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DIRECTED EVOLUTION OF BIOCATALYSTS FOR ASYMMETRIC HYDROGEN ATOM TRANSFER REACTIONS

Award Number: R35GM162850
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2031

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DIRECTED EVOLUTION OF BIOCATALYSTS FOR ASYMMETRIC HYDROGEN ATOM TRANSFER REACTIONS - Project Summary The rise of biocatalysis is transforming synthetic chemistry by enabling highly selective and sustainable transformations. Despite advances, achieving precise stereocontrol in radical-mediated reactions remains a significant frontier. This interdisciplinary research program integrates expertise in organic chemistry, protein engineering, bioinorganic chemistry, and computational modeling to design and evolve enzymatic catalysts for metal-hydride-mediated radical reactions—a versatile yet historically challenging class of asymmetric transformations with broad synthetic utility. These engineered biocatalysts will unlock stereoselective olefin functionalization, enabling diverse carbon-carbon bond-forming and reductive processes without precedent in natural biochemistry. Mechanistic studies will reveal the principles behind these new enzymatic functions, enabling rational design of future biocatalysts. These biocatalysts will advance pharmaceutical synthesis and the construction of complex molecules important to human health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $420,981 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	2/27/2026	NEW	$420,981
														Subtotal = $420,981

Grand Total All Awards = $420,981

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DIRECTED EVOLUTION OF BIOCATALYSTS FOR ASYMMETRIC HYDROGEN ATOM TRANSFER REACTIONS

Award Number: R35GM162850

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2031

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