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 | Issue Date FY: 2025 ( Subtotal = $3,106,254 ) |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01EY021731 | PHOTOTRANSDUCTION IN HEALTH AND DISEASE - Administrative Supplement | 000 | 13 | NIH | 11/15/2024 | $55,812 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01ES033670 | Targets and targeting of immunometabolism in chronic PM2.5 exposure | 001 | 4 | NIH | 11/8/2024 | $94,385 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01ES033670 | Targets and targeting of immunometabolism in chronic PM2.5 exposure | 000 | 4 | NIH | 11/7/2024 | $402,500 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI172944 | Development and evaluation of a second-generation fungerp for systemic and cutaneous C. auris infection | 001 | 3 | NIH | 11/8/2024 | $19,457 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI172944 | Development and evaluation of a second-generation fungerp for systemic and cutaneous C. auris infection | 000 | 3 | NIH | 10/25/2024 | $629,110 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL156987 | Impact of microfibril turnover on vascular development and disease | 000 | 4 | NIH | 11/6/2024 | $362,250 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA269816 | Detection, Radiosensitization and Theranostic Targeting of Metastatic Breast Cancer by PTPmu | 000 | 3 | NIH | 11/6/2024 | $601,330 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21CA280151 | Exploring SGLTs as Theranostic Targets for Cancer Metastasis | 000 | 2 | NIH | 11/13/2024 | $178,530 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AG080924 | SSH1-Nrf2 nexus in tipping the balance between degeneration and protection in tauopathies. | 000 | 3 | NIH | 11/15/2024 | $460,922 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R03CA273468 | c-Myc regulation by TGF-beta signaling as a therapeutic target in Osteosarcoma | 000 | 2 | NIH | 11/14/2024 | $80,500 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA269354 | Magnetic Resonance Fingerprinting of Tumor Vascular Perfusion and Acidosis | 000 | 3 | NIH | 10/31/2024 | $588,205 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DC021795 | Calcium Regulation in Cochlear Cells | 000 | 1 | NIH | 11/12/2024 | $673,048 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R35GM134896 | Structure and Function of Pentameric Ligand-Gated Ion Channels | 000 | 5 | NIH | 11/6/2024 | $0 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F31NS122176 | Identifying novel targets and mechanistic role of 8,9 unsaturated sterol accumulation on enhancement of oligodendrocyte formation | 001 | 3 | NIH | 10/23/2024 | -$12,959 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD105892 | Patient-Centered Outcomes of Sacrocolpopexy versus Uterosacral Ligament Suspension for the Treatment of Uterovaginal Prolapse | 000 | 4 | NIH | 11/8/2024 | $0 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U24NS107270 | Case Western Reserve University StrokeNet University Regional Coordinating Center | 002 | 6 | NIH | 11/8/2024 | $495,774 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R35GM152080 | Regulation of gasdermins through protease processing and other post-translational modifications. | 000 | 1 | NIH | 11/14/2024 | $0 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R35GM148115 | H3K9me3-based gene silencing and cellular identity | 000 | 2 | NIH | 11/11/2024 | $0 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U01CA257638 | Quantifying and Personalizing the Clinical Benefit of Metastasis-Directed Therapy in Men with De Novo Oligometastatic Prostate Cancer | 001 | 2 | NIH | 11/8/2024 | $0 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U54CA254566 | Lung cancer in East Africa and the relationship to HIV-1 infection: epidemiology, molecular characterization and imaging | 000 | 5 | NIH | 11/1/2024 | $0 |
| | 2025 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R35GM141603 | Innate Immune signal transduction specificity in inflammatory disease | 000 | 3 | NIH | 11/7/2024 | $0 |
| | 2025 | 2023 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA217992 | Mechanisms of lincDUSP Oncogenic Effects in Colon Cancer | 000 | 5 | NIH | 10/25/2024 | $0 |
| | 2025 | 2023 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30HL160111 | Assessing vascular permeability and nanobubble extravasation with contrast-enhanced ultrasound imaging | 000 | 2 | NIH | 10/23/2024 | $0 |
| | 2025 | 2023 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R00AG057808 | Exploring Mechanisms of Pathogenicity in C9ORF72 Frontotemporal Dementia and Amyotrophic Lateral Sclerosis | 000 | 5 | NIH | 10/9/2024 | -$193 |
| | 2025 | 2023 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F31NS122176 | Identifying novel targets and mechanistic role of 8,9 unsaturated sterol accumulation on enhancement of oligodendrocyte formation | 000 | 2 | NIH | 10/23/2024 | -$2,833 |
| | 2025 | 2023 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30MH122173 | Regulation of Pet1/FEV binding and chromatin accessibility during serotonergic neuron development | 000 | 4 | NIH | 10/23/2024 | $0 |
| | 2025 | 2023 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01NR018023 | Reducing stroke risk in African-American men | 000 | 5 | NIH | 10/9/2024 | $0 |
| | 2025 | 2023 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01FD005409 | Phase 2 study of the NNP for Grasp and Trunk in SCI: IDEG140225-11-13-2014 | 000 | 5 | FDA | 11/8/2024 | $0 |
| | 2025 | 2023 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R00AG068359 | Conformational properties of misfolded protein aggregates in cases involving the co-occurrence of prion disease and Alzehimer's disease or prion disease and CTE | 000 | 4 | NIH | 11/7/2024 | -$2,554 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21AI159770 | GAIT complex formation and Mycobacterium tuberculosis | 000 | 2 | NIH | 10/29/2024 | -$517 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U01CA248226 | RadxTools for assessing tumor treatment response on imaging | 001 | 3 | NIH | 11/6/2024 | -$275 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U01CA248226 | RadxTools for assessing tumor treatment response on imaging | 000 | 3 | NIH | 11/6/2024 | -$429 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | K12CA076917 | Clinical Oncology Research Program (CORP) | 000 | 25 | NIH | 11/5/2024 | -$98,008 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21AI154055 | Targeting Escherichia coli PBP1b using fragment-based approaches | 000 | 2 | NIH | 10/29/2024 | $0 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI150830 | Structural Biophysics of HIV Splicing and Transcriptional Control | 000 | 8 | NIH | 10/22/2024 | -$91,408 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI150830 | Structural Biophysics of HIV Splicing and Transcriptional Control | 000 | 8 | NIH | 10/22/2024 | -$152,685 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U24NS107270 | Case Western Reserve University StrokeNet University Regional Coordinating Center | 001 | 5 | NIH | 11/8/2024 | -$305,730 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01NS109532 | Role of skin prions in disease transmission and diagnostic testing of human prion disease | 000 | 5 | NIH | 11/13/2024 | -$6,987 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21NR019337 | Massively high-throughput profiling of the circulating antibody pool for identification of diagnostic signatures with utility for stroke triage | 000 | 2 | NIH | 11/12/2024 | $0 |
| | 2025 | 2022 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK042191 | Cytokines and Inflammatory Bowel Disease | 000 | 30 | NIH | 11/7/2024 | -$33,193 |
| | 2025 | 2021 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AG057557 | An Integrated Reverse Engineering Approach Toward Rapid drug Re positioning for Alzheimer's Disease | 000 | 5 | NIH | 11/4/2024 | $0 |
| | 2025 | 2021 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U24NS107270 | Case Western Reserve University StrokeNet University Regional Coordinating Center | 000 | 4 | NIH | 11/8/2024 | -$190,044 |
| | 2025 | 2021 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21AI161275 | Identification of Host Directed Drug Targets for SARS-CoV-2 Using Transposon Mutagenesis | 000 | 1 | NIH | 11/7/2024 | $0 |
| | 2025 | 2021 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U01CA257638 | Quantifying and Personalizing the Clinical Benefit of Metastasis-Directed Therapy in Men with De Novo Oligometastatic Prostate Cancer | 000 | 1 | NIH | 11/5/2024 | $0 |
| | 2025 | 2020 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01EB025197 | Characterization and Quantification of Myelin in the Central Nervous System | 000 | 2 | NIH | 10/1/2024 | -$112,185 |
| | 2025 | 2020 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01EB025197 | Characterization and Quantification of Myelin in the Central Nervous System | 001 | 2 | NIH | 10/24/2024 | -$525,568 |
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| Issue Date FY: 2024 ( Subtotal = $209,816,600 ) (Continued on the next page) |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01DA060489 | The impact of poly-substance use on the crosstalk between microglia, astrocytes, and neurons that regulates HIV latency | 000 | 1 | NIH | 5/14/2024 | $708,638 |
| | 2024 | 2024 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-1712 | CUYAHOGA | USA | R01EY022310 | International Advancing genomics through the AMD Genomics Consortium (IAMDGC) | 000 | 11 | NIH | 6/28/2024 | $525,434 |
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