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Nicotine and Neuroprotection in Parkinson's Disease

Award Number: U10NS044471
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Nicotine and Neuroprotection in Parkinson's Disease - DESCRIPTION (provided by applicant): Parkinson's disease (PD) is progressive neurodegenerative disorder. A combination of medical and surgical treatments has improved the quality of the lives of most PD patients. But the relentless progression of degeneration of the substantial nigra and consequent loss of dopamine in the basal ganglia ultimately leads to a severe debilitating state. Efforts to slow the disease even to a small degree will extend the life span and improve the quality of a patient's life and reduce the national burden of cost of care of PD patients.At present there are no drugs that can slow the progression of the disease. In this proposal it is hypothesized, that among all the available compounds, nicotine shows significant promise to be a neuroprotective agent for the degenerating dopaminergic neurons in PD. We will discuss evidence to support that: 1. Nicotine is neuroprotective in several models of neurotoxicity, 2. The neuroprotective effects of nicotine are mediated via several well established cell survival and anti-apoptotic molecular cascades, 3. The degenerating dopaminergic neurons in PD do show evidence of apoptotic death, 4. Nicotine is neuroprotective in animal models of PD, and 5. Nicotine's neuroprotective actions are accomplished by the activation of P13K/Akt antiapoptotic pathways by alpha4 - beta2 and aIpha7 - beta2 nicotinic receptors, which are abundant in the substantial nigra and striatum. A tentative research plan to conduct clinical trial using Transdermal nicotine patches is also proposed.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2014	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	9/19/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $48,197 )
2013	2013	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	12/31/2012	COMPETING CONTINUATION	$48,197
														Subtotal = $48,197

Issue Date FY: 2012 ( Subtotal = $43,446 )
2012	2012	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	3/1/2012	NON-COMPETING CONTINUATION	$43,446
														Subtotal = $43,446

Issue Date FY: 2011 ( Subtotal = $47,782 )
2011	2011	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	8	6/16/2011	NON-COMPETING CONTINUATION	$47,782
2011	2010	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	4/30/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $47,782

Issue Date FY: 2010 ( Subtotal = $113,822 )
2010	2010	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	5/26/2010	NON-COMPETING CONTINUATION	$53,417
2010	2010	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	7	9/29/2010	NON-COMPETING CONTINUATION	$0
2010	2010	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	7	8/20/2010	SUPPLEMENT FOR EXPANSION	$42,600
2010	2010	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	7	9/27/2010	NON-COMPETING CONTINUATION	$17,805
														Subtotal = $113,822

Issue Date FY: 2009 ( Subtotal = $28,671 )
2009	2009	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	2/27/2009	EXTENSION WITH OR WITHOUT FUNDS	$28,671
2009	2007	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	12/24/2008	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2009	2007	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	2/27/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $28,671

Issue Date FY: 2007 ( Subtotal = $22,352 )
2007	2007	ALTON OCHSNER MEDICAL FOUNDATION	1516 JEFFERSON HIGHWAY	NEW ORLEANS	LA	70121	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	8/31/2007	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$22,352
														Subtotal = $22,352

Issue Date FY: 2006 ( Subtotal = $28,400 )
2006	2006	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/21/2006	NON-COMPETING CONTINUATION	$28,400
														Subtotal = $28,400

Issue Date FY: 2003 ( Subtotal = $104,197 )
2003	2003	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/29/2003	NON-COMPETING CONTINUATION	$104,197
														Subtotal = $104,197

Issue Date FY: 2002 ( Subtotal = $104,197 )
2002	2002	LSU HEALTH SCIENCES CENTER/NIH	433 BOLIVAR STREET	NEW ORLEANS	LA	70112	ORLEANS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/23/2002	NEW	$104,197
														Subtotal = $104,197

Grand Total All Awards = $541,064

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Nicotine and Neuroprotection in Parkinson's Disease

Award Number: U10NS044471

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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