Monday, February 16, 2026 2/16/2026

Function and Regulation of Stress-Induced Adaptive Condensates

Award Number: R35GM144278
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2026

Group Awards By:

View Award Description

Function and Regulation of Stress-Induced Adaptive Condensates - Project Summary A conceptual and empirical revolution is occurring in our understanding of the eukaryotic heat-shock response. Heat shock has long been conceived of as a proteotoxic stress, triggering formation of toxic aggregates of denatured proteins, which must be cleaned up by induced heat shock proteins. Recent results from our group and others have established a complementary paradigm: temperature acts as a physiological signal, triggering the adaptive formation of biomolecular condensates with specific cellular functions, and the condensation process is regulated by heat shock proteins. Crucially, in the proteotoxic model, aggregates are trash, but in the adaptive condensation model, they are functional treasure. Using an integrated set of biochemical, cell biological, and evolutionary approaches established over the past decade, we are pursuing three linked areas: 1) identifying and dissecting the cellular functions of particular heat-shock and stress-induced condensates of protein and mRNA; 2) studying the regulation of condensation and dispersal, focusing on the specificity of physiological condensates and their remodeling and reversal by stress-induced molecular chaperones; and 3) probing the sensation and transduction of temperature into adaptive responses in fungi which rely on warm-blooded hosts for growth or dispersal, and in the temperature-dependent activation of cells in the vertebrate immune system during fever. In addition to fundamental insights into the operation and organization of eukaryotic cells, these studies promise to shed light on intracellular aggregation processes known to be dysregulated during neurodegenerative disease, uncover new mechanisms for the control of fungi, and provide new molecular insight into how fever promotes immune-cell activation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $508,559 )
2026	2026	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	5	1/15/2026	SUPPLEMENT FOR EXPANSION	$97,909
2026	2026	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	5	1/6/2026	NON-COMPETING CONTINUATION	$410,650
														Subtotal = $508,559

Issue Date FY: 2025 ( Subtotal = $554,187 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	002	4	1/21/2025	SUPPLEMENT FOR EXPANSION	$97,909
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	4	12/18/2024	NON-COMPETING CONTINUATION	$410,650
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	003	4	8/5/2025	NON-COMPETING CONTINUATION	$45,628
2025	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	3	11/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $554,187

Issue Date FY: 2024 ( Subtotal = $577,178 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	3	12/28/2023	NON-COMPETING CONTINUATION	$410,650
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	3	5/21/2024	SUPPLEMENT FOR EXPANSION	$120,900
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	002	3	6/27/2024	NON-COMPETING CONTINUATION	$45,628
														Subtotal = $577,178

Issue Date FY: 2023 ( Subtotal = $456,693 )
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	2	3/23/2023	NON-COMPETING CONTINUATION	$45,669
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	2	12/29/2022	NON-COMPETING CONTINUATION	$411,024
														Subtotal = $456,693

Issue Date FY: 2022 ( Subtotal = $500,737 )
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	1	12/22/2021	NEW	$500,737
														Subtotal = $500,737

Grand Total All Awards = $2,597,354

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Function and Regulation of Stress-Induced Adaptive Condensates

Award Number: R35GM144278

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer