Wednesday, July 2, 2025 7/2/2025

Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape Change

Award Number: R35GM135160
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2029

Group Awards By:

View Award Description

Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape Change - PROJECT SUMMARY TRIM9 and TRIM67 are brain- and cancer-enriched E3 ubiquitin ligases implicated in neurodevelopment, neuronal function and maintenance, and cancer. The overarching long-term goal of this research program is to define how TRIM9 and TRIM67 promote cellular shape change in developing neurons and migrating melanoma. Specifically, we are studying shape change in the context of neuronal morphogenesis and function, and melanoma cell motility and metastasis. TRIM9 and TRIM67 are situated at the interface of receptors for the extracellular guidance cue netrin, cytoskeletal remodeling proteins, and membrane trafficking proteins. The amalgamation of our published, preprinted, and preliminary data indicates that TRIM9 and TRIM67 are potent regulators of the cytoskeleton, membrane remodeling in response to netrin. We hypothesize these functions converge upon the diverse cell shape changes in developing neurons and migrating melanoma. Our studies support the hypothesis that the ligases function via nondegradative ubiquitination, a vastly understudied post- translational modification. More work is needed to confirm the broad relevance of this modification and to define the mechanisms by which TRIM9 and TRIM67 function in neurons and in melanoma. The uniqueness and conceptual innovation of this research program includes investigating brain-enriched E3 ubiquitin ligases in neurons and cancer, discovering nondegradative functions of ubiquitin that provide rapid, reversible regulation, and identifying mechanisms connecting netrin receptors to diverse cellular shape changes. We will continue to exploit TRIM9 and TRIM67 as a handle to define mechanisms of cellular shape change in developing neurons and migrating melanoma. Overarching questions and hypotheses are presented in themes of regulation of A) the cytoskeleton and adhesion, B) membrane remodeling, and C) receptors and signaling pathways. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $443,311 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	003	6	1/17/2025	COMPETING CONTINUATION	$443,311
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	006	6	5/15/2025	COMPETING CONTINUATION	$30,830
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	5	1/9/2025	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	5	11/5/2024	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	004	5	5/15/2025	NON-COMPETING CONTINUATION	-$28,545
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	5	1/9/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	005	5	5/15/2025	SUPPLEMENT FOR EXPANSION	-$2,284
														Subtotal = $443,311

Issue Date FY: 2024 ( Subtotal = $410,714 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	5	6/24/2024	NON-COMPETING CONTINUATION	$38,027
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	5	12/21/2023	SUPPLEMENT FOR EXPANSION	$30,433
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	5	11/17/2023	NON-COMPETING CONTINUATION	$342,254
														Subtotal = $410,714

Issue Date FY: 2023 ( Subtotal = $361,298 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	4	3/21/2023	NON-COMPETING CONTINUATION	$38,027
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	4	11/29/2022	NON-COMPETING CONTINUATION	$342,254
2023	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	3	1/30/2023	SUPPLEMENT FOR EXPANSION	-$18,983
														Subtotal = $361,298

Issue Date FY: 2022 ( Subtotal = $424,497 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	003	3	8/29/2022	SUPPLEMENT FOR EXPANSION	$34,730
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	3	6/23/2022	NON-COMPETING CONTINUATION	$38,028
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	3	5/31/2022	SUPPLEMENT FOR EXPANSION	$9,486
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	3	11/22/2021	NON-COMPETING CONTINUATION	$342,253
														Subtotal = $424,497

Issue Date FY: 2021 ( Subtotal = $470,281 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	2	3/3/2021	NON-COMPETING CONTINUATION	$38,028
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	2	9/13/2021	SUPPLEMENT FOR EXPANSION	$90,000
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	2	11/20/2020	NON-COMPETING CONTINUATION	$342,253
														Subtotal = $470,281

Issue Date FY: 2020 ( Subtotal = $719,862 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	1	6/23/2020	SUPPLEMENT FOR EXPANSION	$199,361
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	1	11/29/2019	NEW	$380,281
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	1	8/19/2020	SUPPLEMENT FOR EXPANSION	$140,220
														Subtotal = $719,862

Grand Total All Awards = $2,829,963

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape Change

Award Number: R35GM135160

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer