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Defining principles shaping microbial niches in the early life gut

Award Number: R35GM138369
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2030

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Defining principles shaping microbial niches in the early life gut - PROJECT SUMMARY The microbiota is essential for human health and early life colonization by microbes is key for development and long-term fitness. Perturbations to assembly of this microbial community can have long-term consequences for the host. Moreover, disrupted community assembly can lead to outgrowth and long-term persistence of pathogens in the gut. The ecological rules that underlie establishment of a beneficial microbial community are not well understood and we still know very little about the molecular processes that govern early colonization and niche establishment by important early life microbes. Defining the fundamental principles of microbial colonization, assembly, and succession are critical to understanding what makes a healthy microbiota and will provide a roadmap for preventing the negative consequences of perturbation to this ecosystem. Here, we will i.) define the nutritional and environmental factors that shape early life microbiota colonization and assembly and ii.) determine strategies that early life colonizing pathogens use to establish a successful niche in the infant gut. This work will shed light on key axes of competition that shape the ultimate success of early colonizers and define the molecular strategies that pathogens exploit to establish niches early in life. Completion of this proposal will lead to the discovery of novel factors and molecular mechanisms shaping early life establishment of a healthy microbiome and provide new insights into previously unappreciated aspects of early life microbial ecology. Our ultimate goal is to generate a comprehensive understanding of early life ecology that will guide the creation of tools to prevent the effects of perturbation to host-microbiota homeostasis. Moreover, defining the niche space that pathogenic organisms inhabit in the early life gut will lead to innovative therapeutic strategies to prevent establishment and promote decolonization of pathogens in early life.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $489,500 )
2026	2026	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	000	6	2/16/2026	COMPETING CONTINUATION	$489,500
														Subtotal = $489,500

Issue Date FY: 2024 ( Subtotal = $440,000 )
2024	2024	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	000	5	7/1/2024	NON-COMPETING CONTINUATION	$440,000
														Subtotal = $440,000

Issue Date FY: 2023 ( Subtotal = $440,000 )
2023	2023	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	000	4	7/20/2023	NON-COMPETING CONTINUATION	$440,000
														Subtotal = $440,000

Issue Date FY: 2022 ( Subtotal = $440,000 )
2022	2022	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	000	3	7/27/2022	NON-COMPETING CONTINUATION	$440,000
2022	2022	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	001	3	8/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $440,000

Issue Date FY: 2021 ( Subtotal = $440,000 )
2021	2021	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	000	2	7/16/2021	NON-COMPETING CONTINUATION	$440,000
														Subtotal = $440,000

Issue Date FY: 2020 ( Subtotal = $440,000 )
2020	2020	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Biomedical Research and Research Training	000	1	8/24/2020	NEW	$440,000
														Subtotal = $440,000

Grand Total All Awards = $2,689,500

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Defining principles shaping microbial niches in the early life gut

Award Number: R35GM138369

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2030

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