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 | Issue Date FY: 2025 ( Subtotal = $86,366,212 ) (Continued on the next page) |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH125958 | Optimized Affective Computing Measures of Social Processes and Negative Valence in Youth Psychopathology | 000 | 5 | NIH | 1/21/2025 | $695,590 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08DK128606 | Novel gene discovery in disorders of the liver and biliary tree | 000 | 4 | NIH | 11/1/2024 | $163,836 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R61NS135584 | Database Harmonization for Creation and Validation of Outcome Assessments and Prediction Tools for Metachromatic Leukodystrophy (MLD) | 000 | 1 | NIH | 5/26/2025 | $1,049,035 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U01DK135002 | Assessing Diabetes Risk Origins in Teens (ADROIT) | 000 | 3 | NIH | 2/14/2025 | $749,173 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | F32MH135724 | HIV and ART Disruptions in Glial Cell Lipid Metabolism and its Effect on Adolescent Myelination | 000 | 2 | NIH | 3/6/2025 | $84,592 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI184976 | Genetic determinates of SPI1 expression and activity in human germinal center B cells | 000 | 1 | NIH | 2/1/2025 | $820,623 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK133453 | Leveraging early-life microbes to prevent type 1 diabetes | 002 | 3 | NIH | 6/12/2025 | $73,156 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK133453 | Leveraging early-life microbes to prevent type 1 diabetes | 000 | 3 | NIH | 3/3/2025 | $658,400 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH122465 | Sustainment of Mental Health Supports in Under-Resourced Urban Schools | 000 | 5 | NIH | 1/28/2025 | $647,682 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R61NS130216 | Development of Translatable Neurophysiological Biomarkers to Accelerate Therapeutic Development in Rett Syndrome | 000 | 3 | NIH | 3/26/2025 | $701,399 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DE032332 | Functional analysis of ESRP1/2 and CTNND1 gene variants in orofacial cleft | 001 | 3 | NIH | 5/7/2025 | $61,330 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DE032332 | Functional analysis of ESRP1/2 and CTNND1 gene variants in orofacial cleft | 000 | 3 | NIH | 1/17/2025 | $551,976 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI147118 | Mechanobiology of the immune synapse: signal integration via actin dynamics | 000 | 9 | NIH | 11/1/2024 | $413,263 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U24NS131172 | GLIA-CTN Genomic Expert Curation Panel | 000 | 3 | NIH | 6/27/2025 | $359,546 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U19NS132301 | Replication study of in vivo postnatal gene editing for metabolic liver disease in the nonhuman primate model | 000 | 2 | NIH | 5/6/2025 | $29,667 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08CA286762 | Calming the Cytokine Storm: Unraveling the Biology of CRS and ICANS | 000 | 2 | NIH | 6/9/2025 | $248,509 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | P20DK140504 | Personalizing Outcomes of Nephrolithiasis in Youth (PONY) | 000 | 2 | NIH | 4/18/2025 | $391,028 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08CA277013 | Optimizing outcomes for children and young adults with relapse of B-cell acute lymphoblastic leukemia after CD19-targeted chimeric antigen receptor T-cell therapy | 000 | 3 | NIH | 2/14/2025 | $180,885 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21AI185720 | Identifying cellular proteins associated with AAV genomes | 000 | 2 | NIH | 5/22/2025 | $205,330 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R35GM151087 | Developing C. elegans as a model to understand tRNA-fragment biogenesis and function | 000 | 3 | NIH | 6/4/2025 | $445,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK118155 | Administrative supplement for Intersection of signaling pathways and transcription factors regulating islet development | 002 | 7 | NIH | 5/28/2025 | $89,208 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK118155 | Administrative supplement for Intersection of signaling pathways and transcription factors regulating islet development | 001 | 7 | NIH | 12/12/2024 | $563,705 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH136706 | Linking mitochondrial and synaptic weakness to schizophrenia | 000 | 2 | NIH | 1/23/2025 | $552,074 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL162715 | Impact of