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 | Issue Date FY: 2026 ( Subtotal = $216,168,707 ) (Continued on the next page) |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R13CA317939 | 2026 SoCal Genome Stability Symposium | 000 | 1 | NIH | 8/25/2026 | $20,000 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21HL177731 | Familial hypercholesterolemia: missed opportunities and potential disparities in atherosclerotic cardiovascular disease prevention | 000 | 1 | NIH | 7/10/2026 | $235,500 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R13CA317939 | 2026 SoCal Genome Stability Symposium | 000 | 1 | NIH | 8/25/2026 | $2,000 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32EY037536 | Scalable Prime Editor Evolution for Correction of Inherited Retinal Diseases | 001 | 1 | NIH | 4/3/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32EY037536 | Scalable Prime Editor Evolution for Correction of Inherited Retinal Diseases | 000 | 1 | NIH | 4/3/2026 | $79,480 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30EY039130 | Elucidation the Epigenetic and Transcriptional Landscape of Spinocerebellar Type 7 Retinal Degeneration | 001 | 1 | NIH | 6/22/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30EY039130 | Elucidation the Epigenetic and Transcriptional Landscape of Spinocerebellar Type 7 Retinal Degeneration | 000 | 1 | NIH | 6/22/2026 | $48,179 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI202391 | A Bioinorganic Approach to Coordinate Covalent Protease Inhibitors | 000 | 1 | NIH | 7/1/2026 | $196,250 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31HL182220 | Identifying novel microproteins and protein translation mechanisms involved in the development of atherosclerosis | 000 | 2 | NIH | 9/9/2026 | $43,595 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI198692 | Therapeutic potential and mechanism of action of leelamine-derived isonitriles for malaria and babesiosis | 000 | 1 | NIH | 5/11/2026 | $823,548 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31NS149735 | Developing innovative small-molecule lysosomal degraders for pathogenic protein aggregates in human disease | 001 | 1 | NIH | 5/11/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31NS149735 | Developing innovative small-molecule lysosomal degraders for pathogenic protein aggregates in human disease | 000 | 1 | NIH | 5/11/2026 | $47,896 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21HD122115 | GYS1 Oligonucleotide Treatment as a Substrate Inhibitor for Pompe disease | 000 | 1 | NIH | 8/21/2026 | $431,750 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AI191957 | Improving the "kick" in HIV "kick and kill" cure approaches | 000 | 1 | NIH | 4/6/2026 | $47,383 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM163463 | Natural Product-Inspired Advances in Stereoselective Synthesis | 000 | 1 | NIH | 8/5/2026 | $526,832 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA287116 | Mechanisms of immunosuppression triggered by checkpoint blockade immunotherapy | 000 | 1 | NIH | 4/6/2026 | $648,626 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32AG097046 | Investigating the interface between epigenetics and metabolism underlying memory formation in the adult and aging brain | 000 | 1 | NIH | 8/19/2026 | $76,300 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI202117 | Regulatory mechanisms for production of infectious Chlamydia | 000 | 1 | NIH | 8/7/2026 | $760,663 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | H79SM091137 | iEDAPT-CHR-P: An Integrated Stepped-Care Program for Youth at Clinical High Risk for Psychosis in Orange County | 000 | 1 | SAMHSA | 8/12/2026 | $650,000 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30MH143517 | Developmental transcriptomics of the Paraventricular Thalamus | 001 | 1 | NIH | 8/7/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30MH143517 | Developmental transcriptomics of the Paraventricular Thalamus | 000 | 1 | NIH | 8/7/2026 | $47,383 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI190786 | Vectorial Capacity of Invasive Anopheles stephensi in Ethiopia | 000 | 1 | NIH | 8/13/2026 | $196,250 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG096669 | Longitudinal relationships between Alzheimer's disease pathophysiology, local sleep expression, and sleep-dependent memory across preclinical stages | 001 | 1 | NIH | 4/30/2026 | $0 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG096669 | Longitudinal relationships between Alzheimer's disease pathophysiology, local sleep expression, and sleep-dependent memory across preclinical stages | 000 | 1 | NIH | 1/26/2026 | $619,099 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM163899 | Macromolecular Structure and Mechanism of Innate Immune Complexes | 000 | 1 | NIH | 6/29/2026 | $365,267 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AA032274 | Modeling a national Graduated-BAC per se policy for 21-24 y/o drivers to reduce alcohol impaired driving injury and fatal crashes | 000 | 2 | NIH | 8/3/2026 | $686,967 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI198742 | Developing a Malaria Intelligence System and Mobile Decision-Support App to Enhance Malaria Prevention and Control in Kenya | 000 | 1 | NIH | 8/20/2026 | $667,643 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F30AG094274 | Deciphering the roles of APOE4 and amyloid-beta in Alzheimer's disease progression | 000 | 1 | NIH | 8/25/2026 | $47,896 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DC023290 | Cochlear-Implant Pitch Perception Enhanced by a Penetrating Auditory-Nerve Electrode | 000 | 1 | NIH | 7/6/2026 | $530,902 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | RC2TR004919 | A Novel Machine Learning-Enabled Metabolic Imaging Platform for Physiologically Relevant, Predictive Drug Efficacy Testing | 000 | 1 | NIH | 8/21/2026 | $3,024,289 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA308352 | Type 1 Innate Lymphoid Cells: Mechanisms and Anti-AML Potential | 000 | 1 | NIH | 4/7/2026 | $586,364 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AG099684 | Unveiling Selective Vulnerability to Alzheimer's Disease in an Aging Population | 000 | 1 | NIH | 8/18/2026 | $47,896 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00AT012494 | Nutrition-based interventions to ameliorate pain in sickle cell disease | 000 | 3 | NIH | 8/12/2026 | $249,000 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI196970 | Molecular Architecture of the Vaccinia virus factory | 000 | 1 | NIH | 2/10/2026 | $235,500 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA309212 | Protoacoustic Imaging for 3D Mapping the Bragg Peak in Real Time during Proton Therapy | 000 | 1 | NIH | 4/6/2026 | $648,049 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG078201 | Microglia dysregulation and SYK signaling in Alzheimer's disease | 000 | 2 | NIH | 3/3/2026 | $537,718 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI191078 | Vancomycin-Teixobactin Conjugates | 000 | 1 | NIH | 2/17/2026 | $404,866 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI196939 | Functional Expansion of Regulatory T Cells to Limit CNS Autoimmunity | 000 | 1 | NIH | 1/29/2026 | $431,750 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM163464 | Mechanisms of the Hippo pathway in growth control | 000 | 1 | NIH | 7/22/2026 | $399,220 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HL177288 | A Transcatheter Pulmonary Valve System for the Growing Hearts of Young Children | 000 | 1 | NIH | 7/23/2026 | $760,016 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00DA062328 | The role of valence encoding amygdala ensembles in avoidance behavior | 000 | 3 | NIH | 6/25/2026 | $248,999 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI192615 | Optimization of the Pyrroloiminoquinone Scaffold for Malaria and Babesiosis Treatment | 000 | 1 | NIH | 7/23/2026 | $783,811 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM161208 | Nitrogenase - From mechanistic investigation to heterologous expression | 000 | 1 | NIH | 3/13/2026 | $503,280 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM161209 | Nitrogenase - Where Haber-Bosch meets Fischer-Tropsch | 000 | 1 | NIH | 3/13/2026 | $487,953 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DC023614 | SCOPE Screening Children's Oral Proficiency in English | 001 | 1 | NIH | 8/11/2026 | $645,741 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DC023614 | SCOPE Screening Children's Oral Proficiency in English | 001 | 1 | NIH | 8/11/2026 | -$645,741 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DC023614 | SCOPE Screening Children's Oral Proficiency in English | 000 | 1 | NIH | 7/30/2026 | $645,742 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AG081893 | Patch for hemodynamic and hemorrhage monitoring | 000 | 1 | NIH | 2/3/2026 | $408,504 |
| | 2026 | 2026 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00AR083536 | Decoding the repair and immunomodulatory functions of lymphatic vessels in wound healing | 000 | 4 | NIH | 2/5/2026 | $249,000 |
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