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Southwest Strategies to Innovate Emergency Care Clinical Trials Network (SW SIREN)

Award Number: U24NS100685
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2017
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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Southwest Strategies to Innovate Emergency Care Clinical Trials Network (SW SIREN) - Medical and traumatic emergency conditions affecting the cardiac, respiratory, nervous, and hematologic systems collectively account for the overwhelming preponderance of death and disability affecting Americans. The ongoing COVID- 19 pandemic has brought into stark relief the importance of emergency care research to rapidly evaluate treatments, and the disproportionate burden that underserved populations suffer. It is imperative that new approaches for timely diagnosis and equitable treatment of these conditions be efficiently developed. This renewal application is to continue and evolve the effective Southwest Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SW SIREN) Hub and Spoke system to conduct high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, and hematologic, and traumatic conditions. The SW SIREN consortium will leverage strong regionalized prehospital-medical center partnerships in major population centers in the Southwest (Los Angeles, Orange, and San Diego counties in California, Denver, Colorado, and Clark County, Nevada), with a continued focus on recruitment of underrepresented populations. The Hub-and-Spoke consortium is comprised of the Award Hub, 5 Core Spoke Medical Centers, 83 Additional Spoke Hospitals, and 5 County EMS systems. Within the consortium are a total of 10 tertiary-quaternary academic centers able to participate in complex intervention trials and an extensive range of frontline hospitals able to participate in simple pragmatic trials. Building upon our success in training and mentorship of fellows and mid-career clinical trialists, we will utilize six Clinical and Translational Science Awards and seven universities to identify and elevate the next generation of SIREN clinical trialists. Twelve Advisory Panels with expertise in specific disease and research domains will facilitate trial implementation within the consortium and serve as a resource to the Hub leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high-quality pragmatic clinical trials in several different types of emergency disorders afflicting adults and children throughout the Southwest; 2) facilitate collaboration between emergency medicine physicians, disease specialists, and EMS systems throughout the Southwest in trial design and execution; 3) provide an educational environment that provides opportunities for designated SW SIREN junior faculty fellows to participate in clinical trial research under the supervision of experienced investigators and disseminates knowledge about emergency care to medical students, residents, fellows, and allied health professionals; and 4) ensure equitable participation of a substantial number of patients with emergency conditions in SIREN clinical trials, including women, children, Hispanic-Americans, African-Americans, and other traditionally underrepresented populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $328,778 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	12/27/2024	NON-COMPETING CONTINUATION	$328,778
														Subtotal = $328,778

Issue Date FY: 2024 ( Subtotal = $354,349 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	7	4/10/2024	NON-COMPETING CONTINUATION	$25,571
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	005	7	7/1/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10920 WILSHIRE BLVD STE 500	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	7	2/12/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	1/19/2024	NON-COMPETING CONTINUATION	$328,778
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10920 WILSHIRE BLVD STE 500	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	2/12/2024	COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	006	6	9/10/2024	COMPETING CONTINUATION	$6,024
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	6	1/31/2024	COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	007	5	9/10/2024	SUPPLEMENT FOR EXPANSION	-$6,024
														Subtotal = $354,349

Issue Date FY: 2023 ( Subtotal = $379,308 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	1/24/2023	COMPETING CONTINUATION	$379,308
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	6	5/26/2023	COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	6	7/17/2023	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	1/16/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $379,308

Issue Date FY: 2022 ( Subtotal = $83,229 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	5/27/2022	SUPPLEMENT FOR EXPANSION	$83,229
2022	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/17/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $83,229

Issue Date FY: 2021 ( Subtotal = $148,301 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	5	5/19/2021	NON-COMPETING CONTINUATION	$148,301
2021	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	4/14/2021	NON-COMPETING CONTINUATION	$0
2021	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $148,301

Issue Date FY: 2020 ( Subtotal = $148,301 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	4	6/23/2020	NON-COMPETING CONTINUATION	$148,301
2020	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	3/6/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	3	6/15/2020	NON-COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	3/6/2020	NON-COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/14/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $148,301

Issue Date FY: 2019 ( Subtotal = $148,301 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/24/2019	NON-COMPETING CONTINUATION	$148,301
														Subtotal = $148,301

Issue Date FY: 2018 ( Subtotal = $148,239 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	6/6/2018	NON-COMPETING CONTINUATION	$148,239
														Subtotal = $148,239

Issue Date FY: 2017 ( Subtotal = $257,135 )
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	7/10/2017	NEW	$257,135
														Subtotal = $257,135

Grand Total All Awards = $1,995,941

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Southwest Strategies to Innovate Emergency Care Clinical Trials Network (SW SIREN)

Award Number: U24NS100685

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2017

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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