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 | Issue Date FY: 2026 ( Subtotal = $195,070,914 ) (Continued on the next page) |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI190786 | Vectorial Capacity of Invasive Anopheles stephensi in Ethiopia | 000 | 1 | NIH | 8/13/2026 | $196,250 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI198742 | Developing a Malaria Intelligence System and Mobile Decision-Support App to Enhance Malaria Prevention and Control in Kenya | 000 | 1 | NIH | 8/20/2026 | $667,643 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DC023290 | Cochlear-Implant Pitch Perception Enhanced by a Penetrating Auditory-Nerve Electrode | 000 | 1 | NIH | 7/6/2026 | $530,902 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30EY039130 | Elucidation the Epigenetic and Transcriptional Landscape of Spinocerebellar Type 7 Retinal Degeneration | 001 | 1 | NIH | 6/22/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30EY039130 | Elucidation the Epigenetic and Transcriptional Landscape of Spinocerebellar Type 7 Retinal Degeneration | 000 | 1 | NIH | 6/22/2026 | $48,179 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31NS149735 | Developing innovative small-molecule lysosomal degraders for pathogenic protein aggregates in human disease | 000 | 1 | NIH | 5/11/2026 | $47,896 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI193989 | Discovery and preliminary characterization of proteins required for Mycobacterium tuberculosis heme degradation | 000 | 1 | NIH | 7/3/2026 | $205,216 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | K12TR006003 | ICTS Mentored Career Development Core | 000 | 1 | NIH | 3/9/2026 | $756,000 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG096669 | Longitudinal relationships between Alzheimer's disease pathophysiology, local sleep expression, and sleep-dependent memory across preclinical stages | 001 | 1 | NIH | 4/30/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG096669 | Longitudinal relationships between Alzheimer's disease pathophysiology, local sleep expression, and sleep-dependent memory across preclinical stages | 000 | 1 | NIH | 1/26/2026 | $619,099 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM163899 | Macromolecular Structure and Mechanism of Innate Immune Complexes | 000 | 1 | NIH | 6/29/2026 | $365,267 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01GM163338 | Targeted Protein Degradation Utilizing Rpn-13 | 000 | 1 | NIH | 4/24/2026 | $448,510 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32AG097046 | Investigating the interface between epigenetics and metabolism underlying memory formation in the adult and aging brain | 000 | 1 | NIH | 8/19/2026 | $76,300 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30MH143517 | Developmental transcriptomics of the Paraventricular Thalamus | 001 | 1 | NIH | 8/7/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30MH143517 | Developmental transcriptomics of the Paraventricular Thalamus | 000 | 1 | NIH | 8/7/2026 | $47,383 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | H79SM091137 | iEDAPT-CHR-P: An Integrated Stepped-Care Program for Youth at Clinical High Risk for Psychosis in Orange County | 000 | 1 | SAMHSA | 8/12/2026 | $650,000 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA307676 | Mechanisms and Functional Roles of PARP1 Hyperactivation in Cancer | 000 | 1 | NIH | 6/26/2026 | $639,707 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | K99DE034828 | Identifying non-coding sources of mammalian craniofacial variation | 000 | 1 | NIH | 4/24/2026 | $128,191 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21CA307778 | Harnessing Nutritional Modulation to Enhance Cancer Drug Potency | 001 | 1 | NIH | 6/22/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21CA307778 | Harnessing Nutritional Modulation to Enhance Cancer Drug Potency | 000 | 1 | NIH | 3/19/2026 | $403,686 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | RF1AG090869 | Linking Daily Dynamics of Social Connection to Physical Cognitive Functioning | 000 | 1 | NIH | 6/26/2026 | $2,550,958 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | K23EY036491 | Spatial Frequency Domain Imaging to Investigate Mechanistic Constituents in Active Thyroid Eye Disease | 000 | 2 | NIH | 4/27/2026 | $257,920 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AA032274 | Modeling a national Graduated-BAC per se policy for 21-24 y/o drivers to reduce alcohol impaired driving injury and fatal crashes | 000 | 2 | NIH | 8/3/2026 | $686,967 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI198692 | Therapeutic potential and mechanism of action of leelamine-derived isonitriles for malaria and babesiosis | 000 | 1 | NIH | 5/11/2026 | $823,548 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI202391 | A Bioinorganic Approach to Coordinate Covalent Protease Inhibitors | 000 | 1 | NIH | 7/1/2026 | $196,250 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31NS149735 | Developing innovative small-molecule lysosomal degraders for pathogenic protein aggregates in human disease | 001 | 1 | NIH | 5/11/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL177188 | Development of integrated OCT/US/PAT system for intravascular Imaging | 000 | 2 | NIH | 6/18/2026 | $589,908 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | K08DK142008 | Investigation of Urethral Dysfunction in Female Urinary Incontinence | 000 | 2 | NIH | 3/25/2026 | $174,701 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS130616 | Neurotoxicity of particulate matter and its interaction with APOE in neurodegeneration | 000 | 3 | NIH | 8/14/2026 | $668,150 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R03DA062573 | Vitamin C protect against nicotine induced lung ailment | 000 | 2 | NIH | 6/18/2026 | $78,500 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AI192129 | Evaluating the combination effect of autophagy induction and CAR T cell therapy on "Kick-and-Kill" HIV reservoir depletion | 000 | 2 | NIH | 8/7/2026 | $47,134 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DA064341 | Neural mechanisms of motivational and cognitive impairment in opioid withdrawal | 000 | 2 | NIH | 5/27/2026 | $665,240 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI190954 | Characterization of a novel histidine phosphotransfer system involved in the virulence of Mycobacterium tuberculosis | 000 | 1 | NIH | 1/28/2026 | $141,712 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG076835 | Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brain | 000 | 5 | NIH | 4/1/2026 | $721,033 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI194582 | Increasing Breadth of Immune Response by Single-Dose Influenza Vaccines | 000 | 1 | NIH | 4/1/2026 | $721,365 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21TR006265 | Accelerated Antibody Evolution Under Functional Selection | 000 | 1 | NIH | 5/4/2026 | $413,771 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AG081893 | Patch for hemodynamic and hemorrhage monitoring | 000 | 1 | NIH | 2/3/2026 | $408,504 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AG093390 | Correction of VCP Disease Pathology with Antisense Oligonucleotides | 000 | 1 | NIH | 5/4/2026 | $431,750 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21EY038406 | Exploring Novel Mechanisms of Obstructive Meibomian gland Dysfunction | 000 | 1 | NIH | 5/4/2026 | $431,750 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | K99GM164832 | Integrating physics-based and machine learning methods to accelerate computational drug design | 000 | 1 | NIH | 7/28/2026 | $126,489 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31HL182233 | Innate immune pathway activation in endothelial cells by circulating bile acids during atherosclerosis | 001 | 1 | NIH | 6/15/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31HL182233 | Innate immune pathway activation in endothelial cells by circulating bile acids during atherosclerosis | 000 | 1 | NIH | 6/15/2026 | $43,323 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01MH139931 | Sex- and hormone-dependent differences in memory vulnerability to acute traumatic stress | 000 | 1 | NIH | 7/30/2026 | $802,256 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DA066575 | Mechanistic interrogation of the medial habenula's role in regulating drug-induced behaviors | 000 | 1 | NIH | 7/30/2026 | $697,617 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HD119090 | BB2-MC: Long-term benefits of Baby Books on parenting and child outcomes in middle childhood | 000 | 1 | NIH | 6/19/2026 | $620,013 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R33HL175860 | Maternal Obstetric Monitoring System (MOMS): a Postpartum Hemorrhage (PPH) Wearable Monitor | 000 | 2 | NIH | 8/3/2026 | $355,785 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL186358 | A Nanomaterial-Engineered Proteomic Platform to Map Curvature-Dependent Cardiac Signaling | 000 | 1 | NIH | 6/10/2026 | $711,796 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI191078 | Vancomycin-Teixobactin Conjugates | 000 | 1 | NIH | 2/17/2026 | $404,866 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG078201 | Microglia dysregulation and SYK signaling in Alzheimer's disease | 000 | 2 | NIH | 3/3/2026 | $537,718 |
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