We propose a training program that will recruit two postdoctoral scholars per year for a two-year fellowship
devoted to research on the pathophysiology of trauma. The goals of this training program are to nurture
talented individuals in the areas of basic, translational, and clinical investigation, to teach them to design and
implement successful research projects, and to provide them a background in the ethics and methods of
scientific research. We are particularly interested in training individuals who will become the next generation of
investigators in several areas related to the physiologic response to and recovery from trauma, burn, and
traumatic shock, such as inflammatory and immunologic factors, resuscitative mechanisms, sepsis,
hemorrhagic shock, organ system dysfunction, and wound healing and regeneration.
The training program includes two years of full-time effort conducting research under the supervision of one or
more of a large group of talented Research Training Faculty mentors, often involving collaboration across
disciplines and departments. Trainee appointments begin with a three-day course in the Responsible Conduct
of Research and in several other training activities geared toward protection of the rights and welfare of and
the regulatory requirements for conducting research with human subjects and for the humane care and use of
laboratory animals. In addition, fellows complete a Master’s of Public Health (MPH) degree, with an emphasis
in biostatistics, critical appraisal of medical literature, research methodology, project management, and
grantsmanship, as well as ongoing weekly seminars. Trainees are required to present their research at grand
rounds and research conferences, to submit abstracts to national meetings, and to publish their work.
Program leadership includes a Training Advisory Committee to assist the Program Director in recruiting and
selecting trainees, approving trainee research and didactic plans, matching trainees with Research Training
Faculty, and monitoring of program activities, and a Program Evaluation Committee to provide overall program
evaluation. The Diversity Recruitment and Retention Committee assists the Program Co-Director in efforts to
attract and retain members of underrepresented groups to increase the diversity of the training program.
All of the Research Training Faculty in the program are established investigators with current NIH or other
extramural funding and are experienced mentors of physician-scientists. Faculty members have diverse
interests, allowing multiple candidates to find appropriate mentors within the training program, and there is a
strong institutional history of multidisciplinary collaboration. Clinician-Scientist mentors provide career
guidance and additional support to trainees with regard to the multiple roles filled by contemporary academic
trauma and burn surgeons involved in research, clinical, educational, and outreach activities.
There is a growing demand for academic trauma and burn surgeons to guide subsequent generations of
providers and lead the development of innovative treatments. This grant is designed to help meet this need.