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Comparative Toxicogenomics Database (CTD)

Award Number: U24ES033155
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Comparative Toxicogenomics Database (CTD) - ABSTRACT Most human diseases involve interactions between genetic and environmental factors. Although the environment is implicated in most chronic diseases, the etiology and mechanisms of action underlying these diseases remain unclear. It is estimated that more than 80,000 chemicals are currently used in commerce, challenging elucidation about chemical mechanisms-of-action and prioritization of environmental health research. Integration of diverse data is required to understand environment- disease associations, mechanisms of chemical action, toxicity prediction and development of effective therapeutic interventions. In 2004, the Comparative Toxicogenomics Database (CTD; http://ctdbase.org) was launched publicly to address an unmet need for a public data resource dedicated exclusively to advancing understanding about environment-disease connections. Today, through diversified funding approaches and in response to the evolving needs of the environmental health research community, CTD provides a combination of richly annotated data describing chemical- gene-phenotype-disease networks, exposure information, and novel analysis tools that enable user- driven discoveries about environmental influences on human health. Currently, CTD provides >2.5 million manually curated relationships for 16,400 chemicals, 51,300 genes/proteins, 5,500 phenotypes, and 7,200 diseases, contextualized with over 870 anatomical terms from approximately 600 species. CTD curated data has been integrated into >145 other biomedical resources further extending the reach of its impact. CTD has become a valued resource on which the environmental health research community relies. We are requesting funding to: 1) continue advancing understanding about the complex connections between environmental exposures and human health through ongoing manual curation of chemicals, genes, phenotypes, diseases and exposure data from the scientific literature; evaluation and integration of select external data sets; and baseline technical support; 2) enhance curation efficiency through further development of our text-mining and online curation tools; and 3) selectively restructure existing code, software, and database design (refactoring) to improve the structure and performance of CTD. This proposed project will protect and extend NIH investments in CTD and ensure the ongoing provision of this key resource for the environmental health research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,437,727 )
2025	2025	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	5	7/31/2025	NON-COMPETING CONTINUATION	$1,437,727
														Subtotal = $1,437,727

Issue Date FY: 2024 ( Subtotal = $1,434,687 )
2024	2024	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Environmental Health	001	4	7/2/2024	NON-COMPETING CONTINUATION	$1,434,687
2024	2023	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Environmental Health	000	3	4/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,434,687

Issue Date FY: 2023 ( Subtotal = $1,469,487 )
2023	2023	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	001	3	5/25/2023	NON-COMPETING CONTINUATION	$1,469,487
2023	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	000	2	1/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,469,487

Issue Date FY: 2022 ( Subtotal = $1,443,807 )
2022	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	000	2	6/24/2022	NON-COMPETING CONTINUATION	$1,443,807
														Subtotal = $1,443,807

Issue Date FY: 2021 ( Subtotal = $1,248,836 )
2021	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Environmental Health	000	1	8/20/2021	NEW	$1,248,836
														Subtotal = $1,248,836

Grand Total All Awards = $7,034,544

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Comparative Toxicogenomics Database (CTD)

Award Number: U24ES033155

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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