Thursday, November 21, 2024 11/21/2024

Analytical pipelines for data and model integration: finding informed pathways for antimicrobial resistance control

Award Number: R35GM134934
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Routinely-collected data generated in surveillance and diagnostic laboratories and medical records contain information valuable for understanding the transmission of antimicrobial resistant pathogens. This information can be harnessed to inform transmission models and to design and evaluate mitigation strategies. However, current modeling approaches often focus on addressing one resistance on a pathogen at a time which leads to key features of resistant pathogen dynamics such as multidrug resistance and pathogen interactions to not be commonly addressed. In order to capitalize on the data being generated via surveillance and diagnostic activity, we propose to carry out the following research activities: 1) we will develop graphical models to integrate multiple data streams (phenotypic, genotypic resistances and metadata) to support analysis and visualization of complex resistant patterns and joint distribution of resistances, 2) we will apply and evaluate the analytical pipeline to data collected in national-level surveillance systems, 3) we will develop and evaluate agent-based models for pathogen transmission in health-care settings that incorporate multidrug resistance features and pathogen interactions and apply graphical modeling approaches to analyze and validate the models, and 4) we will disseminate the tools by creating open source packages and through website implementation. With the developed tools we will provide a path to quantify changes on complex resistance patterns over time or across sources, identify drugs that can lead to further selection of first choice drugs, identify cluster of risk factor for resistance and evaluate vaccination, antibiotic stewardship and heterogeneity interventions in the presence of pathogen and resistance interactions. The challenges of dealing with multiple streams of data and complex models are not unique to infectious disease research. The developed workflows will be applicable to a broad spectrum of biomedical research questions, particularly those that involve the collection of mixed data and simultaneous genotypic and phenotypic data. Similarly, agent-based models are increasingly used across all biomedical disciplines, from molecular biology to epidemiology, and therefore advances in their analyses can have a broader positive impact in multiple biomedical disciplines.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Biomedical Research and Research Training	000	5	11/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $427,994 )
2024	2024	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Biomedical Research and Research Training	000	5	12/21/2023	NON-COMPETING CONTINUATION	$385,195
2024	2024	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27695	WAKE	USA	Biomedical Research and Research Training	001	5	6/20/2024	NON-COMPETING CONTINUATION	$42,799
														Subtotal = $427,994

Issue Date FY: 2023 ( Subtotal = $427,994 )
2023	2023	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Biomedical Research and Research Training	000	4	12/15/2022	NON-COMPETING CONTINUATION	$385,195
2023	2023	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Biomedical Research and Research Training	001	4	2/17/2023	NON-COMPETING CONTINUATION	$42,799
														Subtotal = $427,994

Issue Date FY: 2022 ( Subtotal = $427,994 )
2022	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Biomedical Research and Research Training	000	3	1/4/2022	NON-COMPETING CONTINUATION	$385,195
2022	2022	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Biomedical Research and Research Training	001	3	6/28/2022	NON-COMPETING CONTINUATION	$42,799
														Subtotal = $427,994

Issue Date FY: 2021 ( Subtotal = $427,994 )
2021	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Biomedical Research and Research Training	001	2	2/25/2021	NON-COMPETING CONTINUATION	$42,799
2021	2021	NORTH CAROLINA STATE UNIVERSITY	2601 WOLF VILLAGE WAY	RALEIGH	NC	27607	WAKE	USA	Biomedical Research and Research Training	000	2	12/23/2020	NON-COMPETING CONTINUATION	$385,195
														Subtotal = $427,994

Issue Date FY: 2020 ( Subtotal = $427,994 )
2020	2020	NORTH CAROLINA STATE UNIVERSITY	2701 SULLIVAN DR STE 240	RALEIGH	NC	27695	WAKE	USA	Biomedical Research and Research Training	000	1	12/16/2019	NEW	$427,994
														Subtotal = $427,994

Grand Total All Awards = $2,139,970

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Analytical pipelines for data and model integration: finding informed pathways for antimicrobial resistance control

Award Number: R35GM134934

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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