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Photonics-based Fluorescence Imaging for Research, Diagnostics, and Pathology

Award Number: R35GM144147
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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Photonics-based Fluorescence Imaging for Research, Diagnostics, and Pathology - Abstract - Photonics-based Fluorescence Imaging for Research, Diagnostics and Pathology During the past several decades fluorescence detection has become a central technology throughout the biosciences. The basic applications include studies of biomolecule function, properties of cell membranes and localization of target molecules in cells. The more clinical applications include immunoassays, flow cytometry, point-of-care diagnostics, genetic testing, and cell imaging by fluorescence microscopy. Fluorescence is expanding to include in-vivo measurements on brain tissues using multi-photon excitation. While fluorescence technology has advanced, it has not kept pace with the advances in electronics and array detectors (cameras). The sizes of optical components such as lenses and filters are much larger than electronic components as can be seen from a cell phone with millions of transistors, but only one or two lenses in a cell phone. This mismatch in size cannot be circumvented by making smaller lenses, filters or fiber optics. These optical components require dimensions of many wavelengths to manipulate freely propagating light. We propose to overcome this limitation by using fluorophores positioned within sub-wavelength near-field distances from the plasmonic, photonic or plasmonic multi-layer structures (MLS). We are NOT proposing to use the fluorophores as electronic components, but rather to directly couple their emission into CMOS imaging detectors with MLSs without free-space propagation of light. The MLS controls the propagation of optical energy, can separate wavelengths and can direct the energy (coupled photons) towards nearby detectors. This concept will provide the basis for new devices for research and medicine. To demonstrate the usefulness of these devices we have established collaborations with senior faculty in the School of Medicine. These collaborations include detection of weak binding in drug discovery or high throughput screening (HTS) because much of the HTS is used with drug fragments which bind weakly to target molicules. Most of the MLS retain spatial information in the x-y plane which allows either ensemble or virus particle counting assays for HIV and the Covid-19 virus SARS-CoV-2. The wide field of view will allow whole slide imaging of pathology specimens. Our goal is to develop this new area of near-field effects in fluorescence, with easy to fabricate strruvtures, to enable a new generation of instruments and devices for fluorescence detection in research, sensing and imaging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $386,250 )
2026	2026	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	001	5	3/23/2026	NON-COMPETING CONTINUATION	$38,625
2026	2026	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	5	1/26/2026	NON-COMPETING CONTINUATION	$347,625
														Subtotal = $386,250

Issue Date FY: 2025 ( Subtotal = $386,250 )
2025	2025	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	002	4	8/29/2025	NON-COMPETING CONTINUATION	$38,625
2025	2025	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	001	4	1/27/2025	NON-COMPETING CONTINUATION	$347,625
2025	2024	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	3	11/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $386,250

Issue Date FY: 2024 ( Subtotal = $386,250 )
2024	2024	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	3	1/17/2024	NON-COMPETING CONTINUATION	$347,625
2024	2024	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	001	3	6/18/2024	NON-COMPETING CONTINUATION	$38,625
														Subtotal = $386,250

Issue Date FY: 2023 ( Subtotal = $386,250 )
2023	2023	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	001	2	2/27/2023	NON-COMPETING CONTINUATION	$38,625
2023	2023	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	2	1/26/2023	NON-COMPETING CONTINUATION	$347,625
														Subtotal = $386,250

Issue Date FY: 2022 ( Subtotal = $386,250 )
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Biomedical Research and Research Training	000	1	1/5/2022	NEW	$386,250
														Subtotal = $386,250

Grand Total All Awards = $1,931,250

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Photonics-based Fluorescence Imaging for Research, Diagnostics, and Pathology

Award Number: R35GM144147

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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