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 | Issue Date FY: 2025 ( Subtotal = $153,760,137 ) (Continued on the next page) |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR083552 | Addressing the Research Gap in Mitochondrial Myopathy with Validated Outcome Measures and Natural History | 000 | 2 | NIH | 8/4/2025 | $590,378 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK118155 | Intersection of signaling pathways and transcription factors regulating islet development | 003 | 7 | NIH | 7/3/2025 | $62,635 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK118155 | Intersection of signaling pathways and transcription factors regulating islet development | 002 | 7 | NIH | 5/28/2025 | $89,208 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK118155 | Intersection of signaling pathways and transcription factors regulating islet development | 001 | 7 | NIH | 12/12/2024 | $563,705 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | P20DK140504 | Personalizing Outcomes of Nephrolithiasis in Youth (PONY) | 000 | 2 | NIH | 4/18/2025 | $391,028 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21AI185720 | Identifying cellular proteins associated with AAV genomes | 000 | 2 | NIH | 5/22/2025 | $205,330 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R35GM151087 | Developing C. elegans as a model to understand tRNA-fragment biogenesis and function | 000 | 3 | NIH | 6/4/2025 | $445,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R35GM119465 | Unraveling mechanisms of genome regulation to understand and improvehuman health | 002 | 10 | NIH | 7/1/2025 | $445,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08CA277013 | Optimizing outcomes for children and young adults with relapse of B-cell acute lymphoblastic leukemia after CD19-targeted chimeric antigen receptor T-cell therapy | 000 | 3 | NIH | 2/14/2025 | $180,885 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08CA286762 | Calming the Cytokine Storm: Unraveling the Biology of CRS and ICANS | 000 | 2 | NIH | 6/9/2025 | $248,509 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR083245 | FGFR3 Activities in the Control of Skeletal Growth | 000 | 2 | NIH | 3/5/2025 | $646,442 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08AI193172 | From inhibitors to enzymatic deficiencies: exploring alterations in erythrocyte glycolysis as an antimalarial strategy. | 000 | 1 | NIH | 7/7/2025 | $187,056 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08HL177281 | Dysregulation of transcription factors and chromatin architecture in Trisomy 21 hematopoietic disorders | 000 | 1 | NIH | 8/13/2025 | $158,976 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL179221 | Proteolytic Regulation of Factor VIII Before and After Activation | 000 | 1 | NIH | 8/13/2025 | $636,982 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL160748 | Preserving Genome Integrity In AAV-Mediated Gene Therapy | 001 | 4 | NIH | 8/14/2025 | $64,523 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HD117422 | Pediatric Acute Respiratory distress syndrome MAnagement (PARMA) | 000 | 1 | NIH | 8/15/2025 | $767,069 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL160748 | Preserving Genome Integrity In AAV-Mediated Gene Therapy | 000 | 4 | NIH | 2/28/2025 | $580,716 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21DE034541 | Role of hyaluronan in YAP signaling on TMJ health and pathology | 000 | 1 | NIH | 6/25/2025 | $507,006 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R03HD119150 | Optimizing Usability, Generalizability, and Impact of CAPNET Multicenter Child Abuse Research Network Data | 000 | 1 | NIH | 7/29/2025 | $178,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL177014 | Endothelial cell targeting of factor VIII for hemophilia A | 000 | 1 | NIH | 7/29/2025 | $888,836 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA237562 | Elucidating the role of the noncoding genome in neuroblastoma | 001 | 5 | NIH | 5/21/2025 | $40,260 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA237562 | Elucidating the role of the noncoding genome in neuroblastoma | 000 | 5 | NIH | 3/14/2025 | $362,340 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K23HL177271 | Developing a framework for designing the next generation of pediatric ARDS trials | 000 | 1 | NIH | 7/23/2025 | $180,174 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | F32DE035372 | Microfracture-based Repair for Temporomandibular Joint Osteoarthritis | 000 | 1 | NIH | 7/22/2025 | $78,840 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL180443 | Origins of neonatal lung myofibroblasts | 001 | 1 | NIH | 8/12/2025 | -$594,583 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL180443 | Origins of neonatal lung myofibroblasts | 001 | 1 | NIH | 8/12/2025 | $594,583 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL180443 | Origins of neonatal lung myofibroblasts | 000 | 1 | NIH | 8/5/2025 | $594,583 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | OT2OD037960 | Multimodal machine learning for diagnosis and mechanistic phenotyping of inherited diseases | 000 | 1 | NIH | 6/6/2025 | $1,156,956 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K23NS140491 | Outcome measures and quantitative EEG biomarkers in SYNGAP1-related disorders | 000 | 1 | NIH | 7/31/2025 | $220,050 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08HL173625 | Air pollution sensitivity in pediatric asthma | 000 | 1 | NIH | 8/7/2025 | $135,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA258524 | Tracking Peripheral T-Cell Repertoire Changes for Preoperative and Early Ovarian Cancer Diagnosis | 001 | 5 | NIH | 5/22/2025 | $83,785 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR061758 | Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome | 001 | 14 | NIH | 5/19/2025 | $27,104 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA258524 | Tracking Peripheral T-Cell Repertoire Changes for Preoperative and Early Ovarian Cancer Diagnosis | 000 | 5 | NIH | 2/12/2025 | $754,071 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR061758 | Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome | 000 | 14 | NIH | 3/14/2025 | $348,480 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R00HL177827 | Determining genetic mechanisms that drive in vitro hematopoiesis | 000 | 1 | NIH | 7/15/2025 | $445,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA248501 | Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma | 001 | 5 | NIH | 5/22/2025 | $39,500 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HD114705 | Comprehensive identification and functional study of Esrp-regulated isoforms during epithelial-mesenchymal transition. | 000 | 1 | NIH | 3/12/2025 | $763,886 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA248501 | Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma | 000 | 5 | NIH | 2/13/2025 | $355,506 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01NS144826 | Neurological pathophysiology of disrupted O-glycosylation in congenital disorders of glycosylation | 000 | 1 | NIH | 7/31/2025 | $719,498 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | F32HL175927 | Role of dietary fatty acids in shaping lung macrophage homeostasis and inflammatory function | 000 | 1 | NIH | 8/1/2025 | $75,520 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K23HD119673 | Neurocognitive Outcomes and the Trajectory of Recovery One-year After Pediatric Sepsis | 000 | 1 | NIH | 8/11/2025 | $181,438 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | P01CA217959 | Discovering and Exploiting Mechanisms of Neuroblastoma Therapy Resistance | 001 | 7 | NIH | 3/28/2025 | $2,202,503 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R25HD118212 | PARTNERS: Program to Advance Research and Transdisciplinary TraiNing in the CarE of PeRsons with Down Syndrome | 001 | 1 | NIH | 8/13/2025 | -$1,188,561 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA271523 | Novel Regulation of Oncogenic NRAS Signaling in Myeloid Malignancies | 001 | 4 | NIH | 5/22/2025 | $54,731 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R25HD118212 | PARTNERS: Program to Advance Research and Transdisciplinary TraiNing in the CarE of PeRsons with Down Syndrome | 000 | 1 | NIH | 8/1/2025 | $1,921,102 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA271523 | Novel Regulation of Oncogenic NRAS Signaling in Myeloid Malignancies | 000 | 4 | NIH | 3/14/2025 | $492,582 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA273328 | Re-Engaging AYA Survivors in Cancer-Related Healthcare (REACH): A Sequential Multiple Assignment Randomized Trial (SMART) | 001 | 3 | NIH | 5/22/2025 | $71,238 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA273328 | Re-Engaging AYA Survivors in Cancer-Related Healthcare (REACH): A Sequential Multiple Assignment Randomized Trial (SMART) | 000 | 3 | NIH | 3/14/2025 | $641,163 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI187174 | Defining the role of enterococci in reshaping Clostridioides difficile infection | 000 | 1 | NIH | 7/25/2025 | $812,200 |
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