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 | Issue Date FY: 2024 ( Subtotal = $63,240,432 ) (Continued on the next page) |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01CA252224 | Targeting Oncostatin M-Receptor to Suppress Metastasis and Therapy Failure | 000 | 4 | NIH | 2/14/2024 | $371,530 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01GM138696 | Role of epithelial cell intracellular trafficking in the innate immune response to adenovirus infection | 000 | 4 | NIH | 3/6/2024 | $331,497 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01HD103676 | A novel mechanism for inflammation-induced preterm birth via PR-A phosphorylation | 000 | 4 | NIH | 3/28/2024 | $435,327 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | F30CA257076 | Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancer | 000 | 4 | NIH | 12/28/2023 | $52,694 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | K01DK127008 | Effect of an Anti-Inflammatory Diet on Gut Homeostasis in Active and Experimental Crohn's Disease | 000 | 4 | NIH | 12/12/2023 | $121,770 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01CA248019 | The Role of HIF1A-DNMT3A axis in AML1/ETO-Driven Acute MyelogenousLeukemia | 000 | 4 | NIH | 11/30/2023 | $572,092 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01AI155907 | Biomaterials-based metabolic rescue of dendritic cells for vaccine design | 001 | 4 | NIH | 2/27/2024 | $330,909 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01CA260847 | PSMA-targeted AuNPs for MR guided radiotherapy and radiosensitization | 000 | 4 | NIH | 1/22/2024 | $598,276 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | K01DK125526 | The Intestinal Mycobiome and IBD | 000 | 4 | NIH | 2/23/2024 | $121,770 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01DK128347 | Gut Microbe-Derived Nitric Oxide As A Signal To Host: Role In Normal Physiology And In Disease | 000 | 4 | NIH | 2/26/2024 | $318,780 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01CA256791 | Role of Erbb3 kinase activity in colorectal tumorigenesis. | 000 | 4 | NIH | 2/5/2024 | $406,531 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | F30CA250254 | Role of SerpinB3 in glioblastoma cancer stem cells | 000 | 5 | NIH | 12/20/2023 | $52,694 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01NS120689 | Retooling innate immunity: An investigation of TLR-mediated glial priming across lifespan | 000 | 4 | NIH | 12/14/2023 | $362,250 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | F30EY031566 | Identification of novel phosphodiesterase (PDE)-modulating compounds and characterization of associated cytoprotective pathways in lightdamagedretina | 000 | 4 | NIH | 12/4/2023 | $52,694 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | K08DK135933 | A comprehensive approach to understanding the genetic causes of urinary stone disease: combining monogenic and polygenic analyses | 000 | 1 | NIH | 12/22/2023 | $163,036 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R00GM143550 | Integration of metabolism and chromatin in regulating gene expression in vivo | 000 | 3 | NIH | 12/26/2023 | $249,000 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R21CA288449 | Roles of gut-breast axis in breast pathophysiology | 000 | 1 | NIH | 4/5/2024 | $225,803 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01MH130476 | The role of heparan sulfate modification on neurexin1 in synapse development | 000 | 1 | NIH | 11/17/2023 | $376,437 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01CA275910 | MIZ1 Activation in Triple-negative Breast Cancer Racial Disparities | 000 | 1 | NIH | 1/11/2024 | $617,723 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R21CA280151 | Exploring SGLTs as Theranostic Targets for Cancer Metastasis | 000 | 1 | NIH | 11/28/2023 | $236,000 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R37CA278982 | Role of LRG1 in colorectal cancer tumorigenesis | 000 | 1 | NIH | 2/1/2024 | $368,288 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01CA287672 | Optimizing anti-wild-type IDH1 therapy in pancreatic cancer | 000 | 1 | NIH | 2/16/2024 | $690,929 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R21CA280426 | Development of a novel, CNS-penetrant synthetic triterpenoid for pediatric high-grade glioma. | 000 | 1 | NIH | 11/30/2023 | $225,803 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R03CA273468 | c-Myc regulation by TGF-beta signaling as a therapeutic target in Osteosarcoma | 000 | 1 | NIH | 11/22/2023 | $80,500 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R21ES036031 | Healthy Futures Research Study: Linking somatic mutation rate with baseline exposure in East Palestine | 000 | 1 | NIH | 2/8/2024 | $161,000 