Monday, February 16, 2026 2/16/2026

Exploiting Unconventional Building Blocks in Chemical Synthesis

Award Number: R35GM139593
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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Exploiting Unconventional Building Blocks in Chemical Synthesis - Project Summary/Abstract The central objective of this application is to harness unconventional synthetic building blocks for the development of new, reliable, and efficient, methodologies. These methodologies are intended to enable the construction of stereochemically-rich scaffolds, including those seen in naturally occurring small molecules and medicines. The development of new methods and the syntheses of complex small molecules continues to be vital areas of research. Most medicinal agents on the market are prepared by organic synthesis, including the large majority of all new drugs that have become available over the past several decades. The chemical structures of new drug entities are becoming increasingly complex, providing an increased need for chemists to develop new methods that can reliably build intricate structures. Our proposal involves strained intermediate chemistry, with a particular focus on pi-bond containing compounds that are geometrically distorted. The distortion leads to heightened reactivity, which we ultimately leverage to access complex scaffolds and provide new synthetic strategies. We will develop methods associated with transient intermediates that display bent geometries, such as cyclic allenes and cyclic 1,2,3- trienes, that otherwise prefer linear geometries in the acyclic form. Alkenes that are geometrically distorted from an ordinary trigonal planar geometry due to twisting or pyramidalization, including anti-Bredt olefins, will be pursued. Lastly, the scope and limitations of these methodologies will be probed in the context of enantioselective natural product synthesis. Collectively, our efforts will establish the concept that historically avoided strained intermediates that possess geometrically-distorted structures can be strategically exploited to assemble complex molecular architectures.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $583,660 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	7	1/8/2026	NON-COMPETING CONTINUATION	$583,660
														Subtotal = $583,660

Issue Date FY: 2025 ( Subtotal = $708,102 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	004	5	7/14/2025	NON-COMPETING CONTINUATION	-$232,919
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	002	5	12/31/2024	NON-COMPETING CONTINUATION	$524,067
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	005	6	7/18/2025	COMPETING CONTINUATION	$324,256
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	4	12/9/2024	SUPPLEMENT FOR EXPANSION	$13,725
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	003	5	1/2/2025	SUPPLEMENT FOR EXPANSION	$78,973
2025	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	4	11/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $708,102

Issue Date FY: 2024 ( Subtotal = $800,093 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	4	1/16/2024	NON-COMPETING CONTINUATION	$524,067
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	4	5/20/2024	NON-COMPETING CONTINUATION	$58,229
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	002	4	9/17/2024	SUPPLEMENT FOR EXPANSION	$217,797
														Subtotal = $800,093

Issue Date FY: 2023 ( Subtotal = $627,710 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	002	3	4/6/2023	NON-COMPETING CONTINUATION	$58,229
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	1/19/2023	NON-COMPETING CONTINUATION	$524,067
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	3	1/20/2023	SUPPLEMENT FOR EXPANSION	$45,414
														Subtotal = $627,710

Issue Date FY: 2022 ( Subtotal = $660,148 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	002	2	6/22/2022	NON-COMPETING CONTINUATION	$58,230
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	2	2/2/2022	NON-COMPETING CONTINUATION	$524,066
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	2	2/3/2022	SUPPLEMENT FOR EXPANSION	$77,852
														Subtotal = $660,148

Issue Date FY: 2021 ( Subtotal = $518,671 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	1	8/23/2021	SUPPLEMENT FOR EXPANSION	$32,439
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	1/20/2021	NEW	$486,232
														Subtotal = $518,671

Grand Total All Awards = $3,898,384

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Exploiting Unconventional Building Blocks in Chemical Synthesis

Award Number: R35GM139593

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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