analyzing data from the processing of islet cells and from ICR clinical trials, to optimize islet cell isolation and the safety and efficacy of islet cell transplants in humans. Project direction will be provided by a team led by ABCC Director and PI Dr. Joyce Niland, and including Dr. David Ikle, Co-Director for Biostatistics, and Dr. Douglas Stahl, Co-Director for Biomedical Informatics. These investigators have extensive experience managing biostatistics, clinical trials and biomedical informatics resources required to support multi-center clinical trials and basic science investigations. In addition, they will leverage technology for clinical trials data management being developed under the Fully Integrated Research Standards and Technology (FIRST) initiative funded by National Center for Research Resources (NCRR) to provide essential informatics resources to the ten ICR centers participating in this project. The ABCC will work closely with the NCRR and the Steering Committee under a cooperative agreement designed to ensure the safe and efficient development of optimal islet cell transplantation strategies using current Good Manufacturing Practice (cGMP) compliant facilities at each ICR in collaboration with local, regional and national organ procurement organizations and transplant registries. In addition to providing administrative support and informatics infrastructure, the ABCC will monitor ICRs for cGMP and current Good Laboratory Practice (GLP) compliance and will provide expertise in clinical trial design and statistical analysis to facilitate development of clinical trials and to analyze pooled data in the central database to optimize islet cell transplant outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	002	5	2/26/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2007	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	001	5	2/26/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2006	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	000	5	2/26/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	004	5	6/11/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2007	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	002	5	10/30/2008	SUPPLEMENT FOR EXPANSION	$0
2009	2007	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	003	5	6/11/2009	SUPPLEMENT FOR EXPANSION	$0
2009	2006	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	001	5	6/11/2009	NON-COMPETING CONTINUATION	$0
2009	2006	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	000	5	10/30/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $1,550,230 )
2008	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	002	5	9/23/2008	SUPPLEMENT FOR EXPANSION	$1,550,230
														Subtotal = $1,550,230

Issue Date FY: 2007 ( Subtotal = $1,558,613 )
2007	2007	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	001	5	9/22/2007	SUPPLEMENT FOR EXPANSION	$1,558,613
														Subtotal = $1,558,613

Issue Date FY: 2006 ( Subtotal = $1,455,005 )
2006	2006	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	000	5	9/26/2006	NON-COMPETING CONTINUATION	$1,455,005
														Subtotal = $1,455,005

Issue Date FY: 2004 ( Subtotal = $2,509,205 )
2004	2004	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	001	3	9/27/2004	SUPPLEMENT FOR EXPANSION	$210,000
2004	2004	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	National Center for Research Resources	000	3	9/24/2004	NON-COMPETING CONTINUATION	$2,299,205
														Subtotal = $2,509,205

Issue Date FY: 2003 ( Subtotal = $7,212,659 )
2003	2003	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Indicates awards funded from multiple programs	000	2	9/26/2003	OTHER REVISION	$7,212,659
														Subtotal = $7,212,659

Issue Date FY: 2002 ( Subtotal = $984,161 )
2002	2002	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	UNKNOWN	000	1	9/19/2002	NEW	$984,161
														Subtotal = $984,161

Grand Total All Awards = $15,269,873

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NATIONAL ISLET CELL CONSORTIUM COORDINATING CENTER

Award Number: U42RR017673

ORGANIZATION: NATIONAL CENTER FOR RESEARCH RESOURCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2002

PERIOD OF PERFORMANCE END DATE: 01/31/2010

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