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 | Issue Date FY: 2025 ( Subtotal = $43,187,708 ) (Continued on the next page) |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI187202 | Chronic STAT3 signaling in STAT3 GOF causes CD8 T cell dysfunction via CD39 upregulation | 000 | 1 | NIH | 12/20/2024 | $658,426 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R03CA293992 | Long-read, single-cell RNA sequencing of high-risk neuroblastoma samples | 001 | 1 | NIH | 12/26/2024 | $0 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08AI182477 | Modeling and prediction of allergic trajectories in children | 000 | 1 | NIH | 12/4/2024 | $151,444 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R03CA287169 | Identification and characterization of genetic risk factors in pediatric brain tumors | 000 | 2 | NIH | 11/25/2024 | $178,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | F32DA062486 | Targeting Dentate Gyrus to Disrupt Fentanyl-Linked Context Memories | 001 | 1 | NIH | 12/16/2024 | $0 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA258524 | Tracking Peripheral T-Cell Repertoire Changes for Preoperative and Early Ovarian Cancer Diagnosis | 000 | 5 | NIH | 2/12/2025 | $754,071 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R03CA293992 | Long-read, single-cell RNA sequencing of high-risk neuroblastoma samples | 002 | 1 | NIH | 1/27/2025 | $0 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HD100421 | Effects of Sleep on Bone Density and Strength in Adolescence: A Prospective Longitudinal Study | 000 | 5 | NIH | 1/21/2025 | $586,448 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH122465 | Sustainment of Mental Health Supports in Under-Resourced Urban Schools | 000 | 5 | NIH | 1/28/2025 | $647,682 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH125958 | Optimized Affective Computing Measures of Social Processes and Negative Valence in Youth Psychopathology | 000 | 5 | NIH | 1/21/2025 | $695,590 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HS029500 | Implementing vancomycin-sparing regimens in preterm infants | 000 | 2 | AHRQ | 1/22/2025 | $244,080 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI184976 | Genetic determinates of SPI1 expression and activity in human germinal center B cells | 000 | 1 | NIH | 2/1/2025 | $820,623 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH136706 | Linking mitochondrial and synaptic weakness to schizophrenia | 000 | 2 | NIH | 1/23/2025 | $552,074 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | F32DA062486 | Targeting Dentate Gyrus to Disrupt Fentanyl-Linked Context Memories | 000 | 1 | NIH | 12/16/2024 | $76,756 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL164536 | Decellularized cartilage and progenitor cells for laryngotracheal reconstruction | 000 | 1 | NIH | 1/23/2025 | $772,400 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01NS119977 | Pathomechanisms of SCN3A-related neurodevelopmental disorder | 000 | 5 | NIH | 11/20/2024 | $466,472 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01NS110869 | Interneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndrome | 001 | 6 | NIH | 12/18/2024 | $645,791 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U01TR005355 | Personalized prime editing as a platform for hepatic inborn errors of metabolism | 000 | 1 | NIH | 11/27/2024 | $1,427,560 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R03CA293992 | Long-read, single-cell RNA sequencing of high-risk neuroblastoma samples | 000 | 1 | NIH | 12/16/2024 | $178,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH134965 | 2/2 - Neurodevelopmental Trajectories in 22q11.2 Deletion Syndrome in Adolescence and Young Adulthood | 000 | 2 | NIH | 12/10/2024 | $411,666 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH107506 | A longitudinal study of brain development in children with autism | 001 | 8 | NIH | 11/15/2024 | $68,484 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI182049 | The B22 family of orthopoxvirus virulence factors: Investigating structure/function of these potent, multifaceted immunoevasins | 000 | 2 | NIH | 12/10/2024 | $719,964 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K23HL151381 | Leveraging implementation and behavioral science to reduce harmful overuse of diagnostic testing in critically ill children | 000 | 5 | NIH | 12/10/2024 | $175,519 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K23HL161309 | Understanding longitudinal microbiome change in relation to immunologic outcomes in pediatric SCT recipients. | 000 | 4 | NIH | 12/10/2024 | $185,652 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21AI182619 | Potent Signal 1 as a noncanonical Signal 3: antigen location, and peptide:MHCII complex density and half-life as drivers of CD4+ T cell differentiation | 000 | 1 | NIH | 11/21/2024 | $267,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI179680 | The molecular circuits controlling human T follicular regulatory cell development | 000 | 1 | NIH | 12/9/2024 | $781,685 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R03CA293992 | Long-read, single-cell RNA sequencing of high-risk neuroblastoma samples | 003 | 1 | NIH | 3/3/2025 | $0 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH133843 | Precision brain charts for imaging-genomics of schizophrenia and the psychosis spectrum | 000 | 3 | NIH | 3/11/2025 | $663,129 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI103280 | MEP pathway resistance in Plasmodium falciparum | 000 | 13 | NIH | 3/11/2025 | $452,870 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK133453 | Leveraging early-life microbes to prevent type 1 diabetes | 000 | 3 | NIH | 3/3/2025 | $658,400 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK134717 | Vitamin D control of calorie allocation to muscle | 000 | 3 | NIH | 2/17/2025 | $458,947 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | F32MH135724 | HIV and ART Disruptions in Glial Cell Lipid Metabolism and its Effect on Adolescent Myelination | 000 | 2 | NIH | 3/6/2025 | $84,592 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR083245 | FGFR3 Activities in the Control of Skeletal Growth | 000 | 2 | NIH | 3/5/2025 | $646,442 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01NS082046 | Normal and Pathological Function of the Dentate Gyrus | 001 | 13 | NIH | 3/26/2025 | $511,249 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH129970 | Behavioral pattern separation: orchestration by lateral entorhinal cortex-hippocampal circuitry | 000 | 3 | NIH | 3/27/2025 | $601,308 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R61NS130216 | Development of Translatable Neurophysiological Biomarkers to Accelerate Therapeutic Development in Rett Syndrome | 000 | 3 | NIH | 3/26/2025 | $701,399 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21DK139507 | Implications of gastrointestinal motility and diet on irritable bowel syndrome associated symptoms | 001 | 1 | NIH | 3/5/2025 | $0 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21AI182619 | Potent Signal 1 as a noncanonical Signal 3: antigen location, and peptide:MHCII complex density and half-life as drivers of CD4+ T cell differentiation | 001 | 1 | NIH | 2/20/2025 | -$267,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21AI182619 | Potent Signal 1 as a noncanonical Signal 3: antigen location, and peptide:MHCII complex density and half-life as drivers of CD4+ T cell differentiation | 001 | 1 | NIH | 2/20/2025 | $267,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA271523 | Novel Regulation of Oncogenic NRAS Signaling in Myeloid Malignancies | 000 | 4 | NIH | 3/14/2025 | $492,582 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA269788 | IDP mediated transcriptional stabilization as a cause of AML | 000 | 4 | NIH | 3/14/2025 | $212,790 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA237562 | Elucidating the role of the noncoding genome in neuroblastoma | 000 | 5 | NIH | 3/14/2025 | $362,340 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR061758 | Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome | 000 | 14 | NIH | 3/14/2025 | $348,480 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA273328 | Re-Engaging AYA Survivors in Cancer-Related Healthcare (REACH): A Sequential Multiple Assignment Randomized Trial (SMART) | 000 | 3 | NIH | 3/14/2025 | $641,163 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | F32AR085486 | Skeletal Patterning Orchestrated by RUNX2 and RUNX3 | 000 | 1 | NIH | 3/13/2025 | $73,828 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HD114705 | Comprehensive identification and functional study of Esrp-regulated isoforms during epithelial-mesenchymal transition. | 000 | 1 | NIH | 3/12/2025 | $763,886 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R00HL177830 | NET stabilization: mechanistic and therapeutic studies studying the role of NETs in thromboinflammatory disease | 000 | 1 | NIH | 3/17/2025 | $445,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA262260 | A stalled chromatin regulatory network that mediates the oncogenic activity of Meningioma-1 | 000 | 4 | NIH | 3/18/2025 | $394,632 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HG013355 | Utilizing long-read sequencing to resolve inconclusive diagnoses and uncertainty in genetic testing | 000 | 2 | NIH | 3/20/2025 | $400,500 |
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