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R35GM152080 | Regulation of gasdermins through protease processing and other post-translational modifications. | 000 | 1 | NIH | 2/8/2024 | $402,500 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01CA272621 | Role of YB1 in health disparities in triple negative breast cancer | 000 | 2 | NIH | 3/19/2024 | $419,739 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01HL172894 | S-Nitrosoglutathione therapy for oxidant disease of the neonatal airways and lung | 000 | 1 | NIH | 4/12/2024 | $533,073 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | AY2AX000011 | OMEGA: Orchestrating Multifaceted Engineering for Growing Artificial Joints | 000 | 1 | NIH | 3/26/2024 | $20,404,251 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | F30HD114399 | Investigating the Structural Basis of Human Glycine Receptor Modulation for Neurodevelopmental Disorders | 000 | 1 | NIH | 12/1/2023 | $52,694 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01DK137973 | A Novel Nitrosylase Prevents Hypoglycemia and Mediates Insulin Resistance | 000 | 1 | NIH | 12/8/2023 | $506,342 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01CA278633 | Dual action immunostimulatory nanoparticles for treatment of aggressive cancers | 000 | 1 | NIH | 3/1/2024 | $81,180 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R21MD018435 | Using spatial analytics and social determinants of health to redefine critical access to medical transport services for rural populations | 000 | 2 | NIH | 12/24/2023 | $181,125 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | F31EY035156 | Src Inhibition Induces Selective Autophagic Killing of T. gondii Independently of EGF Receptor | 000 | 2 | NIH | 4/4/2024 | $41,294 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R25DC020919 | IMPACT: Promoting Diversity and the Success of Underrepresented Minority Students in the Clinical and Research Workforce for Communication Sciences and Disorders | 000 | 2 | NIH | 3/21/2024 | $264,185 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01HG012384 | Mapping heritable chromatin loop variants with allele-specific Hi-C analysis | 000 | 2 | NIH | 1/17/2024 | $572,425 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01NS129876 | Investigation of brain-originating circRNAs as targets in blood-based stroke triage diagnostics | 000 | 2 | NIH | 2/20/2024 | $534,645 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R03AG080287 | Reduced allelic dosage of CLP1 attenuates cognitive dysfunction and pathological burden in transgenic mouse models of Alzheimer?s disease | 000 | 2 | NIH | 11/6/2023 | $139,685 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R21AI169561 | Functional genomic characterization of diverse bat innate immune mechanisms | 000 | 2 | NIH | 10/24/2023 | $181,125 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R03AI173549 | Structural studies of gasdermin E and its recognition by caspase-3. | 000 | 2 | NIH | 10/25/2023 | $72,450 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R21AG075573 | Targeting 15-PGDH in Age-Related Hematologic Disease | 000 | 2 | NIH | 11/15/2023 | $217,350 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01AI172944 | Development and evaluation of a second-generation fungerp for systemic and cutaneous C. auris infection | 000 | 2 | NIH | 11/1/2023 | $583,710 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01HL167199 | Pericoronary fat: MACE risk from non-contrast CT and the role of iodine perfusion in contrast CT | 000 | 2 | NIH | 2/1/2024 | $700,142 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01HL165218 | Cardiovascular risk from comprehensive evaluation of the CT calcium score exam | 000 | 2 | NIH | 2/29/2024 | $707,321 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01MH130367 | Long-range GABAergic inhibition coordinates hippocampal-subcortical circuit activity in memory formation | 000 | 2 | NIH | 1/19/2024 | $436,518 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01HL167159 | 5 D impulse mapping in the embryonic heart | 000 | 2 | NIH | 2/8/2024 | $619,134 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | F30HD110088 | Dissecting the role of IER3IP1 in neurogenesis and brain malformation | 000 | 2 | NIH | 3/13/2024 | $52,694 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01NS128226 | Structural diversity of cervid prions and phenotypic variation of chronic wasting disease | 000 | 2 | NIH | 3/4/2024 | $362,251 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | K01DK128304 | Using transcriptomics and ex vivo organotypic models to discover mechanisms of APOL1-associated podocytopathies | 000 | 2 | NIH | 11/8/2023 | $130,741 |
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