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Molecular Mechanisms of Disease

Award Number: T32GM136593
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Molecular Mechanisms of Disease - Project Summary This proposal seeks funding to continue support for the Molecular Mechanisms of Disease (MMoD) predoctoral training program at the University of Nebraska-Lincoln. The MMoD program addresses the NIH training focus of Cellular, Biochemical, and Molecular Sciences by providing advanced training and career development in biomedical research centered on molecular interactions and chemical transformations. The goal of the program is to develop outstanding new scientists who work in collaborative multi-disciplinary teams to research disease mechanisms using quantitative approaches that ultimately yield tangible strategies for prevention and therapy. To accomplish this goal, the program recruits high-quality, motivated predoctoral trainees with a strong interest in the underlying causes of human disease and engage them in mentored, cutting-edge research. Program outcomes from the last four years indicate strong progress toward our goal with 17 appointed trainees thus far. The MMoD program provides collaborative training in mechanistic disease research in the areas of molecular signaling, metabolic integrity, oxidative stress and redox biology, and disease microenvironment. The mentoring team spans seven departments and three colleges and includes 32 faculty members from early-stage to established investigators with strong histories in biomedical research funding and graduate student mentoring. The MMoD program will (1) Provide a rigorous curriculum and innovative, collaborative research opportunities for six predoctoral trainees per year (NIH-supported) to become experts in the mechanistic study of human disease; (2) Cultivate an interactive and inclusive training environment that enables trainees to develop professional skills in communication, leadership, proposal-writing, scholarship, entrepreneurship, and teaching; and 3) Build a cohort of trainees from diverse perspectives that have the knowledge and ability to work at the crossroads of different disciplines in their future careers as PhD scientists. Trainees will conduct research rotations in year 1 before choosing a faculty mentor, and will be supported by NIH T32 funding for up to two years beginning in their second year of their five-year program. Selection of new trainees for NIH support will be competitive and includes an original collaborative proposal bridging disciplinary boundaries for innovative thesis research. Trainees will take a flexible core curriculum that emphasizes writing and quantitative biology skills. Students in the MMoD program acquire skills in evidence-based education, quantitative and critical analysis, and rigor and reproducibility in research. They also gain professional experiences related to intellectual property and the pharmaceutical industry in preparation for potential career options. The MMoD program provides a framework that enables trainees to gain a broad knowledge base; actively seek research collaborations; produce an outstanding record of original published research; and develop presentation, proposal-writing, and leadership skills that position them for future excellence as independent researchers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $302,682 )
2025	2025	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	6	6/11/2025	COMPETING CONTINUATION	$302,682
														Subtotal = $302,682

Issue Date FY: 2024 ( Subtotal = $253,734 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	5	8/20/2024	NON-COMPETING CONTINUATION	$253,734
2024	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	4	1/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $253,734

Issue Date FY: 2023 ( Subtotal = $257,439 )
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	4	9/7/2023	NON-COMPETING CONTINUATION	$257,439
														Subtotal = $257,439

Issue Date FY: 2022 ( Subtotal = $251,335 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	3	5/25/2022	NON-COMPETING CONTINUATION	-$6
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	3	5/11/2022	NON-COMPETING CONTINUATION	$251,341
														Subtotal = $251,335

Issue Date FY: 2021 ( Subtotal = $231,695 )
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	2	5/25/2021	NON-COMPETING CONTINUATION	$231,695
														Subtotal = $231,695

Issue Date FY: 2020 ( Subtotal = $228,352 )
2020	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	1	6/12/2020	NEW	$228,352
														Subtotal = $228,352

Grand Total All Awards = $1,525,237

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Molecular Mechanisms of Disease

Award Number: T32GM136593

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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