| | | | | | | | | | | | | | | | |
| | |
 | Issue Date FY: 2025 ( Subtotal = $3,820,604 ) (Continued on the next page) |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK112955 | Repurposing rifampin to reduce elevated levels of blood and urine calcium in patients with inactivating mutations of CYP24A1 | 000 | 8 | NIH | 11/20/2024 | $657,228 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI172841 | Pathogenicity of the emerging pathogen Kingella kingae | 000 | 3 | NIH | 10/31/2024 | $445,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH107506 | A longitudinal study of brain development in children with autism | 001 | 8 | NIH | 11/15/2024 | $68,484 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH107506 | A longitudinal study of brain development in children with autism | 000 | 8 | NIH | 11/12/2024 | $75,426 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08DK128606 | Novel gene discovery in disorders of the liver and biliary tree | 000 | 4 | NIH | 11/1/2024 | $163,836 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI147118 | Mechanobiology of the immune synapse: signal integration via actin dynamics | 000 | 9 | NIH | 11/1/2024 | $413,263 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL162715 | Impact of Obesity on Lung Macrophage Metabolism and Inflammation | 000 | 3 | NIH | 11/26/2024 | $540,803 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01NS120099 | INJURY-INDUCED SPATIAL MEMORY IMPAIRMENTS ARE LINKED TO UNCOORDINATED HIPPOCAMPAL NEURONAL FIRING | 000 | 4 | NIH | 11/29/2024 | $396,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R03CA287169 | Identification and characterization of genetic risk factors in pediatric brain tumors | 000 | 2 | NIH | 11/25/2024 | $178,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U01TR005355 | Personalized prime editing as a platform for hepatic inborn errors of metabolism | 000 | 1 | NIH | 11/27/2024 | $1,427,560 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01NS119977 | Pathomechanisms of SCN3A-related neurodevelopmental disorder | 000 | 5 | NIH | 11/20/2024 | $466,472 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21AI182619 | Potent Signal 1 as a noncanonical Signal 3: antigen location, and peptide:MHCII complex density and half-life as drivers of CD4+ T cell differentiation | 000 | 1 | NIH | 11/21/2024 | $267,000 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08AI151265 | Functions for novel IL-15-responsive macrophages in the uterus during pregnancy | 000 | 5 | NIH | 11/14/2024 | $185,328 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI187335 | Manipulation of the DNA damage response and the proteome on viral genomes during Herpes Simplex Virus (HSV) infection | 000 | 1 | NIH | 11/14/2024 | $651,832 |
| | 2025 | 2025 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01AI181999 | Cul5 regulates lung ILC2 cells during helminth infection | 000 | 1 | NIH | 11/14/2024 | $659,341 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA283058 | The interface of transcription, DNA damage and epigenetics: A therapeutic vulnerability of the EWS-FLI1 transcription factor | 000 | 2 | NIH | 11/5/2024 | -$429,113 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01DK118155 | Intersection of signaling pathways and transcription factors regulating islet development | 000 | 6 | NIH | 10/18/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K23MH119976 | Health Coaching to Improve Comprehensive HIV and Sexually Transmitted Infection Prevention in Adolescent Primary Care | 000 | 5 | NIH | 10/24/2024 | -$58,495 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | RL1HD107777 | Collaborative Pediatric Critical Care Research Network - Clinical Site | 000 | 4 | NIH | 10/11/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08DK131253 | Dissecting the mechanisms behind biphasic beta cell disease caused by mutations in HNF1alpha | 000 | 4 | NIH | 10/9/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | H9E53192 | Transition for Youth with Autism and/or Epilepsy Demonstration Projects | 01 | 1 | HRSA | 11/8/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | NU65PS923759 | The Adolescent Initiative Mobile Health Team | 01 | 3 | CDC | 10/3/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | M0131292 | Behavioral Health Workforce Education and Training (BHWET) Program | 01 | 8 | HRSA | 10/18/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U2CHL156291 | Integrating Imaging-based Infrastructure into the INCLUDE Data Hub | 000 | 5 | NIH | 11/26/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL168066 | Multidimensional phenotype classification in grade 3 BPD | 000 | 2 | NIH | 11/28/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | UG1HD104252 | HEAL Initiative: Antenatal Opioid Exposure Longitudinal Study Consortium | 000 | 2 | NIH | 11/20/2024 | $1 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R35GM134863 | Mitochondrial respiratory chain disease mechanistic and therapeutic modeling | 000 | 5 | NIH | 11/8/2024 | $0 |
