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Modulating Glial Fate and Function in Development and Disease

Award Number: R35NS116842
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Modulating Glial Fate and Function in Development and Disease - SUMMARY Many of the 100 billion neurons in the human central nervous system require a protective and insulating coating called myelin to function properly. Loss or damage of this myelin coating underlies many neurological disorders and therefore regeneration of new myelin is an important part of improving health for patients with multiple sclerosis (MS), neuromyelitis optica (NMO), and other myelin diseases such as the pediatric leukodystrophies. Without myelin, certain nerve cells cannot properly conduct electrical impulses, leading to weakness, fatigue, loss of vision, cognitive decline, and physical incapacity. We have developed a novel regenerative approach to identify important new potential treatments for patients with myelin loss or dysfunction that is built upon our expertise in stem cell biology. Our overall goal is to utilize the in vitro mouse and human stem cell platforms that we have developed to define the central mechanisms responsible for preventing myelin development and function across the full range of myelin disorders. We seek to discover novel therapeutic interventions that can modulate the function or regeneration of oligodendrocytes and astrocytes to restore myelination and neurological function. For multiple sclerosis, we have already defined a central mechanism to stimulate myelin regeneration and identified potent small molecules that can reverse paralysis in mouse models of disease. Moving forward, we seek to leverage our innovative technologies and experience in multiple sclerosis to identify disease- and context-specific effectors of myelin dysfunction and provide the basis for new therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $683,922 )
2025	2025	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	5/29/2025	NON-COMPETING CONTINUATION	$683,922
														Subtotal = $683,922

Issue Date FY: 2024 ( Subtotal = $663,404 )
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	5/6/2024	NON-COMPETING CONTINUATION	$663,404
														Subtotal = $663,404

Issue Date FY: 2023 ( Subtotal = $710,756 )
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/15/2023	NON-COMPETING CONTINUATION	$710,756
														Subtotal = $710,756

Issue Date FY: 2022 ( Subtotal = $764,422 )
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/31/2022	NON-COMPETING CONTINUATION	$764,422
														Subtotal = $764,422

Issue Date FY: 2021 ( Subtotal = $737,588 )
2021	2021	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/27/2021	SUPPLEMENT FOR EXPANSION	$53,666
2021	2021	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/3/2021	NON-COMPETING CONTINUATION	$683,922
														Subtotal = $737,588

Issue Date FY: 2020 ( Subtotal = $649,538 )
2020	2020	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/28/2020	NEW	$649,538
														Subtotal = $649,538

Grand Total All Awards = $4,209,630

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Modulating Glial Fate and Function in Development and Disease

Award Number: R35NS116842

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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