Obesity on Lung Macrophage Metabolism and Inflammation | 000 | 3 | NIH | 11/26/2024 | $540,803 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01NS120099 | INJURY-INDUCED SPATIAL MEMORY IMPAIRMENTS ARE LINKED TO UNCOORDINATED HIPPOCAMPAL NEURONAL FIRING | 000 | 4 | NIH | 11/29/2024 | $396,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK134585 | Resolving Uncertainty in Alagille Syndrome Diagnostics | 000 | 3 | NIH | 6/17/2025 | $616,391 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R00DA051315 | Neurometabolic profile of tobacco smoking in HIV-infected Individuals | 000 | 5 | NIH | 6/26/2025 | $249,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08HD111688 | Comprehensive Pediatric Phenotyping for Evidence-Based Diagnosis in Genetic Disease | 000 | 3 | NIH | 5/1/2025 | $148,824 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | DP2AI164319 | Engineering synthetic cellular crosstalk for transplantation tolerance | 000 | 4 | NIH | 1/17/2025 | $527,222 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH134965 | 2/2 - Neurodevelopmental Trajectories in 22q11.2 Deletion Syndrome in Adolescence and Young Adulthood | 000 | 2 | NIH | 12/10/2024 | $411,666 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | P30HS029755 | PEDSnet Scholars: A National Pediatric Learning Health System Embedded Scientist Training and Research Program | 000 | 2 | AHRQ | 12/23/2024 | $973,541 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R34MH132718 | Implementation strategies for caregiver and teacher use of behavioral interventions with ADHD: A pilot study | 000 | 2 | NIH | 5/28/2025 | $264,065 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R33GM146159 | Pediatric Sepsis Biorepository and Clinical Database | 000 | 4 | NIH | 4/11/2025 | $694,755 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21TR005192 | RepSox and its analog for prophylactic intervention in RUNX1 haploinsufficiency FPDMM | 000 | 1 | NIH | 6/4/2025 | $489,500 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL119479 | Regulation of Hemoglobin Switching | 001 | 12 | NIH | 2/28/2025 | $614,926 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R25TR005269 | Predoctoral Preparatory Program (P3) in Translational Research | 000 | 2 | NIH | 4/1/2025 | $98,855 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL168066 | Multidimensional phenotype classification in grade 3 BPD | 001 | 3 | NIH | 6/10/2025 | $838,922 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | NU65PS923759 | The Adolescent Initiative Mobile Health Team | 00 | 4 | CDC | 4/2/2025 | $400,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | T7700012 | TRAINING BEHAVIORAL PEDIATRICIANS: THE MCHB/PA | 00 | 32 | HRSA | 6/17/2025 | $283,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HD114705 | Comprehensive identification and functional study of Esrp-regulated isoforms during epithelial-mesenchymal transition. | 000 | 1 | NIH | 3/12/2025 | $763,886 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR083245 | FGFR3 Activities in the Control of Skeletal Growth | 001 | 2 | NIH | 5/7/2025 | $50,279 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR083245 | FGFR3 Activities in the Control of Skeletal Growth | 000 | 2 | NIH | 3/5/2025 | $646,442 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL160748 | Preserving Genome Integrity In AAV-Mediated Gene Therapy | 000 | 4 | NIH | 2/28/2025 | $580,716 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA248501 | Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma | 001 | 5 | NIH | 5/22/2025 | $39,500 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA248501 | Mechanistic biomarkers to enable Bcl2 inhibitor therapies for neuroblastoma | 000 | 5 | NIH | 2/13/2025 | $355,506 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR061758 | Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome | 001 | 14 | NIH | 5/19/2025 | $27,104 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AR061758 | Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome | 000 | 14 | NIH | 3/14/2025 | $348,480 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA258524 | Tracking Peripheral T-Cell Repertoire Changes for Preoperative and Early Ovarian Cancer Diagnosis | 001 | 5 | NIH | 5/22/2025 | $83,785 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA258524 | Tracking Peripheral T-Cell Repertoire Changes for Preoperative and Early Ovarian Cancer Diagnosis | 000 | 5 | NIH | 2/12/2025 | $754,071 |
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