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Ultrafast bioimaging

Award Number: R35GM128761
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2018
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Ultrafast bioimaging - Project Summary: This renewal application aims to support the PI in developing an intelligent ultrafast bioimaging program that could open a new area of investigation and lead to a series of fundamental scientific discoveries. Space and time, two critical physical dimensions, constitute the basis of modern metrology. In bio- imaging, as recognized by the 2014 Nobel Prize in chemistry, there have been breathtaking advances in improving spatial resolution, resulting in an impressive arsenal of nanoscopic tools that can break the diffraction limit of light. Despite the importance, pursuing a high temporal resolution has only recently gained attention. The motivation to develop methods for ultrafast imaging originates from the landscape shift of contemporary biology from morphological explorations and phenotypic probing of organisms to seeking quantitative insights into underlying mechanisms at molecular levels. The transient molecular events occur at a timescale varying from a few nanoseconds that molecules glow in their fluorescence lifetime to tens of femtoseconds that molecules take to vibrate. Therefore, ultrafast imaging is essential for observing and characterizing such dynamic events. With support from an ESI MIRA grant, we have established a highly productive research program and developed several ultrafast imaging tools that showed great potential for biological studies. However, several key challenges are still yet to be addressed, such as low light-detection sensitivity at high speed. To solve these problems and further expand the realm of our program, I propose to bring in artificial intelligence and explore a new research direction, intelligent ultrafast bioimaging. Our core idea is to treat an optical imaging system as an encoder-decoder pair, where the imaging system optically encodes a scene on the sensor by physical measurements; an electronic decoder then estimates the object's properties from the raw sensor data. Rather than directly measuring the properties of a biological system, we will acquire encoded measurements through a computational imaging scheme. We will also develop physics-informed machine-learning methods to seamlessly integrate data with physics models in biological systems and codesign the machine-learning algorithms with ultrafast imaging hardware in a holistic manner as an end-to-end optimization problem. We expect that such synergy will lead to a new generation of ultrafast imagers and ultimately reshape many fields in biomedical research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $456,032 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	9	4/2/2026	NON-COMPETING CONTINUATION	$456,032
														Subtotal = $456,032

Issue Date FY: 2025 ( Subtotal = $456,032 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	8	4/11/2025	NON-COMPETING CONTINUATION	$456,032
2025	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	7	11/21/2024	COMPETING CONTINUATION	$0
														Subtotal = $456,032

Issue Date FY: 2024 ( Subtotal = $455,805 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	7	4/18/2024	COMPETING CONTINUATION	$455,805
2024	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	6	3/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $455,805

Issue Date FY: 2022 ( Subtotal = $379,665 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	000	6	9/6/2022	NON-COMPETING CONTINUATION	$379,665
														Subtotal = $379,665

Issue Date FY: 2021 ( Subtotal = $351,966 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	002	5	8/30/2021	NON-COMPETING CONTINUATION	$351,966
2021	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Biomedical Research and Research Training	001	3	6/27/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$52,516
2021	2019	UNIVERSITY OF ILLINOIS	352 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	2	6/27/2021	NON-COMPETING CONTINUATION	-$52,516
														Subtotal = $351,966

Issue Date FY: 2020 ( Subtotal = $312,596 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Biomedical Research and Research Training	003	4	8/20/2020	NON-COMPETING CONTINUATION	$357,858
2020	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	2	7/13/2020	NON-COMPETING CONTINUATION	-$291,175
2020	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Biomedical Research and Research Training	002	3	7/13/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$395,440
2020	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	001	2	7/13/2020	SUPPLEMENT FOR EXPANSION	-$149,527
														Subtotal = $312,596

Issue Date FY: 2019 ( Subtotal = $499,147 )
2019	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	001	2	8/20/2019	SUPPLEMENT FOR EXPANSION	$149,527
2019	2019	UNIVERSITY OF ILLINOIS	364 HENRY ADMINISTRATION BLDG	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	2	7/30/2019	NON-COMPETING CONTINUATION	$349,620
														Subtotal = $499,147

Issue Date FY: 2018 ( Subtotal = $320,320 )
2018	2018	UNIVERSITY OF ILLINOIS	506 S WRIGHT ST STE 364	URBANA	IL	61801	CHAMPAIGN	USA	Biomedical Research and Research Training	000	1	7/31/2018	NEW	$320,320
														Subtotal = $320,320

Grand Total All Awards = $3,231,563

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Ultrafast bioimaging

Award Number: R35GM128761

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2018

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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