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The role of depression in cognitive decline of oldest-old African Americans

Award Number: SC3GM144199
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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The role of depression in cognitive decline of oldest-old African Americans - PROJECT SUMMARY/ABSTRACT Older adults (85 and older), the fastest growing segment of the population, are at very high risk of dementia. Some minority groups, such as African Americans, are at higher risk of dementia compared to Whites. However, little is known about the risk factors that might be involved in their high susceptibility to dementia. Depression, one of the most frequent and debilitating psychiatric conditions in older adults, has been consistently associated with cognitive decline in Whites. Although depression in African Americans is more chronic and untreated, compared with Whites, only a handful of studies have investigated the relationship between depression and cognitive decline in this racial/ethnic group. To our knowledge, this relationship has not been examined in oldest-old (≥80) African Americans. Chronic inflammation is also associated with both depression and cognitive decline. Because depression and inflammation are treatable conditions, better understanding of their role in cognition may lead to reduced dementia risk in this very high risk, growing, and understudied population. This study will examine the inter-relationships of depression and inflammation with change in cognition over time in 192 non-demented community-dwelling oldest-old African Americans. We will examine the following three Specific Aims: Aim 1: To examine the association between depression measures and cognitive decline over time. We hypothesize that: a) Depression is related to a greater rate of cognitive decline. b) Based on compelling preliminary data, apathy is the depression measure hypothesized to be most strongly related to a greater rate of cognitive decline. Aim 2: To examine the association between baseline inflammation and cognitive decline. We hypothesize that higher levels of inflammatory cytokines at baseline are related to a greater rate of cognitive decline. Aim 3: To examine the inter-relationships of depression, inflammation and cognitive decline. a) We hypothesize that inflammation serves as a moderator in the relationship between depression and cognitive decline in oldest-old African Americans. If significant results are generated, they can lead to increasing public awareness about the importance of timely depression diagnosis and development of mechanism-based effective and well-targeted treatment for the oldest-old community of African Americans, who are at particularly high-risk for dementia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $107,265 )
2025	2025	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD W	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	4	5/1/2025	NON-COMPETING CONTINUATION	$107,265
														Subtotal = $107,265

Issue Date FY: 2024 ( Subtotal = $106,399 )
2024	2024	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD W	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	001	3	6/18/2024	NON-COMPETING CONTINUATION	$10,640
2024	2024	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD W	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	3	4/2/2024	NON-COMPETING CONTINUATION	$95,759
														Subtotal = $106,399

Issue Date FY: 2023 ( Subtotal = $105,632 )
2023	2023	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	2	4/14/2023	NON-COMPETING CONTINUATION	$105,632
														Subtotal = $105,632

Issue Date FY: 2022 ( Subtotal = $104,885 )
2022	2022	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	1	5/13/2022	NEW	$104,885
														Subtotal = $104,885

Grand Total All Awards = $424,181

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The role of depression in cognitive decline of oldest-old African Americans

Award Number: SC3GM144199

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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