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Mechanistic studies of essential membrane transporters

Award Number: R35GM151970
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Mechanistic studies of essential membrane transporters - Membrane transporters are essential for cellular life and are generally understudied compared to other membrane proteins, such as GPCR and ion channels. The long-term goal is to pursue a fundamental mechanistic understanding of membrane transporters closely related to human diseases. In this proposal, the overall objective is to extend our previous research on members of human SLC and bacterial siderophore ABC importers. The rationale is that, with detailed knowledge about the structure-function relationship of these membrane transporters, it will be possible to design small molecules explicitly targeting them to have physiological effects. To accomplish the goal, we expect to pursue the following three projects: 1) understanding the substrate selectivity and promiscuity; 2) probing the connection between transporters’ unique structural features and their function; and 3) searching for small molecule inhibitors/activators of the transporters. The approach involved in this proposal is multidisciplinary, including biochemistry, structural biology, microbiology, cell biology, molecular dynamics simulation, and various methodologies of biophysics. This proposal is significant because it is expected to reveal the basic molecular mechanisms of essential membrane transporters and provide scientific justification for further development of drugs targeting these transporters.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $333,198 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Biomedical Research and Research Training	002	2	8/25/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$333,198
2025	2024	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	001	1	8/25/2025	NEW	$0
2025	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	000	1	11/6/2024	NEW	$0
														Subtotal = $333,198

Issue Date FY: 2024 ( Subtotal = $346,711 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Biomedical Research and Research Training	000	1	8/22/2024	NEW	$346,711
														Subtotal = $346,711

Grand Total All Awards = $679,909

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Mechanistic studies of essential membrane transporters

Award Number: R35GM151970

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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