| | 2025 | 2024 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01CA275767 | PET Biomarker for synaptic density changes after radiation therapy | 000 | 1 | NIH | 11/13/2024 | $0 |
| | 2025 | 2023 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MH118327 | Predicting Autism and Social Functioning from Computer Vision Analyses of Motor Synchrony During Dyadic Interactions | 000 | 5 | NIH | 11/11/2024 | $0 |
| | 2025 | 2023 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R03TR004604 | Mechanistic and Therapeutic Studies using a Xenotransplanted RUNX1-Haploinsufficient Murine Model | 000 | 1 | NIH | 10/25/2024 | -$7 |
| | 2025 | 2023 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL054926 | Reactive Species in Vascular Disease: Mechanisms of Injury | 000 | 24 | NIH | 10/24/2024 | $0 |
| | 2025 | 2023 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL163798 | Socio-ecological factors linked to co-occurring early childhood sleep health disparities and developmental outcomes | 001 | 2 | NIH | 10/27/2024 | -$796,115 |
| | 2025 | 2023 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | NU65PS923759 | The Adolescent Initiative Mobile Health Team | 01 | 3 | CDC | 10/3/2024 | $0 |
| | 2025 | 2023 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R13HD113378 | Precision Rehabilitation Research for Children with Neuromotor Conditions (APTA Academy of Pediatric Physical Therapy Research Summit 6) | 000 | 1 | NIH | 11/27/2024 | $0 |
| | 2025 | 2023 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U01HG011175 | Utilizing Polygenic Risk to Understand and Improve Outcomes: A Model For Overturning Health Disparities Through Minority-Enriched Genomics Healthcare | 000 | 4 | NIH | 11/22/2024 | $0 |
| | 2025 | 2023 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | T32DK101371 | Training Program in the Genetic Basis of Pediatric Gastrointestinal Disorders | 000 | 10 | NIH | 11/19/2024 | -$42,143 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R33HL151253 | Positive Airway Pressure For The Treatment Of The Obstructive Sleep Apnea Syndrome In Children With Down Syndrome | 001 | 4 | NIH | 11/4/2024 | -$1,029,494 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21HG011912 | Integration of multimodal cancer predisposition genetic counseling practices within the pediatric oncology setting | 000 | 2 | NIH | 11/6/2024 | $0 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R21NS123477 | Reverse transcriptase inhibition as a novel therapeutic approach for ADAR-1-related Aicardi Goutières Syndrome | 000 | 1 | NIH | 10/22/2024 | $0 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01HL163798 | Socio-ecological factors linked to co-occurring early childhood sleep health disparities and developmental outcomes | 000 | 1 | NIH | 10/27/2024 | -$306,608 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MD011598 | Reducing Disparities in Early Intervention Use: The Opening Doors to Early Intervention Study | 001 | 5 | NIH | 10/10/2024 | $0 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R01MD011598 | Reducing Disparities in Early Intervention Use: The Opening Doors to Early Intervention Study | 000 | 5 | NIH | 10/10/2024 | $0 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U01CA232563 | Cassette exons in neoplastic pro-B-cells: implications for immunotherapy | 000 | 1 | NIH | 10/17/2024 | -$12 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | NU65PS923759 | The Adolescent Initiative Mobile Health Team | 01 | 3 | CDC | 10/3/2024 | $0 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | U79SM080048 | Center for Pediatric Traumatic Stress (CPTS) | 000 | 5 | SAMHSA | 11/13/2024 | -$860 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K24HL143281 | Midcareer Investigator Award in Patient-Oriented Research in Pediatric Rare Lung Diseases | 000 | 5 | NIH | 11/27/2024 | $0 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08CA273531 | Elucidating Critical Dependencies Underlying Therapeutic Evasion in Philadelphia Chromosome-like Acute Lymphoblastic Leukemia | 000 | 1 | NIH | 11/21/2024 | -$27,344 |
| | 2025 | 2022 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | K08DK120934 | Defining the role of CRH-expressing neurons in Barrington's Nucleus (BN) and Characterizing the other neuronal subpopulations in BN | 000 | 4 | NIH | 11/13/2024 | $0 |
| | 2025 | 2021 | THE CHILDREN'S HOSPITAL OF PHILADELPHIA | 3401 CIVIC CENTER BLVD | PHILADELPHIA | PA | 19104-4319 | PHILADELPHIA | USA | R33HL151253 | Positive Airway Pressure For The Treatment Of The Obstructive Sleep Apnea Syndrome In Children With Down Syndrome | 002 | 3 | NIH | 11/4/2024 | -$1,207 |
|
