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Analysis of cis-regulation in synthetic and genomic enhancers

Award Number: R35GM161206
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Analysis of cis-regulation in synthetic and genomic enhancers - PROJECT SUMMARY A majority of heritable disease-causing variation resides in the non-coding portions of the genome. The leading hypothesis is that these variants perturb the functions of cis-regulatory elements, such as enhancers. Our field has made strong progress identifying the DNA-binding specificities of the transcription factors that comprise enhancers. Based on these specificities, the field has also made strong progress identifying enhancers in the genome. However, we still lack robust models that predict the effects of sequence variations on enhancer activities. Our hypothesis is that this lack of predictive power stems from a lack of understanding of 1) the cooperative and competitive interactions within enhancers between sites for different transcription factors, 2) the interactions between enhancers and their chromatin environments, and 3) the interactions between enhancers and their cell-type specific trans environments. We aim to identify and quantify these types of interactions with the goal of improving models that predict the effects of genetic variation on gene expression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $453,908 )
2026	2026	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Biomedical Research and Research Training	000	1	9/9/2026	NEW	$453,908
														Subtotal = $453,908

Grand Total All Awards = $453,908

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Analysis of cis-regulation in synthetic and genomic enhancers

Award Number: R35GM161206

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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