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BLOOD AND MARROW TRANSPLANT CLINICAL RESEARCH NETWORK

Award Number: U01HL069278
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2001
PERIOD OF PERFORMANCE END DATE: 07/31/2011

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BLOOD AND MARROW TRANSPLANT CLINICAL RESEARCH NETWORK - DESCRIPTION (provided by applicant): Hematopoietic stem cell (HCT) transplantation offers curative therapy for a variety of malignant and non-malignant disorders. It is limited by donor availability, transplant related toxicity, graft vs. host disease (GVHD), malignant relapse, infections, and for some patients, reduction in their posttransplant quality of life. Continuing progress from the previous funding period, the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) proposes to develop and execute scientifically meritorious, prospective clinical trials addressing key issues in HCT. We will conduct multicenter Phase II and more importantly, prospective Phase III trials in six key areas including: alternative donors and graft sources; regimen related toxicity; GVHD; disease recurrence; infection and immune reconstitution; and late effects and quality of life. Due to the complexity of pediatric transplantation, especially in those with rare inherited disorders, which are complex and difficult to study, we will devote special attention and focused scientific expertise to using the coordinated strength of the Network to improve BMT outcomes for this unique population. The BMT CTN will also amplify and leverage Network resources through collaborative research and ancillary studies of biologic endpoints that will be integrated with and complement clinical endpoints. The Network will also seek active collaboration with other scientific bodies including NCI- funded Cancer Cooperative Groups to improve the efficiency of clinical transplant studies for the large number of patients who could benefit from BMT and to maximize our successful completion of high quality and high priority clinical trials. (End of abstract.)


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $150,505 )
2010	2010	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	10	7/9/2010	NON-COMPETING CONTINUATION	$150,505
														Subtotal = $150,505

Issue Date FY: 2009 ( Subtotal = $35,910 )
2009	2009	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	9	7/27/2009	NON-COMPETING CONTINUATION	$35,910
														Subtotal = $35,910

Issue Date FY: 2008 ( Subtotal = $1 )
2008	2008	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	8	7/25/2008	NON-COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2007 ( Subtotal = $1 )
2007	2007	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	7	9/6/2007	NON-COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2006 ( Subtotal = $435,502 )
2006	2006	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	6	9/25/2006	COMPETING CONTINUATION	$435,502
														Subtotal = $435,502

Issue Date FY: 2004 ( Subtotal = $405,000 )
2004	2004	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	4	8/26/2004	NON-COMPETING CONTINUATION	$405,000
														Subtotal = $405,000

Issue Date FY: 2003 ( Subtotal = $405,000 )
2003	2003	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	3	9/1/2003	OTHER REVISION	$405,000
														Subtotal = $405,000

Issue Date FY: 2002 ( Subtotal = $405,000 )
2002	2002	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	2	9/9/2002	NON-COMPETING CONTINUATION	$405,000
														Subtotal = $405,000

Issue Date FY: 2001 ( Subtotal = $405,000 )
2001	2001	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Blood Diseases and Resources Research	000	1	9/30/2001	NEW	$405,000
														Subtotal = $405,000

Grand Total All Awards = $2,241,919

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BLOOD AND MARROW TRANSPLANT CLINICAL RESEARCH NETWORK

Award Number: U01HL069278

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2001

PERIOD OF PERFORMANCE END DATE: 07/31/2011

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