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 | Issue Date FY: 2025 ( Subtotal = $137,783,265 ) (Continued on the next page) |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HG012384 | Mapping heritable chromatin loop variants with allele-specific Hi-C analysis | 001 | 3 | NIH | 4/25/2025 | $64,892 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HG012384 | Mapping heritable chromatin loop variants with allele-specific Hi-C analysis | 000 | 3 | NIH | 1/17/2025 | $584,018 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01NS126253 | Therapeutic Targeting of WDR5 in the Glioblastoma Perivascular Niche | 000 | 3 | NIH | 6/13/2025 | $456,585 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD110367 | The role of the female and male reproductive microenvironment in fertility fitness | 000 | 3 | NIH | 4/18/2025 | $598,274 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD110512 | Paracrine control of the maternal-fetal interface critical for pregnancy wellness | 000 | 3 | NIH | 5/12/2025 | $560,036 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL166241 | Engineered polymeric adjuvants for heart-redirected targeting and gene therapy | 000 | 2 | NIH | 5/14/2025 | $594,531 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | T32GM152319 | Medical Scientist Training Program at Case Western Reserve University | 000 | 2 | NIH | 5/30/2025 | $1,632,261 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | T32GM152319 | Medical Scientist Training Program at Case Western Reserve University | 001 | 2 | NIH | 8/8/2025 | $60,545 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R35GM160336 | Heme-Based Immune Dysregulation in Critical Illness | 000 | 1 | NIH | 7/23/2025 | $402,500 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL156928 | Altered Circadian Rhythm Regulation in Cystic Fibrosis | 000 | 4 | NIH | 3/20/2025 | $563,589 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD104601 | Sleep disparities' role in adolescent fatigue and functioning: A mixed-methods study | 001 | 4 | NIH | 4/22/2025 | $59,785 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD104601 | Sleep disparities' role in adolescent fatigue and functioning: A mixed-methods study | 000 | 4 | NIH | 3/18/2025 | $538,064 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DA060489 | The impact of poly-substance use on the crosstalk between microglia, astrocytes, and neurons that regulates HIV latency | 001 | 2 | NIH | 3/3/2025 | $637,775 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL167159 | 5 D impulse mapping in the embryonic heart | 000 | 3 | NIH | 2/27/2025 | $613,429 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DA060489 | The impact of poly-substance use on the crosstalk between microglia, astrocytes, and neurons that regulates HIV latency | 002 | 2 | NIH | 4/10/2025 | $70,863 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA287672 | Optimizing anti-wild-type IDH1 therapy in pancreatic cancer | 001 | 2 | NIH | 5/22/2025 | $66,105 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA287672 | Optimizing anti-wild-type IDH1 therapy in pancreatic cancer | 000 | 2 | NIH | 3/14/2025 | $594,955 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD115952 | Refining Immune Heterogeneity in Pediatric Sepsis Multiple Organ Dysfunction Syndrome | 000 | 1 | NIH | 7/28/2025 | $739,487 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R33AI169629 | The role of RNA m6A modification in the regulation of HIV latency and reactivation | 000 | 4 | NIH | 7/23/2025 | $713,048 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30CA306185 | Investigating the role of BAFF in CAR-T cell associated adverse events | 001 | 1 | NIH | 7/16/2025 | $0 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI187662 | Evaluating human T cells specific for Mycobacterium tuberculosis antigens that are processed and presented by infected macrophages | 000 | 1 | NIH | 7/29/2025 | $813,450 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30CA306185 | Investigating the role of BAFF in CAR-T cell associated adverse events | 000 | 1 | NIH | 7/16/2025 | $54,538 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK113185 | Comprehensive characterization of HNF1A-driven beta-cell heterogeneity | 001 | 7 | NIH | 6/24/2025 | $597,761 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F31NS141481 | Pathological Inflammation Alters Oligodendrocyte Differentiation and Function | 001 | 1 | NIH | 7/25/2025 | $0 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F31NS141481 | Pathological