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 | Issue Date FY: 2025 ( Subtotal = $21,219,996 ) (Continued on the next page) |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL160857 | Mechanisms of oxygen off-loading from red blood cells in murine models of human disease | 000 | 4 | NIH | 1/8/2025 | $589,880 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL156987 | Impact of microfibril turnover on vascular development and disease | 000 | 4 | NIH | 11/6/2024 | $362,250 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21CA280151 | Exploring SGLTs as Theranostic Targets for Cancer Metastasis | 000 | 2 | NIH | 11/13/2024 | $178,530 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | U24NS107270 | Case Western Reserve University StrokeNet University Regional Coordinating Center | 003 | 7 | NIH | 12/23/2024 | $1 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA297621 | Anticancer ELNP nanovaccines for curative treatmentof pancreatic cancer | 000 | 1 | NIH | 11/19/2024 | $654,681 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA248019 | The Role of HIF1A-DNMT3A axis in AML1/ETO-Driven Acute MyelogenousLeukemia | 000 | 5 | NIH | 11/19/2024 | $572,091 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL176819 | Leveraging HSF1 Attenuation to Transform Clonal Hematopoiesis into Beneficial Hematopoiesis | 000 | 1 | NIH | 12/3/2024 | $735,085 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA269816 | Detection, Radiosensitization and Theranostic Targeting of Metastatic Breast Cancer by PTPmu | 000 | 3 | NIH | 11/6/2024 | $601,330 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01ES033670 | Targets and targeting of immunometabolism in chronic PM2.5 exposure | 001 | 4 | NIH | 11/8/2024 | $94,385 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01ES033670 | Targets and targeting of immunometabolism in chronic PM2.5 exposure | 000 | 4 | NIH | 11/7/2024 | $402,500 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R35GM141603 | Innate Immune signal transduction specificity in inflammatory disease | 001 | 4 | NIH | 1/17/2025 | $362,250 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R35GM148115 | H3K9me3-based gene silencing and cellular identity | 001 | 3 | NIH | 1/17/2025 | $362,250 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA269354 | Magnetic Resonance Fingerprinting of Tumor Vascular Perfusion and Acidosis | 000 | 3 | NIH | 10/31/2024 | $588,205 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DC021795 | Calcium Regulation in Cochlear Cells | 000 | 1 | NIH | 11/12/2024 | $673,048 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AG080924 | SSH1-Nrf2 nexus in tipping the balance between degeneration and protection in tauopathies. | 000 | 3 | NIH | 11/15/2024 | $460,922 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI172944 | Development and evaluation of a second-generation fungerp for systemic and cutaneous C. auris infection | 001 | 3 | NIH | 11/8/2024 | $19,457 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI172944 | Development and evaluation of a second-generation fungerp for systemic and cutaneous C. auris infection | 000 | 3 | NIH | 10/25/2024 | $629,110 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R25NS135590 | Research Immersion in Brain, Spinal cord (RIBS), & Peripheral nerves for URM High School Students | 000 | 2 | NIH | 11/19/2024 | $135,000 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | K08DK135933 | A comprehensive approach to understanding the genetic causes of urinary stone disease: combining monogenic and polygenic analyses | 000 | 2 | NIH | 12/13/2024 | $161,535 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30DK128944 | AKR1a1 as a novel therapeutic target for Non-Alcoholic Fatty Liver Disease | 000 | 4 | NIH | 1/14/2025 | $53,974 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA256791 | Role of Erbb3 kinase activity in colorectal tumorigenesis. | 000 | 5 | NIH | 1/14/2025 | $392,637 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA256791 | Role of Erbb3 kinase activity in colorectal tumorigenesis. | 001 | 5 | NIH | 1/17/2025 | $199,962 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HG012384 | Mapping heritable chromatin loop variants with allele-specific Hi-C analysis | 000 | 3 | NIH | 1/17/2025 | $584,018 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01EB025741 | Improved Detection of Prostate Cancer with Nanoparticle-based Ultrasound Contrast Agents Targeted to PSMA | 001 | 6 | NIH | 1/15/2025 | $486,829 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01GM125844 | Defining Molecular Interactions that Drive Mitochondrial Fission | 000 | 7 | NIH | 12/26/2024 | $286,243 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI191807 | The role of the precursor HIV-1 protease in drug resistance. | 000 | 1 | NIH | 1/2/2025 | $507,792 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R33AT010806 | Enhancing Exercise and Psychotherapy to Treat Comorbid Addiction and Pain for ImprovingAdherence to Medication Assisted Treatment in Opioid Use Disorders | 000 | 4 | NIH | 1/2/2025 | $870,587 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA295877 | A Clinical Trial of Cancer Prevention by Biomarker Based Detections of Barrett's Esophagus and Its Progression | 000 | 1 | NIH | 1/3/2025 | $1,623,261 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA269604 | MR Fingerprinting based Quantitative Imaging and Analysis Platform (MRF-QIA) for brain tumors. | 000 | 3 | NIH | 12/23/2024 | $501,133 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK119506 | Novel Regulation of Renal Function by S-Nitrosylation | 000 | 7 | NIH | 11/28/2024 | $486,601 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UM1AI069501 | Case Clinical Trials Unit | 000 | 19 | NIH | 11/25/2024 | $375,117 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UM1AI069501 | Case Clinical Trials Unit | 000 | 19 | NIH | 11/25/2024 | $993,342 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AG076051 | Mechanism of white matter pathology in Alzheimer's disease | 000 | 4 | NIH | 11/28/2024 | $546,748 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R34MH134912 | Youth Empowerment and Safety Intervention for Systems-involved Sexual and Gender Minority Youth at Risk of Suicide | 001 | 1 | NIH | 1/2/2025 | $14,347 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R34MH134912 | Youth Empowerment and Safety Intervention for Systems-involved Sexual and Gender Minority Youth at Risk of Suicide | 000 | 1 | NIH | 12/3/2024 | $265,019 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01MH129294 | The role of subcortical inputs to the hippocampal CA3 region in fear memory | 000 | 3 | NIH | 11/25/2024 | $335,694 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01MD019185 | Randomized Control Trial of Positive Peers mHealth app as a clinic-based intervention to optimize HIV outcomes among young, minority persons living with HIV | 000 | 2 | NIH | 11/28/2024 | $1,019,943 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL173186 | Radiomics-based risk prediction of heart failure using CT calcium score exam | 000 | 1 | NIH | 12/12/2024 | $742,395 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01MH130476 | The role of heparan sulfate modification on neurexin1 in synapse development | 000 | 2 | NIH | 12/4/2024 | $355,524 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA296150 | Leveraging Community-Based Food Pantry Settings for Provision of Tobacco Cessation Treatment | 000 | 1 | NIH | 12/12/2024 | $667,828 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01NS120689 | Retooling innate immunity: An investigation of TLR-mediated glial priming across lifespan | 000 | 5 | NIH | 12/11/2024 | $362,250 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI171104 | Selective Inhibitors of T Cell Activation Target Exportin-1 at Cys528 to Suppress Pathological T Cell Activation | 000 | 3 | NIH | 12/18/2024 | $498,038 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA196643 | Mechanisms of metabolic reprogramming by PIK3CA oncogenic mutations | 000 | 7 | NIH | 12/5/2024 | $362,250 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA297778 | EphA1 homotypic and EphA1-EphA2 heterotypic interactions in cell regulation | 000 | 1 | NIH | 12/5/2024 | $693,134 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F31AT012592 | Developing Real-world Understanding of Medical Music therapy using the Electronic Health Record (DRUMMER) | 000 | 2 | NIH | 12/9/2024 | $48,974 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | K01DK127008 | Effect of an Anti-Inflammatory Diet on Gut Homeostasis in Active and Experimental Crohn's Disease | 000 | 5 | NIH | 12/6/2024 | $121,770 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21CA280426 | Development of a novel, CNS-penetrant synthetic triterpenoid for pediatric high-grade glioma. | 000 | 2 | NIH | 12/13/2024 | $169,353 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA288626 | Cyclin D1 as a driver of HNSCC | 000 | 1 | NIH | 12/17/2024 | $465,404 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK137973 | A Novel Nitrosylase Prevents Hypoglycemia and Mediates Insulin Resistance | 000 | 2 | NIH | 12/18/2024 | $455,708 |
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