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 | Issue Date FY: 2025 ( Subtotal = $45,321,940 ) (Continued on the next page) |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EB032366 | Enhanced Imaging of the Fetal Brain Microstructure | 001 | 4 | NIH | 1/15/2025 | $434,209 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21EY035792 | Probing the molecular basis of refractive index in lens proteins | 000 | 2 | NIH | 1/15/2025 | $178,224 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI178440 | Serological Biomarkers for Monitoring Human-Vector Contact by Invasive Anopheles stephensi in Africa | 000 | 2 | NIH | 11/29/2024 | $190,363 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21CA280564 | Therapeutic targeting of VHL-deficient clear cell renal cell carcinoma | 000 | 2 | NIH | 1/7/2025 | $188,682 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA272680 | Effectiveness of Out-of-Pocket Cost COMmunication and Financial Navigation (CostCOM) in Cancer Patients | 000 | 3 | NIH | 12/6/2024 | $551,777 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA266457 | Phase 1 Evaluation of Enhanced Natural Killer Cells as a Treatment Strategy in Non-Small cell Lung Cancer Patients Refractory to PD-1/PD-L1 Immune Checkpoint Inhibitors | 001 | 4 | NIH | 12/23/2024 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA276470 | Aberrant V(D)J recombination in B cells initiates lymphoid malignancy | 000 | 2 | NIH | 1/13/2025 | $308,394 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01MH128306 | Testing a Memory-Based Hypothesis for Anhedonia | 000 | 3 | NIH | 1/14/2025 | $631,303 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01ES025767 | Toxicological importance of CYP3A4 catalysis and inhibition | 000 | 9 | NIH | 1/13/2025 | $561,595 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01MD015186 | Sleep and health disparities among Asian Americans: roles of stressors and protective factors | 000 | 5 | NIH | 12/22/2024 | $601,457 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30HD110233 | Deciphering Mechanisms of Limb Malformations Caused by Noncoding Variants In Vivo | 000 | 3 | NIH | 12/20/2024 | $45,863 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL162687 | Reciprocal effects between scaffold geometry and ventricular vortex flow on viability and performance of tissue-engineered mitral valve | 000 | 3 | NIH | 12/20/2024 | $505,017 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R03EB035333 | A novel tool to quantify hypoxia burden from clinical sleep studies | 000 | 2 | NIH | 12/20/2024 | $70,550 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32HD114452 | Evaluating pain communication and understanding in interpreted medical encounters in a pediatric emergency department | 000 | 2 | NIH | 1/20/2025 | $78,328 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI185349 | The Role of Interferon Lambda in Alpha Herpesvirus Neuroinvasion | 000 | 1 | NIH | 1/27/2025 | $471,159 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA297834 | Decode polyadenylation in health and disease | 000 | 1 | NIH | 1/21/2025 | $667,379 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI168063 | Tissue-Specific Mechanisms of Regulatory T Cells in the CNS during Autoimmune Encephalomyelitis | 000 | 4 | NIH | 1/22/2025 | $489,842 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EY032948 | Retinal sheet transplant impact on functional organization of visual cortex in retinal degenerate animal models | 000 | 4 | NIH | 3/14/2025 | $575,017 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EY034501 | Precision genome editing in vivo to treat retinal diseases | 000 | 3 | NIH | 3/14/2025 | $618,911 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EY031834 | Integration and functionality of retinal organoid transplants | 000 | 5 | NIH | 3/14/2025 | $554,601 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EY034519 | Chemical Biology of the Visual Pigments | 000 | 3 | NIH | 3/14/2025 | $449,125 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL153724 | The state of energy in the right ventricle of patients with pulmonary arterial hypertension | 002 | 4 | NIH | 3/12/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA266457 | Phase 1 Evaluation of Enhanced Natural Killer Cells as a Treatment Strategy in Non-Small cell Lung Cancer Patients Refractory to PD-1/PD-L1 Immune Checkpoint Inhibitors | 002 | 4 | NIH | 3/12/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21TR005032 | Autonomous Platform for Pulsatile Soluble Stimulation | 000 | 2 | NIH | 3/13/2025 | $211,950 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA266042 | Defining the Mechanism of Genome Rearrangements in Ph-Like ALL to Determine Predictive Markers in High-Risk Hispanic Populations | 001 | 4 | NIH | 3/12/2025 | $366,163 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01MH137156 | Understanding output circuits of the lateral entorhinal cortex | 000 | 1 | NIH | 3/17/2025 | $625,108 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS121764 | The laminar organization of 'index' versus 'attribute' coding in neocortex | 000 | 3 | NIH | 3/19/2025 | $650,507 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA271172 | Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments | 000 | 4 | NIH | 3/20/2025 | $485,814 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | P01CA288662 | Tipping Points in Cancer | 000 | 1 | NIH | 3/19/2025 | $2,186,372 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EB026705 | Development of a fast scanning, extended field-of-view multiphoton microscope for clinical skin imaging | 000 | 7 | NIH | 3/20/2025 | $525,093 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31CA295037 | A methyl arginine targeting chimera for the lysosomal degradation of intracellular proteins | 000 | 1 | NIH | 3/20/2025 | $45,975 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG067073 | Using nicotine to reverse age-related auditory processing deficits | 000 | 5 | NIH | 3/19/2025 | $499,478 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | UG3CA290368 | Nautral products for targeting Skp2 in cancer interception | 000 | 2 | NIH | 3/28/2025 | $300,263 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG071683 | Oligodendrocyte heterogeneity in Alzheimer' s disease | 000 | 3 | NIH | 3/19/2025 | $556,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM153231 | Development of new methods and strategies for the synthesis of complex molecules | 001 | 2 | NIH | 1/8/2025 | $336,303 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI168130 | Regulation of inflammatory gene expression during SARS2 infection | 000 | 4 | NIH | 1/10/2025 | $725,413 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AG082485 | Neuropathological and spatial transcriptome brain maps in Octodon degus, a natural Alzheimer's disease rodent model | 000 | 2 | NIH | 11/14/2024 | $45,458 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM140890 | Activity-Based DNA-Encoded Library Technology | 001 | 5 | NIH | 1/8/2025 | $339,029 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00HD100593 | Fetal Programming of Human Newborn Energy Homeostasis Brain Networks | 000 | 5 | NIH | 1/8/2025 | $224,100 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | H8000461 | Health Center Program | 04 | 23 | HRSA | 1/13/2025 | $83,333 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI158503 | Developing broad-spectrum therapeutics against C. difficile toxins | 000 | 5 | NIH | 1/10/2025 | $748,253 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM130377 | Ion Channel Transporter Interactions | 001 | 7 | NIH | 1/9/2025 | $404,401 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R33HD102988 | Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings | 000 | 3 | NIH | 1/8/2025 | $300,417 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HG014004 | Smart Laser Capturing Microscope for Genome Wide Single Cell Spatial Transcriptomics | 000 | 1 | NIH | 1/8/2025 | $260,910 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG076835 | Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brain | 000 | 4 | NIH | 3/7/2025 | $648,932 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM148236 | Accelerating drug discovery via ML-guided iterative design and optimization | 001 | 3 | NIH | 3/24/2025 | $531,346 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EY019896 | Developing A Tissue-Targeted Ocular HSV Therapeutic Vaccine | 000 | 13 | NIH | 3/24/2025 | $409,999 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA193466 | Computational and Experimental Modeling of Alternative Polyadenylation | 000 | 10 | NIH | 2/14/2025 | $324,276 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01MH126285 | Nucleus accumbens circuits for regulating cue-motivated behavior | 000 | 5 | NIH | 3/11/2025 | $540,053 |
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