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A Periplasmic Global Regulator, ExoR,for Bacterial Invasion of Host Cells

Award Number: SC3GM081147
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2007
PERIOD OF PERFORMANCE END DATE: 03/31/2023

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A Periplasmic Global Regulator, ExoR,for Bacterial Invasion of Host Cells - DESCRIPTION (provided by applicant): Almost all host-invading bacteria have to turn on the expression of their genes required for host invasion including virulence genes at the optimal place and time for maximum effect. These bacteria rely on their sensing mechanisms to detect the presence of host-specific signals, including ionic or pH changes. Our most recent study shows that a group of 47 bacteria share a sensing mechanism, the ExoR-ExoS/ChvI (RSI) invasion switch, which is best understood in Sinorhizobium meliloti. The S. meliloti RSI invasion switch controls the expression of hundreds of bacterial genes involved in invasion and growth in symbiotic plant cells. The host specific signals for the S. meliloti RSI invasion switch, however, remain unknown. Our long-term objective is to understand how S. meliloti and its related pathogenic bacteria sense the presence of a host and create ways to block or alter the sensing mechanism for the benefit of human health. Our current research objective is to identify the host specific signals for the S. meliloti RSI invasion switch. Our recent findings have led us to focus the changes of S. meliloti cells in the infection chamber, where S. meliloti launches their invasion of host cells. This enclosed infection chamber is formed inside a curled root hair but topologically outside the root hair. Our current hypothesis is that plant growth changes ionic concentrations and pH on the root hair surface relative to the surrounding soil due to the pumping of ions in and out of root hairs. The infection chamber is topologically outside the root hair so that ionic concentrations and pH will be similarly changed from those in the soil. This hypothesis is supported by our previously published work on the molecular mechanism of the RSI model and our preliminary results showing that the RSI switch is involved in sensing ionic changes. We propose to 1) determine the ionic changes sensed by the RSI switch, and 2) determine the molecular mechanism governing RSI sensing of ionic changes. The successful completion of the proposed research will show bacterial pathogens can detect unique ionic concentrations on host surface to activate the expression of their virulence genes and provide insights on the bacterial molecular ionic sensing mechanism. Since all living organisms take up and secrete ions, our findings could impact studies of bacterial host sensing mechanisms in general.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$6,176 )
2024	2019	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD W	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	10	12/5/2023	NON-COMPETING CONTINUATION	-$6,176
														Subtotal = -$6,176

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	10	4/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	10	3/23/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $123,750 )
2019	2019	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	10	3/8/2019	NON-COMPETING CONTINUATION	$123,750
														Subtotal = $123,750

Issue Date FY: 2018 ( Subtotal = $123,750 )
2018	2018	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	9	3/5/2018	NON-COMPETING CONTINUATION	$111,375
2018	2018	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	001	9	5/11/2018	NON-COMPETING CONTINUATION	$12,375
														Subtotal = $123,750

Issue Date FY: 2017 ( Subtotal = $123,750 )
2017	2017	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	000	8	3/17/2017	NON-COMPETING CONTINUATION	$111,375
2017	2017	RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK	250 BEDFORD PARK BLVD	BRONX	NY	10468	BRONX	USA	Biomedical Research and Research Training	001	8	6/20/2017	NON-COMPETING CONTINUATION	$12,375
														Subtotal = $123,750

Issue Date FY: 2016 ( Subtotal = $123,750 )
2016	2016	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Biomedical Research and Research Training	000	7	4/1/2016	COMPETING CONTINUATION	$123,750
														Subtotal = $123,750

Issue Date FY: 2012 ( Subtotal = $121,028 )
2012	2012	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Biomedical Research and Research Training	000	6	7/30/2012	NON-COMPETING CONTINUATION	$121,028
														Subtotal = $121,028

Issue Date FY: 2011 ( Subtotal = $121,028 )
2011	2011	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Biomedical Research and Research Training	000	5	7/29/2011	NON-COMPETING CONTINUATION	$121,028
														Subtotal = $121,028

Issue Date FY: 2010 ( Subtotal = $122,250 )
2010	2010	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Biomedical Research and Research Training	001	4	9/1/2010	COMPETING CONTINUATION	$122,250
2010	2009	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Biomedical Research and Research Training	000	3	8/31/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $122,250

Issue Date FY: 2009 ( Subtotal = $257,073 )
2009	2009	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Trans-NIH Recovery Act Research Support	001	3	8/28/2009	SUPPLEMENT FOR EXPANSION	$134,823
2009	2009	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Biomedical Research and Research Training	000	3	7/24/2009	NON-COMPETING CONTINUATION	$122,250
														Subtotal = $257,073

Issue Date FY: 2008 ( Subtotal = $122,250 )
2008	2008	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Biomedical Research and Research Training	000	2	7/31/2008	NON-COMPETING CONTINUATION	$122,250
														Subtotal = $122,250

Issue Date FY: 2007 ( Subtotal = $122,250 )
2007	2007	CUNY, RESEARCH FOUNDATION	230 WEST 41ST STREET	NEW YORK	NY	10036	NEW YORK	USA	Biomedical Research and Research Training	000	1	8/17/2007	NEW	$122,250
														Subtotal = $122,250

Grand Total All Awards = $1,354,703

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A Periplasmic Global Regulator, ExoR,for Bacterial Invasion of Host Cells

Award Number: SC3GM081147

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2007

PERIOD OF PERFORMANCE END DATE: 03/31/2023

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