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Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms

Award Number: R35GM134744
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary/Abstract The control of gene expression in mammals relies in part on modifications to cytosine residues in DNA, which exist in at least five forms: cytosine (C), 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC), 5- formylcytosine (5fC) and 5-carboxylcytosine (5caC). DNA methyltransferases methylate cytosine at the 5- position, generating 5mC in the genome. Ten-eleven translocation (Tet) dioxygenases convert 5mC to 5hmC, 5fC, and 5caC in three consecutive oxidation reactions. These modifications are dynamically regulated during development and cell differentiation. To understand the function of these modifications and the regulatory mechanisms that control the levels and genomic distribution of the five forms of the cytosine, we propose to study the enzymes/proteins that generate, read, and remove these DNA modifications as well as associated histone methylation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $526,340 )
2024	2024	THE UNIVERISTY OF TEXAS MD ANDERSON CANCER CENTER, A COMPONENT OF THE UNIVERISTY OF TEXAS SYSTEM	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	5	1/10/2024	NON-COMPETING CONTINUATION	$526,340
														Subtotal = $526,340

Issue Date FY: 2023 ( Subtotal = $834,820 )
2023	2023	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	001	4	3/24/2023	NON-COMPETING CONTINUATION	$58,480
2023	2023	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	002	4	7/27/2023	SUPPLEMENT FOR EXPANSION	$250,000
2023	2023	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	4	12/19/2022	NON-COMPETING CONTINUATION	$526,340
														Subtotal = $834,820

Issue Date FY: 2022 ( Subtotal = $584,820 )
2022	2022	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	3	12/31/2021	NON-COMPETING CONTINUATION	$526,341
2022	2022	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	001	3	7/22/2022	NON-COMPETING CONTINUATION	$58,479
														Subtotal = $584,820

Issue Date FY: 2021 ( Subtotal = $584,820 )
2021	2021	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	2	12/11/2020	NON-COMPETING CONTINUATION	$526,340
2021	2021	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	001	2	3/4/2021	NON-COMPETING CONTINUATION	$58,480
														Subtotal = $584,820

Issue Date FY: 2020 ( Subtotal = $584,820 )
2020	2020	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Biomedical Research and Research Training	000	1	12/24/2019	NEW	$584,820
														Subtotal = $584,820

Grand Total All Awards = $3,115,620

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Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and Mechanisms

Award Number: R35GM134744

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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