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Effect of Heavy Backpack Load Carriage on Acute Blood Flow, Nerve Conduction, Biomechanics and Dexterity of the Upper Limbs

Award Number: SC3GM139683
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/19/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Effect of Heavy Backpack Load Carriage on Acute Blood Flow, Nerve Conduction, Biomechanics and Dexterity of the Upper Limbs - Project Summary First responder, military, and law enforcement personnel regularly carry backpack loads of up to 60% body weight. Use of the hands and fingers is often needed during or immediately after load carriage, but loads applied via backpack straps can constrict blood flow and compress the brachial plexus nerves of the upper limb. These factors can potentially lead to pain, injury and impaired use of the upper limbs. Understanding the acute effects of heavy load carriage on upper limb physiology will aid development of field-based functional measures to reduce the risk of injury and prevent long-term loss of hand function. Persons who regularly carry heavy backpack loads for occupational purposes report incidences of pack palsy, a disability causing lack of sensation and weakness in the hands. The proposed work aims to investigate relationships among physiological changes, manual functional deficits during pack carriage, and pack palsy. It is unclear how the magnitude and duration of backpack carriage affects acute changes in grip strength, pinch strength, manual dexterity and light touch sensory threshold. The overall hypothesis is that walking with backpack load will cause changes in upper limb blood flow, edema, and nerve conduction. Further, we expect these physiological changes will result in measurable differences in manual dexterity, strength, and light touch sensory threshold that will change with increasing load in the backpack and duration of time walking with load. To address the hypotheses, I will determine the relative acute changes in upper limb blood flow, edema and nerve conduction before and after walking with heavy backpack load. I will also identify quantitative changes in blood flow, grip strength, pinch strength and manual dexterity at load levels of 15% and 30% body weight as compared to a control condition. I will explore the effects of walking time with backpack load on upper limb blood flow and light touch sensory threshold of the fingers which may be affected by nerve compression from backpack straps. This much needed research will improve understanding of upper limb physiological and neuromuscular changes with backpack carriage. The innovative methodology will allow study of multiple upper limb physiological changes simultaneously. Increased understanding of backpack carriage could improve prevention of brachial plexus injury and therefore reduce incidences of weakness or loss of hand function. Application of this work could lead to early diagnosis of brachial plexus compression by means of functional measures. Results of this work may improve hand function, injury prevention, and treatment of the upper extremity for those who carry heavy backpacks in an occupational or recreational setting.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $111,750 )
2024	2024	CALIFORNIA STATE UNIVERSITY SAN MARCOS CORP	333 S TWIN OAKS VALLEY RD	SAN MARCOS	CA	92096	SAN DIEGO	USA	Biomedical Research and Research Training	000	4	3/22/2024	NON-COMPETING CONTINUATION	$100,575
2024	2024	CALIFORNIA STATE UNIVERSITY SAN MARCOS CORP	333 S TWIN OAKS VALLEY RD	SAN MARCOS	CA	92096	SAN DIEGO	USA	Biomedical Research and Research Training	001	4	6/6/2024	NON-COMPETING CONTINUATION	$11,175
														Subtotal = $111,750

Issue Date FY: 2023 ( Subtotal = $111,750 )
2023	2023	CALIFORNIA STATE UNIVERSITY SAN MARCOS CORP	333 S TWIN OAKS VALLEY RD	SAN MARCOS	CA	92096	SAN DIEGO	USA	Biomedical Research and Research Training	000	3	3/31/2023	NON-COMPETING CONTINUATION	$111,750
														Subtotal = $111,750

Issue Date FY: 2022 ( Subtotal = $101,529 )
2022	2022	CALIFORNIA STATE UNIVERSITY SAN MARCOS CORPORATION	333 S TWIN OAKS VALLEY RD	SAN MARCOS	CA	92096	SAN DIEGO	USA	Biomedical Research and Research Training	000	2	3/28/2022	NON-COMPETING CONTINUATION	$91,376
2022	2022	CALIFORNIA STATE UNIVERSITY SAN MARCOS CORPORATION	333 S TWIN OAKS VALLEY RD	SAN MARCOS	CA	92096	SAN DIEGO	USA	Biomedical Research and Research Training	001	2	6/15/2022	NON-COMPETING CONTINUATION	$10,153
														Subtotal = $101,529

Issue Date FY: 2021 ( Subtotal = $105,202 )
2021	2021	CALIFORNIA STATE UNIVERSITY SAN MARCOS CORPORATION	333 S TWIN OAKS VALLEY RD	SAN MARCOS	CA	92096	SAN DIEGO	USA	Biomedical Research and Research Training	001	1	5/6/2021	NEW	$0
2021	2021	CALIFORNIA STATE UNIVERSITY SAN MARCOS CORPORATION	333 S TWIN OAKS VALLEY RD	SAN MARCOS	CA	92096	SAN DIEGO	USA	Biomedical Research and Research Training	000	1	4/19/2021	NEW	$105,202
														Subtotal = $105,202

Grand Total All Awards = $430,231

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Effect of Heavy Backpack Load Carriage on Acute Blood Flow, Nerve Conduction, Biomechanics and Dexterity of the Upper Limbs

Award Number: SC3GM139683

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/19/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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