Monday, February 16, 2026 2/16/2026

Mechanisms and impacts of chromatin looping

Award Number: R35GM128645
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/19/2018
PERIOD OF PERFORMANCE END DATE: 12/31/2028

Group Awards By:

View Award Description

Mechanisms and impacts of chromatin looping - Project Abstract Chromatin looping is thought to play a critical role in gene regulation, human development, and response to external stimuli by connecting regulatory loci with gene promoters. Most chromatin loops are thought to form via loop extrusion; however, recent work has uncovered loops and other chromatin structures formed via phase separation. How these loops form and how they impact gene transcription and other phenotypes remains poorly understood in part because they have only been studied in a handful of contexts and in part because we lack the adequate tools to study them. The goal of this research is to develop new computational and experimental tools to study 3D chromatin structure and to apply these tools to understand the mechanisms and impacts of phase separation-driven chromatin loops. We will map and characterize phase separation- driven chromatin loops formed in response to various external stimuli (project 1). We will develop experimental tools to manipulate these loops and apply them to explore their mechanisms of formation, quantify their impact on gene transcription, and identify molecules that can disrupt them (project 2). And we will develop computational tools that will enable robust analysis, interpretation, and visualization of these newly discovered 3D chromatin structures (project 3). The results of this research will determine both the scope and general principles of phase separation-driven looping and provide new tools for the gene regulation community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $410,940 )
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	8	1/19/2026	NON-COMPETING CONTINUATION	$410,940
														Subtotal = $410,940

Issue Date FY: 2025 ( Subtotal = $456,600 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	7	12/24/2024	NON-COMPETING CONTINUATION	$410,940
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	7	8/14/2025	NON-COMPETING CONTINUATION	$45,660
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	6	11/14/2024	COMPETING CONTINUATION	$0
														Subtotal = $456,600

Issue Date FY: 2024 ( Subtotal = $456,600 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	003	6	6/5/2024	COMPETING CONTINUATION	$52,800
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	001	6	12/18/2023	COMPETING CONTINUATION	$456,600
2024	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	002	5	6/5/2024	NON-COMPETING CONTINUATION	-$52,800
2024	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	5	12/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $456,600

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	5	8/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $383,163 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	5	6/15/2022	NON-COMPETING CONTINUATION	$383,163
														Subtotal = $383,163

Issue Date FY: 2021 ( Subtotal = $383,326 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	4	6/2/2021	NON-COMPETING CONTINUATION	$383,326
														Subtotal = $383,326

Issue Date FY: 2020 ( Subtotal = $383,484 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	3	6/19/2020	NON-COMPETING CONTINUATION	$383,484
														Subtotal = $383,484

Issue Date FY: 2019 ( Subtotal = $532,427 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	2	7/1/2019	NON-COMPETING CONTINUATION	$383,637
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Trans-NIH Research Support	001	2	9/16/2019	SUPPLEMENT FOR EXPANSION	$148,790
														Subtotal = $532,427

Issue Date FY: 2018 ( Subtotal = $382,407 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Biomedical Research and Research Training	000	1	7/19/2018	NEW	$382,407
														Subtotal = $382,407

Grand Total All Awards = $3,388,947

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Mechanisms and impacts of chromatin looping

Award Number: R35GM128645

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/19/2018

PERIOD OF PERFORMANCE END DATE: 12/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer