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 | Issue Date FY: 2025 ( Subtotal = $40,417,229 ) (Continued on the next page) |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA296150 | Leveraging Community-Based Food Pantry Settings for Provision of Tobacco Cessation Treatment | 000 | 1 | NIH | 12/12/2024 | $667,828 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL173186 | Radiomics-based risk prediction of heart failure using CT calcium score exam | 000 | 1 | NIH | 12/12/2024 | $742,395 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA269354 | Magnetic Resonance Fingerprinting of Tumor Vascular Perfusion and Acidosis | 000 | 3 | NIH | 10/31/2024 | $588,205 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL156928 | Altered Circadian Rhythm Regulation in Cystic Fibrosis | 000 | 4 | NIH | 3/20/2025 | $563,589 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA275910 | MIZ1 Activation in Triple-negative Breast Cancer Racial Disparities | 000 | 2 | NIH | 3/19/2025 | $555,952 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UG1HD040544 | Case Western Reserve University Center of the NICHD MFMU Network | 001 | 26 | NIH | 3/28/2025 | $354,189 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AG085316 | Identifying T cell determinants of heritable Frontotemporal dementia | 000 | 2 | NIH | 3/20/2025 | $580,183 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL165218 | Cardiovascular risk from comprehensive evaluation of the CT calcium score exam | 000 | 3 | NIH | 3/28/2025 | $690,422 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA266050 | The Microbiome and Mucosal Immunity in Cervical Cancer Disparities | 000 | 4 | NIH | 3/20/2025 | $547,754 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA235152 | Smart nanoparticles regulating oncogenic IncRNA for breast cancer therapy | 000 | 7 | NIH | 2/12/2025 | $364,605 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL160857 | Mechanisms of oxygen off-loading from red blood cells in murine models of human disease | 000 | 4 | NIH | 1/8/2025 | $589,880 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R03CA273468 | c-Myc regulation by TGF-beta signaling as a therapeutic target in Osteosarcoma | 000 | 2 | NIH | 11/14/2024 | $80,500 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R35GM134896 | Structure and Function of Pentameric Ligand-gated Ion Channels | 001 | 6 | NIH | 1/29/2025 | $684,250 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R37CA278982 | Role of LRG1 in colorectal cancer tumorigenesis | 000 | 2 | NIH | 1/8/2025 | $331,459 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI155907 | Biomaterials-based metabolic rescue of dendritic cells for vaccine design | 000 | 5 | NIH | 1/15/2025 | $356,647 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01EB025741 | Improved Detection of Prostate Cancer with Nanoparticle-based Ultrasound Contrast Agents Targeted to PSMA | 001 | 6 | NIH | 1/15/2025 | $486,829 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U24NS107270 | Case Western Reserve University StrokeNet University Regional Coordinating Center | 003 | 7 | NIH | 12/23/2024 | $1 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA269604 | MR Fingerprinting based Quantitative Imaging and Analysis Platform (MRF-QIA) for brain tumors. | 000 | 3 | NIH | 12/23/2024 | $501,133 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R34MH134912 | Youth Empowerment and Safety Intervention for Systems-involved Sexual and Gender Minority Youth at Risk of Suicide | 001 | 1 | NIH | 1/2/2025 | $14,347 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA256791 | Role of Erbb3 kinase activity in colorectal tumorigenesis. | 000 | 5 | NIH | 1/14/2025 | $392,637 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UM1AI069501 | Case Clinical Trials Unit | 000 | 19 | NIH | 11/25/2024 | $375,117 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UM1AI069501 | Case Clinical Trials Unit | 000 | 19 | NIH | 11/25/2024 | $993,342 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01MH129294 | The role of subcortical inputs to the hippocampal CA3 region in fear memory | 000 | 3 | NIH | 11/25/2024 | $335,694 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R33AT010806 | Enhancing Exercise and Psychotherapy to Treat Comorbid Addiction and Pain for ImprovingAdherence to Medication Assisted Treatment in Opioid Use Disorders | 000 | 4 | NIH | 1/2/2025 | $870,587 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30DK128944 | AKR1a1 as a novel therapeutic target for Non-Alcoholic Fatty Liver Disease | 000 | 4 | NIH | 1/14/2025 | $53,974 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01GM125844 | Defining Molecular Interactions that Drive Mitochondrial Fission | 000 | 7 | NIH | 12/26/2024 | $286,243 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI191807 | The role of the precursor HIV-1 protease in drug resistance. | 000 | 1 | NIH | 1/2/2025 | $507,792 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA196643 | Mechanisms of metabolic reprogramming by PIK3CA oncogenic mutations | 000 | 7 | NIH | 12/5/2024 | $362,250 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01MH130476 | The role of heparan sulfate modification on neurexin1 in synapse development | 000 | 2 | NIH | 12/4/2024 | $355,524 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA252224 | Targeting Oncostatin M-Receptor to Suppress Metastasis and Therapy Failure | 000 | 5 | NIH | 1/27/2025 | $371,530 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA297778 | EphA1 homotypic and EphA1-EphA2 heterotypic interactions in cell regulation | 000 | 1 | NIH | 12/5/2024 | $693,134 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL172894 | S-Nitrosoglutathione therapy for oxidant disease of the neonatal airways and lung | 000 | 2 | NIH | 1/27/2025 | $533,073 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | D43TW010319 | Microbiology and Immunology Training for HIV and HIV-Related Research in Uganda (MITHU) | 000 | 10 | NIH | 3/24/2025 | $50,000 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL126900 | Restoration and Function of S-Nitrosothiol in Stored Blood | 000 | 8 | NIH | 3/7/2025 | $510,505 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL157405 | Tyrosine Kinases and Thrombosis | 000 | 4 | NIH | 2/28/2025 | $366,636 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL126747 | Optical Tools to Assess the Role of Cardiac Function in the Development of Congenital Heart Defects | 000 | 10 | NIH | 2/14/2025 | $683,011 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21ES036031 | Healthy Futures Research Study: Linking somatic mutation rate with baseline exposure in East Palestine | 000 | 2 | NIH | 3/11/2025 | $547,386 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DA060489 | The impact of poly-substance use on the crosstalk between microglia, astrocytes, and neurons that regulates HIV latency | 001 | 2 | NIH | 3/3/2025 | $637,775 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | D43TW012260 | Strengthening Research Capacity in Innovative Global Health Technologies for Non-Communicable Diseases in Uganda | 000 | 4 | NIH | 3/10/2025 | $246,419 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA299332 | Creating a transient metabolic catastrophe for AML therapy | 000 | 1 | NIH | 3/11/2025 | $491,357 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21CA288449 | Roles of gut-breast axis in breast pathophysiology | 000 | 2 | NIH | 3/3/2025 | $169,353 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R34MH134912 | Youth Empowerment and Safety Intervention for Systems-involved Sexual and Gender Minority Youth at Risk of Suicide | 002 | 1 | NIH | 3/21/2025 | $0 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL167199 | Pericoronary fat: MACE risk from non-contrast CT and the role of iodine perfusion in contrast CT | 000 | 3 | NIH | 3/4/2025 | $689,912 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R00EY034168 | Nanoparticle-Based Tracking of Retinal Ganglion Cell Transplant | 000 | 3 | NIH | 2/25/2025 | $249,000 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA292487 | Targeting Leukemia Stem Cells with Small Molecule Heat Shock Transcription Factor 1 Degrader | 000 | 1 | NIH | 2/24/2025 | $502,516 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL146676 | Computer modeling of myosin binding protein C and its effects on cardiac contraction | 000 | 6 | NIH | 3/5/2025 | $613,202 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UG1CA233234 | Case Comprehensive Cancer Center NCTN Lead Academic Participating Site | 000 | 6 | NIH | 3/6/2025 | $892,012 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01MH130367 | Long-range GABAergic inhibition coordinates hippocampal-subcortical circuit activity in memory formation | 000 | 3 | NIH | 2/19/2025 | $412,267 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK128143 | Estrogen-mediated immune regulation in human and experimental inflammatory bowel disease | 000 | 5 | NIH | 3/5/2025 | $355,097 |
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