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 | Issue Date FY: 2025 ( Subtotal = $67,942,926 ) (Continued on the next page) |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R03EB035333 | A novel tool to quantify hypoxia burden from clinical sleep studies | 000 | 2 | NIH | 12/20/2024 | $70,550 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00MH122663 | The role of context in sleep-related memory reactivation in humans | 002 | 5 | NIH | 4/24/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00MH122663 | The role of context in sleep-related memory reactivation in humans | 000 | 5 | NIH | 1/24/2025 | $211,651 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI168130 | Regulation of inflammatory gene expression during SARS2 infection | 000 | 4 | NIH | 1/10/2025 | $725,413 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA259370 | Circadian Clock and Myc-dependent Regulation of Cellular Transformation | 000 | 4 | NIH | 11/21/2024 | $514,625 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG086441 | Lateral entorhinal cortex dysfunction in an APP knock-in model of Alzheimer's disease | 000 | 2 | NIH | 4/28/2025 | $486,172 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA290115 | A vascularized microphysiological system (MPS) platform for modeling peritoneal carcinomatosis | 000 | 2 | NIH | 4/23/2025 | $469,117 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DK134342 | The Role of Kisspeptin in Metabolism Regulation | 000 | 2 | NIH | 4/1/2025 | $445,553 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA276470 | Aberrant V(D)J recombination in B cells initiates lymphoid malignancy | 000 | 2 | NIH | 1/13/2025 | $308,394 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01HD111936 | Identifying the mechanisms of adaptive speech perception | 000 | 2 | NIH | 4/3/2025 | $332,334 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DE033732 | Impact of Medicaid Pregnancy Dental Benefits on Dental Care Access Among Pregnant People and Young Children | 000 | 2 | NIH | 3/26/2025 | $404,095 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21CA280564 | Therapeutic targeting of VHL-deficient clear cell renal cell carcinoma | 000 | 2 | NIH | 1/7/2025 | $188,682 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21EY035792 | Probing the molecular basis of refractive index in lens proteins | 000 | 2 | NIH | 1/15/2025 | $178,224 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG068992 | Cell autonomous and non-cell autonomous phenotypes due to genetic risk for late onset Alzheimers disease | 000 | 3 | NIH | 4/8/2025 | $650,726 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI181315 | Role of TREM2 in host defense and immunity during infection | 000 | 2 | NIH | 4/24/2025 | $188,300 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F31AI178923 | Chemoproteomic discovery of secreted microbial enzymes for engineered probiotics | 000 | 2 | NIH | 4/17/2025 | $46,067 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EB032366 | Enhanced Imaging of the Fetal Brain Microstructure | 003 | 4 | NIH | 2/26/2025 | $472,118 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EB032366 | Enhanced Imaging of the Fetal Brain Microstructure | 001 | 4 | NIH | 1/15/2025 | $434,209 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI178613 | Larval Ecology of Invasive Anopheles stephensi in Ethiopia | 000 | 2 | NIH | 12/3/2024 | $215,127 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00HD100593 | Fetal Programming of Human Newborn Energy Homeostasis Brain Networks | 001 | 5 | NIH | 4/11/2025 | $24,900 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R00HD100593 | Fetal Programming of Human Newborn Energy Homeostasis Brain Networks | 000 | 5 | NIH | 1/8/2025 | $224,100 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DA055849 | Ventral Pallidum Circuits Underlying Preclinical Models of Opioid Addiction | 001 | 3 | NIH | 4/9/2025 | $35,325 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01DA055849 | Ventral Pallidum Circuits Underlying Preclinical Models of Opioid Addiction | 000 | 3 | NIH | 1/17/2025 | $317,925 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21TR005032 | Autonomous Platform for Pulsatile Soluble Stimulation | 000 | 2 | NIH | 3/13/2025 | $211,950 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG082127 | Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regions | 001 | 3 | NIH | 3/7/2025 | $1,817,870 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI158503 | Developing broad-spectrum therapeutics against C. difficile toxins | 000 | 5 | NIH | 1/10/2025 | $748,253 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM148236 | Accelerating drug discovery via ML-guided iterative design and optimization | 001 | 3 | NIH | 3/24/2025 | $531,346 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | K22CA272915 | Augmenting cancer checkpoint immunotherapies via microbially-derived metabolites | 000 | 3 | NIH | 11/22/2024 | $142,625 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21AI178440 | Serological Biomarkers for Monitoring Human-Vector Contact by Invasive Anopheles stephensi in Africa | 000 | 2 | NIH | 11/29/2024 | $190,363 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AG072587 | Structural and Biological Characterization of Diverse Oligomers Derived from Abeta | 000 | 3 | NIH | 4/1/2025 | $396,728 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | UG3CA290368 | Nautral products for targeting Skp2 in cancer interception | 000 | 2 | NIH | 3/28/2025 | $300,263 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01EB026705 | Development of a fast scanning, extended field-of-view multiphoton microscope for clinical skin imaging | 000 | 7 | NIH | 3/20/2025 | $525,093 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | P01CA288662 | Tipping Points in Cancer | 000 | 1 | NIH | 3/19/2025 | $2,186,372 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA266042 | Defining the Mechanism of Genome Rearrangements in Ph-Like ALL to Determine Predictive Markers in High-Risk Hispanic Populations | 001 | 4 | NIH | 3/12/2025 | $366,163 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA266042 | Defining the Mechanism of Genome Rearrangements in Ph-Like ALL to Determine Predictive Markers in High-Risk Hispanic Populations | 002 | 4 | NIH | 4/10/2025 | $0 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01MH137156 | Understanding output circuits of the lateral entorhinal cortex | 000 | 1 | NIH | 3/17/2025 | $625,108 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R21DA059798 | "Cue Labeling as a Tool to Regulate Craving During Abstinence from Smoking”. | 000 | 2 | NIH | 2/28/2025 | $215,391 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI177428 | Structural studies of the OrfX-type progenitor toxin complex of botulinum neurotoxin | 000 | 1 | NIH | 2/25/2025 | $616,816 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01MH126285 | Nucleus accumbens circuits for regulating cue-motivated behavior | 000 | 5 | NIH | 3/11/2025 | $540,053 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA193466 | Computational and Experimental Modeling of Alternative Polyadenylation | 000 | 10 | NIH | 2/14/2025 | $324,276 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM157311 | Defining the mechanisms that drive novel cyclic nucleotide signaling in immune defense | 000 | 1 | NIH | 1/31/2025 | $379,823 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R35GM153231 | Development of new methods and strategies for the synthesis of complex molecules | 001 | 2 | NIH | 1/8/2025 | $336,303 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01AI185349 | The Role of Interferon Lambda in Alpha Herpesvirus Neuroinvasion | 000 | 1 | NIH | 1/27/2025 | $471,159 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | F32HD114452 | Evaluating pain communication and understanding in interpreted medical encounters in a pediatric emergency department | 000 | 2 | NIH | 1/20/2025 | $78,328 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01NS121227 | Mitochondrial Zn2+ accumulation and the induction of ischemic neurodegeneration | 000 | 4 | NIH | 12/23/2024 | $505,515 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R01CA272680 | Effectiveness of Out-of-Pocket Cost COMmunication and Financial Navigation (CostCOM) in Cancer Patients | 000 | 3 | NIH | 12/6/2024 | $551,777 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | R37CA283575 | Targeting Metabolic Crosstalk in Pancreatic Cancer | 000 | 2 | NIH | 4/10/2025 | $400,786 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01AI180164 | Impact of aging on human B cell vaccine responses | 000 | 2 | NIH | 4/17/2025 | $565,200 |
| | 2025 | 2025 | UNIVERSITY OF CALIFORNIA IRVINE | 160 ALDRICH HALL | IRVINE | CA | 92697-0001 | ORANGE | USA | U01EY034594 | Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE) | 000 | 3 | NIH | 3/27/2025 | $393,500 |
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