Wednesday, July 16, 2025 7/16/2025

The control of gene expression by eukaryotic ribonucleases

Award Number: R35GM130370
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2029

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The control of gene expression by eukaryotic ribonucleases - Project Summary/Abstract RNA processing and degradation mechanisms play critical functions in the control of gene expression. Not only do they regulate global transcripts abundance, but they also provide quality control mechanisms to eliminate improperly processed or mis-localized transcripts. Work in our laboratory focuses on two main aspects of RNA-based regulatory processes. The first axis of research is focused on the function of nuclear ribonucleases and of nuclear RNA degradation pathways. Nuclear RNA processing and degradation by the RNA exosome, RNase III and the Rex exonucleases play important roles in ribosome biogenesis and in controlling expression of genes in response to stress. Work presented in this proposal will focus on determining the function of nuclear ribonucleases on regulating the expression of key chromatin remodeling factors during stress and on identifying the role of the cancer-linked ribonuclease Rexo4 in mammalian ribosomal RNA processing. The second area of focus of our group is to understand the impact of splicing inactivation on global gene expression. We have analyzed the function of splicing factors in vivo using RNA sequencing and shown that splicing inactivation results in the accumulation of hybrid mRNA-snoRNA (hmsnoRNAs) species which accumulate in the cytoplasm. We will continue these studies by investigating the function of several conserved splicing factors in global gene expression and by analyzing the global impact of splicing inactivation on the proteome, including the translation of hmsnoRNAs. Overall, the proposed studies are expected to have a high impact on our understanding of the mechanisms by which post-transcriptional processes globally regulate gene expression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $450,765 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	003	7	5/14/2025	NON-COMPETING CONTINUATION	$450,765
2025	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	002	6	11/18/2024	COMPETING CONTINUATION	$113,565
2025	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	6	11/15/2024	COMPETING CONTINUATION	$0
2025	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	5	11/18/2024	NON-COMPETING CONTINUATION	-$113,565
														Subtotal = $450,765

Issue Date FY: 2024 ( Subtotal = $450,765 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	6	7/12/2024	COMPETING CONTINUATION	$450,765
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	002	5	7/23/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	5	7/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $450,765

Issue Date FY: 2023 ( Subtotal = $394,636 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	5	3/24/2023	NON-COMPETING CONTINUATION	$39,464
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	5	12/22/2022	NON-COMPETING CONTINUATION	$355,172
														Subtotal = $394,636

Issue Date FY: 2022 ( Subtotal = $394,636 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	4	7/25/2022	NON-COMPETING CONTINUATION	$39,465
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	4	12/9/2021	NON-COMPETING CONTINUATION	$355,171
														Subtotal = $394,636

Issue Date FY: 2021 ( Subtotal = $394,636 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Biomedical Research and Research Training	001	3	3/4/2021	NON-COMPETING CONTINUATION	$39,465
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Biomedical Research and Research Training	000	3	12/11/2020	NON-COMPETING CONTINUATION	$355,171
														Subtotal = $394,636

Issue Date FY: 2020 ( Subtotal = $394,636 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Biomedical Research and Research Training	001	2	3/12/2020	NON-COMPETING CONTINUATION	$39,465
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Biomedical Research and Research Training	000	2	1/1/2020	NON-COMPETING CONTINUATION	$355,171
														Subtotal = $394,636

Issue Date FY: 2019 ( Subtotal = $394,636 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Biomedical Research and Research Training	000	1	12/11/2018	NEW	$394,636
														Subtotal = $394,636

Grand Total All Awards = $2,874,710

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The control of gene expression by eukaryotic ribonucleases

Award Number: R35GM130370

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2029

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