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 | Issue Date FY: 2025 ( Subtotal = $51,880,634 ) (Continued on the next page) |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA252224 | Targeting Oncostatin M-Receptor to Suppress Metastasis and Therapy Failure | 000 | 5 | NIH | 1/27/2025 | $371,530 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA297778 | EphA1 homotypic and EphA1-EphA2 heterotypic interactions in cell regulation | 000 | 1 | NIH | 12/5/2024 | $693,134 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL172894 | S-Nitrosoglutathione therapy for oxidant disease of the neonatal airways and lung | 000 | 2 | NIH | 1/27/2025 | $533,073 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA292487 | Targeting Leukemia Stem Cells with Small Molecule Heat Shock Transcription Factor 1 Degrader | 000 | 1 | NIH | 2/24/2025 | $502,516 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD109299 | tDCS During Contralaterally Controlled FES for Upper Extremity Hemiplegia | 000 | 3 | NIH | 4/11/2025 | $690,693 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R00EY034168 | Nanoparticle-Based Tracking of Retinal Ganglion Cell Transplant | 000 | 3 | NIH | 2/25/2025 | $249,000 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UG1CA233234 | Case Comprehensive Cancer Center NCTN Lead Academic Participating Site | 000 | 6 | NIH | 3/6/2025 | $892,012 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK128143 | Estrogen-mediated immune regulation in human and experimental inflammatory bowel disease | 000 | 5 | NIH | 3/5/2025 | $355,097 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F31EY035156 | Src Inhibition Induces Selective Autophagic Killing of T. gondii Independently of EGF Receptor | 000 | 3 | NIH | 4/4/2025 | $45,574 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL146676 | Computer modeling of myosin binding protein C and its effects on cardiac contraction | 000 | 6 | NIH | 3/5/2025 | $613,202 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01EB032709 | Gradient-Free Quantitative MRI using a Combination of B1-Selective Excitation and Fingerprinting | 000 | 4 | NIH | 3/26/2025 | $657,625 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01NS128226 | Structural diversity of cervid prions and phenotypic variation of chronic wasting disease | 000 | 3 | NIH | 4/9/2025 | $402,500 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AG076649 | Collision of Alzheimers disease and COVID-19 pandemic in the United States: risks, outcomes, disparities and treatments | 000 | 2 | NIH | 4/16/2025 | $709,298 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01MH130367 | Long-range GABAergic inhibition coordinates hippocampal-subcortical circuit activity in memory formation | 000 | 3 | NIH | 2/19/2025 | $412,267 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01EY021731 | PHOTOTRANSDUCTION IN HEALTH AND DISEASE | 001 | 14 | NIH | 2/20/2025 | $415,554 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01GM115234 | Regulatory Mechanisms of Glycoprotein Sialylation | 002 | 9 | NIH | 4/10/2025 | $524,860 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | K01DK128304 | Using transcriptomics and ex vivo organotypic models to discover mechanisms of APOL1-associated podocytopathies | 000 | 3 | NIH | 2/19/2025 | $130,741 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK128463 | Role of Sam68 in Proinflammatory Signaling | 000 | 4 | NIH | 2/20/2025 | $506,054 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA280981 | Novel radiomic signatures for treatment response to neoadjuvant therapy in rectal cancers | 000 | 2 | NIH | 4/10/2025 | $548,446 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | K01DK125526 | The Intestinal Mycobiome and IBD | 000 | 5 | NIH | 2/27/2025 | $121,770 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DK124590 | Role of chive-derived exosome-like nanoparticles in suppressing inflammation in obesity | 000 | 5 | NIH | 2/20/2025 | $323,470 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL167159 | 5 D impulse mapping in the embryonic heart | 000 | 3 | NIH | 2/27/2025 | $613,429 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DA060489 | The impact of poly-substance use on the crosstalk between microglia, astrocytes, and neurons that regulates HIV latency | 002 | 2 | NIH | 4/10/2025 | $70,863 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01GM154832 | Molecular interactions and regulatory events in telomere maintenance | 000 | 2 | NIH | 4/21/2025 | $422,899 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA287672 | Optimizing anti-wild-type IDH1 therapy in pancreatic cancer | 000 | 2 | NIH | 3/14/2025 | $594,955 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL070985 | Salt-Sensitive Hypertension: Role of renal superoxide | 000 | 17 | NIH | 4/21/2025 | $745,559 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01NS121374 | Study of AR transcriptional network in stem cell model of SBMA | 000 | 5 | NIH | 4/21/2025 | $422,543 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD104601 | Sleep disparities' role in adolescent fatigue and functioning: A mixed-methods study | 001 | 4 | NIH | 4/22/2025 | $59,785 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AI151588 | Donor-specific B cells in Transplantation. | 001 | 6 | NIH | 4/22/2025 | $467,791 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01EB034660 | Fluorescence image guided surgery, adjuvant PDT, and the immune response | 000 | 2 | NIH | 4/14/2025 | $577,657 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R03AG084948 | Pathogenic Role of APP E590D in Alzheimer’s Disease. | 000 | 2 | NIH | 4/14/2025 | $144,900 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD110367 | The role of the female and male reproductive microenvironment in fertility fitness | 000 | 3 | NIH | 4/18/2025 | $598,274 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01NS129876 | Investigation of brain-originating circRNAs as targets in blood-based stroke triage diagnostics | 000 | 3 | NIH | 4/15/2025 | $596,115 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HD104601 | Sleep disparities' role in adolescent fatigue and functioning: A mixed-methods study | 000 | 4 | NIH | 3/18/2025 | $538,064 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AR078343 | Local immunometabolism modulating biomaterials for immunosuppressive applications | 000 | 5 | NIH | 3/17/2025 | $303,855 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UG1HD040544 | Case Western Reserve University Center of the NICHD MFMU Network | 001 | 26 | NIH | 3/28/2025 | $354,189 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | S10OD036418 | Acquisition of a dedicated and integrated HD-MS instrument | 000 | 1 | NIH | 4/3/2025 | $750,000 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01AG085316 | Identifying T cell determinants of heritable Frontotemporal dementia | 000 | 2 | NIH | 3/20/2025 | $580,183 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | UG1HD021364 | NICHD Neonatal Research Network Clinical Center - Case Western Reserve University | 000 | 40 | NIH | 4/3/2025 | $354,200 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA266050 | The Microbiome and Mucosal Immunity in Cervical Cancer Disparities | 000 | 4 | NIH | 3/20/2025 | $547,754 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DC014701 | Circuit architecture and dynamics in odor representation and perception | 002 | 10 | NIH | 4/23/2025 | $661,310 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01CA272621 | Role of YB1 in health disparities in triple negative breast cancer | 000 | 3 | NIH | 4/21/2025 | $419,739 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HG012384 | Mapping heritable chromatin loop variants with allele-specific Hi-C analysis | 001 | 3 | NIH | 4/25/2025 | $64,892 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30DK143695 | Investigating the regulation of T cell-mediated autoimmunity in type 1 diabetes by microRNA146a | 000 | 1 | NIH | 4/23/2025 | $53,974 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL175410 | Assessment of the Impact of antihypertensive Medications on vascular and renal outcomes in Chronic Kidney Disease (AIM-CKD) | 000 | 2 | NIH | 4/25/2025 | $576,914 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01HL126747 | Optical Tools to Assess the Role of Cardiac Function in the Development of Congenital Heart Defects | 000 | 10 | NIH | 2/14/2025 | $683,011 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R01DC016696 | Mechanisms of Developmental Plasticity in the Mammalian Olfactory System | 001 | 6 | NIH | 3/7/2025 | $611,674 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | F30HD114399 | Investigating the Structural Basis of Human Glycine Receptor Modulation for Neurodevelopmental Disorders | 000 | 2 | NIH | 3/7/2025 | $53,974 |
| | 2025 | 2025 | CASE WESTERN RESERVE UNIVERSITY | 10900 EUCLID AVE | CLEVELAND | OH | 44106-4901 | CUYAHOGA | USA | R21EB036161 | Autonomous Gaze Coaching for Virtual Reality Telesurgical Simulators | 000 | 2 | NIH | 3/25/2025 | $163,634 |
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