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Mechanomolecular regulation of cell division

Award Number: R35GM156188
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/23/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2029

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Mechanomolecular regulation of cell division - PROJECT SUMMARY Cell division is a physical process when the genome - distributed across the replicated chromosomes - is equally separated prior to cleavage into two daughter cells. Given its central importance to life, integrated physical and biochemical fail-safe mechanisms have evolved to make cell division a high-fidelity process. However, natural selection does not yield perfection and failures in cell division result in aneuploidy, which causes a majority of miscarriages in the first trimester, birth defects, and has been implicated in tumorigenesis and cancer metastasis. Our long-term goal is to characterize fundamental and conserved mechano-molecular mechanisms of cell divi- sion. In the proposed work, we will combine advanced live-cell imaging approaches with molecular and biochem- ical methods to advance two areas of inquiry central to successful cell division. First, we will investigate the functional contributions of extremely large intrinsically disordered regions (ELIDRs) in proteins at the kinetochore and perichromosomal layer. Second, we will study how a phenomenon called branching microtubule nucleation is regulated to promote efficient and timely capture of chromosomes by spindle microtubules. A more compre- hensive understanding of how the complex biological processes of cell division are orchestrated by mechanical and biochemical pathways will be foundational to treating diseases stemming from improper cell division.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $438,629 )
2025	2025	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Biomedical Research and Research Training	000	1	1/23/2025	NEW	$438,629
														Subtotal = $438,629

Grand Total All Awards = $438,629

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Mechanomolecular regulation of cell division

Award Number: R35GM156188

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/23/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2029

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