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Virus-host interactions: a multi-scale training program

Award Number: T32AI007319
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/30/1988
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Virus-host interactions: a multi-scale training program - This proposal is a competing renewal application for continuing support of a T32 training grant entitled “Virus- host interactions: a multi-scale training program.” The program, formerly called Molecular Biology of Eukaryotic Viruses, was established at the University of California, Irvine (UCI) in 1988. During its 30-year history, the goal of this program has been to broadly train Ph.D. graduate students in the fundamental aspects of molecular and cellular virology as they relate to virus-host interactions, viral pathogenesis, regulation of viral gene expression, virus structure/proteomics, and applications of virus/phage technologies. During the current review period (9/14-8/19), eight predoctoral students were supported by this training program. For the upcoming budget period, three pre-doctoral trainee positions are requested, consistent with previous renewals of this program. Due to evolving faculty research expertise and the emergence of new virus/phage- related disciplines, the scope of proposed training areas will be broadened to also include interdisciplinary research and training programs in host responses to viral infections, bacteriophages in the human microbiome and the environment, and mathematical modeling of virus dynamics. There are 13 faculty mentors for this program, representing eight academic departments at UCI. Nearly all faculty members from these departments participate in the Cellular and Molecular Biosciences graduate program (CMB) at UCI, which oversees recruitment, admission, and first-year training of predoctoral students. The majority of the T32 training grant trainees are part of the Immunology and Microbiology focus area in the CMB program. Three of the training preceptors are affiliated with the Department of Ecology & Evolutionary Biology, and research in these labs will focus on (i) viruses/bacteriophages in the environment, (ii) viruses associated with the human microbiome, and (iii) in vivo virus dynamics. All trainees in the proposed training program will take formal course work that includes an integrated set of core courses in molecular virology/pathogenesis, phage-host interactions, mathematical modeling of virus spread, and a Virology Journal Club as well as electives and seminar courses in their areas of research specialization. The virology training faculty have major research strengths in virus-host interactions including the immune response to viral infections, regulation of viral gene expression, structural virology and viral proteomics, viral pathogenesis, control of emerging virus infections, viruses/bacteriophages in the human and environmental microbiome, modeling of virus populations, molecular evolution of viruses, virus gene therapy, and drug delivery via viral vectors. Our research programs cover a wide range of DNA and RNA viruses, including herpes simplex virus, varicella zoster virus, vaccinia virus, adeno-associated virus, bacteriophages, retroviruses (HIV), filoviruses, arenaviruses, flaviviruses, and picornaviruses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $137,020 )
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	001	35	7/1/2024	NON-COMPETING CONTINUATION	$137,020
2024	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	34	10/20/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $137,020

Issue Date FY: 2023 ( Subtotal = $138,793 )
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	34	6/22/2023	NON-COMPETING CONTINUATION	$138,793
														Subtotal = $138,793

Issue Date FY: 2022 ( Subtotal = $135,846 )
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	33	6/29/2022	NON-COMPETING CONTINUATION	$135,846
														Subtotal = $135,846

Issue Date FY: 2021 ( Subtotal = $124,824 )
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	001	32	6/22/2021	NON-COMPETING CONTINUATION	$124,593
2021	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	31	10/27/2020	COMPETING CONTINUATION	$231
														Subtotal = $124,824

Issue Date FY: 2020 ( Subtotal = $123,939 )
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	001	31	6/1/2020	COMPETING CONTINUATION	$124,170
2020	2018	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	30	3/6/2020	NON-COMPETING CONTINUATION	-$231
														Subtotal = $123,939

Issue Date FY: 2018 ( Subtotal = $120,387 )
2018	2018	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	30	6/15/2018	NON-COMPETING CONTINUATION	$120,387
														Subtotal = $120,387

Issue Date FY: 2017 ( Subtotal = $118,793 )
2017	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	001	29	7/14/2017	NON-COMPETING CONTINUATION	$1,517
2017	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	29	7/11/2017	NON-COMPETING CONTINUATION	$117,276
														Subtotal = $118,793

Issue Date FY: 2016 ( Subtotal = $114,779 )
2016	2016	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	28	6/8/2016	NON-COMPETING CONTINUATION	$114,779
														Subtotal = $114,779

Issue Date FY: 2015 ( Subtotal = $115,839 )
2015	2015	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	27	5/13/2015	NON-COMPETING CONTINUATION	$115,839
														Subtotal = $115,839

Issue Date FY: 2014 ( Subtotal = $112,417 )
2014	2014	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	001	26	7/17/2014	COMPETING CONTINUATION	$112,417
2014	2012	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	25	11/1/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $112,417

Issue Date FY: 2012 ( Subtotal = $104,630 )
2012	2012	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	25	6/21/2012	NON-COMPETING CONTINUATION	$104,630
														Subtotal = $104,630

Issue Date FY: 2011 ( Subtotal = $94,333 )
2011	2011	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	24	8/12/2011	NON-COMPETING CONTINUATION	$94,333
														Subtotal = $94,333

Issue Date FY: 2010 ( Subtotal = $101,869 )
2010	2010	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	001	23	6/21/2010	NON-COMPETING CONTINUATION	$101,869
2010	2009	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	22	12/28/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $101,869

Issue Date FY: 2009 ( Subtotal = $101,208 )
2009	2009	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	002	22	7/7/2009	NON-COMPETING CONTINUATION	$101,208
2009	2008	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	21	10/16/2008	COMPETING CONTINUATION	$0
2009	2008	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	001	21	12/5/2008	COMPETING CONTINUATION	$0
														Subtotal = $101,208

Issue Date FY: 2008 ( Subtotal = $100,547 )
2008	2008	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	21	8/11/2008	COMPETING CONTINUATION	$100,547
														Subtotal = $100,547

Issue Date FY: 2007 ( Subtotal = $92,416 )
2007	2007	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	20	7/19/2007	NON-COMPETING CONTINUATION	$92,416
														Subtotal = $92,416

Issue Date FY: 2006 ( Subtotal = $92,416 )
2006	2006	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	19	6/9/2006	NON-COMPETING CONTINUATION	$92,416
														Subtotal = $92,416

Issue Date FY: 2005 ( Subtotal = $92,412 )
2005	2005	UNIVERSITY OF CALIFORNIA, IRVINE							Microbiology and Infectious Diseases Research	000	18	7/25/2005	NON-COMPETING CONTINUATION	$92,412
														Subtotal = $92,412

Issue Date FY: 2004 ( Subtotal = $62,288 )
2004	2004	UNIVERSITY OF CALIFORNIA, IRVINE							Microbiology and Infectious Diseases Research	000	17	8/20/2004	NON-COMPETING CONTINUATION	$62,288
														Subtotal = $62,288

Issue Date FY: 2003 ( Subtotal = $89,811 )
2003	2003	UNIVERSITY OF CALIFORNIA, IRVINE							Microbiology and Infectious Diseases Research	000	16	8/15/2003	COMPETING CONTINUATION	$89,811
														Subtotal = $89,811

Issue Date FY: 2002 ( Subtotal = $84,919 )
2002	2002	UNIVERSITY OF CALIFORNIA, IRVINE	UC IRVINE	IRVINE	CA	92717		USA	Microbiology and Infectious Diseases Research	000	15	8/30/2002	NON-COMPETING CONTINUATION	$84,919
														Subtotal = $84,919

Grand Total All Awards = $2,485,119

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Virus-host interactions: a multi-scale training program

Award Number: T32AI007319

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/30/1988

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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