Inflammation Alters Oligodendrocyte Differentiation and Function | 000 | 1 | NIH | 7/25/2025 | $49,538 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R00NS135194 | Targeted Neuroplasticity via vagus nerve stimulation to improve urinary dysfunction after spinal cord injury | 000 | 2 | NIH | 8/14/2025 | $249,000 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI189290 | Bioinspired Point of Care Testing for HIV/HBV Co-infection | 000 | 1 | NIH | 7/7/2025 | $354,570 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | K99HL179260 | Atomic-level Structural-omics of Platelet Membrane Proteins via Multi-scale Structural Biology Approaches | 000 | 1 | NIH | 7/15/2025 | $121,003 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | T32TR004521 | Clinical and Translational Science Collaborative of Northern Ohio, CTSA Predoctoral T32 at Case Western Reserve University | 000 | 1 | NIH | 7/8/2025 | $456,728 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30CA294611 | MR Fingerprinting for Characterization and Prediction of Glioblastoma Infiltration | 000 | 1 | NIH | 7/10/2025 | $54,538 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA292487 | Targeting Leukemia Stem Cells with Small Molecule Heat Shock Transcription Factor 1 Degrader | 000 | 1 | NIH | 2/24/2025 | $502,516 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30HD114399 | Investigating the Structural Basis of Human Glycine Receptor Modulation for Neurodevelopmental Disorders | 001 | 2 | NIH | 6/2/2025 | $564 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30HD114399 | Investigating the Structural Basis of Human Glycine Receptor Modulation for Neurodevelopmental Disorders | 000 | 2 | NIH | 3/7/2025 | $53,974 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL146676 | Computer modeling of myosin binding protein C and its effects on cardiac contraction | 003 | 6 | NIH | 7/16/2025 | $68,133 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL146676 | Computer modeling of myosin binding protein C and its effects on cardiac contraction | 000 | 6 | NIH | 3/5/2025 | $613,202 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UG1CA233234 | Case Comprehensive Cancer Center NCTN Lead Academic Participating Site | 001 | 6 | NIH | 7/22/2025 | $520,340 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UG1CA233234 | Case Comprehensive Cancer Center NCTN Lead Academic Participating Site | 000 | 6 | NIH | 3/6/2025 | $892,012 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | K08CA276819 | Targeting myeloid cells to increase efficacy of immunotherapy against brain tumors. | 002 | 3 | NIH | 8/4/2025 | $211,464 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK124590 | Role of chive-derived exosome-like nanoparticles in suppressing inflammation in obesity | 001 | 5 | NIH | 6/12/2025 | $35,941 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK124590 | Role of chive-derived exosome-like nanoparticles in suppressing inflammation in obesity | 000 | 5 | NIH | 2/20/2025 | $323,470 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL126900 | Restoration and Function of S-Nitrosothiol in Stored Blood | 001 | 8 | NIH | 7/16/2025 | $56,724 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL126900 | Restoration and Function of S-Nitrosothiol in Stored Blood | 000 | 8 | NIH | 3/7/2025 | $510,505 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA235152 | Smart nanoparticles regulating oncogenic IncRNA for breast cancer therapy | 003 | 7 | NIH | 5/28/2025 | $40,510 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA235152 | Smart nanoparticles regulating oncogenic IncRNA for breast cancer therapy | 000 | 7 | NIH | 2/12/2025 | $364,605 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL172894 | S-Nitrosoglutathione therapy for oxidant disease of the neonatal airways and lung | 000 | 2 | NIH | 1/27/2025 | $533,073 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA252224 | Targeting Oncostatin M-Receptor to Suppress Metastasis and Therapy Failure | 001 | 5 | NIH | 5/22/2025 | $41,280 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA252224 | Targeting Oncostatin M-Receptor to Suppress Metastasis and Therapy Failure | 000 | 5 | NIH | 1/27/2025 | $371,530 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK128463 | Role of Sam68 in Proinflammatory Signaling | 001 | 4 | NIH | 6/26/2025 | $56,227 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK128463 | Role of Sam68 in Proinflammatory Signaling | 000 | 4 | NIH | 2/20/2025 | $506,054 |
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