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Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)

Award Number: U24NS107224
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2018
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) - ABSTRACT The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) is a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC is based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which serves as the Hub of the consortium, and has joined forces with the Children’s Hospital of Philadelphia (CHOP) and 13 additional member hospitals ( Spokes ) located in geographically and ethnically diverse areas in and around Philadelphia. The PRSTNCC thereby unites comprehensive stroke centers, primary stroke centers, and a regional pediatric center, providing access to a broad and diverse population of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Multiple Principal Investigators (MPIs) Scott Kastner, MD, and Brett Cucchiara, MD, has extensive experience conducting multicenter stroke clinical trials, and has been a major contributor to the current NIH Stroke Net. The PRSTNCC infrastructure supports efficient and effective conduct of stroke trials among the participant hospitals. Research support and expertise are provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub provides ongoing support for data collection and transfer during trial execution, and provides timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we are training a new generation of stroke researchers and coordinators in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $390,120 )
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	11/29/2024	NON-COMPETING CONTINUATION	$390,120
2025	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	11/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $390,120

Issue Date FY: 2024 ( Subtotal = $433,467 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	11/28/2023	COMPETING CONTINUATION	$433,467
														Subtotal = $433,467

Issue Date FY: 2023 ( Subtotal = $324,943 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	5	8/29/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	7/27/2023	SUPPLEMENT FOR EXPANSION	$150,381
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	4/27/2023	SUPPLEMENT FOR EXPANSION	$174,562
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	5	8/30/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	8/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $324,943

Issue Date FY: 2022 ( Subtotal = $322,000 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	7/14/2022	NON-COMPETING CONTINUATION	$322,000
														Subtotal = $322,000

Issue Date FY: 2021 ( Subtotal = $322,000 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/2/2021	NON-COMPETING CONTINUATION	$322,000
														Subtotal = $322,000

Issue Date FY: 2020 ( Subtotal = $322,000 )
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	7/31/2020	NON-COMPETING CONTINUATION	$322,000
2020	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	2/26/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $322,000

Issue Date FY: 2019 ( Subtotal = $348,784 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	7/24/2019	NON-COMPETING CONTINUATION	$322,000
2019	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/29/2018	NEW	$26,784
2019	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	4/12/2019	NEW	$0
														Subtotal = $348,784

Issue Date FY: 2018 ( Subtotal = $322,000 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/3/2018	NEW	$322,000
														Subtotal = $322,000

Grand Total All Awards = $2,785,314

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Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)

Award Number: U24NS107224

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2018

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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