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Case Western Reserve University StrokeNet University Regional Coordinating Center

Award Number: U24NS107270
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/19/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Case Western Reserve University StrokeNet University Regional Coordinating Center - We propose to continue to serve as a Regional Coordinating Center (RCC) for StrokeNet that will continue to perform stroke related clinical trials, bring new trials to the network and train new stroke investigators. Our RCC includes University Hospitals of Cleveland (UH), Cleveland Clinic (CC), MetroHealth Medical Center (MH) and the Louis Stokes Cleveland VA Medical Center (LSVA), allaffliated with Case Western Reserve University (CWRU). Our RCC, initially funded in 2013 and renewed in 2018, subsequently expanded to include additional sites in Toledo (Mercy St Vincent Medical Center or Mercy St Vincent), Columbus (OhioHealth), Grand Rapids, MI (SpectrumHealth, now Corewell),Morgantown, WV [West Virginial University (WVU)] and Pittsburgh, PA [AlleghenyHealth (AH)]. We also trimmed the number of sites by removing several sitesthat were not actively screening or enrolling in StrokeNet. Our RCC contains a variety of hospitals types including a county hospital with a large emergency department, a VA hospital, multiple urban academic medical centers, and an academic medical center in a rural state ensuring a diverse patient and study population. Our key personel represent investigators from Neurology, Neurosurgery, Emergency Medicine, Neurointerventionalists, Neurointensivists, Pediatric Neurologists, Neuroradiologists and Vascular surgeons, Physical Medicine and Rehabilitation specialists choosen on the basis of merit. Our RCC has a track record of enrolling patients in acute treatment, prevention and rehabilitation studies. We have brought new projects to the network and have representatives on all of the working groups. Our RCC includes 8 Comprehensive Stroke Centers, state of the art transportation resources including critical care air transport with physicians and nurse practicioners on board and hospital systems with mobile stroke units that administer thrombolytics in the field or en route to the hospital. We have special expertise in penumbral imaging, acute endovascular therapy and rehabilitation,especially functional electrical stimulation. We propose to continue the current leadershipWith co-PIs Dr Sophia Sundararajan and Dr. Ken Uchino and representatives from each of the nine hospitals. David Haney will continue as Project Manager and Dr Irene Katzan will continue as the Training Director. This will oversee the RCC, but also provide mentorship for more junior investigators. Our leadership succession plan has already successfully mentored Drs Sundararajan and Uchino who assumed roles asCo-PIs with the 2018 renewal of the RCC. With the expertise and resources detailed in this application, the Case Western Reserve University RCC will be well positioned to enhance the structure and organization of our RCC and further accelerate participation in clinical trials for stroke acute intervention, prevention and rehabilitation in both adults and children.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $429,468 )
2026	2026	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	3/25/2026	NON-COMPETING CONTINUATION	$429,468
														Subtotal = $429,468

Issue Date FY: 2025 ( Subtotal = $1 )
2025	2025	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	12/23/2024	NON-COMPETING CONTINUATION	$1
2025	2025	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	7	9/26/2025	NON-COMPETING CONTINUATION	$0
2025	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	11/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1

Issue Date FY: 2024 ( Subtotal = $429,468 )
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	12/19/2023	COMPETING CONTINUATION	$429,468
2024	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/11/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $429,468

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	8/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $305,730 )
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	8/1/2022	NON-COMPETING CONTINUATION	$305,730
														Subtotal = $305,730

Issue Date FY: 2021 ( Subtotal = $309,402 )
2021	2021	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/1/2021	NON-COMPETING CONTINUATION	$309,402
														Subtotal = $309,402

Issue Date FY: 2020 ( Subtotal = $313,005 )
2020	2020	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	7/30/2020	NON-COMPETING CONTINUATION	$313,005
2020	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/15/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $313,005

Issue Date FY: 2019 ( Subtotal = $565,927 )
2019	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	2	9/14/2019	NON-COMPETING CONTINUATION	$316,700
2019	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	3/26/2019	NEW	$0
2019	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	12/18/2018	NEW	-$55,677
2019	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/13/2018	NEW	$304,904
														Subtotal = $565,927

Issue Date FY: 2018 ( Subtotal = $320,000 )
2018	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/3/2018	NEW	$320,000
														Subtotal = $320,000

Grand Total All Awards = $2,673,001

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Case Western Reserve University StrokeNet University Regional Coordinating Center

Award Number: U24NS107270

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/19/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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