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 | Issue Date FY: 2025 ( Subtotal = $103,882,614 ) (Continued on the next page) |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00HD100593 | Fetal Programming of Human Newborn Energy Homeostasis Brain Networks | 001 | 5 | NIH | 4/11/2025 | $24,900 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00HD100593 | Fetal Programming of Human Newborn Energy Homeostasis Brain Networks | 000 | 5 | NIH | 1/8/2025 | $224,100 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21TR005032 | Autonomous Platform for Pulsatile Soluble Stimulation | 000 | 2 | NIH | 3/13/2025 | $211,950 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI158503 | Developing broad-spectrum therapeutics against C. difficile toxins | 000 | 5 | NIH | 1/10/2025 | $748,253 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG082127 | Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regions | 002 | 3 | NIH | 6/9/2025 | $161,589 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG082127 | Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regions | 001 | 3 | NIH | 3/7/2025 | $1,817,870 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | T32AR083870 | MAXIMUS: MAXimizing Training in MUScle Research | 000 | 2 | NIH | 6/5/2025 | $202,625 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM157311 | Defining the mechanisms that drive novel cyclic nucleotide signaling in immune defense | 000 | 1 | NIH | 1/31/2025 | $379,823 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI185349 | The Role of Interferon Lambda in Alpha Herpesvirus Neuroinvasion | 000 | 1 | NIH | 1/27/2025 | $471,159 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM153231 | Development of new methods and strategies for the synthesis of complex molecules | 001 | 2 | NIH | 1/8/2025 | $336,303 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32HD114452 | Evaluating pain communication and understanding in interpreted medical encounters in a pediatric emergency department | 001 | 2 | NIH | 6/9/2025 | $1,224 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32HD114452 | Evaluating pain communication and understanding in interpreted medical encounters in a pediatric emergency department | 000 | 2 | NIH | 1/20/2025 | $78,328 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA283575 | Targeting Metabolic Crosstalk in Pancreatic Cancer | 001 | 2 | NIH | 5/22/2025 | $44,533 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA283575 | Targeting Metabolic Crosstalk in Pancreatic Cancer | 000 | 2 | NIH | 4/10/2025 | $400,786 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01AI180164 | Impact of aging on human B cell vaccine responses | 000 | 2 | NIH | 4/17/2025 | $565,200 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS121227 | Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration | 000 | 4 | NIH | 12/23/2024 | $505,515 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA272680 | Effectiveness of Out-of-Pocket Cost COMmunication and Financial Navigation (CostCOM) in Cancer Patients | 001 | 3 | NIH | 6/2/2025 | $61,308 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA272680 | Effectiveness of Out-of-Pocket Cost COMmunication and Financial Navigation (CostCOM) in Cancer Patients | 000 | 3 | NIH | 12/6/2024 | $551,777 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U19AI172725 | MDRO Carriage, Transmission, Sequelae, and Prevention in Nursing Homes | 001 | 3 | NIH | 5/9/2025 | $3,252,905 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01DA053826 | Dynamic epigenomic landscape of opioid abuse following early-life adversity | 000 | 4 | NIH | 6/23/2025 | $691,904 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM145254 | Regulation and impact of alternative splicing in biology and disease | 002 | 4 | NIH | 6/10/2025 | $392,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35NS122140 | La Spada Outstanding Investigator Award | 000 | 5 | NIH | 5/9/2025 | $1,162,302 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS130044 | Investigation of neural ensembles driving pain chronification | 000 | 3 | NIH | 11/8/2024 | $304,346 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HD113752 | STRESS, MEMORY, AND RUMINATION IN MALTREATED ADOLESCENTS | 000 | 2 | NIH | 4/16/2025 | $617,307 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01HG011745 | Pediatric Mendelian Genomics Research Center | 000 | 5 | NIH | 5/1/2025 | $2,074,563 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01EY034594 | Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE) | 000 | 3 | NIH | 3/27/2025 | $393,500 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U24MH133236 | UC Irvine Center for the production and distribution of cell-type-specific viral targeting reagents | 000 | 3 | NIH | 4/25/2025 | $945,779 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01ES025767 | Toxicological importance of CYP3A4 catalysis and inhibition | 000 | 9 | NIH | 1/13/2025 | $561,595 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI184196 | Nucleic acid-containing immune complexes and immune activation | 000 | 2 | NIH | 6/20/2025 | $196,250 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL153724 | The state of energy in the right ventricle of patients with pulmonary arterial hypertension | 002 | 4 | NIH | 3/12/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AG082485 | Neuropathological and spatial transcriptome brain maps in Octodon degus, a natural Alzheimer's disease rodent model | 001 | 2 | NIH | 5/29/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL153724 | The state of energy in the right ventricle of patients with pulmonary arterial hypertension | 001 | 4 | NIH | 12/19/2024 | $561,825 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AG082485 | Neuropathological and spatial transcriptome brain maps in Octodon degus, a natural Alzheimer's disease rodent model | 000 | 2 | NIH | 11/14/2024 | $45,458 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01AG076791 | Cell-type-specific neural circuit connectomes in the mouse models of aging and Alzheimer's disease | 001 | 4 | NIH | 6/20/2025 | $2,591,567 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R33HD102988 | Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings | 000 | 3 | NIH | 1/8/2025 | $300,417 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA271172 | Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments | 003 | 4 | NIH | 5/22/2025 | $53,979 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA271172 | Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments | 001 | 4 | NIH | 4/25/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA271172 | Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments | 000 | 4 | NIH | 3/20/2025 | $485,814 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG067073 | Using nicotine to reverse age-related auditory processing deficits | 001 | 5 | NIH | 6/10/2025 | $44,400 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG067073 | Using nicotine to reverse age-related auditory processing deficits | 000 | 5 | NIH | 3/19/2025 | $499,478 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EY034501 | Precision genome editing in vivo to treat retinal diseases | 000 | 3 | NIH | 3/14/2025 | $618,911 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DK121146 | Epigenetic Regulation of Mitochondrial Homeostasis and Energy Metabolism | 001 | 7 | NIH | 6/23/2025 | $493,084 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EY034519 | Chemical Biology of the Visual Pigments | 000 | 3 | NIH | 3/14/2025 | $449,125 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21TR005645 | Accelerating the translation of oligonucleotide therapeutics by enhancing delivery | 000 | 1 | NIH | 6/16/2025 | $419,398 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | T32GM154637 | Medical Scientist Training Program | 000 | 1 | NIH | 6/16/2025 | $584,450 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | P30CA062203 | Cancer Center Support Grant | 000 | 27 | NIH | 3/6/2025 | $2,117,142 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS121764 | The laminar organization of 'index' versus 'attribute' coding in neocortex | 000 | 3 | NIH | 3/19/2025 | $650,507 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS116273 | Seizure localization for epilepsy surgery using high frequency electrophysiological markers | 000 | 5 | NIH | 2/20/2025 | $283,396 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI185311 | Basic immunological toolbox for genus Peromsycus, infection tolerant reservoirs of zoonotic agents | 000 | 1 | NIH | 6/26/2025 | $431,750 |
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