Wednesday, March 12, 2025 3/12/2025

Optimization of Clear Optically Matched Panoramic Access Channel Technique (COMPACT) for large-scale deep-brain neurophotonic interface

Award Number: U01NS118302
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

Optimization of Clear Optically Matched Panoramic Access Channel Technique (COMPACT) for large-scale deep-brain neurophotonic interface With the advance of sensitive molecular indicators and actuators, neurophotonics has become a powerful paradigm for discovering the principles underlying neural circuit functions. However, a major obstacle of using light to study neurons located deep in the mammalian brain is the limited access depth. Even with the advance of multiphoton microscopy, the majority of implementation for imaging the mammalian brain is limited to ~ 1 mm in depth. The majority of the mouse brain still remains inaccessible to cellular resolution measurement, not to mention the brain of larger mammals. To image deep brain regions, invasive miniature optical probes are required. One key issue with these optical probes is the tiny tissue access volume which limits the number of neurons to be imaged and reduces the success rate of experiments. Towards large-scale deep-brain neurophotonic interface, we have recently developed Clear Optically Matched Panoramic Access Channel Technique (COMPACT), which can effectively increase the tissue access volume by ~ three orders of magnitude. To maximize the impact of the COMPACT platform, we propose to optimize COMPACT in three major areas. First, we will further miniaturize the implementation of COMPACT. Second, we will enable COMPACT based fiber photometry and optogenetics. For these two applications, we can further reduce the capillary diameter to 160 μm. Multiple capillaries can be inserted in the mammalian brain to create the neurophotonic interface “highway” system. This development will complement the existing paradigm of mesoscale sampling with electrode array probes by providing an optical version of whole-brain-access high-capacity recording and modulation system. Third, we will develop head-mounted two-photon COMPACT system for freely moving animal studies. To benchmark the system performance, we will carry out extensive in vivo measurement of neuronal structure and activity in the living mouse brain. Specifically, we will quantify and optimize the imaging resolution, signal-to-noise ratio, and maximum imaging depth outside capillary. Moreover, we will simplify and automate the operation procedure so that it can be easily adopted by neurobiologists. With the progress of the technology development, we will also work to broadly disseminate the COMPACT based technologies. In addition to scientific publication, we will develop a comprehensive website similar to that of the Miniscope project to include the detailed mechanical and optical design files, system calibration and alignment routines, surgical procedures, and customized control software. The ultimate goal is to make COMPACT robust, turn-key, and broadly available to transform how we use light to study mammalian brains.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $386,452 )
2025	2025	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE # 1100	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	12/26/2024	NON-COMPETING CONTINUATION	$386,452
														Subtotal = $386,452

Issue Date FY: 2024 ( Subtotal = $386,452 )
2024	2024	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE # 1100	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	8/30/2024	NON-COMPETING CONTINUATION	$0
2024	2024	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE STE 1900	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	11/10/2023	NON-COMPETING CONTINUATION	$386,452
														Subtotal = $386,452

Issue Date FY: 2023 ( Subtotal = $429,390 )
2023	2023	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE STE 1900	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/25/2022	NON-COMPETING CONTINUATION	$386,452
2023	2023	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE STE 1900	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	1/31/2023	NON-COMPETING CONTINUATION	$42,938
														Subtotal = $429,390

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE STE 1900	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	6/24/2022	NEW	$0
2022	2020	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE STE 1900	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	7/26/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	PURDUE UNIVERSITY	155 S GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/3/2021	NEW	$0
2021	2020	PURDUE UNIVERSITY	155 S GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/5/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $443,140 )
2020	2020	PURDUE UNIVERSITY	155 S GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/22/2020	NEW	$443,140
2020	2020	PURDUE UNIVERSITY	155 S GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	9/23/2020	NEW	$0
														Subtotal = $443,140

Grand Total All Awards = $1,645,434

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Optimization of Clear Optically Matched Panoramic Access Channel Technique (COMPACT) for large-scale deep-brain neurophotonic interface

Award Number: U01NS118302

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer